{"id":37641,"date":"2021-12-16T00:31:41","date_gmt":"2021-12-15T16:31:41","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=37641"},"modified":"2021-11-29T10:44:35","modified_gmt":"2021-11-29T02:44:35","slug":"%e8%aa%8d%e8%ad%98%e8%a1%80%e8%85%a6%e5%b1%8f%e9%9a%9c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=37641","title":{"rendered":"\u8a8d\u8b58\u8840\u8166\u5c4f\u969c"},"content":{"rendered":"

\u8166\u7d44\u7e54\u5167\u7684\u6bdb\u7d30\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u7dca\u5bc6\u76f8\u9023\uff0c\u5167\u76ae\u7d30\u80de\u4e4b\u9593\u6c92\u6709\u9593\u9699\uff0c\u6bdb\u7d30\u8840\u7ba1\u5916\u8868\u9762\u5e7e\u4e4e\u70ba\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u5305\u570d\uff0c\u5f62\u6210\u4e86\u8840\u6f3f\u8207\u8166\u810a\u9ad3\u6db2\u4e4b\u9593\u7684\u969c\u58c1\uff0d\u8840\u8166\u5c4f\u969c\uff08BBB\uff09\uff0c\u4f4d\u65bc\u8166\u7d30\u80de\u8207\u8840\u6db2\u4e4b\u9593\uff0c\u53ef\u4ee5\u4f5c\u70ba\u9078\u64c7\u6027\u963b\u6b62\u67d0\u4e9b\u7269\u8cea\u7531\u8840\u6db2\u9032\u5165\u5927\u8166\u7684\u5c4f\u969c\u3002BBB\u56b4\u683c\u8abf\u7bc0\u96e2\u5b50\u3001\u5206\u5b50\u548c\u7d30\u80de\u5728\u8840\u6db2\u548c\u8584\u58c1\uff08parenchyma\uff09\u7d44\u7e54\u4e4b\u9593\u7684\u904b\u52d5\uff0c\u5c0d\u795e\u7d93\u5143\u529f\u80fd\u4fdd\u8b77\u81f3\u95dc\u91cd\u8981\u3002\u7136\u800c\uff0cBBB\u7684\u5b58\u5728\u5c0d\u8166\u90e8\u75be\u75c5\u7684\u85e5\u7269\u6cbb\u7642\u4ea6\u6709\u76f8\u7576\u5f71\u97ff\u3002<\/strong><\/span><\/p>\n

\"\"<\/a>
\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u4eba\u9ad4\u4e09\u5927\u5c4f\u969c<\/strong><\/span><\/p>\n

\u773e\u6240\u7686\u77e5\uff0c\u4eba\u9ad4\u6709\u4e09\u9053\u514d\u75ab\u9632\u7dda\uff0c\u8ca0\u8cac\u62b5\u79a6\u75c5\u539f\u9ad4\u7684\u653b\u64ca\u3002\u76ae\u819a\u3001\u9ecf\u819c\u53ca\u5206\u6ccc\u7269\u662f\u7b2c\u4e00\u9053\u7269\u7406\u3001\u5316\u5b78\u9632\u7dda\uff0c\u5b9b\u5982\u76fe\u724c\u62b5\u64cb\u5916\u4f86\u7570\u7269\u7684\u5165\u4fb5\uff1b\u767d\u8840\u7403\u3001\u5de8\u566c\u7d30\u80de\u3001\u7d44\u7e54\u751f\u5316\u6210\u5206\uff08\u5982\u5e72\u64fe\u7d20\u3001\u6eb6\u83cc\u9176\u3001\u03b2-\u6eb6\u89e3\u7d20\uff09\u7b49\u514d\u75ab\u5c0f\u5175\u5247\u4f5c\u70ba\u7b2c\u4e8c\u9053\u7d30\u80de\u6027\u9632\u79a6\u9632\u7dda\uff1b\u7b2c\u4e09\u9053\u9632\u7dda\u662f\u5c08\u4e00\u6027\u7684\u514d\u75ab\u5927\u5c07\u8ecdB\u7d30\u80de\u8207T\u7d30\u80de\u3002\u9664\u4e86\u514d\u75ab\u7cfb\u7d71\u4e4b\u5916\uff0c\u4eba\u9ad4\u66f4\u64c1\u6709\u300c\u4e09\u5927\u5c4f\u969c\u300d\uff0c\u5f77\u5f7f\u662f\u570d\u7246\u963b\u64cb\u5916\u4f86\u7570\u7269\uff0c\u5305\u62ec\u80ce\u76e4\u5c4f\u969c\uff08placental barrier\uff09\u3001\u8178\u9053\u5c4f\u969c\uff08intestinal barrier\uff09\u8207\u8840\u8166\u5c4f\u969c\uff08blood-brain barrier, BBB\uff09\uff0c\u5176\u4e2d\u4ee5\u5f8c\u8005\u6700\u70ba\u91cd\u8981\u3002<\/p>\n

    \n
  1. \u80ce\u76e4\u5c4f\u969c\uff1a\u80ce\u76e4\u7531\u7d68\u6bdb\u819c\u3001\u7d68\u6bdb\u9593\u9699\u548c\u6bcd\u9ad4\u5b50\u5bae\u7d44\u7e54\uff08\u57fa\u86fb\u819c\uff09\u69cb\u6210\uff0c\u9023\u63a5\u6bcd\u9ad4\u548c\u80ce\u5152\u3002\u7d68\u6bdb\u819c\u542b\u6709\u7d68\u6bdb\uff0c\u53ef\u5438\u6536\u6c27\u6c23\u548c\u990a\u5206\uff0c\u4e26\u6392\u6cc4\u4ee3\u8b1d\u5ee2\u7269\u3002\u5728\u598a\u5a20\u671f\u9593\uff0c\u6bcd\u89aa\u8207\u80ce\u5152\u7684\u8840\u6db2\u5206\u958b\uff0c\u4e92\u4e0d\u5e72\u64fe\uff0c\u540c\u6642\u53c8\u9032\u884c\u9078\u64c7\u6027\u7684\u7269\u8cea\u4ea4\u63db\uff0c\u6b64\u7a2e\u73fe\u8c61\u7a31\u70ba\u80ce\u76e4\u5c4f\u969c\uff08\u7d68\u6bdb\u7d44\u7e54\u8207\u5b50\u5bae\u8840\u7ac7\u9593\u7684\u969c\u853d\uff09\uff0c\u4f46\u901a\u900f\u6027\u8207\u4e00\u822c\u6bdb\u7d30\u8840\u7ba1\u7121\u986f\u8457\u5dee\u7570\uff0c\u5927\u591a\u6578\u85e5\u7269\u90fd\u80fd\u7a7f\u900f\u6b64\u5c4f\u969c\u800c\u9032\u5165\u80ce\u5152\u5faa\u74b0\u3002<\/li>\n
  2. \u8178\u9053\u5c4f\u969c\uff1a\u8178\u9053\u5167\u5b58\u5728\u8a31\u591a\u7d30\u83cc\uff0c\u5f7c\u6b64\u5236\u7d04\uff0c\u76f8\u4e92\u4f9d\u5b58\uff0c\u69cb\u6210\u4e00\u500b\u8907\u96dc\u7684\u5171\u751f\u751f\u614b\u7cfb\uff0d\u6b63\u5e38\u83cc\u53e2\uff08normal flora\uff09\u3002\u8178\u9053\u4e0a\u76ae\u7d30\u80de\u542b\u6709\u5206\u9694\u8178\u8154\u7269\u8cea\u800c\u5177\u6709\u5c4f\u969c\u529f\u80fd\uff0c\u53ef\u6709\u6548\u5730\u963b\u64cb\u8178\u9053\u83cc\u5165\u4fb5\uff0c\u4e5f\u9632\u6b62\u5206\u6ccc\u7684\u6bd2\u7d20\u5411\u8178\u8154\u5916\u7684\u7d44\u7e54\u3001\u5668\u5b98\u64f4\u6563\u3002<\/li>\n
  3. \u8840\u8166\u5c4f\u969c\uff1a\u4ea6\u7a31\u8166\u8840\u7ba1\u969c\u58c1\u6216\u8840\u8166\u969c\u58c1\uff0c\u4fc2\u6307\u5728\u8840\u7ba1\u548c\u8166\u4e4b\u9593\u5b58\u6709\u53ef\u9078\u64c7\u6027\u963b\u6b62\u67d0\u4e9b\u7269\u8cea\u7531\u8840\u6db2\u9032\u5165\u5927\u8166\u7684\u300c\u969c\u58c1\u300d\u3002\u8166\u90e8\u5fae\u8840\u7ba1\u5167\u76ae\u7d30\u80de\u4e0d\u50c5\u7dca\u5bc6\u76f8\u63a5\uff0c\u5468\u570d\u4ea6\u88ab\u661f\u72c0\u81a0\u7d30\u80de\u7684\u7a81\u8d77\u7e8f\u7e5e\u800c\u69cb\u6210\u9078\u64c7\u6027\u969c\u58c1\u3002BBB \u4e26\u975e\u55ae\u4e00\u7684\u7269\u7406\u5be6\u9ad4\uff0c\u800c\u662f\u5177\u6709\u4e00\u7cfb\u5217\u7d9c\u5408\u751f\u7406\u529f\u80fd\u7684\u5167\u76ae\u7d30\u80de\uff0c\u53ef\u9650\u5236\u8840\u7ba1\u901a\u900f\u6027\uff0c\u53ea\u6709\u8840\u6db2\u4e2d\u7684\u5c0f\u5206\u5b50\uff08\u5982\u6c27\u6c23\u3001\u4e8c\u6c27\u5316\u78b3\uff09\u3001\u8102\u6eb6\u6027\u7269\u8cea\uff08\u5982\u9152\u7cbe\u3001\u5c3c\u53e4\u4e01\uff09\u3001\u8461\u8404\u7cd6\u53ca\u80fa\u57fa\u9178\u7b49\u53ef\u4ee5\u901a\u904e\uff0c\u4f46\u5927\u5206\u5b50\u7269\u8cea\uff08\u5982\u85e5\u7269\u3001\u86cb\u767d\u8cea\uff09\u5247\u4e0d\u6613\u901a\u904e\u3002<\/li>\n<\/ol>\n

    \u8840\u8166<\/strong>\u5c4f\u969c<\/strong>\u5c0d\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u4fdd\u8b77\u529f\u80fd<\/strong><\/span><\/p>\n

    BBB\u80fd\u5920\u9650\u5236\u6709\u6bd2\u7269\u8cea\u53ca\u75c5\u539f\u9ad4\u9032\u5165\u8166\u548c\u810a\u9ad3\uff0c\u53ef\u4fdd\u8b77\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u4e0d\u53d7\u8840\u6db2\u4e2d\u300c\u5916\u4f86\u7269\u8cea\u300d\u7684\u50b7\u5bb3\uff0c\u4e26\u9632\u6b62\u5176\u53d7\u5230\u4f86\u81ea\u8eab\u9ad4\u5176\u4ed6\u90e8\u4f4d\u4e4b\u6fc0\u7d20\u53ca\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u4e4b\u5f71\u97ff\u3002\u56e0\u6b64\uff0cBBB\u82e5\u906d\u5230\u7a81\u7834\uff0c\u5e38\u6703\u5f15\u767c\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\uff0c\u76f8\u95dc\u75be\u75c5\u8209\u4f8b\u5982\u4e0b\uff1a<\/p>\n

      \n
    1. \u591a\u767c\u6027\u786c\u5316\u75c7\uff08Multiple sclerosis\uff09\uff1a\u88ab\u8a8d\u70ba\u662f\u4e00\u7a2e\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\uff0c\u96d6\u7136\u75c5\u56e0\u4ecd\u4e0d\u660e\uff0c\u4f46\u53ef\u80fd\u662f\u56e0\u70ba\u907a\u50b3\u3001\u74b0\u5883\u6216\u53d7\u75c5\u6bd2\u611f\u67d3\u7684\u523a\u6fc0\u800c\u5f15\u767c\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u9ad3\u9798\u6240\u9020\u6210\u3002\u4f7f\u7528\u6838\u78c1\u5171\u632f\u986f\u5f71\uff08Magnetic resonance imaging<\/em>, MRI\uff09\u767c\u73fe\u60a3\u8005\u7684BBB\u53d7\u5230\u7834\u58de\uff0c\u624d\u4f7fT\u7d30\u80de\u5f97\u4ee5\u9032\u5165\u810a\u9ad3\u800c\u7834\u58de\u9ad3\u9798\u3002<\/li>\n
    2. \u8996\u795e\u7d93\u810a\u9ad3\u708e\uff08Neuromyelitis optica\uff09\uff1a\u4e00\u7a2e\u8996\u795e\u7d93\u548c\u810a\u9ad3\u540c\u6642\u767c\u708e\u7684\u53bb\u9ad3\u9798\u75be\u75c5\uff0c\u75c7\u72c0\u985e\u4f3c\u591a\u767c\u6027\u786c\u5316\u75c7\uff0c\u9808\u7d93\u7531MRI\u53ca\u6297\u9ad4\u6aa2\u6e2c\u624d\u53ef\u78ba\u8a3a\u3002\u6b64\u75c5\u7684\u81f4\u75c5\u6a5f\u8f49\u96d6\u4ecd\u5f85\u91d0\u6e05\uff0c\u4f46\u53ef\u521d\u6b65\u78ba\u5b9a\u662f\u56e0\u70ba\u6c34\u901a\u90534\u865f\u86cb\u767d\uff08aquaporin-4, AQP4\uff09\u81ea\u9ad4\u6297\u9ad4\uff08autoantibody\uff09\u7a7f\u904eBBB\u5230\u9054\u8166\u90e8\u6709\u95dc\u3002<\/li>\n
    3. \u9032\u884c\u6027\u591a\u767c\u6027\u767d\u8166\u75c5\u8b8a\uff08Progressive multifocal leukoencephalopathy\uff09\uff1a\u4e00\u7a2e\u9032\u884c\u6027\u4e2d\u6a1e\u795e\u7d93\u53bb\u9ad3\u9798\u75be\u75c5\uff0c\u75c5\u8b8a\u7684\u4f4d\u7f6e\u767c\u751f\u5728\u5927\u8166\u7684\u767d\u8cea\uff0c\u7531\u591a\u7624\u75c5\u6bd2\u79d1\uff08Polymaviridae\uff09\u7684John Cunningham\uff08JC\uff09\u75c5\u6bd2\u91cd\u65b0\u6d3b\u5316\u6240\u5f15\u8d77\u7684\uff0c\u5e38\u898b\u65bc\u514d\u75ab\u529f\u80fd\u4f4e\u4e0b\u7684\u60a3\u8005\uff0c\u56e0\u4f3a\u6a5f\u6027\u611f\u67d3\u800c\u81f4\u75c5\u3002\u8fd1\u5e74\u767c\u73fe\u6b64\u75c5\u767c\u751f\u65bc\u67d0\u4e9b\u611b\u6ecb\u75c5\u60a3\u8005\uff0c\u75c5\u6bd2\u6f5b\u4f0f\u5728\u814e\u81df\u53caB\u7d30\u80de\uff0c\u7576B\u7d30\u80de\u88ab\u6d3b\u5316\u5f8c\uff0c\u75c5\u6bd2\u96a8\u5176\u7a7f\u904eBBB\u800c\u9032\u5165\u8166\u90e8\uff0c\u5728\u81a0\u8cea\u7d30\u80de\u5167\u8907\u88fd\u4e26\u7834\u58de\u9019\u4e9b\u7d30\u80de\u3002<\/li>\n<\/ol>\n

      \u8840\u8166\u969c\u58c1\u5c0d\u8166\u90e8\u75be\u75c5\u85e5\u7269\u6cbb\u7642\u7684\u5f71\u97ff<\/strong><\/span><\/p>\n

      \u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08\u8166\u3001\u810a\u9ad3\uff09\u4e00\u65e6\u767c\u751f\u75be\u75c5\uff0c\u56e0\u5927\u90e8\u5206\u85e5\u7269\u53d7BBB\u7684\u963b\u64cb\u800c\u7121\u6cd5\u9032\u5165\u75c5\u8b8a\u4f4d\u7f6e\uff0c\u6240\u4ee5\u901a\u5e38\u5f88\u96e3\u6cbb\u7642\uff0c\u4f8b\u5982\uff1a\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\uff08Alzheimer\u2019s disease\uff0c\u4fd7\u7a31\u5931\u667a\u75c7\u3001\u8001\u5e74\u75f4\u5446\u75c7\uff09\u3001\u5df4\u91d1\u68ee\u6c0f\u75c7\uff08Parkinson's disease\uff09\u3001\u808c\u840e\u7e2e\u6027\u810a\u9ad3\u5074\u7d22\u786c\u5316\u75c7\uff08Amyotrophic lateral sclerosis\uff0c\u4fd7\u7a31\u6f38\u51cd\u4eba\uff09\u53ca\u8166\u7624\uff08Brain tumor\uff0cglioblastoma<\/em> multiforme\uff09\u7b49\u75be\u75c5\u3002\u8a31\u591a\u7528\u65bc\u6cbb\u7642\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u7684\u85e5\u7269\u88ab\u767c\u73fe\uff0c\u4f46\u56e0\u7121\u6cd5\u901a\u904e BBB \u800c\u7121\u6cd5\u81e8\u5e8a\u61c9\u7528\uff0c\u6240\u4ee5\u9664\u4e86\u958b\u767c\u65b0\u7684\u5019\u9078\u85e5\u7269\u5916\uff0c\u79d1\u5b78\u5bb6\u9084\u7814\u767c\u7528\u65bc\u5927\u8166\u9776\u5411\u7684\u73fe\u6709\u85e5\u7269\u7684\u65b0\u914d\u65b9\u3002\u5e78\u904b\u5730\uff0c\u8fd1\u5e74\u5df2\u767c\u73fe\u6709\u4e9b\u75c5\u6bd2\u548c\u5948\u7c73\u7c92\u5b50\u53ef\u4ee5\u901a\u904eBBB\uff0c\u5229\u7528\u9019\u4e9b\u5c0d\u4eba\u7121\u6bd2\u7684\u8f09\u9ad4\u651c\u5e36\u6709\u7279\u5b9a\u7642\u6548\u7684\u85e5\u7269\u7a7f\u8d8aBBB\uff0c\u53ef\u6709\u6548\u7684\u6cbb\u7642\u76f8\u95dc\u75be\u75c5\u3002\u96a8\u8457 BBB \u7684\u5206\u5b50\u7d50\u69cb\u5f97\u5230\u66f4\u597d\u7684\u95e1\u660e\uff0c\u8a31\u591a\u5927\u8166\u9776\u5411\u7684\u95dc\u9375\u65b9\u6cd5\u5df2\u88ab\u767c\u73fe\uff0c\u8209\u4f8b\u5982\u4e0b\uff1a<\/p>\n

        \n
      1. \u751f\u7406\u904b\u8f38\u6a5f\u5236\uff1a\u5438\u9644\u4ecb\u5c0e\u7684\u80de\u541e\u4f5c\u7528\uff08adsorptive-mediated transcytosis\uff09\u3001\u4e3b\u52d5\u5916\u6392\u6cf5\u7684\u6291\u5236\u4f5c\u7528\uff08inhibition of active efflux pumps\uff09\u3001\u53d7\u9ad4\u4ecb\u5c0e\u7684\u8f49\u904b\uff08receptor-mediated transport\uff09\u3001\u7d30\u80de\u4ecb\u5c0e\u7684\u5167\u541e\u4f5c\u7528\uff08cell-mediated endocytosis\uff09\u548c\u80bd\u8f09\u9ad4\u7684\u4f7f\u7528\uff08use of peptide vector\uff09\u3002<\/li>\n
      2. \u85e5\u7269\u905e\u9001\u7b56\u7565\uff1a\u5fae\u7403\uff08microsphere\uff09\u3001\u53ef\u751f\u7269\u964d\u89e3\u6027\u7684\u6676\u5713\uff08biodegradable wafer\uff09\u548c\u81a0\u9ad4\u85e5\u7269\u8f09\u9ad4\u7cfb\u7d71\uff08\u5982\u8102\u8cea\u9ad4\u3001\u5948\u7c73\u7c92\u5b50\u3001\u5948\u7c73\u51dd\u81a0\u3001\u6a39\u679d\u72c0\u805a\u5408\u7269\u3001\u81a0\u675f\u3001\u7c73\u4e73\u6db2\u3001\u805a\u5408\u7269\u56ca\u6ce1\u3001\u5916\u6ccc\u9ad4\u548c\u91cf\u5b50\u9ede\u7b49\uff09\u905e\u9001\u3002<\/li>\n<\/ol>\n

         <\/p>\n

        \u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

          \n
        1. Daneman R, Prat A. The blood-brain barrier.<\/a> Cold Spring Harb Perspect Biol. 2015 Jan 5;7(1): a020412. doi: 10.1101\/cshperspect.a 020412.<\/li>\n
        2. Sweeney MD, Sagare AP, Zlokovic BV. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018 Mar;14(3):133-150. doi: 10.1038\/nrneurol.2017.188. Epub 2018 Jan 29.<\/li>\n
        3. Profaci CP, Munji RN, Pulido RS, Daneman R. The blood-brain barrier in health and disease: Important unanswered questions. J Exp Med. 2020 Apr 6;217(4):e20190062. doi: 10.1084\/jem.20190062.<\/li>\n
        4. Patel MM, Patel BM. Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain. CNS Drugs. 2017 Feb;31(2):109-133. doi: 10.1007\/s40263-016-0405-9.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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