{"id":38557,"date":"2019-10-21T00:00:23","date_gmt":"2019-10-20T16:00:23","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=38557"},"modified":"2022-01-04T00:40:59","modified_gmt":"2022-01-03T16:40:59","slug":"%e6%94%b9%e5%af%ab%e8%a8%98%e6%86%b61-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=38557","title":{"rendered":"\u6539\u5beb\u8a18\u61b6(1\/2)"},"content":{"rendered":"<div class=\"single-post-media clr\">\n<div class=\"post-thumbnail\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2019\/08\/nerve-cell-2213009_1920.jpg\" alt=\"\u6539\u5beb\u8a18\u61b6(1\/2)\" width=\"500\" height=\"333\" \/><\/div>\n<\/div>\n<div class=\"entry clr\">\n<div class=\"pf-content\">\n<p><strong>\u64b0\u6587\uff0fNicola Davis<\/strong><strong>\u2502\u8b6f\u8005\uff0f\u8521\u627f\u5fd7<br \/>\n<\/strong><strong>\u8f49\u8f09\u81ea\u300aBBC<\/strong><strong>\u77e5\u8b58\u300b2014<\/strong><strong>\u5e747<\/strong><strong>\u6708\u7b2c35<\/strong><strong>\u671f<\/strong><\/p>\n<p>\u662f\u4e0d\u662f\u66fe\u7d93\u671f\u671b\u64c1\u6709\u66f4\u597d\u7684\u8a18\u61b6\u529b\uff0c\u9019\u6a23\u4f60\u5c31\u80fd\u5920\u66f4\u8f15\u9b06\u8a18\u4f4f\u59d3\u540d\u3001\u65e5\u671f\u548c\u81c9\u5b54\uff0c\u751a\u81f3\u8003\u8a66\u8003\u51fa\u66f4\u597d\u7684\u6210\u7e3e\uff1f\u8981\u4e0d\u7136\u5c31\u628a\u5931\u6557\u6200\u60c5\u7684\u8a18\u61b6\u5168\u90e8\u6cef\u9664\uff0c\u597d\u6bd4Michel Gondry\u57f7\u5c0e\u7684\u5967\u65af\u5361\u5f97\u734e\u96fb\u5f71\u300a\u738b\u724c\u51a4\u5bb6\u300b\uff08<em>Eternal Sunshine of the Spotless Mind<\/em>\uff09\u5287\u4e2d\u4eba\u7269\u7684\u505a\u6cd5\uff1f\u6216\u8005\u5c31\u4f86\u4e00\u6bb5\u865b\u64ec\u65c5\u884c\uff0c\u50cf\u963f\u8afe\u5728\u79d1\u5e7b\u7d93\u5178\u300a\u9b54\u9b3c\u7e3d\u52d5\u54e1\u300b\uff08<em>Total Recall<\/em>\uff09\u7247\u4e2d\u98fe\u6f14\u7684Douglas Quaid\u90a3\u6a23\uff0c\u900f\u904e\u76f4\u63a5\u690d\u5165\u8166\u4e2d\u7684\u865b\u5047\u8a18\u61b6\uff0c\u4f86\u8d9f\u592a\u967d\u7cfb\u4e4b\u65c5\uff1f<\/p>\n<p>\u5594\uff0c\u9019\u985e\u7642\u6cd5\u6709\u53ef\u80fd\u6bd4\u4f60\u60f3\u7684\u4f86\u5f97\u66f4\u5feb\uff0c\u56e0\u70ba\u79d1\u5b78\u5bb6\u5df2\u7d93\u958b\u5275\u9577\u8db3\u9032\u5c55\uff0c\u61c2\u5f97\u5982\u4f55\u62b9\u9664\u3001\u589e\u9032\u8a18\u61b6\uff0c\u751a\u81f3\u5275\u9020\u8a18\u61b6\u3002<\/p>\n<p>\u300c\u8a18\u61b6\u662f\u975e\u5e38\u91cd\u8981\u7684\u8a8d\u77e5\u5411\u5ea6\uff0c\u300d\u82f1\u570b\u6771\u82f1\u5409\u5229\u5927\u5b78\u8cc7\u6df1\u7814\u7a76\u54e1David Vauzour\u8868\u793a\uff0c\u300c\u9019\u4e0d\u55ae\u662f\u6307\u4f60\u7684\u8a18\u61b6\u80fd\u529b\uff0c\u9084\u5305\u62ec\u4f60\u80fd\u8a18\u4f4f\u4ec0\u9ebc\u3002\u6709\u4e9b\u8a18\u61b6\u77ed\u66ab\u4fdd\u7559\u5f8c\u5c31\u53bb\u9664\u4e86\uff0c\u4f46\u6700\u91cd\u8981\u7684\u8a18\u61b6\u5c31\u6703\u8caf\u5b58\u5728\u8166\u4e2d\uff0c\u9084\u80fd\u4efb\u610f\u53d6\u51fa\u3002\u9019\u7a2e\u7fd2\u5f97\u65b0\u8cc7\u8a0a\u4e26\u8caf\u5b58\u3001\u56de\u61b6\u7684\u6b77\u7a0b\uff0c\u727d\u6d89\u5230\u5f88\u8907\u96dc\u7684\u8166\u529f\u80fd\u4e92\u52d5\u4f5c\u7528\u3002\u300d<\/p>\n<p>\u9996\u5148\u6211\u5011\u5f97\u5148\u5f04\u6e05\u695a\u9019\u7a2e\u8907\u96dc\u4e4b\u6975\u7684\u795e\u7d93\u548c\u5316\u5b78\u4f5c\u7528\u7db2\u7d61\uff0c\u4e86\u89e3\u4eba\u8166\u5982\u4f55\u8caf\u5b58\u3001\u56de\u60f3\u8a18\u61b6\u5167\u5bb9\uff0c\u6700\u5f8c\u6211\u5011\u624d\u53ef\u80fd\u91d0\u6e05\u5982\u4f55\u64cd\u63a7\u8a18\u61b6\u3002<\/p>\n<h3><strong>\u62b9\u9664\u8a18\u61b6<\/strong><\/h3>\n<p>\u5c0d\u8a31\u591a\u4eba\u4f86\u8b1b\uff0c\u62b9\u9664\u8a18\u61b6\u6703\u5e36\u4f86\u4e00\u500b\u9053\u5fb7\u96e3\u984c\u3002\u8a18\u61b6\u7576\u7136\u53ef\u4ee5\u662f\u6975\u5927\u559c\u6a02\u7684\u6839\u6e90\uff0c\u7136\u800c\u5b83\u4e5f\u53ef\u80fd\u662f\u6975\u5927\u75db\u82e6\u7684\u6839\u6e90\uff0c\u597d\u6bd4\u7f79\u60a3\u5275\u50b7\u5f8c\u58d3\u529b\u75c7\u5019\u7fa4\uff08PTSD\uff09\u6216\u906d\u53d7\u6bd2\u766e\u6bd2\u5bb3\u7684\u72c0\u6cc1\uff0c\u5c31\u9019\u7a2e\u60c5\u6cc1\uff0c\u62b9\u9664\u8a18\u61b6\u6216\u8a31\u662f\u89e3\u6c7a\u4e4b\u9053\u3002\u5275\u50b7\u5f8c\u58d3\u529b\u75c7\u5019\u7fa4\u60a3\u8005\u6703\u4e0d\u65b7\u6d6e\u73fe\u5275\u50b7\u8a18\u61b6\u3002\u76f8\u540c\u9053\u7406\uff0c\u5438\u6bd2\u6210\u766e\u7684\u4eba\u5247\u6703\u628a\u67d0\u4e9b\u7fd2\u6163\u548c\u5148\u524d\u7684\u6b23\u5feb\u611f\u53d7\u9023\u7d50\u5728\u4e00\u8d77\uff0c\u800c\u9019\u7a2e\u5feb\u611f\u5c31\u6703\u523a\u6fc0\u4ed6\u5011\u6e34\u6c42\u6bd2\u54c1\u3002\u82e5\u80fd\u6e05\u9664\u6216\u58d3\u6291\u7279\u5b9a\u8a18\u61b6\uff0c\u90a3\u9ebc\u5c31\u80fd\u5920\u9810\u9632\u5275\u50b7\u60c5\u7dd2\u548c\u6709\u5bb3\u884c\u70ba\u3002<\/p>\n<h4><strong>\u8f5f\u64ca\u8a18\u61b6<\/strong><\/h4>\n<p>\u90a3\u9ebc\u8a18\u61b6\u5230\u5e95\u8a72\u600e\u6a23\u62b9\u9664\uff1fVauzour\u8aaa\u660e\uff0c\u300c\u7814\u7a76\u4eba\u54e1\u63a1\u7528\u4e86\u4e00\u7a2e\u4e09\u968e\u6bb5\u6a21\u578b\uff0c\u4f86\u63cf\u8ff0\u8166\u5b50\u5982\u4f55\u5b78\u7fd2\u548c\u8a18\u61b6\uff0c\u9019\u4e09\u500b\u968e\u6bb5\u662f\uff1a\u7fd2\u5f97\uff08acquisition\uff09\u3001\u978f\u56fa\uff08consolidation\uff0c\u53c8\u8b6f\u56fa\u5316\uff09\u548c\u63d0\u53d6\uff08retrieval\uff09\uff0c\u7576\u4e2d\u4efb\u4f55\u4e00\u9053\u904e\u7a0b\u53d7\u4e86\u640d\u50b7\uff0c\u5c31\u6703\u9020\u6210\u8a18\u61b6\u8870\u9000\u3002\u300d<\/p>\n<p>\u9019\u88e1\u63d0\u51fa\u4e00\u500b\u904b\u7528\u8a18\u61b6\u978f\u56fa\u904e\u7a0b\u7684\u7814\u7a76\uff0c\u90a3\u662f\u8377\u862d\u5167\u6885\u4ea8\u5927\u5b78\uff08RadboudUniversity Nijmegen\uff09\u7684Marijn Kroes\u548c\u5e7e\u4f4d\u540c\u4e8b\u505a\u7684\u4e00\u9805\u300c\u53d7\u8a66\u8005\u5167\u64cd\u5f04\u300d\u7814\u7a76\u3002\u8a18\u61b6\u6703\u4e0d\u65b7\u5728\u5fc3\u4e2d\u91cd\u5beb\u6216\u8005\u518d\u6b21\u978f\u56fa\uff0c\u6709\u9ede\u50cf\u662f\u786c\u789f\u91cd\u7d44\u4f5c\u696d\u3002\u4e0d\u904e\u96fb\u64ca\u75d9\u6523\u6cbb\u7642\u6cd5\uff08\u7de8\u8a3b\uff1aECT\uff0c\u53c8\u7a31\u96fb\u7642\u6cd5\uff0c\u662f\u85c9\u7531\u96fb\u64ca\u8166\u90e8\u8a98\u767c\u75d9\u6523\u4f86\u6cbb\u7642\u7cbe\u795e\u75be\u75c5\u7684\u7642\u6cd5\u3002\uff09\u537b\u4f3c\u4e4e\u80fd\u9810\u9632\u8a18\u61b6\u5728\u300c\u518d\u978f\u56fa\u300d\u8655\u7406\u968e\u6bb5\u88ab\u91cd\u5beb\u6216\u6539\u52d5\u3002\u8a72\u5718\u968a\u9019\u4e00\u98052013\u5e74\u7684\u7814\u7a76\u767c\u8868\u5728\u300a\u81ea\u7136\u795e\u7d93\u79d1\u5b78\u300b\uff08<em>Nature Neuroscience<\/em>\uff09\u671f\u520a\uff0c\u7814\u7a76\u62db\u52df\u56e0\u6182\u9b31\u75c7\u63a5\u53d7\u96fb\u64ca\u75d9\u6523\u6cbb\u7642\u7684\u4eba\u53c3\u8207\uff0c\u5411\u4ed6\u5011\u5448\u73fe\u4e00\u6bb5\u4ee4\u4eba\u4e0d\u5b89\u7684\u5716\u6587\u6545\u4e8b\uff0c\u9694\u4e86\u4e00\u9031\u518d\u63d0\u9192\u53d7\u8a66\u8005\u9019\u6bb5\u60c5\u7bc0\uff0c\u4e26\u7d66\u4e88\u96fb\u64ca\u6cbb\u7642\u3002\u7d50\u679c\u5c31\u628a\u4ed6\u5011\u5c0d\u9019\u6bb5\u75db\u82e6\u8a18\u6558\u7684\u8a18\u61b6\u5b8c\u5168\u62b9\u53bb\u3002<\/p>\n<div id=\"attachment_82755\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"wp-image-82755\" src=\"https:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2019\/10\/%E6%93%9A%E4%BF%A1%E8%A8%98%E6%86%B6%E6%98%AF%E8%B2%AF%E5%AD%98%E6%96%BC%E6%A8%B9%E7%AA%81%E6%A3%98%EF%BC%8C%E4%B9%9F%E5%B0%B1%E6%98%AF%E6%9C%AC%E5%9C%96%E6%89%80%E7%A4%BA%E5%BE%9E%E6%A8%B9%E7%AA%81%E9%95%B7%E5%87%BA%E7%9A%84%E4%B8%80%E6%A0%B9%E6%A0%B9%E6%AF%9B%E9%AB%AE%E7%8B%80%E7%BA%96%E7%B4%B0%E7%B5%90%E6%A7%8B%EF%BC%8C%E8%80%8C%E6%A8%B9%E7%AA%81%E5%89%87%E6%98%AF%E5%BE%9E%E7%A5%9E%E7%B6%93%E5%85%83%E4%B8%BB%E7%B4%B0%E8%83%9E%E9%AB%94%E5%88%86%E5%8F%89%E5%87%BA%E4%BE%86%E3%80%82.jpg\" alt=\"\" width=\"365\" height=\"431\" \/><\/p>\n<p class=\"wp-caption-text\">\u64da\u4fe1\u8a18\u61b6\u662f\u8caf\u5b58\u65bc\u6a39\u7a81\u68d8\uff0c\u4e5f\u5c31\u662f\u672c\u5716\u6240\u793a\u5f9e\u6a39\u7a81\u9577\u51fa\u7684\u4e00\u6839\u6839\u6bdb\u9aee\u72c0\u7e96\u7d30\u7d50\u69cb\uff0c\u800c\u6a39\u7a81\u5247\u662f\u5f9e\u795e\u7d93\u5143\u4e3b\u7d30\u80de\u9ad4\u5206\u53c9\u51fa\u4f86\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1aScience Photo Library\uff09<\/p>\n<\/div>\n<p>\u53e6\u6709\u4e9b\u4eba\u63a1\u884c\u5316\u5b78\u9580\u8def\uff0c\u4e5f\u505a\u51fa\u4e86\u76f8\u4eff\u7a81\u7834\u767c\u73fe\uff0c\u597d\u6bd4\u7f8e\u570b\u52a0\u5dde\u8056\u5730\u7259\u54e5\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\uff08Scripps Research Institute\uff09Courtney Miller\u535a\u58eb\u9818\u5c0e\u7684\u4e00\u98052013\u5e74\u7814\u7a76\u5c31\u9a57\u8b49\u4e86\u9019\u9ede\u3002Miller\u8a66\u5716\u5e6b\u7532\u57fa\u5b89\u975e\u4ed6\u547d\u6210\u766e\u4eba\u58eb\u6e05\u9664\u6bd2\u54c1\u4f7f\u7528\u76f8\u95dc\u8a18\u61b6\uff0c\u671f\u80fd\u5faa\u6b64\u5354\u52a9\u4ed6\u5011\u6212\u6bd2\u3002<\/p>\n<p>\u300c\u795e\u7d93\u5143\u9760\u6a39\u7a81\u68d8\uff08dendritic spine\uff09\u9019\u7a2e\u5c0f\u578b\u7d50\u69cb\u5f7c\u6b64\u76f8\u9023\uff0c\u6211\u5011\u8a8d\u70ba\u9019\u5c31\u662f\u8a18\u61b6\u7684\u5be6\u9ad4\u8caf\u5b58\u8655\u6240\uff0c\u300dMiller\u535a\u58eb\u89e3\u91cb\u3002\u300c\u6a39\u7a81\u68d8\u7d50\u69cb\u7531\u4e00\u7a2e\u652f\u67b6\u8ca0\u8cac\u7dad\u7e6b\uff0c\u652f\u67b6\u7d44\u6210\u55ae\u5143\u70ba\u808c\u52d5\u86cb\u767d\uff08actin\uff09\uff0c\u9019\u7a2e\u86cb\u767d\u8cea\u80fd\u652f\u6301\u5728\u8a18\u61b6\u751f\u6210\u6642\u7522\u751f\u7684\u795e\u7d93\u5143\u9023\u7d50\uff0c\u5f9e\u800c\u4fc3\u9032\u5f62\u6210\u8a18\u61b6\u3002\u9019\u7a2e\u808c\u52d5\u86cb\u767d\u55ae\u5143\u7d50\u5408\u5f62\u6210\u9577\u93c8\u4e26\u589e\u5927\u6a39\u7a81\u68d8\uff0c\u9084\u80fd\u7a69\u5b9a\u7279\u5b9a\u795e\u7d93\u5143\u9023\u7d50\uff0c\u628a\u8a18\u61b6\u8caf\u5b58\u4e0b\u4f86\u3002\u300d<\/p>\n<p>\u300c\u5c31\u4f60\u7684\u5c0b\u5e38\u8a18\u61b6\u65b9\u9762\uff0c\u300d\u5979\u88dc\u5145\u8aaa\u660e\uff0c\u300c\u5404\u500b\u808c\u52d5\u86cb\u767d\u55ae\u5143\u90fd\u5468\u8f49\u5f97\u975e\u5e38\u7de9\u6162\uff0c\u9802\u90e8\u5148\u6709\u4e00\u500b\u812b\u96e2\uff0c\u63a5\u8457\u5f9e\u5e95\u90e8\u53e6\u5916\u88dc\u4e0a\u4e00\u500b\u3002\u4e0d\u904e\u4f7f\u7528\u7532\u57fa\u5b89\u975e\u4ed6\u547d\u7684\u6642\u5019\uff0c\u5f62\u6210\u8a18\u61b6\u6642\u9019\u4e9b\u55ae\u5143\u5c31\u79fb\u52d5\u5f97\u975e\u5e38\u5feb\u901f\u3002\u6240\u4ee5\u6211\u5011\u5229\u7528\u9019\u9ede\uff0c\u8b93\u52d5\u7269\u4f7f\u7528\u7d05\u6d77\u6d77\u7dbf\u7d20A\uff08Latrunculin 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