{"id":39364,"date":"2022-03-07T00:15:44","date_gmt":"2022-03-06T16:15:44","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=39364"},"modified":"2022-02-10T09:48:41","modified_gmt":"2022-02-10T01:48:41","slug":"%e6%9e%9c%e8%a0%85%e6%98%af%e9%87%8f%e8%ba%ab%e8%a8%82%e4%bd%9c%e7%99%8c%e7%97%87%e7%b2%be%e6%ba%96%e9%86%ab%e7%99%82%e7%9a%84%e5%b9%95%e5%be%8c%e6%8e%a8%e6%89%8b","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=39364","title":{"rendered":"\u679c\u8805\u662f\u91cf\u8eab\u8a02\u4f5c\u764c\u75c7\u7cbe\u6e96\u91ab\u7642\u7684\u5e55\u5f8c\u63a8\u624b"},"content":{"rendered":"
\"\"<\/a>
\u5716\u7247\u4f86\u6e90:motionelements.com<\/figcaption><\/figure>\n

 <\/strong>\u679c\u8805\u662f\u6700\u4f73\u7684\u751f\u547d\u79d1\u5b78\u7814\u7a76\u6a21\u5f0f\u751f\u7269\u4e4b\u4e00\uff0c\u7279\u5225\u662f\u5728\u907a\u50b3\u5b78\u7684\u767c\u5c55\u4e0a\u3002\u5efa\u7acb\u5728\u524d\u4eba\u7684\u7814\u7a76\u6210\u679c\u4e4b\u4e0a\uff0c\u73fe\u4eca\u8a31\u591a\u7684\u751f\u7269\u57fa\u56e0\u5df2\u7d93\u5b8c\u5168\u89e3\u78bc\uff0c\u5305\u542b\u4eba\u985e\u5728\u5167\uff0c\u76ee\u524d\u66f4\u767c\u73fe\u679c\u8805\u6709\u90e8\u5206\u57fa\u56e0\u8207\u4eba\u985e\u6975\u70ba\u76f8\u4f3c\uff0c\u8b93\u4eba\u5011\u4e0d\u53ea\u5f9e\u5206\u5b50\u751f\u7269\u7684\u5c64\u7d1a\u8a8d\u8b58\u4e0d\u540c\u7684\u7269\u7a2e\uff0c\u77ad\u89e3\u7269\u7a2e\u6f14\u5316\u3001\u9077\u79fb\u53ca\u6027\u72c0\u8868\u73fe\u7684\u6a5f\u5236\uff0c\u6700\u8fd1\u79d1\u5b78\u5bb6\u66f4\u5c07\u9019\u9805\u5de5\u5177\u61c9\u7528\u65bc\u75be\u75c5\u7684\u5206\u6790\uff0c\u7576\u524d\u6700\u4ee4\u4eba\u632f\u596e\u7684\u5c31\u662f\u764c\u75c7\u76f8\u95dc\u7684\u7814\u7a76\uff0c\u672a\u4f86\u53ef\u671b\u85c9\u7531\u5efa\u7acb\u679c\u8805\u7684\u591a\u57fa\u56e0\u6a21\u7d44\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u8a2d\u8a08\u8a02\u4f5c\u500b\u4eba\u5316\u7684\u7cbe\u6e96\u6cbb\u7642\u3002<\/strong><\/span><\/p>\n

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\u5728 2016\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u5206\u6790\u7d50\u8178\u764c\u7684\u57fa\u56e0\u5f8c\uff0c\u767c\u73fe\u67d0\u4e9b\u7d50\u8178\u764c\u60a3\u8005\u662f\u7531\u55ae\u4e00\u7684 rasG12V \u57fa\u56e0\u8b8a\u7570\u6240\u9020\u6210\uff0c\u800c\u67d0\u4e9b\u60a3\u8005\u7684\u81f4\u764c\u6a5f\u5236\u5247\u662f\u7531 rasG12V\u3001p53RNAi\u3001ptenRNAi\u53ca apcRNAi \u56db\u7a2e\u57fa\u56e0\u540c\u6642\u8abf\u63a7\u3002\u56e0\u6b64\uff0c\u4ed6\u5011\u5c07\u4eba\u985e\u7d50\u8178\u764c\u7684\u57fa\u56e0\u8f49\u6b96\u5230\u679c\u8805\u8eab\u4e0a\uff0c\u5728\u679c\u8805\u57fa\u56e0\u4e2d\u5efa\u7acb\u76f8\u5c0d\u61c9\u7684\u591a\u57fa\u56e0\u6a21\u7d44\uff0c\u9664\u4e86\u89c0\u5bdf\u8f49\u6b96\u57fa\u56e0\u5c0d\u679c\u8805\u7d50\u8178\u9020\u6210\u7684\u751f\u7406\u8b8a\u5316\uff0c\u66f4\u5728\u7814\u7a76\u904e\u7a0b\u4e2d\u986f\u73fe\u4e86\u4eba\u985e\u7d50\u8178\u764c\u7684\u75be\u75c5\u7279\u5fb5\u3002\u6b64\u5916\uff0c\u4ed6\u5011\u4f7f\u7528 16 \u7a2e\u4e0d\u540c\u7684\u6a19\u9776\u85e5\u7269\u9032\u884c\u6e2c\u8a66\uff0c\u767c\u73fe\u7576\u764c\u75c7\u50c5\u7531\u4e00\u500b rasG12V \u57fa\u56e0\u8abf\u63a7\u6642\uff0c\u670912 \u7a2e\u85e5\u7269\u53ef\u4ee5\u6291\u5236\u764c\u7d30\u80de\u751f\u9577\uff0c\u800c\u7576\u56db\u7a2e\u57fa\u56e0\u540c\u6642\u53c3\u8207\u764c\u7d30\u80de\u8868\u73fe\u6642\uff0c\u55ae\u7368\u4f7f\u7528\u4efb\u4f55\u6a19\u9776\u85e5\u7269\u90fd\u7121\u6548\uff0c\u986f\u793a\u591a\u57fa\u56e0\u6a21\u7d44\u5728\u8a98\u767c\u764c\u75c7\u4ee5\u53ca\u85e5\u7269\u6297\u85e5\u6027\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272\uff0c\u4ea6\u8b49\u660e\u9019\u500b\u6a21\u7d44\u53ef\u4ee5\u5354\u52a9\u77ad\u89e3\u4e0d\u540c\u57fa\u56e0\u7684\u81f4\u764c\u6f5b\u80fd\uff08tumorgenic potential\uff09\u8207\u8f49\u79fb\u6f5b\u80fd\uff08etastatic potential\uff09\u3002<\/p>\n

\u5728 2019\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u958b\u767c\u4e00\u7a2e\u500b\u4eba\u5316\u6cbb\u7642\u7684\u65b0\u65b9\u6cd5\u4ee5\u6cbb\u7642\u8010\u85e5\u7684\u8f49\u79fb\u6027 KRAS \u7a81\u8b8a\u578b\u7d50\u8178\u76f4\u8178\u764c\u60a3\u8005\u3002\u4ed6\u5011\u5c0d\u816b\u7624\u57fa\u56e0\u7d44\u9032\u884c\u5ee3\u6cdb\u5206\u6790\u78ba\u5b9a\u4e86\u4e5d\u500b\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\uff0c\u958b\u767c\u4e86\u6539\u8b8a\u679c\u8805\u5f8c\u8178\u4e2d\u4e5d\u500b\u57fa\u56e0\u7684\u76f4\u7cfb\u540c\u6e90\u7269\u7684\u8f49\u57fa\u56e0\u6a21\u578b\uff0c\u4f7f\u7528\u8a72\u5e73\u53f0\u7684\u4eba\u5de5\u667a\u6167\u7be9\u9078\u78ba\u5b9a\u66f2\u7f8e\u66ff\u5c3c\u52a0\u4e0a\u5511\u4f86\u81a6\u9178\u9e7d\uff08trametinib plus zoledronate\uff09\u4f5c\u70ba\u5019\u9078\u6cbb\u7642\u7d44\u5408\u3002\u4ed6\u5011\u767c\u73fe\u6b64\u7a2e\u6cbb\u7642\u7d44\u5408\u5c0d\u60a3\u8005\u7522\u751f\u4e86\u986f\u8457\u7684\u53cd\u61c9\uff0c\u76ee\u6a19\u548c\u975e\u76ee\u6a19\u75c5\u8b8a\u8868\u73fe\u51fa\u5f37\u70c8\u7684\u90e8\u5206\u53cd\u61c9\uff0c\u4e26\u5728 11 \u500b\u6708\u5167\u4fdd\u6301\u7a69\u5b9a\u3002\u986f\u73fe\u85c9\u7531\u89e3\u6c7a\u75be\u75c5\u7684\u57fa\u56e0\u7d44\u8907\u96dc\u6027\uff0c\u9019\u7a2e\u500b\u4eba\u5316\u6cbb\u7642\u65b9\u6cd5\u53ef\u4ee5\u70ba\u9811\u56fa\u6027\u75be\u75c5\uff08\u5982 KRAS \u7a81\u8b8a\u578b\u7d50\u8178\u76f4\u8178\u764c\uff09\u63d0\u4f9b\u4e00\u500b\u66ff\u4ee3\u6cbb\u7642\u7684\u9078\u64c7\u3002<\/p>\n

\u5728 2021\u5e74\uff0c\u5df4\u57fa\u65af\u5766\u7814\u7a76\u4eba\u54e1\u63d0\u51fa\u4e86\u679c\u8805\u4e2d\u8178\u4e0a\u76ae\u7d30\u80de\u5167\u751f\u7269\u5206\u5b50\u8abf\u63a7\u7684\u4e94\u500b\u6a21\u578b\uff0c\u4e26\u4f7f\u7528\u7d50\u8178\u76f4\u8178\u764c\u60a3\u8005\u7279\u7570\u6027\u7a81\u8b8a\u6578\u64da\u5c0d\u4e4b\u9032\u884c\u8a6e\u91cb\uff0c\u7528\u4f86\u958b\u767c\u85c9\u52a9\u96fb\u8166\u6a21\u64ec\u7684\u679c\u8805\uff0d\u75c5\u60a3\u6a21\u578b \uff08in silico Drosophila Patient Model, DPM\uff09\u3002\u4ed6\u5011\u4f7f\u7528\u7d30\u80de\u985e\u578b\u7279\u7570\u6027 RNA-seq \u57fa\u56e0\u8868\u9054\u6578\u64da\u4f86\u8a6e\u91cb\u4e26\u9a57\u8b49\u9019\u4e9b\u6a21\u578b\uff0c\u63a5\u8457\u958b\u767c\u4e86\u4e09\u500b\u7d50\u8178\u76f4\u8178\u764c\u6848\u4f8b\u7814\u7a76\u4ee5\u8a55\u4f30\u6a21\u578b\u4e2d\u7684\u7d30\u80de\u547d\u904b\u3002DPM \u5206\u6790\u7372\u5f97\u7684\u7d50\u679c\u6709\u52a9\u65bc\u4e0b\u5217\u4e8b\u9805\u7684\u767c\u5c55\uff1a\uff081\uff09\u95e1\u660e\u7d50\u8178\u76f4\u8178\u816b\u7624\u767c\u751f\u904e\u7a0b\u7684\u7d30\u80de\u547d\u904b\u6f14\u8b8a\uff1b\uff082\uff09\u9a57\u8b49\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7684\u4e5d\u7a2e\u7d50\u8178\u76f4\u8178\u764c\u85e5\u7269\u7684\u7d30\u80de\u6bd2\u6027\uff1b\uff083\uff09\u8a2d\u8a08\u6700\u4f73\u7684\u500b\u4eba\u5316\u6cbb\u7642\u7d44\u5408\u3002\u500b\u4eba\u5316\u6cbb\u7642\u6a21\u578b\u6709\u52a9\u65bc\u78ba\u5b9apaclitaxel-regorafenib\u3001paclitaxel-bortezomib\u3001docetaxel-bortezomib \u6216paclitaxel-imatinib\u7684\u85e5\u7269\u5354\u540c\u7d44\u5408\uff0c\u7528\u65bc\u6cbb\u7642\u4e0d\u540c\u7684\u7d50\u8178\u76f4\u8178\u764c\u60a3\u8005\u3002\u4ed6\u5011\u4f7f\u7528\u9019\u56db\u7a2e\u85e5\u7269\u7d44\u5408\u5c0d6 \u540d\u7d50\u8178\u76f4\u8178\u764c\u60a3\u8005\u9032\u884c\u5f8c\u7e8c\u6cbb\u7642\uff0c\u986f\u793a\u764c\u7d30\u80de\u51cb\u4ea1\u589e\u52a0 100%\uff0c\u4f46\u662f\u589e\u6b96\u537b\u6e1b\u5c11 100%\uff0c\u7814\u7a76\u7d50\u679c\u6982\u8ff0\u4e86\u7d50\u8178\u76f4\u8178\u816b\u7624\u767c\u751f\u7684\u65b0\u8def\u7dda\u53ca\u7528\u65bc\u500b\u4eba\u5316\u7d44\u5408\u7642\u6cd5\u7684\u767c\u5c55\u3002<\/p>\n

\u4e0a\u8ff0\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u63ed\u793a\u4e86\u764c\u75c7\u6cbb\u7642\u7684\u65b0\u5951\u6a5f\uff0c\u5c07\u4f86\u53ef\u4ee5\u900f\u904e\u764c\u7d30\u80de\u63a1\u6a23\u53ca\u57fa\u56e0\u5b9a\u5e8f\uff0c\u4ee5\u5efa\u7acb\u500b\u4eba\u5316\u7684\u764c\u75c7\u57fa\u56e0\u6a21\u7d44\uff0c\u4e26\u5c07\u76f8\u5c0d\u61c9\u7684\u57fa\u56e0\u8f49\u6b96\u81f3\u679c\u8805\uff0c\u85c9\u6b64\u6a21\u578b\u9032\u884c\u6e2c\u8a66\u548c\u7be9\u9078\u5404\u7a2e\u4e0d\u540c\u7684\u6a19\u9776\u85e5\u7269\uff0c\u4e26\u8a55\u4f30\u85e5\u7269\u6548\u679c\uff0c\u70ba\u764c\u75c7\u60a3\u8005\u8a2d\u8a08\u8a02\u4f5c\u5c08\u5c6c\u7684\u7cbe\u6e96\u6cbb\u7642\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

    \n
  1. Bangi E, Murgia C, Teague A, Smibert P, Esernio J, Gruszczynski N, Yeykal C, Sansom O and Cagan R. Abstract 34: A Drosophila approach to personalized cancer therapeutics. Clinical Cancer Research, January 1, 2016. doi:<\/strong>10.1158\/1557-3265.<\/li>\n
  2. Gondal MN, Butt RN, Shah OS, Sultan MU, Mustafa G, Nasir Z, Hussain R, Khawar H, Qazi R, Tariq M, Faisal A, Chaudhary SU. A Personalized Therapeutics Approach Using an In Silico Drosophila Patient Model Reveals Optimal Chemo- and Targeted Therapy Combinations for Colorectal Cancer. Front Oncol. 2021 Jul 16;11:692592. doi: 10.3389\/fonc.2021.692592. eCollection 2021.<\/li>\n
  3. Bangi E, Ang C, Smibert P, Uzilov AV, Teague AG, Antipin Y, Chen R, Hecht C, Gruszczynski N, Yon WJ, Malyshev D, Laspina D, Selkridge I, Rainey H, Moe AS, Lau CY, Taik P, Wilck E, Bhardwaj A, Sung M, Kim S, Yum K, Sebra R, Donovan M, Misiukiewicz K, Schadt EE, Posner MR, Cagan RL. A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer. Sci Adv. 2019 May 22;5(5):eaav6528. doi: 10.1126\/sciadv.aav6528. eCollection 2019 May.<\/li>\n
  4. Das T, Cagan R. Drosophila as a novel therapeutic discovery tool for thyroid cancer. Thyroid. 2010 Jul;20(7):689-95. doi: 10.1089\/thy.2010.1637..<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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