

{"id":37929,"date":"2022-01-19T00:51:53","date_gmt":"2022-01-18T16:51:53","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=37929"},"modified":"2021-12-27T09:25:23","modified_gmt":"2021-12-27T01:25:23","slug":"%e5%ac%b0%e5%85%92%e5%8d%8a%e5%a4%9c%e5%93%ad%e9%ac%a7%e8%88%87%e6%af%8d%e4%b9%b3%e7%9a%84%e7%87%9f%e9%a4%8a%e7%b4%a0%e6%9c%89%e9%97%9c%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=37929","title":{"rendered":"\u5b30\u5152\u534a\u591c\u54ed\u9b27\u8207\u6bcd\u4e73\u7684\u71df\u990a\u7d20\u6709\u95dc\uff1f"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u71df\u990a\u651d\u53d6\u8ddf\u6bcd\u5b50\u4f5c\u606f\u6709\u95dc\uff0c\u6240\u4ee5\u8abf\u6574\u5b30\u5152\u8207\u6bcd\u4e73\u5abd\u5abd\u7684\u71df\u990a\u651d\u53d6\u6709\u6a5f\u6703\u6539\u5584\u6bcd\u5b50\u7684\u7761\u7720\u554f\u984c\u3002\u56e0\u70ba\u5ca9\u85fb\u7cd6\u8f49\u79fb\u9176\u7b2c\u4e8c\u578b\uff08FUT2\uff09\u53ef\u5f71\u97ff\u6bcd\u4e73\u5be1\u7cd6\u7684\u7a2e\u985e\u8207\u542b\u91cf\u53ca\u7dad\u751f\u7d20 B12 \u7684\u542b\u91cf\uff0c\u800c\u8207\u6bcd\u5b50\u7761\u7720\u4f5c\u606f\u6709\u95dc\u3002\u6bcd\u89aa\u8981\u6539\u5584\u54fa\u80b2\u5b30\u5152\u7684\u751f\u6d3b\uff0c\u9996\u5148\u8981\u4e86\u89e3\u81ea\u8eab\u662f\u4f55\u7a2e\u9ad4\u8cea\uff0c\u900f\u904e\u6bcd\u4e73\u71df\u990a\u57fa\u56e0\u6aa2\u6e2c\u4f86\u7cbe\u6e96\u4e86\u89e3\u81ea\u5df1\u5c6c\u65bc FUT2 \u5206\u6ccc\u578b\u9084\u662f\u975e\u5206\u6ccc\u578b\uff0c\u64da\u4ee5\u898f\u5283\u9069\u5408\u7684\u71df\u990a\u65b9\u91dd\uff0c\u9078\u64c7\u589e\u52a0\u6bcd\u4e73\u71df\u990a\u3001\u63d0\u4f9b\u5b30\u5152\u984d\u5916\u7684\u71df\u990a\u6216\u4e8c\u8005\u4e26\u884c\uff0c\u53ef\u8b93\u6bcd\u5b50\u4f5c\u606f\u8207\u7761\u7720\u5f97\u5230\u78ba\u5be6\u7684\u6539\u5584\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_37939\" aria-describedby=\"caption-attachment-37939\" style=\"width: 373px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/8494646.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-37939\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/8494646.png\" alt=\"\" width=\"373\" height=\"350\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/8494646.png 1113w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/8494646-300x281.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/8494646-768x720.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/8494646-1024x961.png 1024w\" sizes=\"(max-width: 373px) 100vw, 373px\" \/><\/a><figcaption id=\"caption-attachment-37939\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u71df\u990a\u651d\u53d6\u8ddf\u6bcd\u5b50\u4f5c\u606f\u6709\u95dc<\/strong><\/span><\/p>\n<p>\u5a66\u5973\u65bc\u61f7\u5b55\u671f\u9593\uff0c\u5bb9\u6613\u56e0\u6fc0\u7d20\u5206\u6ccc\u53ca\u8eab\u9ad4\u5f62\u72c0\u8b8a\u5316\u800c\u5c0e\u81f4\u5fc3\u795e\u4e0d\u5be7\u3001\u65e5\u591c\u985b\u5012\u6216\u904e\u5ea6\u7126\u616e\uff0c\u4f7f\u5f97\u7761\u7720\u54c1\u8cea\u4e0d\u4f73\uff0c\u61f7\u5b55\u5f8c\u671f\u751a\u81f3\u6703\u6709\u6c34\u816b\u3001\u8840\u58d3\u904e\u9ad8\u6216\u8840\u7cd6\u904e\u9ad8\u7684\u73fe\u8c61\u3002\u9806\u5229\u751f\u7522\u5f8c\u53c8\u9808\u61c9\u5c0d\u52de\u5fc3\u52de\u529b\u7684\u80b2\u5152\u5de5\u4f5c\uff0c\u751f\u6d3b\u5341\u5206\u5fd9\u788c\uff0c\u800c\u4e14\u53ef\u80fd\u7531\u65bc\u5b30\u5152\u7cbe\u795e\u592a\u597d\u3001\u597d\u52d5\u3001\u54ed\u9b27\u3001\u665a\u4e0a\u4e0d\u7761\u89ba\u6216\u665a\u4e0a\u9700\u8981\u559d\u5976\u7b49\u56e0\u7d20\uff0c\u800c\u9020\u6210\u6bcd\u89aa\u7761\u7720\u4e0d\u8db3\u6216\u5931\u7720\u3002<\/p>\n<p>\u5c0e\u81f4\u5b30\u5152\u534a\u591c\u54ed\u9b27\u7684\u539f\u56e0\u6709\u5f88\u591a\uff0c\u5982\u809a\u5b50\u9913\uff0c\u8178\u80c3\u8139\u6c23\u3001\u8178\u7d5e\u75db\u6216\u6392\u5c3f\u3001\u6392\u4fbf\u7b49\uff0c\u96d6\u7136\u53ef\u4ee5\u900f\u904e\u5b30\u5152\u6309\u6469\u8207\u8abf\u6574\u65e5\u9593\u9935\u5976\u91cf\u3001\u6642\u9593\u53ca\u6b21\u6578\u7b49\u65b9\u6cd5\u4f86\u6539\u5584\uff0c\u4f46\u662f\u6bcd\u89aa\u7684\u5065\u5eb7\u8207\u4f5c\u606f\u4e5f\u662f\u80b2\u5152\u7684\u91cd\u8981\u8ab2\u984c\uff0c\u5982\u4f55\u9054\u5230\u6bcd\u89aa\u8207\u5b30\u5152\u4f5c\u606f\u4e00\u81f4\u975e\u5e38\u91cd\u8981\u3002\u6700\u8fd1\u5df2\u6709\u8d8a\u4f86\u8d8a\u591a\u7684\u8b49\u64da\u986f\u793a\uff0c\u8abf\u6574\u5b30\u5152\u8207\u6bcd\u4e73\u5abd\u5abd\u7684\u71df\u990a\u651d\u53d6\u6709\u52a9\u65bc\u6539\u5584\u6bcd\u5b50\u7684\u4f5c\u606f\u8207\u7761\u7720\u554f\u984c\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u6bcd\u4e73\u7684\u95dc\u9375\u71df\u990a\u7d20\uff1a\u5ca9\u85fb\u7cd6\u8f49\u79fb\u9176\u7b2c\u4e8c\u578b\uff08<\/strong><strong>FUT2<\/strong><strong>\uff09<\/strong><\/span><\/p>\n<p>\u534a\u4e73\u7cd6\u82f7 2-\u03b1-\u5de6\u65cb-\u5ca9\u85fb\u7cd6\u8f49\u79fb\u9176\u7b2c\u4e8c\u578b\uff08Galactoside 2-alpha-L-fucosyltransferase 2\uff09\u7c21\u7a31\u5ca9\u85fb\u7cd6\u8f49\u79fb\u9176\u7b2c\u4e8c\u578b\uff08Fucosyltransferase 2, FUT2\uff09\uff0c\u4e43\u7531\u4eba\u985e\u7684<em>FUT2<\/em>&nbsp;\u57fa\u56e0\u4f86\u8868\u73fe\uff0c\u6bcd\u4e73\u7684FUT2\u529f\u80fd\u8207\u6bcd\u5b50\u7761\u7720\u4f5c\u606f\u6709\u95dc\u3002FUT2 \u70ba\u4eba\u9ad4\u5167\u4fee\u98fe\u91a3\u985e\u57fa\u5718\u7684\u9175\u7d20\uff0c\u53ef\u4f9d\u57fa\u56e0\u578b\u5206\u70ba\u6b63\u5e38\u7684\u300c\u5206\u6ccc\u578b\u300d\u8207\u6709\u7f3a\u9677\u7684\u300c\u975e\u5206\u6ccc\u578b\u300d\u3002<\/p>\n<p>\u529f\u80fd\u6b63\u5e38\u7684FUT2\u5206\u6ccc\u578b\u53ef\u5c0d\u5be1\u7cd6\u5206\u5b50\u9032\u884c\u5ca9\u85fb\u7cd6\u57fa\u5718\u7684\u6dfb\u52a0\u4f5c\u7528\uff0c\u53cd\u4e4bFUT2\u975e\u5206\u6ccc\u578b\u5247\u7121\u6b64\u529f\u80fd\u3002FUT2 \u5728\u4eba\u9ad4\u626e\u6f14\u95dc\u9375\u89d2\u8272\uff0c\u4f8b\u5982\uff1a\u5728\u9020\u8840\u529f\u80fd\u4e0a\uff0c\u53ef\u4fee\u98fe\u7d05\u8840\u7403\u8868\u9762\u91a3\u86cb\u767d\u7684\u91a3\u985e\u57fa\u5718\uff0c\u8207 \u4eba\u985eABO \u8840\u578b\u7684\u5f62\u6210\u6709\u95dc\uff1b\u65bc\u6d88\u5316\u9053\u5fae\u74b0\u5883\u4e2d\uff0c\u53ef\u5f71\u97ff\u8178\u9053\u4e0a\u76ae\u7d30\u80de\u88fd\u9020\u7684\u5be1\u91a3\uff1b\u5728\u8178\u9053\u83cc\u76f8\u65b9\u9762\uff0cFUT2\u5206\u6ccc\u578b\u7684\u53ef\u767c\u73fe\u591a\u7a2e\u4e73\u9178\u687f\u83cc\uff0c\u800c\u975e\u5206\u6ccc\u578b\u7684\u5e7e\u4e4e\u770b\u4e0d\u5230\u4e73\u9178\u687f\u83cc\u3002\u6700\u91cd\u8981\u7684\u662f\uff0cFUT2 \u5728\u6bcd\u4e73\u5169\u5927\u95dc\u9375\u71df\u990a\u7d20\u4e2d\u626e\u6f14\u91cd\u8981\u529f\u80fd\uff1a\u4e00\u662f\u5f71\u97ff\u6bcd\u4e73\u5be1\u7cd6\u7684\u7a2e\u985e\u8207\u542b\u91cf\uff0c\u4e8c\u662f\u8207\u7dad\u751f\u7d20 B12 \u7684\u542b\u91cf\u7dad\u6301\u6709\u95dc\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>FUT2\u5206\u6ccc\u578b\u8207\u975e\u5206\u6ccc\u578b\u6bcd\u89aa\u7684\u6bd4\u8f03<\/strong><\/span><\/p>\n<p>\u7dad\u751f\u7d20 B12\u70ba\u4e2d\u5fc3\u542b\u6709\u4e00\u500b\u9237\u96e2\u5b50\u7684\u74b0\u72c0\u7d50\u69cb\uff0c\u53c8\u7a31\u9237\u80fa\u7d20\ufe59cyanocobalamin\ufe5a\uff0c\u4e3b\u8981\u53c3\u8207DNA\u3001RNA\u7684\u5408\u6210\u53ca\u91a3\u985e\u3001\u86cb\u767d\u8cea\u3001\u8102\u80aa\u7684\u4ee3\u8b1d\uff0c\u76f8\u95dc\u6587\u737b\u4e5f\u6307\u51fa\u8840\u4e2d\u7dad\u751f\u7d20 B12 \u542b\u91cf\u8f03\u4f4e\u7684\u5973\u6027\u7684\u7761\u7720\u54c1\u8cea\u8f03\u5dee\u3002\u7dad\u751f\u7d20 B12\u6703\u8207\u553e\u6db2\u4e2d\u7684\u55dc\u9237\u86cb\u767d\uff08Cobalophilin\uff09\u6216\u80c3\u4e2d\u7684B12\u7d50\u5408\u86cb\u767d\uff08haptocorrin\uff09\u7d50\u5408\uff0c\u9032\u5165\u8178\u9053\u5f8c\u7d93\u904e\u80f0\u86cb\u767d\u9176\u4f5c\u7528\uff0c\u91cb\u51fa\u7684\u7dad\u751f\u7d20B12\u6703\u8207\u80c3\u58c1\u7d30\u80de\u5206\u6ccc\u7684\u5167\u5728\u56e0\u5b50\uff08intrinsic factor\uff0cIF\uff09\u7d50\u5408\u6210IF- B12\u8907\u5408\u7269\uff0c\u8ff4\u8178\u9ecf\u819c\u7684\u4e0a\u76ae\u7d30\u80de\u63a5\u53d7\u5668\u901a\u904e\u5167\u566c\u4f5c\u7528\uff08endocytosis\uff09\u4f7f\u5176\u9032\u5165\u7d30\u80de\u5167\uff0c\u518d\u8207\u8f49\u9237\u80fa\u7d20\uff08transcobalamin II\uff09\u7d50\u5408\u5f8c\uff0c\u5927\u90e8\u5206\u904b\u9001\u81f3\u809d\u81df\u5132\u5b58\uff0c\u5c11\u90e8\u5206\u904b\u8f38\u5230\u5168\u8eab\u7d44\u7e54\u52a0\u4ee5\u5229\u7528\uff0c\u800c\u672a\u7d93\u5229\u7528\u7684B12\u7d93\u809d\u81df\u4ee3\u8b1d\u5f8c\u96a8\u81bd\u6c41\u6392\u51fa\u3002<\/p>\n<p>\u76f8\u8f03\u65bc\u975e\u5206\u6ccc\u578b\uff0cFUT2\u5206\u6ccc\u578b\u5abd\u5abd\u7684\u6bcd\u4e73\u5be1\u7cd6\u7a2e\u985e\u660e\u986f\u8c50\u5bcc\u8a31\u591a\uff0c\u5be1\u91a3\u542b\u91cf\u4e5f\u5dee\u4e86 7 \u500d\u4e4b\u591a\u3002\u6bcd\u4e73\u5be1\u7cd6\u662f\u4fc3\u9032\u5b30\u5152\u8178\u9053\u76ca\u751f\u83cc\u751f\u9577\u7684\u4fc3\u9032\u56e0\u5b50\uff0c\u53ef\u6291\u5236\u58de\u83cc\u751f\u9577\u8207\u75c5\u539f\u9ad4\u5165\u4fb5\uff0c\u5e6b\u52a9\u5b30\u5152\u5efa\u7acb\u826f\u597d\u7684\u8178\u9053\u83cc\u76f8\u8207\u514d\u75ab\u80fd\u529b\u3002\u7136\u800c\uff0c\u56e0\u70ba\u5206\u6ccc\u578b\u7684\u529f\u80fd\u6b63\u5e38\uff0c\u800c\u6703\u53bb\u4fee\u98fe Haptocorrin \u86cb\u767d\u7684\u8868\u9762\u7d50\u69cb\uff0c\u4f7f\u5176\u8207\u7dad\u751f\u7d20 B12 \u7684\u7d50\u5408\u80fd\u529b\u964d\u4f4e\u3002\u9019\u6703\u4f7f Haptocorrin \u86cb\u767d\u7121\u6cd5\u4fdd\u8b77\u7dad\u751f\u7d20 B12 \u800c\u4e0d\u88ab\u751f\u7269\u6027\u5206\u89e3\uff0c\u4f7f\u5f97FUT2\u5206\u6ccc\u578b\u5abd\u5abd\u6bcd\u4e73\u7684\u7dad\u751f\u7d20 B12 \u6fc3\u5ea6\u8207\u542b\u91cf\u53cd\u800c\u8f03\u4f4e\u3002\u53cd\u4e4b\uff0cFUT2\u975e\u5206\u6ccc\u578b\u5abd\u5abd\u96d6\u7136\u6bcd\u4e73\u4e2d\u7684\u5be1\u7cd6\u7a2e\u985e\u8207\u542b\u91cf\u8f03\u5c11\uff0c\u4f46\u537b\u80fd\u7dad\u6301\u8f03\u9ad8\u7684\u7dad\u751f\u7d20 B12 \u542b\u91cf\uff08\u8868 1\uff09\u3002<\/p>\n<p>\u5df2\u6709\u7814\u7a76\u5831\u544a\u986f\u793a\uff0c\u7528FUT2\u5206\u6ccc\u578b\u5abd\u5abd\u6bcd\u4e73\u54fa\u9935\u7684\u5b30\u5152\u767c\u751f\u8179\u7009\u548c\u8139\u6c23\u7684\u6a5f\u7387\u8f03\u4f4e\uff0c\u4e5f\u8f03\u4e0d\u6613\u51fa\u73fe\u8178\u7d5e\u75db\u3002\u7136\u800c\uff0c\u5206\u6ccc\u578b\u5abd\u5abd\u7684\u5b30\u5152\u534a\u591c\u96d6\u7136\u8f03\u5c11\u54ed\u9b27\uff0c\u4f46\u5abd\u5abd\u4ecd\u53ef\u80fd\u6703\u56e0\u7dad\u751f\u7d20 B12\u542b\u91cf\u8f03\u4f4e\uff0c\u800c\u5448\u73fe\u7761\u7720\u54c1\u8cea\u8f03\u5dee\u7684\u73fe\u8c61\u3002\u53e6\u4e00\u65b9\u9762\uff0cFUT2\u975e\u5206\u6ccc\u578b\u5abd\u5abd\u5373\u4f7f\u7dad\u751f\u7d20 B12\u542b\u91cf\u5145\u8db3\uff0c\u7761\u7720\u54c1\u8cea\u8f03\u4f73\uff0c\u4f46\u5be6\u969b\u4e0a\u5b30\u5152\u537b\u53ef\u80fd\u56e0\u70ba\u6d88\u5316\u9053\u554f\u984c\uff0c\u767c\u751f\u8179\u7009\u8207\u8139\u6c23\u7684\u6a5f\u7387\u8f03\u9ad8\uff0c\u5bb9\u6613\u5728\u591c\u9593\u54ed\u9b27\uff0c\u4f7f\u5f97\u6bcd\u89aa\u5e38\u9700\u534a\u591c\u8d77\u5e8a\u7167\u9867\uff08\u8868 1\uff09\u3002<\/p>\n<p>&nbsp;\u88681\uff1aFUT2\u5206\u6ccc\u578b\u53ca\u975e\u5206\u6ccc\u578b\u7684\u6bd4\u8f03<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"141\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; \u6bd4\u8f03<\/p>\n<p>\u985e\u578b<\/td>\n<td width=\"139\">\u6bcd\u4e73\u7684\u5be1\u7cd6\u7a2e\u985e\u53ca\u542b\u91cf<\/td>\n<td width=\"139\">\u6bcd\u4e73\u7684\u7dad\u751f\u7d20 B12\u542b\u91cf<\/td>\n<td width=\"139\">\u6bcd\u89aa\u7684\u7761\u7720\u54c1\u8cea<\/td>\n<td width=\"139\">\u5b30\u5152\u767c\u751f\u8179\u7009\u548c\u8139\u6c23\u6a5f\u7387<\/td>\n<\/tr>\n<tr>\n<td width=\"141\">FUT2\u5206\u6ccc\u578b<\/td>\n<td width=\"139\">\u591a<\/td>\n<td width=\"139\">\u4f4e<\/td>\n<td width=\"139\">\u5dee<\/td>\n<td width=\"139\">\u4f4e<\/td>\n<\/tr>\n<tr>\n<td width=\"141\">FUT2\u975e\u5206\u6ccc\u578b<\/td>\n<td width=\"139\">\u5c11<\/td>\n<td width=\"139\">\u9ad8<\/td>\n<td width=\"139\">\u4f73<\/td>\n<td width=\"139\">\u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u6bcd\u89aa\u8981\u6539\u5584\u54fa\u80b2\u5b30\u5152\u7684\u65b0\u751f\u6d3b\uff0c\u9996\u5148\u5f9e\u4e86\u89e3\u81ea\u8eab\u662f\u4f55\u7a2e\u9ad4\u8cea\u958b\u59cb\u3002\u82e5\u5abd\u5abd\u9577\u671f\u5931\u7720\u3001\u7761\u7720\u4e0d\u8db3\u6216\u54c1\u8cea\u4e0d\u4f73\uff0c\u5fc3\u60c5\u8207\u6388\u4e73\u91cf\u5c07\u5927\u53d7\u5f71\u97ff\u3002\u8981\u6539\u5584\u9019\u7a2e\u60c5\u5f62\uff0c\u5abd\u5abd\u53ef\u900f\u904e\u6bcd\u4e73\u71df\u990a\u57fa\u56e0\u6aa2\u6e2c\u4f86\u7cbe\u6e96\u4e86\u89e3\u81ea\u5df1\u5c6c\u65bc FUT2 \u5206\u6ccc\u578b\u9084\u662f\u975e\u5206\u6ccc\u578b\uff0c\u85c9\u6b64\u898f\u5283\u6700\u9069\u5408\u500b\u4eba\u7684\u71df\u990a\u65b9\u91dd\uff0c\u63a1\u7528\u589e\u52a0\u6bcd\u4e73\u71df\u990a\u3001\u63d0\u4f9b\u5b30\u5152\u984d\u5916\u7684\u71df\u990a\u88dc\u5145\u6216\u4e8c\u8005\u4e26\u884c\u7684\u65b9\u6cd5\uff0c\u9806\u5229\u8b93\u6bcd\u5b50\u4f5c\u606f\u8207\u7761\u7720\u7372\u5f97\u78ba\u5be6\u7684\u6539\u5584\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n<ol>\n<li>Vandenplas Y, Ludwig T, Bouritius H, Alliet P, Forde D, Peeters S, Huet F, Hourihane J. Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic. Acta Paediatr. 2017 Jul;106(7):1150-1158. doi: 10.1111\/apa.13844. Epub 2017 Apr 19.<\/li>\n<li>Tanwar VS, Chand MP, Kumar J, Garg G, Seth S, Karthikeyan G, Sengupta S. Common variant in FUT2 gene is associated with levels of vitamin B12 in Indian population. Vinay Singh Tanwar, Mandeep P Chand, Jitender Kumar, Gaurav Garg, Sandeep Seth, Ganesan Karthikeyan, Shantanu Sengupta. Gene. 2013 Feb 15;515(1):224-8. doi: 10.1016\/j.gene.2012.11.021. Epub 2012 Nov 29.<\/li>\n<li>Al-Musharaf S, Alabdulaaly A, Bin Mujalli H, Alshehri H, Alajaji H, Bogis R, Alnafisah R, Alfehaid S, Alhodaib H, Murphy AM, Hussain SD, Sabico S, McTernan PG, Al-Daghri N. Sleep Quality Is Associated with Vitamin B12 Status in Female Arab Students. Int J Environ Res Public Health. 2021 Apr 25;18(9):4548. doi: 10.3390\/ijerph18094548.<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rausch+P&amp;cauthor_id=22068912\">Rausch<\/a>P,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rehman+A&amp;cauthor_id=22068912\">Rehman<\/a> A,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=K%C3%BCnzel+S&amp;cauthor_id=22068912\">K\u00fcnzel<\/a> S,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=H%C3%A4sler+R&amp;cauthor_id=22068912\">H\u00e4sler<\/a> R,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ott+SJ&amp;cauthor_id=22068912\"> Ott<\/a> SJ,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Schreiber+S&amp;cauthor_id=22068912\">Schreiber<\/a> S,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rosenstiel+P&amp;cauthor_id=22068912\">Rosenstiel<\/a> P,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Franke+A&amp;cauthor_id=22068912\">Franke<\/a> A,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Baines+JF&amp;cauthor_id=22068912\"> Baines<\/a> JF. Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19030-5.doi: 10.1073\/pnas.1106408108.&nbsp;Epub 2011 Nov 8. 2011.&nbsp;<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u71df\u990a\u651d\u53d6\u8ddf\u6bcd\u5b50\u4f5c\u606f\u6709\u95dc\uff0c\u6240\u4ee5\u8abf\u6574\u5b30\u5152\u8207\u6bcd\u4e73\u5abd\u5abd\u7684\u71df\u990a\u651d\u53d6\u6709\u6a5f\u6703\u6539\u5584\u6bcd\u5b50\u7684\u7761\u7720\u554f\u984c\u3002\u56e0\u70ba\u5ca9\u85fb\u7cd6\u8f49\u79fb\u9176\u7b2c\u4e8c\u578b\uff08FUT2\uff09\u53ef\u5f71\u97ff\u6bcd\u4e73\u5be1\u7cd6\u7684\u7a2e\u985e\u8207\u542b\u91cf\u53ca\u7dad\u751f\u7d20 B12 \u7684\u542b\u91cf\uff0c\u800c\u8207\u6bcd\u5b50\u7761\u7720\u4f5c\u606f\u6709\u95dc\u3002\u6bcd\u89aa\u8981\u6539\u5584\u54fa\u80b2\u5b30\u5152\u7684\u751f\u6d3b\uff0c\u9996\u5148\u8981\u4e86\u89e3\u81ea\u8eab\u662f\u4f55\u7a2e\u9ad4\u8cea\uff0c\u900f\u904e\u6bcd\u4e73\u71df\u990a\u57fa\u56e0\u6aa2\u6e2c\u4f86\u7cbe\u6e96\u4e86\u89e3\u81ea\u5df1\u5c6c\u65bc FUT2 \u5206\u6ccc\u578b\u9084\u662f\u975e\u5206\u6ccc\u578b\uff0c\u64da\u4ee5\u898f\u5283\u9069\u5408\u7684\u71df\u990a\u65b9\u91dd\uff0c\u9078\u64c7\u589e\u52a0\u6bcd\u4e73\u71df\u990a\u3001\u63d0\u4f9b\u5b30\u5152\u984d\u5916\u7684\u71df\u990a\u6216\u4e8c\u8005\u4e26\u884c\uff0c\u53ef\u8b93\u6bcd\u5b50\u4f5c\u606f\u8207\u7761\u7720\u5f97\u5230\u78ba\u5be6\u7684\u6539\u5584\u3002<\/p>\n","protected":false},"author":20,"featured_media":37939,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1334,5374,5372,5373],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/12\/8494646.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/37929"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=37929"}],"version-history":[{"count":2,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/37929\/revisions"}],"predecessor-version":[{"id":37941,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/37929\/revisions\/37941"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/37939"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=37929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=37929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=37929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}