{"id":39362,"date":"2022-02-15T00:15:41","date_gmt":"2022-02-14T16:15:41","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=39362"},"modified":"2022-01-18T10:37:52","modified_gmt":"2022-01-18T02:37:52","slug":"%e7%82%ad%e7%96%bd%e6%a1%bf%e8%8f%8c%e6%af%92%e7%b4%a0%e8%83%bd%e5%b8%b6%e4%be%86%e6%ad%a2%e7%97%9b%e6%96%b0%e8%a7%a3%e6%96%b9%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=39362","title":{"rendered":"\u70ad\u75bd\u687f\u83cc\u6bd2\u7d20\u80fd\u5e36\u4f86\u6b62\u75db\u65b0\u89e3\u65b9\uff1f"},"content":{"rendered":"

\u70ad\u75bd\u687f\u83cc\u6bd2\u7d20\u56e0\u5176\u53ef\u4f5c\u70ba\u751f\u7269\u6230\u5291\u800c\u60e1\u540d\u662d\u5f70\uff0c\u4f46\u6b64\u6bd2\u7d20\u53d7\u9ad4\u537b\u53ef\u6291\u5236\u75bc\u75db\u8a0a\u606f\u50b3\u905e\uff0c\u6240\u4ee5\u70ad\u75bd\u687f\u83cc\u6bd2\u7d20\u53ef\u5c08\u4e00\u6027\u7684\u7de9\u89e3\u75db\u89ba\u3002\u6b64\u5916\uff0c\u795e\u7d93\u53d7\u9ad4 ANTXR2\u6b62\u75db\u9014\u5f91\u4e26\u4e0d\u6703\u50cf\u9d09\u7247\u985e\u6b62\u75db\u85e5<\/a>\u6703\u9020\u6210\u85e5\u7269\u6210\u766e\u6216\u7522\u751f\u795e\u7d93\u7cfb\u7d71\u526f\u4f5c\u7528\uff0c\u7279\u5225\u662f\u904b\u7528\u4fdd\u8b77\u6027\u6297\u539f\u3001\u6c34\u816b\u56e0\u5b50\u7684\u6b62\u75db\u9014\u5f91\uff0c\u5c0d\u65bc\u7de9\u89e3\u795e\u7d93\u640d\u50b7\u9020\u6210\u7684\u75bc\u75db\u7279\u5225\u6709\u6548\u3002\u7136\u800c\uff0c\u9019\u9805\u5be6\u9a57\u5c1a\u672a\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\uff0c\u800c\u4e14\u6240\u7528\u7684\u70ad\u75bd\u687f\u83cc\u3001\u8089\u6bd2\u687f\u83cc\u50b3\u67d3\u6027\u53ca\u81f4\u547d\u6027\u5747\u6975\u9ad8\uff0c\u6545\u5728\u5be6\u969b\u61c9\u7528\u65bc\u4eba\u9ad4\u6642\u61c9\u5be9\u614e\u8a55\u4f30\u3002<\/strong><\/span><\/p>\n

\"\"<\/a>
\u5716\u7247\u4f86\u6e90\uff1amotionelements.com<\/figcaption><\/figure>\n

\u64b0\u6587\uff0f<\/strong>\u9673\u6df5\u9293<\/p>\n

\u70ad\u75bd\u687f\u83cc\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

\u70ad\u75bd\u687f\u83cc\uff08Bacillus anthracis<\/em>\uff09\u662f\u4e00\u7a2e\u9769\u862d\u6c0f\u967d\u6027\u7d30\u83cc\uff0c\u4e3b\u8981\u5229\u7528\u78b3\u548c\u6c2e\u4f5c\u70ba\u751f\u9577\u548c\u6d3b\u52d5\u7684\u80fd\u91cf\u4f86\u6e90\uff0c\u74b0\u5883\u82e5\u4e0d\u9069\u5408\u5176\u751f\u9577\uff0c\u5247\u5f62\u6210\u82bd\u5b62\uff08\u6216\u7a31\u5185\u5b62\u5b50\uff0cendospore\uff09\uff0c\u4fdd\u5b58\u6642\u9593\u53ef\u9577\u9054\u6578\u5341\u5e74\u751a\u81f3\u66f4\u4e45\uff0c\u74b0\u5883\u8010\u53d7\u6027\u6975\u9ad8\uff0c\u4e00\u65e6\u91cb\u653e\u5230\u9069\u7576\u74b0\u5883\u4e2d\uff0c\u53c8\u80fd\u5feb\u901f\u6d3b\u5316\u9020\u6210\u611f\u67d3\u3002\u70ad\u75bd\u687f\u83cc\u5728\u52d5\u7269\u9ad4\u5167\u4e0d\u6703\u5f62\u6210\u82bd\u5b62\uff0c\u56e0\u82bd\u5b62\u5f62\u6210\u8981\u6709\u6e38\u96e2\u6c27\u5b58\u5728\uff0c\u4e14\u6eab\u5ea6\u9700\u7dad\u630125~28\u2103\uff0c\u6240\u4ee5\u53ea\u6709\u5728\u571f\u58e4\u3001\u57f9\u990a\u57fa\u6216\u52d5\u7269\u5c4d\u9ad4\u5167\u624d\u6709\u82bd\u5b62\u3002\u70ad\u75bd\u687f\u83cc\u7684\u6bd2\u529b\u8207\u83a2\u819c\uff08capsule\uff09\u3001\u70ad\u75bd\u5916\u6bd2\u7d20\uff08anthrax exotoxin\uff09\u6709\u95dc\uff0c\u5f8c\u8005\u7531\u4fdd\u8b77\u6027\u6297\u539f\uff08protective antigen\uff09\u3001\u6c34\u816b\u56e0\u5b50\uff08edema factor\uff09\u53ca\u81f4\u547d\u56e0\u5b50\uff08lethal factor\uff09\u5171\u540c\u7d44\u6210\u3002\u83a2\u819c\u53ef\u4f7f\u70ad\u75bd\u687f\u83cc\u9003\u907f\u767d\u8840\u7403\u7684\u541e\u566c\u4f5c\u7528\u53ca\u6291\u5236\u6bba\u83cc\u6bd2\u7d20\uff0c\u70ad\u75bd\u5916\u6bd2\u7d20\u5247\u6703\u4f7f\u5c40\u90e8\u7d44\u7e54\u6c34\u816b\u53ca\u58de\u6b7b\u3002\u83cc\u9ad4\u53ca\u6bd2\u7d20\u9032\u5165\u8840\u6db2\u5f8c\u64f4\u6563\u5230\u5168\u8eab\uff0c\u4ea6\u53ef\u9032\u5165\u6dcb\u5df4\u7cfb\u7d71\uff0c\u5f15\u8d77\u6dcb\u5df4\u817a\u816b\u3002<\/p>\n

\u70ad\u75bd\u687f\u83cc\u5f15\u8d77\u7684\u70ad\u75bd\u75c5\uff08anthrax\uff09\u662f\u4e00\u7a2e\u6025\u6027\u4eba\u755c\u5171\u901a\u75be\u75c5\uff0c\u50b3\u67d3\u6027\u53ca\u81f4\u6b7b\u7387\u5747\u6975\u9ad8\u3002\u4e3b\u8981\u50b3\u67d3\u9014\u5f91\u662f\u7d93\u7531\u76ae\u819a\uff0c\u5c11\u6578\u7d93\u7531\u547c\u5438\u9053\u6216\u6d88\u5316\u9053\uff0c\u7576\u4eba\u985e\u5438\u5165\u5927\u91cf\u70ad\u75bd\u687f\u83cc\u82bd\u5b62\u6216\u98df\u5165\u53d7\u5230\u611f\u67d3\u7684\u52d5\u7269\uff0c\u70ad\u75bd\u687f\u83cc\u4fbf\u6703\u9032\u5165\u8840\u6db2\u6216\u6dcb\u5df4\u5faa\u74b0\u9020\u6210\u6557\u8840\u75c7\uff0c\u75c5\u7a0b\u767c\u5c55\u76f8\u7576\u5feb\uff0c\u60a3\u8005\u53ef\u80fd\u5728\u6578\u5929\u5167\u4fbf\u6b7b\u4ea1\u3002\u70ad\u75bd\u687f\u83cc\u4ea6\u88ab\u8a8d\u70ba\u53ef\u7528\u4f5c\u751f\u7269\u6b66\u5668\uff0c\u5c6c\u65bc\u7f8e\u570b\u653f\u5e9c\u8a8d\u5b9a\u7684\u516d\u7a2e\u6b66\u5668\u7d1a\uff08A\u7d1a\uff1a\u70ad\u75bd\u687f\u83cc\u3001\u9f20\u75ab\u687f\u83cc\u3001\u5154\u71b1\u6c0f\u687f\u83cc\u3001\u8089\u6bd2\u687f\u83cc\u6bd2\u7d20\u3001\u5929\u82b1\u75c5\u6bd2\u3001\u51fa\u8840\u71b1\u75c5\u6bd2\uff09\u75c5\u539f\u9ad4\u4e4b\u4e00\uff0c2001\u5e74911\u6050\u6016\u653b\u64ca\u4e8b\u4ef6\u4e2d\uff0c\u4fbf\u66fe\u767c\u751f\u904e\u4fe1\u4ef6\u4e2d\u593e\u5e36\u6709\u70ad\u75bd\u687f\u83cc\u7684\u4e8b\u4ef6\u3002<\/p>\n

\u6b62\u75db\u85e5\u7684\u7a2e\u985e<\/strong><\/span><\/p>\n

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1.\u55ae\u7d14\u6b62\u75db\u85e5\uff1a\u50c5\u6709\u6b62\u75db\u7684\u6548\u679c\uff0c\u4e0d\u5177\u6709\u6d88\u708e\u529f\u80fd\uff0c\u5e02\u9762\u4e0a\u76f8\u7576\u5bb9\u6613\u53d6\u5f97\uff0c\u4f46\u4e00\u5929\u7684\u5291\u91cf\u4e0d\u80fd\u5403\u8d85\u904e8\u9846\uff08\u7d044,000\u6beb\u514b\uff09\uff0c\u5426\u5247\u53ef\u80fd\u6703\u6709\u809d\u6bd2\u6027\u767c\u751f\uff0c\u5982\u666e\u62ff\u75bc\uff08Acetaminophen\uff09\u3002<\/p>\n

2.\u975e\u56fa\u9187\u985e\u6d88\u708e\u6b62\u75db\u85e5\uff08Non-Steroidal Anti-Inflammatory Drug, NSAID\uff09\uff1a\u4e3b\u8981\u85c9\u7531\u6291\u5236\u5206\u5e03\u5728\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684 COX-2\uff08Prostaglandin-endoperoxide synthase 2, cyclooxygenase-2\uff09\uff0c\u4ee5\u6e1b\u5c11\u524d\u5217\u817a\u7d20\u7684\u751f\u6210\u800c\u7de9\u89e3\u75bc\u75db\uff0c\u4f46\u8f03\u5bb9\u6613\u5c0e\u81f4\u85e5\u7269\u904e\u654f\uff0c\u5982\u963f\u65af\u5339\u9748\uff08Aspirin\uff09\u3001\u4f0a\u5e03\u6d1b\u82ac\uff08Ibuprofen\uff09\u3001\u8418\u666e\u751f\uff08Naproxen\uff09\u3002<\/p>\n

3.\u9d09\u7247\u985e\u6b62\u75db\u85e5\uff08Opioid analgesics\uff09\uff1a\u4e3b\u8981\u7528\u9014\u662f\u93ae\u75db\uff0c\u901a\u904e\u5b58\u5728\u65bc\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u548c\u6d88\u5316\u7cfb\u7d71\u7684\u9d09\u7247\u985e\u53d7\u9ad4\u8d77\u4f5c\u7528\uff0c\u85e5\u6548\u53cd\u61c9\u53d6\u6c7a\u65bc\u548c\u9d09\u7247\u985e\u85e5\u7269\u7d50\u5408\u7684\u53d7\u9ad4\uff0c\u5c0d\u6e1b\u8f15\u4e0d\u6cbb\u4e4b\u75c7\uff08\u5982\u764c\u75c7\uff09\u6240\u9020\u6210\u7684\u5287\u70c8\u75bc\u75db\u5177\u6709\u826f\u597d\u7684\u6548\u679c\uff0c\u4f46\u53ef\u80fd\u9020\u6210\u85e5\u7269\u6210\u766e\uff0c\u5982\u55ce\u5561\uff08morphine\uff09\u3002<\/p>\n

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 <\/p>\n

\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

    \n
  1. Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, R\u00f6derer P, Nitzsche A, Lu M, Pentelute BL, Br\u00fcstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG. Nat Neurosci. 2021 Dec 20. doi: 10.1038\/s41593-021-00973-8. Online ahead of print.<\/li>\n
  2. Laev SS, Salakhutdinov NF. New Small-molecule Analgesics.<\/a> Curr Med Chem. 2021;28(30):6234-6273. doi: 10.2174\/0929867328666210614122444.<\/li>\n
  3. Matthew MT, Nance PW. Analgesics. Opioids, adjuvants, and others.<\/a> Phys Med Rehabil Clin N Am. 1999 May;10(2):255-73, vii.<\/li>\n
  4. Pilo P, Frey J. Pathogenicity, population genetics and dissemination of Bacillus anthracis<\/em>.<\/a> Infect Genet Evol. 2018 Oct;64:115-125. doi: 10.1016\/j.meegid.2018.06.024. Epub 2018 Jun 20.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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