{"id":38062,"date":"2020-09-09T00:00:01","date_gmt":"2020-09-08T16:00:01","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=38062"},"modified":"2021-12-27T11:56:04","modified_gmt":"2021-12-27T03:56:04","slug":"%e7%ab%99%e5%9c%a8%e7%94%9f%e7%89%a9%e5%ad%b8%e9%82%8a%e4%b8%8a%e7%9a%84%e7%89%a9%e7%90%86%e5%ad%b8%e5%ae%b6","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=38062","title":{"rendered":"\u7ad9\u5728\u751f\u7269\u5b78\u908a\u4e0a\u7684\u7269\u7406\u5b78\u5bb6"},"content":{"rendered":"<div class=\"single-post-media clr\">\n<div class=\"post-thumbnail\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/highscope.ch.ntu.edu.tw\/wordpress\/wp-content\/uploads\/2019\/03\/yeast.jpg\" alt=\"\u7ad9\u5728\u751f\u7269\u5b78\u908a\u4e0a\u7684\u7269\u7406\u5b78\u5bb6\" width=\"431\" height=\"305\" \/><\/div>\n<\/div>\n<div class=\"entry clr\">\n<div class=\"pf-content\">\n<p><strong>\u64b0\u6587\uff0fThania Benios\uff5c\u8b6f\u8005\u2571\u5f35\u4ea6\u8473<\/strong><br \/>\n<strong>\u8f49\u8f09\u81ea\u300a\u79d1\u5b78\u4eba\u300b2008\u5e745\u6708\u7b2c75\u671f<\/strong><\/p>\n<p>\u9b4f\u91d1\u65af\u5e0c\u671b\u80fd\u7528\u6a5f\u5668\u5b78\u7fd2\u4f86\u767c\u5c55\u6a21\u5f0f\uff0c\u4ee5\u9810\u6e2c\u5728\u5404\u7a2e\u72c0\u6cc1\u4e0b\u751f\u7269\u9ad4\u5167\u6240\u6709\u57fa\u56e0\u7684\u8868\u73fe\uff0c\u9032\u800c\u89e3\u91cb\u67d0\u4e9b\u7d30\u80de\u7570\u5e38\u6216\u8f49\u70ba\u764c\u7d30\u80de\u7684\u539f\u56e0\u3002<span 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microarray\uff09\uff0c\u90a3\u662f\u4e00\u7a2e\u6676\u7247\uff0c\u80fd\u81ea\u52d5\u5927\u91cf\u5c55\u793a\u57fa\u56e0\u6d3b\u52d5\u7684\u5168\u8c8c\u53ca\u5176\u5728\u5404\u7a2e\u7d30\u80de\u5167\u8868\u73fe\u7684\u7a0b\u5ea6\u3002\u5229\u7528\u904e\u53bb\u8a8d\u70ba\u96dc\u4e82\u4e0d\u5168\u7684\u8cc7\u6599\uff0c\u751f\u7269\u5b78\u5bb6\u5982\u4eca\u53ef\u63a8\u6e2c\u67d0\u500b\u57fa\u56e0\u5728\u4e0d\u540c\u7d30\u80de\u5167\u662f\u5426\u6703\u8868\u73fe\uff0c\u4e26\u7531\u7522\u751f\u7684\u86cb\u767d\u8cea\u7d44\u5408\u5224\u65b7\u7d30\u80de\u662f\u5426\u5065\u5eb7\u3002<\/p>\n<p>\u4f46\u9810\u6e2c\u9019\u6a23\u7684\u57fa\u56e0\u6d3b\u52d5\uff0c\u9700\u8981\u91d0\u6e05\u5b83\u5011\u7684\u57fa\u672c\u898f\u5247\u3002\u73fe\u4efb\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78\u751f\u7269\u5b78\u526f\u6559\u6388\u7684\u7406\u8ad6\u7269\u7406\u5bb6\u5e03\u68ee\u99ac\u514b\uff08Harmen Bussemaker\uff09\u8aaa\uff1a\u300c\u9577\u4e45\u4ee5\u4f86\uff0c\u9019\u4e9b\u898f\u5247\u90fd\u88ab\u95dc\u5728\u4e00\u500b\u500b\u7d30\u80de\u4e2d\uff0c\u6f14\u5316\u81f3\u4eca\u4ecd\u96b1\u85cf\u4e86\u597d\u6771\u897f\u3002\u300d<\/p>\n<p>\u70ba\u4e86\u627e\u51fa\u9019\u4e9b\u898f\u5247\uff0c\u79d1\u5b78\u5bb6\u9700\u8981\u7d71\u8a08\u6578\u64da\uff0c\u4ee5\u63a8\u8ad6\u57fa\u56e0\u8207\u8abf\u63a7\u86cb\u767d\u8cea\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u4e26\u5c07\u57fa\u56e0\u8207\u86cb\u767d\u8cea\u4e4b\u9593\u7684\u9577\u671f\u52d5\u614b\u6a21\u5f0f\uff0c\u7528\u6578\u5b78\u7684\u65b9\u6cd5\u63cf\u8ff0\u51fa\u4f86\u3002\u53ea\u4e0d\u904e\uff0c\u5c0d\u5f9e\u672a\u7814\u7a76\u904e\u7c92\u5b50\u6216\u884c\u661f\u7b49\u4e3b\u984c\u7684\u7269\u7406\u5b78\u5bb6\u800c\u8a00\uff0c\u7d71\u8a08\u5b78\u6839\u672c\u662f\u7a2e\u8a5b\u5492\uff0c\u82f1\u570b\u7269\u7406\u5b78\u5bb6\u62c9\u585e\u798f\uff08Ernest Rutherford\uff09\u5c31\u66fe\u7d93\u9019\u9ebc\u5f62\u5bb9\uff1a\u300c\u5982\u679c\u4f60\u7684\u5be6\u9a57\u9700\u8981\u7528\u5230\u7d71\u8a08\uff0c\u90a3\u9ebc\u4f60\u61c9\u8a72\u505a\u904e\u66f4\u597d\u7684\u5be6\u9a57\u4e86\u3002\u300d<\/p>\n<p>\u53ef\u662f\uff0c\u9b4f\u91d1\u65af\u8aaa\uff1a\u300c\u4f7f\u7528\u6676\u7247\u7684\u5be6\u9a57\u7528\u4e0d\u8457\u4f60\u52d5\u624b\u5c31\u80fd\u5b8c\u6210\uff0c\u800c\u4e14\u751f\u7269\u5b78\u4e0d\u6703\u7d66\u4f60\u4e00\u500b\u6a21\u5f0f\u53bb\u89e3\u91cb\u90a3\u4e9b\u8cc7\u8a0a\u3002\u300d\u66f4\u6709\u6311\u6230\u7684\u662f\uff0c\u6709\u7121\u6578\u65b9\u5f0f\u53ef\u4ee5\u5f62\u6210DNA\u3001RNA\u548c\u86cb\u767d\u8cea\u7684\u7d44\u4ef6\uff0c\u800c\u4e14\u9084\u6709\u5177\u4e9b\u5fae\u5dee\u7570\u7684\u4e92\u52d5\u898f\u5247\u5728\u5f71\u97ff\u8457\u5b83\u5011\u7684\u6d3b\u52d5\u3002\u56e0\u6b64\uff0c\u60f3\u8981\u5c07\u4e92\u52d5\u6a21\u5f0f\u56de\u6b78\u57fa\u672c\u5c64\u9762\uff0c\u5373\u4f7f\u53ef\u80fd\uff0c\u56f0\u96e3\u5ea6\u4e5f\u5f88\u9ad8\u3002\u6709\u4e9b\u57fa\u56e0\u548c\u86cb\u767d\u8cea\u751a\u81f3\u662f\u672a\u77e5\u7684\uff0c\u7f8e\u570b\u666e\u6797\u65af\u9813\u5927\u5b78\u7684\u751f\u7269\u7269\u7406\u5b78\u5bb6\u5f7c\u4e9e\u96f7\u514b\uff08William Bialek\uff09\u8aaa\uff1a\u300c\u4f60\u6b63\u8a66\u8457\u5229\u7528\u81ea\u5df1\u4e0d\u662f\u975e\u5e38\u4e86\u89e3\u7684\u5de5\u5177\uff0c\u8981\u5728\u81ea\u7136\u754c\u627e\u5230\u4e00\u4e9b\u4ee4\u4eba\u4fe1\u670d\u7684\u6771\u897f\u3002\u4f60\u88ab\u8feb\u6210\u70ba\u4e00\u500b\u4e0d\u53ef\u77e5\u8ad6\u8005\u3002\u300d<\/p>\n<p>\u9b4f\u91d1\u65af\u76f8\u4fe1\uff0c\u8a31\u591a\u6a5f\u5668\u5b78\u7fd2\u7684\u6f14\u7b97\u6cd5\u53ef\u4ee5\u5728\u9019\u7a2e\u689d\u4ef6\u4e0b\u767c\u63ee\u5f88\u597d\u7684\u529f\u80fd\u3002\u4ed6\u8aaa\uff0c\u5373\u4f7f\u6709\u9019\u9ebc\u591a\u8b8a\u6578\uff0c\u300c\u6a5f\u5668\u5b78\u7fd2\u6703\u8b93\u8cc7\u6599\u81ea\u5df1\u6c7a\u5b9a\u54ea\u4e9b\u662f\u6709\u7528\u7684\u90e8\u4efd\u3002\u300d<\/p>\n<p>\u5728\u7f8e\u570b\u52a0\u5dde\u8056\u5df4\u5df4\u62c9\u5e02\u7684\u5361\u7dad\u91cc\u7814\u7a76\u4e2d\u5fc3\uff0c\u9b4f\u91d1\u65af\u8a66\u8457\u5efa\u7acb\u4e00\u5957\u9175\u6bcd\u83cc\u57fa\u56e0\u8abf\u63a7\u7cfb\u7d71\u7684\u6a21\u5f0f\uff0c\u4ee5\u6b78\u7d0d\u57fa\u56e0\u548c\u8abf\u63a7\u56e0\u5b50\u5171\u540c\u5f71\u97ffDNA\u8f49\u9304mRNA\u7684\u6cd5\u5247\u3002\u4ed6\u63a1\u7528\u4e86\u5e7e\u7a2e\u4e0d\u540c\u7684\u6f14\u7b97\u6cd5\uff0c\u7136\u5f8c\u958b\u59cb\u53c3\u52a0\u6709\u95dc\u57fa\u56e0\u8abf\u63a7\u7684\u8a0e\u8ad6\u6703\uff0c\u90a3\u662f\u7531\u7576\u6642\u5728\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78\u6307\u5c0e\u8a08\u7b97\u751f\u7269\u5b78\u7684\u52d2\u65af\u91cc\uff08Christina 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