{"id":39363,"date":"2022-03-01T00:15:43","date_gmt":"2022-02-28T16:15:43","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=39363"},"modified":"2022-01-18T10:31:25","modified_gmt":"2022-01-18T02:31:25","slug":"%e6%94%9d%e5%8f%96%e7%b4%85%e8%82%89%e6%9c%83%e5%a2%9e%e5%8a%a0%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e7%97%85%e9%a2%a8%e9%9a%aa","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=39363","title":{"rendered":"\u651d\u53d6\u7d05\u8089\u6703\u589e\u52a0\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa"},"content":{"rendered":"

\u8089\u985e\u662f\u88dc\u5145\u86cb\u767d\u8cea\u3001\u7926\u7269\u8cea\u53ca\u7dad\u751f\u7d20\u7684\u91cd\u8981\u4f86\u6e90\uff0c\u53d7\u5230\u990a\u751f\u98a8\u6f6e\u5f71\u97ff\uff0c\u5f88\u591a\u4eba\u5728\u6311\u9078\u8089\u985e\u6642\uff0c\u6703\u5728\u7d05\u8089\u8207\u767d\u8089\u4e4b\u9593\u518d\u4e09\u601d\u91cf\uff0c\u8a8d\u70ba\u767d\u8089\u6bd4\u8f03\u5065\u5eb7\uff0c\u800c\u7d05\u8089\u6bd4\u8f03\u4e0d\u5065\u5eb7\u3002\u78ba\u5be6\uff0c\u651d\u53d6\u7d05\u8089\u6703\u589e\u52a0\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\uff0c\u8178\u9053\u83cc\u4ee3\u8b1d\u526f\u7522\u7269\uff0d\u6c27\u5316\u4e09\u7532\u80fa\uff08TMAO\uff09\u662f\u589e\u52a0\u7f79\u75c5\u7387\u7684\u91cd\u8981\u56e0\u5b50\uff08\u81b3\u98df\u8089\u9e7c \u2192 \u03b3BB \u2192 TMA \u2192 TMAO\uff09\u3002\u7279\u5b9a\u57fa\u56e0\u7fa4gbu<\/em>\u7684\u53ad\u6c27\u83cc\u6703\u4e3b\u5c0e TMA\u7684\u4ee3\u8b1d\uff0c\u98f2\u98df\u689d\u4ef6\u5de6\u53f3\u5fae\u751f\u7269 gbuA  <\/em>\u57fa\u56e0\u7684\u6d3b\u6027\uff0c\u651d\u53d6\u7d05\u8089\u6703\u63d0\u9ad8\u5fae\u751f\u7269\u7684 gbuA <\/em>\u57fa\u56e0\u8868\u73fe\u91cf\uff0c\u9032\u800c\u8a98\u767c\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u81f4\u75c5\u56e0\u5b50\u7522\u751f\u3002<\/strong><\/span><\/p>\n

\"\"<\/a>
\u5716\u7247\u4f86\u6e90\uff1aPixabay<\/figcaption><\/figure>\n

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\u7d05\u8089\u548c\u767d\u8089\u7684\u5340\u5206<\/strong><\/span><\/p>\n

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\u7d05\u8089\u53ef\u80fd\u81f4\u764c\u4e14\u98fd\u548c\u8102\u80aa\u9178\u504f\u9ad8 <\/strong><\/span><\/p>\n

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\u7d05\u8089\u4ee3\u8b1d\u7269\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u95dc\u806f\u6027<\/strong><\/span><\/p>\n

\u76ee\u524d\u5df2\u77e5\u7d05\u8089\u5728\u4eba\u9ad4\u4e2d\u7684\u4ee3\u8b1d\u526f\u7522\u7269\uff0d\u6c27\u5316\u4e09\u7532\u80fa\uff08trimethylamine N-oxide, TMAO\uff09\u662f\u589e\u52a0\u7f79\u75c5\u7387\u7684\u91cd\u8981\u56e0\u5b50\u3002\u8089\u9e7c\uff08carnitine\uff09\u662f\u8089\u54c1\u4e2d\u542b\u6709\u7684\u5929\u7136\u7269\u8cea\uff0c\u53ef\u5354\u52a9\u5c07\u8102\u80aa\u9178\u9001\u5165\u7c92\u7dda\u9ad4\u5167\u9032\u884c\u4ee3\u8b1d\uff0c\u8a31\u591a\u8178\u9053\u5fae\u751f\u7269\u53ef\u5c07\u8089\u9e7c\u8f49\u63db\u70ba \u03b3BB\uff08gamma-butyrobetaine\uff09\uff0c\u4f46\u5f88\u5c11\u518d\u53c3\u8207\u5c07 \u03b3BB \u4ee3\u8b1d\u70ba\u4e09\u7532\u80fa\uff08trimethylamine\uff0cTMA\u662fTMAO \u7684\u524d\u9a45\u7269\uff09\u7684\u904e\u7a0b \u3002<\/p>\n

\u57282021\u5e74\uff0c\u7f8e\u570b\u79d1\u5b78\u5bb6\u5728\u4e00\u7bc7\u767c\u8868\u65bc\u300aNature Microbiology\u300b\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5df2\u767c\u73fe\u7d05\u8089\u4ee3\u8b1d\u7269\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u9593\u7684\u5206\u5b50\u4f5c\u7528\u6a5f\u5236\uff0c\u4ed6\u5011\u767c\u73fe\u7279\u5b9a\u8178\u9053\u5fae\u751f\u7269\u7fa4\u6703\u5c07\u651d\u53d6\u8089\u985e\u7684\u4e2d\u9593\u4ee3\u8b1d\u7269\u8f49\u63db\u70ba TMAO \u7684\u524d\u9a45\u7269\uff0c\u6700\u7d42\u589e\u52a0\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u6a5f\u7387\uff1b\u76f8\u53cd\u7684\uff0c\u7d20\u98df\u8005\u7f79\u75c5\u6a5f\u7387\u5247\u8f03\u4f4e\u3002\u4ed6\u5011\u9996\u5148\u5f9e\u8fd1 3,000 \u540d\u53d7\u8a66\u8005\u8840\u6e05\u6a23\u672c\u5206\u6790 \u03b3BB \u6fc3\u5ea6\uff0c\u78ba\u8a8d \u03b3BB \u6fc3\u5ea6\u8d8a\u9ad8\uff0c\u60a3\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u6216\u4e2d\u98a8\u98a8\u96aa\u4e5f\u76f8\u5c0d\u63d0\u5347\u3002\u70ba\u4e86\u89e3\u54ea\u4e9b\u5fae\u751f\u7269\u7fa4\u53c3\u8207\u81f4\u75c5\u56e0\u5b50 TMA \u7684\u4ee3\u8b1d\u9014\u5f91\uff0c\u4ed6\u5011\u63a5\u8457\u4ee5\u53d7\u8a66\u8005\u7684\u7cde\u4fbf\u6a23\u672c\u9032\u884c\u5fae\u751f\u7269\u57f9\u990a\uff0c\u78ba\u8a8d\u53ad\u6c27\u83cc Emergencia timonensis<\/em> \u662f\u5728\u9ad4\u5167\u5c07 \u03b3BB \u4ee3\u8b1d\u70ba TMA \u7684\u4e3b\u8981\u83cc\u7a2e\uff0c\u518d\u5c07\u6b64\u83cc\u9032\u884c DNA \u5b9a\u5e8f\uff0c\u767c\u73fe 6 \u500b\u57fa\u56e0\u7684gbu<\/em>\u57fa\u56e0\u7c07\uff08\u03b3BB utilization gbu<\/em> gene cluster\uff09\u5728 \u03b3BB \u9ad8\u6fc3\u5ea6\u7684\u689d\u4ef6\u4e0b\uff0c\u57fa\u56e0\u8868\u73fe\u91cf\u6703\u589e\u52a0\u3002\u7d50\u5408\u57fa\u56e0\u9078\u6b96\u548c\u529f\u80fd\u7814\u7a76\u78ba\u5b9a\u4e86\u56db\u7a2egbu<\/em>\u57fa\u56e0\uff08gbuA<\/em>\u3001gbuB<\/em>\u3001gbu<\/em>C \u548c gbuE<\/em>\uff09\u5728\u5927\u8178\u687f\u83cc\u4e2d\u5171\u540c\u8868\u9054\u6642\uff0c\u9019\u4e9b\u57fa\u56e0\u662f\u5fc5\u8981\u7684\u4e14\u8db3\u4ee5\u91cd\u8ff0\uff08recapitulate\uff09\u03b3BB \u5411 TMA \u7684\u8f49\u5316\u904e\u7a0b\u3002 \u7814\u7a76\u5718\u968a\u6700\u5f8c\u91dd\u5c0d\u4f86\u81ea\u81e8\u5e8a\u96a8\u6a5f\u98f2\u98df\u5e72\u9810\uff08diet intervention\uff09\u7814\u7a76\u7684\u6a23\u672c (n = 113) \u9032\u884c\u5206\u6790\uff0c\u986f\u73fe\u53d7\u8a66\u8005\u7cde\u4fbf\u6aa2\u9ad4\u4e2d\u5fae\u751f\u7269\u7684 gbuA<\/em> \u57fa\u56e0\u8868\u73fe\u8207\u8840\u6e05\u4e2d\u7684 TMAO \u6210\u6b63\u76f8\u95dc\u6027\uff0c\u53ef\u78ba\u8a8dEmergencia timonensis<\/em>\u53c3\u8207\u7d05\u8089\u7684 \u03b3BB \u4ee3\u8b1d\u904e\u7a0b\u3002\u7814\u7a76\u7d50\u679c\u63ed\u793a\u4e86\u4e00\u500b\u5fae\u751f\u7269\u57fa\u56e0\u7c07\u5c0d\u65bc\u81b3\u98df\u8089\u9e7c \u2192 \u03b3BB \u2192 TMA \u2192 TMAO\u5728\u5bbf\u4e3b\u4e2d\u7684\u8f49\u5316\u81f3\u95dc\u91cd\u8981\uff0c\u4e26\u6703\u63d0\u9ad8\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u98a8\u96aa\u3002<\/p>\n

\u4e0a\u8ff0\u7814\u7a76\u7d50\u679c\u986f\u793a\u651d\u53d6\u7d05\u8089\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u95dc\u806f\u6027\uff0c\u78ba\u8a8d\u8207\u8178\u9053\u5fae\u751f\u7269\u53c3\u8207\u8f49\u63db\u8089\u54c1\u7684\u4e2d\u9593\u4ee3\u8b1d\u7522\u7269\uff08\u5c07 \u03b3BB \u4ee3\u8b1d\u70ba TMA\uff09\u7dca\u5bc6\u76f8\u95dc\uff0c\u4ea6\u5373\u651d\u53d6\u7d05\u8089\u6703\u63d0\u9ad8\u5fae\u751f\u7269\u7684 gbuA<\/em> \u57fa\u56e0\u8868\u73fe\u91cf\uff0c\u9032\u800c\u7522\u751f\u7f79\u60a3\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u81f4\u75c5\u56e0\u5b50\u3002\u6b64\u5916\uff0c\u9019\u500b\u7814\u7a76\u4e5f\u767c\u73fe\u96a8\u8457\u53d7\u8a66\u8005\u7684\u98f2\u98df\u7fd2\u6163\u5f9e\u8089\u98df\u6539\u6210\u7d20\u98df\u5f8c\uff0c gbuA<\/em> \u8868\u73fe\u91cf\u4fbf\u96a8\u4e4b\u964d\u4f4e\uff0c\u9019\u53ef\u80fd\u662f\u900f\u904e\u6539\u8b8a\u98f2\u98df\u7fd2\u6163\u4ee5\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u7684\u4f5c\u6cd5\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

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  1. Buffa JA, Romano KA, Copeland MF, Cody DB, Zhu W, Galvez R, Fu X, Ward K, Ferrell M, Dai HJ, Skye S, Hu P, Li L, Parlov M, McMillan A, Wei X, Nemet I, Koeth RA, Li XS, Wang Z, Sangwan N, Hajjar AM, Dwidar M, Weeks TL, Bergeron N, Krauss RM, Tang WHW, Rey FE, DiDonato JA, Gogonea V, Gerberick GF, Garcia-Garcia JC, Hazen SL. The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism. Nat Microbiol. 2022 Jan;7(1):73-86. doi: 10.1038\/s41564-021-01010-x. Epub 2021 Dec 23.<\/li>\n
  2. Wolk A. Potential health hazards of eating red meat.<\/a> J Intern Med. 2017 Feb;281(2):106-122. doi: 10.1111\/joim.12543. Epub 2016 Sep 6..<\/li>\n
  3. Diallo A, Deschasaux M, Latino-Martel P, Hercberg S, Galan P, Fassier P, All\u00e8s B, Gu\u00e9raud F, Pierre FH, Touvier M. Red and processed meat intake and cancer risk: Results from the prospective NutriNet-Sant\u00e9 cohort study. Int J Cancer. 2018 Jan 15;142(2):230-237. doi: 10.1002\/ijc.31046. Epub 2017 Oct 16..<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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