{"id":37931,"date":"2022-01-26T00:51:55","date_gmt":"2022-01-25T16:51:55","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=37931"},"modified":"2022-01-17T14:46:53","modified_gmt":"2022-01-17T06:46:53","slug":"%e7%99%bd%e8%a1%80%e7%90%83%e7%99%8c%e7%b4%b0%e8%83%9e%e7%9a%84%e4%bc%91%e7%9c%a0%e7%8b%80%e6%85%8b%e5%8f%af%e5%b0%8d%e6%8a%97%e5%8c%96%e5%ad%b8%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=37931","title":{"rendered":"\u767d\u8840\u7403\u764c\u7d30\u80de\u7684\u4f11\u7720\u72c0\u614b\u53ef\u5c0d\u6297\u5316\u5b78\u6cbb\u7642 ?"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u767d\u8840\u75c5\u7684\u7642\u6cd5\u4ee5\u5316\u5b78\u7642\u6cd5\u70ba\u4e3b\uff0c\u4f46\u6709\u6642\u6703\u56e0\u9577\u671f\u526f\u4f5c\u7528\u3001\u6297\u85e5\u6027\u53ca\u9ad8\u5fa9\u767c\u7387\u800c\u7642\u6548\u4e0d\u4f73\u3002\u5728\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u5df2\u77e5\u7279\u5b9a\u764c\u7d30\u80de\u6703\u5728\u9032\u884c\u5316\u7642\u6642\u6703\u9032\u5165\u4f11\u7720\u72c0\u614b\uff0c\u800c\u5177\u6709\u62b5\u6297\u5316\u7642\u7684\u80fd\u529b\uff0c\u800c\u9019\u7a2e\u764c\u7d30\u80de\u7684\u7279\u6027\u662f\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u6a5f\u5236\u555f\u52d5\uff0c\u6240\u4ee5\u9020\u6210\u767d\u8840\u75c5\u5fa9\u767c\u7684\u539f\u56e0\u61c9\u5305\u62ec\u8868\u73fe\u578b\u8b8a\u7570\u8207\u57fa\u56e0\u578b\u8b8a\u7570\u3002\u5728\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u8207\u55ae\u7368\u4f7f\u7528\u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08Azacitidine\uff09\u76f8\u8f03\uff0c\u5df2\u767c\u73fe\u53e3\u670d\u7684\u6a19\u9776\u85e5\u7269\uff08Venetoclax\uff09\u8207\u53bb\u7532\u57fa\u5316\u85e5\u7269\u7684\u5408\u4f75\u7642\u6cd5\uff0c\u5c0d\u6cbb\u7642\u7684\u53cd\u61c9\u7387\u548c\u75c5\u60a3\u7684\u5b58\u6d3b\u7387\u5747\u8f03\u9ad8\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_37937\" aria-describedby=\"caption-attachment-37937\" style=\"width: 700px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/16089535_MotionElements_3d-model-of-green.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-37937\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/16089535_MotionElements_3d-model-of-green.jpg\" alt=\"\" width=\"700\" height=\"394\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/16089535_MotionElements_3d-model-of-green.jpg 700w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/16089535_MotionElements_3d-model-of-green-300x169.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/a><figcaption id=\"caption-attachment-37937\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90www.motionelements.com<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n<p>\u767d\u8840\u75c5\uff08\u8840\u764c\uff09\u7684\u7a2e\u985e\u7531\u8840\u6db2\u5167\u4e0d\u6210\u719f\u7684\u767d\u8840\u7403\u985e\u578b\u4f86\u5340\u5206\uff0c\u53ef\u5206\u70ba\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u3001\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u3001B\u7d30\u80de\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u53ca\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u5171\u56db\u7a2e <strong>\u3002<\/strong>\u767d\u8840\u75c5\u7684\u78ba\u5207\u539f\u56e0\u5c1a\u672a\u5341\u5206\u660e\u77ad\uff0c\u50c5\u77e5\u6089\u8207\u74b0\u5883\u8207\u907a\u50b3\u56e0\u7d20\u5747\u6709\u76f8\u95dc\u6027\uff0c\u5305\u62ec\u9aa8\u9ad3\u5e79\u7d30\u80de\u5167\u7684DNA\u8b8a\u7570\u3001\u57fa\u56e0\u7a81\u8b8a\uff08\u5982\u5510\u6c0f\u75c7\uff09\u3001\u66b4\u9732\u65bc\u6709\u653e\u5c04\u7dda\u6c61\u67d3\u7684\u74b0\u5883\uff08\u5982\u6838\u707d\u8b8a\u5730\u5340\uff09\u3001\u63a5\u89f8\u81f4\u764c\u7269\u8cea\uff08\u5982\u6709\u6a5f\u82ef\uff09\uff0c\u9ad4\u8cea\u7684\u56e0\u7d20\uff08\u764c\u57fa\u56e0\u7684\u8868\u73fe\uff09\u548c\u5438\u83f8\u7b49\uff0c\u53e6\u4eba\u985e\u55dcT\u6dcb\u5df4\u7403\u75c5\u6bd2\u7b2c\u4e00\u578b\uff08Human&nbsp;T-lymphotropic virus 1\uff0cHTLV-1\uff09\u4e5f\u53ef\u80fd\u5c0e\u81f4\u767d\u8840\u75c5\uff0c\u4e3b\u8981\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u5316\u5b78\u7642\u6cd5\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3001\u6a19\u9776\u6cbb\u7642\u53ca\u9aa8\u9ad3\u79fb\u690d\uff0c\u5176\u4e2d\u5316\u7642\u70ba\u767d\u8840\u75c5\u7684\u4e3b\u8981\u7642\u6cd5\u3002<\/p>\n<p>\u56db\u7a2e\u767d\u8840\u75c5\u4e2d\uff0cB \u7d30\u80de\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08B-cell precursor acute lymphoblastic leukemia, BCP-ALL\uff09\u5e38\u767c\u751f\u65bc\u5c0f\u5b69\uff0c\u901a\u5e38\u4f7f\u7528\u5316\u5b78\u6cbb\u7642\uff0c\u7d04\u670970\uff05\u7684\u6cbb\u7652\u6a5f\u6703\uff0c\u800c\u6210\u4eba\u7f79\u75c5\u4e5f\u5148\u4f5c\u5316\u7642\uff0c\u5f85\u7de9\u89e3\u5f8c\uff08\u81e8\u5e8a\u6aa2\u9a57\u627e\u4e0d\u5230\u764c\u7d30\u80de\uff09\u518d\u4f5c\u9aa8\u9ad3\u79fb\u690d\u6cbb\u7642\u3002BCP-ALL\u662f\u4e00\u7a2e\u9020\u6210\u5152\u7ae5\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u60e1\u6027\u75be\u75c5\uff0c\u5373\u4fbf\u5016\u5b58\uff0c\u75c5\u7ae5\u4e5f\u56e0\u70ba\u9ad8\u5f37\u5ea6\u5316\u5b78\u6cbb\u7642\u800c\u6709\u9577\u671f\u526f\u4f5c\u7528\uff0c\u5982\u6389\u9aee\u3001\u53e3\u8154\u9ecf\u819c\u7834\u640d\u53ca\u8179\u7009\u7b49\u3002\u5316\u7642\u96d6\u70ba\u767d\u8840\u75c5\u7684\u7b2c\u4e00\u7dda\u7642\u6cd5\uff0c\u4f46\u9577\u671f\u526f\u4f5c\u7528\u3001\u6297\u85e5\u6027\u53ca\u9ad8\u5fa9\u767c\u7387\u4ecd\u9020\u6210\u6cbb\u7642\u76f8\u7576\u5927\u7684\u6311\u6230\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u7279\u5b9a\u764c\u7d30\u80de\u7684\u4f11\u7720\u72c0\u614b\u53ef\u6297\u5316\u7642<\/strong><\/span><\/p>\n<p>\u70ba\u4f55\u7279\u5b9a\u764c\u7d30\u80de\u6703\u5c0d\u5316\u5b78\u7642\u6cd5\u6709\u6297\u85e5\u6027\uff0c\u4e00\u76f4\u662f\u91ab\u5b78\u754c\u7814\u7a76\u7684\u91cd\u9ede\u3002\u57282021\u5e74\uff0c\u82f1\u570b\u7814\u7a76\u4eba\u54e1\u5728\u767d\u8840\u75c5\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u9032\u884c\u5316\u5b78\u6cbb\u7642\u4ee5\u63a2\u8a0e\u9020\u6210\u764c\u7d30\u80de\u5c0d\u5316\u7642\u7522\u751f\u6297\u6027\u7684\u539f\u56e0\uff0c\u4e26\u65bc\u9996\u6b21\u6cbb\u7642\u5b8c\u6210\u5f8c\uff0c\u5206\u96e2\u51fa\u53ef\u6297\u5316\u7642\u7684\u764c\u7d30\u80de\u3002\u4ed6\u5011\u5c0d\u9019\u4e9b\u764c\u7d30\u80de\u9032\u884c\u5206\u9078\u53ca\u57fa\u56e0\u5b9a\u5e8f\u5f8c\uff0c\u5206\u6790\u7d50\u679c\u986f\u793a\u4e26\u6c92\u6709\u5171\u540c\u7684\u57fa\u56e0\u8b8a\u7570\u7684\u7279\u5fb5\uff0c\u8a31\u591a\u7a81\u8b8a\u4f4d\u9ede\u751a\u81f3\u8207\u672a\u7d93\u6cbb\u7642\u7684\u7d30\u80de\u57fa\u56e0\u5b8c\u5168\u76f8\u540c\uff0c\u4e26\u672a\u767c\u73fe\u6709\u57fa\u56e0\u7a81\u8b8a\u7684\u73fe\u8c61\u3002\u76f8\u53cd\u7684\uff0c\u7814\u7a76\u5718\u968a\u767c\u73fe\u9019\u4e9b\u53ef\u6297\u5316\u7642\u7684\u764c\u7d30\u80de\u7684\u5171\u901a\u7279\u6027\u662f\u8868\u89c0\u907a\u50b3\uff08epigenetics\uff09\u8abf\u63a7\u6a5f\u5236\u555f\u52d5\uff0c\u4f7f\u5f97\u764c\u7d30\u80de\u9032\u5165\u300c\u4f11\u7720\u300d\u72c0\u614b\u7684\u8868\u73fe\u578b\uff08phenotype\uff09\uff0c\u76ee\u524d\u5df2\u77e5\u9aa8\u9ad3\u5e79\u7d30\u80de\u4e5f\u6709\u985e\u4f3c\u7684\u57fa\u56e0\u8868\u73fe\u6a5f\u5236\uff0c\u4f7f\u5176\u9032\u5165\u4f11\u7720\u72c0\u614b\u5132\u5b58\u65bc\u8eab\u9ad4\u5167\u3002\u56e0\u6b64\uff0c\u4ed6\u5011\u9032\u4e00\u6b65\u5206\u6790 BCP-ALL \u60a3\u8005\u6703\u5c0d\u5316\u7642\u6c92\u6709\u53cd\u61c9\u7684\u539f\u56e0\uff0c\u8a8d\u70ba\u767d\u8840\u7403\u764c\u7d30\u80de\u4ea6\u6703\u5728\u9032\u884c\u5316\u7642\u671f\u9593\u9032\u5165\u300c\u4f11\u7720\u300d\u72c0\u614b 28 \u5929\uff0c\u4f7f\u4e4b\u5177\u6709\u62b5\u6297\u5316\u7642\u7684\u80fd\u529b\uff0c\u9019\u9805\u767c\u73fe\u4e5f\u53ef\u7528\u4f5c\u5c07\u4f86\u8abf\u63a7\u764c\u7d30\u80de\u5c0d\u5316\u7642\u53cd\u61c9\u7684\u751f\u7269\u6a19\u8a18\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u767d\u8840\u75c5\u5fa9\u767c\u5169\u5927\u6210\u56e0\uff1a\u8868\u73fe\u578b\u8b8a\u7570\u8207\u57fa\u56e0\u578b\u8b8a\u7570<\/strong><\/span><\/p>\n<p>\u79d1\u5b78\u5bb6\u8981\u964d\u4f4eBCP-ALL\u7684\u5316\u7642\u6297\u6027\u9020\u6210\u7684\u767d\u8840\u75c5\u5fa9\u767c\u7684\u6a5f\u6703\uff0c\u61c9\u7814\u7a76\u4e0b\u5217\u5169\u7a2e\u9020\u6210\u767d\u8840\u7403\u764c\u7d30\u80de\u767c\u751f\u8b8a\u7570\u7684\u6a5f\u5236\uff1a(1)\u8868\u73fe\u578b\u8b8a\u7570\uff1a\u6539\u8b8a\u8868\u89c0\u907a\u50b3\u4fee\u98fe\uff08\u5982DNA \u7532\u57fa\u5316\u3001\u7d44\u86cb\u767d\u4fee\u98fe\u548c\u975e\u7de8\u78bc RNA \u76f8\u95dc\u7684\u57fa\u56e0\u6c89\u9ed8\uff09\u53ef\u4ee5\u8abf\u63a7\u764c\u7d30\u80de\u6d3b\u6027\uff0c\u4f7f\u764c\u7d30\u80de\u5728\u9032\u5165\u4f11\u7720\u72c0\u614b\u6642\uff0c\u4ecd\u6703\u5c0d\u5316\u7642\u7522\u751f\u53cd\u61c9\uff0c\u4f8b\u5982\u65bd\u4e88\u6fc0\u7d20\u985e\u85e5\u7269\u800c\u589e\u52a0\u764c\u7d30\u80de\u7684\u6d3b\u6027\uff0c\u4f7f\u5176\u6d3b\u5316\u4e0d\u9032\u5165\u4f11\u7720\u72c0\u614b\uff0c\u4f46\u9019\u4ea6\u53ef\u80fd\u540c\u6642\u6d3b\u5316\u975e\u85e5\u7269\u4f5c\u7528\u76ee\u6a19\u7684\u6b63\u5e38\u7d30\u80de\uff1b(2)\u57fa\u56e0\u578b\u8b8a\u7570\uff1a\u9808\u89c0\u5bdf\u9577\u671f\u5316\u7642\u5c0d\u65bc\u764c\u7d30\u80de\u7684\u5f71\u97ff\uff0c\u5c24\u5176\u8981\u6ce8\u610f\u662f\u5426\u6703\u9020\u6210\u764c\u7d30\u80de\u7684\u57fa\u56e0\u7a81\u8b8a\u800c\u7522\u751f\u6297\u85e5\u6027\uff0c\u9019\u8207\u8868\u89c0\u907a\u50b3\u662f\u4e0d\u540c\u7684\u4f5c\u7528\u6a5f\u5236\u3002\u56e0\u6b64\uff0c\u6301\u7e8c\u63a2\u8a0e\u767d\u8840\u7403\u764c\u7d30\u80de\u7684\u8868\u73fe\u578b\u8b8a\u7570\u3001\u57fa\u56e0\u578b\u8b8a\u7570\u8207\u764c\u75c7\u5fa9\u767c\u7684\u95dc\u806f\u6027\uff0c\u5c07\u662f\u672a\u4f86\u7684\u7814\u7a76\u91cd\u9ede\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u5408\u4f75\u7642\u6cd5\u662f\u5c0d\u6210\u5e74\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u60a3\u8005\u7684\u4e00\u9053\u66d9\u5149<\/strong><\/span><\/p>\n<p>\u4ee5\u5f80\u5c0d\u5e74\u9577\uff0860\u6b72\u4ee5\u4e0a)\u7684BCP-ALL\u60a3\u8005\u800c\u8a00\uff0c\u901a\u5e38\u6703\u65bd\u4e88\u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08Azacitidine\uff09\u6216\u4f4e\u5291\u91cf\u5316\u5b78\u6cbb\u7642\uff08Cytarabine\uff09\uff0c\u96d6\u85e5\u7269\u7684\u6bd2\u6027\u4e0d\u5927\uff0c\u4f46\u6cbb\u7642\u6210\u6548\u4e0d\u4f73\uff0c\u5b8c\u5168\u7de9\u89e3\u7387\u5927\u7d04\u50c5\u670910-20%\u3002\u5e78\u904b\u5730\uff0c\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\u57282018\u5e74\u6838\u51c6\u53e3\u670d\u7684\u6a19\u9776\u85e5\u7269\uff08Venetoclax\uff0c\u4e00\u7a2e\u53ef\u6291\u5236\u6297\u7d30\u80de\u51cb\u4ea1\u86cb\u767dBCL-2 \u4f5c\u7528\u7684\u5c0f\u5206\u5b50\u85e5\u54c1\uff09\uff0c\u7528\u4f86\u6cbb\u7642\u5e74\u9577\u8005\u7684\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff0c\u8207\u53bb\u7532\u57fa\u5316\u85e5\u7269\u6216\u4f4e\u5291\u91cf\u5316\u5b78\u6cbb\u7642\u4f75\u7528\uff0c\u53ef\u670960-70% \u5b8c\u5168\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8207\u50b3\u7d71\u5316\u5b78\u6cbb\u7642\u76f8\u8fd1\uff0c\u800c\u4e14\u767c\u751f\u767d\u8840\u7403\u4f4e\u4e0b\u5c0e\u81f4\u611f\u67d3\u7684\u6bd4\u7387\u5927\u7d04\u53ea\u670930%\u3002<\/p>\n<p>\u57282020\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u5728\u4e00\u9805\u96a8\u6a5f\u7684\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u53c3\u8207\u7684\u6cbb\u7642\u4eba\u7fa4\u4e2d\u5171\u6709431 \u540d\u60a3\u8005\uff0c\u5176\u4e2d286 \u500b\u4eba\u5408\u4f75\u670d\u7528Azacitidine \u548cVenetoclax \uff0c145 \u500b\u4eba\u5408\u4f75\u670d\u7528Azacitidine \u548c\u5b89\u6170\u5291\u4f5c\u70ba\u5c0d\u7167\u7d44\u3002\u4ed6\u5011\u767c\u73fe\u4f7f\u7528Azacitidine \uff0dVenetoclax\u7684\u60a3\u8005\u5b8c\u5168\u7de9\u89e3\u7684\u6bd4\u7387\u8981\u8f03\u4f7f\u7528Azacitidine\uff0d\u5b89\u6170\u5291\u7684\u5c0d\u7167\u7d44\u66f4\u9ad8\uff0836.7% vs 17.9%\uff1bP&lt;0.001\uff09\uff0c\u800c\u4e14\u8907\u5408\u5b8c\u5168\u7de9\u89e3\uff08\u5b8c\u5168\u7de9\u89e3\u6216\u5b8c\u5168\u7de9\u89e3\u4f46\u8840\u7403\u6578\u672a\u5b8c\u5168\u6062\u5fa9\uff09\u7684\u6bd4\u7387\u4ea6\u66f4\u9ad8\uff0866.4% vs. 28.3%\uff1bP&lt;0.001\uff09\uff0c\u4f46\u4e8c\u8005\u4e3b\u8981\u4e0d\u826f\u4e8b\u4ef6\u548c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u767c\u751f\u7387\u5247\u76f8\u8fd1\u3002\u521d\u6b65\u7814\u7a76\u7d50\u679c\u986f\u793a\u4f75\u7528\u6a19\u9776\u85e5\u7269\uff08Venetoclax\uff09\u548c\u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08Azacitidine\uff09\uff0c\u8207\u55ae\u7368\u4f7f\u7528\u53bb\u7532\u57fa\u5316\u85e5\u7269\u76f8\u8f03\uff0c\u5c0d\u6cbb\u7642\u7684\u53cd\u61c9\u7387\u548c\u75c5\u60a3\u7684\u5b58\u6d3b\u90fd\u6709\u6bd4\u8f03\u5927\u7684\u6548\u76ca\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n<ol>\n<li>Turati VA, Guerra-Assun\u00e7\u00e3o JA, Potter NE, Gupta R, Ecker S, Daneviciute A, Tarabichi M, Webster AP, Ding C, May G, James C, Brown J, Conde L, Russell LJ, Ancliff P, Inglott S, Cazzaniga G, Biondi A, Hall GW, Lynch M, Hubank M, Macaulay I, Beck S, Van Loo P, Jacobsen SE, Greaves M, Herrero J, Enver T. Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia. Nat Cancer. 2021 Aug;2(8):835-852. doi: 10.1038\/s43018-021-00219-3. Epub 2021 Jul 5.<\/li>\n<li>DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH, Konopleva M, D\u00f6hner H, Letai A, Fenaux P, Koller E, Havelange V, Leber B, Esteve J, Wang J, Pejsa V, H\u00e1jek R, Porkka K, Ill\u00e9s \u00c1, Lavie D, Lemoli RM, Yamamoto K, Yoon SS, Jang JH, Yeh SP, Turgut M, Hong WJ, Zhou Y, Potluri J, Pratz KW. Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia. N Engl J Med. 2020 Aug 13;383(7):617-629. doi: 10.1056\/NEJMoa2012971..<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u767d\u8840\u75c5\u7684\u7642\u6cd5\u4ee5\u5316\u5b78\u7642\u6cd5\u70ba\u4e3b\uff0c\u4f46\u6709\u6642\u6703\u56e0\u9577\u671f\u526f\u4f5c\u7528\u3001\u6297\u85e5\u6027\u53ca\u9ad8\u5fa9\u767c\u7387\u800c\u7642\u6548\u4e0d\u4f73\u3002\u5728\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u5df2\u77e5\u7279\u5b9a\u764c\u7d30\u80de\u6703\u5728\u9032\u884c\u5316\u7642\u6642\u6703\u9032\u5165\u4f11\u7720\u72c0\u614b\uff0c\u800c\u5177\u6709\u62b5\u6297\u5316\u7642\u7684\u80fd\u529b\uff0c\u800c\u9019\u7a2e\u764c\u7d30\u80de\u7684\u7279\u6027\u662f\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u6a5f\u5236\u555f\u52d5\uff0c\u6240\u4ee5\u9020\u6210\u767d\u8840\u75c5\u5fa9\u767c\u7684\u539f\u56e0\u61c9\u5305\u62ec\u8868\u73fe\u578b\u8b8a\u7570\u8207\u57fa\u56e0\u578b\u8b8a\u7570\u3002\u5728\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u8207\u55ae\u7368\u4f7f\u7528\u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08Azacitidine\uff09\u76f8\u8f03\uff0c\u5df2\u767c\u73fe\u53e3\u670d\u7684\u6a19\u9776\u85e5\u7269\uff08Venetoclax\uff09\u8207\u53bb\u7532\u57fa\u5316\u85e5\u7269\u7684\u5408\u4f75\u7642\u6cd5\uff0c\u5c0d\u6cbb\u7642\u7684\u53cd\u61c9\u7387\u548c\u75c5\u60a3\u7684\u5b58\u6d3b\u7387\u5747\u8f03\u9ad8\u3002<\/p>\n","protected":false},"author":20,"featured_media":37937,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[5369,5368,5370,5371,5367],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/16089535_MotionElements_3d-model-of-green.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/37931"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=37931"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/37931\/revisions"}],"predecessor-version":[{"id":37938,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/37931\/revisions\/37938"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/37937"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=37931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=37931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=37931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}