{"id":37478,"date":"2021-11-25T00:51:04","date_gmt":"2021-11-24T16:51:04","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=37478"},"modified":"2022-10-11T13:15:12","modified_gmt":"2022-10-11T05:15:12","slug":"%e9%98%b2%e5%a0%b5%e9%87%91%e9%bb%83%e8%89%b2%e8%91%a1%e8%90%84%e7%90%83%e8%8f%8c%e6%84%9f%e6%9f%93%ef%bc%8c%e7%94%a8%e7%b4%b0%e8%8f%8c%e8%bc%89%e9%ab%94%e6%94%bb%e7%a0%b4%e7%94%9f%e7%89%a9%e8%86%9c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=37478","title":{"rendered":"\u9632\u5835\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u611f\u67d3\uff0c\u7528\u7d30\u83cc\u8f09\u9ad4\u653b\u7834\u751f\u7269\u819c\u9632\u8b77\u7f69"},"content":{"rendered":"

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\u5716\u7247\u4f86\u6e90\uff1aPixabay<\/figcaption><\/figure>\n

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\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u7684\u5a01\u8105<\/strong><\/span><\/p>\n

\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\uff08Staphylococcus aureus<\/em>\uff09\u662f\u9769\u862d\u6c0f\u967d\u6027\u7d30\u83cc\uff0c\u5c6c\u65bc\u4e00\u7a2e\u5ee3\u6cdb\u5b58\u65bc\u524d\u9f3b\u54bd\u90e8\u548c\u76ae\u819a\u8868\u9762\u7684\u6b63\u5e38\u83cc\u53e2\uff08normal flora\uff09\uff0c\u901a\u5e38\u5b58\u5728\u65bc\u5927\u591a\u6578\u7684\u5065\u5eb7\u500b\u9ad4\u4e2d\uff0c\u96d6\u7136\u5e73\u6642\u8207\u4eba\u9ad4\u548c\u5e73\u5171\u5b58\uff0c\u4f46\u5728\u4eba\u9ad4\u514d\u75ab\u529f\u80fd\u6e1b\u5f31\u6642\u4ecd\u6703\u9020\u6210\u6a5f\u6703\u6027\u611f\u67d3\uff08opportunistic infection\uff09\uff0c\u6216\u8005\u5728\u6297\u85e5\u6027\u83cc\u682a\u51fa\u73fe\u6642\u4ecd\u6709\u53ef\u80fd\u5f15\u8d77\u56b4\u91cd\u75be\u75c5\uff0c\u8106\u5f31\u7684\u60a3\u8005\u7fa4\u9ad4\u548c\u7d30\u83cc\u7372\u5f97\u591a\u91cd\u6297\u85e5\u6027\u6703\u4f7f\u5f97\u611f\u67d3\u7684\u6709\u6548\u6cbb\u7642\u66f4\u52a0\u56f0\u96e3\u3002\u5177\u6709\u6297\u751f\u7d20\u6297\u85e5\u6027\u7684\u83cc\u682a\uff0c\u4f8b\u5982\u6297\u7532\u6c27\u897f\u6797\uff08methicillin\uff09\u53ca\u6297\u842c\u53e4\u9ef4\u7d20\uff08vancomycin\uff09\u7684\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\uff0c\u5f88\u5bb9\u6613\u901a\u904e\u76f4\u63a5\u63a5\u89f8\u800c\u50b3\u64ad\uff0c\u4f7f\u5f97\u5927\u91cf\u500b\u9ad4\u53d7\u5230\u611f\u67d3\u3002\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u662f\u5f15\u8d77\u9662\u5167\u611f\u67d3\uff08nosocomial infection\uff09\u7684\u4e3b\u8981\u75c5\u539f\u9ad4\u4e4b\u4e00\uff0c\u901a\u5e38\u85c9\u7531\u91ab\u8b77\u4eba\u54e1\u7684\u76f4\u63a5\u63a5\u89f8\u6216\u7531\u65bc\u4fb5\u5165\u6027\u91ab\u7642\u7a0b\u5e8f\uff08\u5982\u624b\u8853\u548c\u91ab\u7642\u5668\u6750\u7684\u690d\u5165\u7b49\uff09\u800c\u50b3\u64ad\uff0c\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u76f8\u95dc\u611f\u67d3\u5c0e\u81f4\u4f4f\u9662\u6642\u9593\u589e\u52a0\u53ca\u4f4f\u9662\u76f8\u95dc\u6b7b\u4ea1\u7387\u63d0\u9ad8\uff0c\u5df2\u9020\u6210\u6c89\u91cd\u7684\u91ab\u7642\u8ca0\u64d4\u3002<\/p>\n

\u751f\u7269\u819c\u5c0d\u7d30\u83cc\u7684\u4fdd\u8b77\u4f5c\u7528<\/strong><\/span><\/p>\n

\u91ab\u7642\u5668\u6750\u690d\u5165\u7269\u7684\u8868\u9762\u901a\u5e38\u5bcc\u542b\u86cb\u767d\u8cea\uff0c\u7d30\u83cc\u8868\u9762\u7684\u7c98\u9644\u57fa\u8cea\u5206\u5b50\uff08adhesive matrix molecule\uff09\u8b58\u5225\u9019\u4e9b\u86cb\u767d\u8cea\u5f8c\uff0c\u4fbf\u6703\u70ba\u751f\u7269\u819c\uff08biofilm\uff09\u7684\u5f62\u6210\u63d0\u4f9b\u4e86\u4e00\u500b\u751f\u614b\u4f4d\uff08niche\uff09\u3002\u751f\u7269\u819c\u662f\u7531\u86cb\u767d\u8cea\u3001DNA \u548c\u591a\u91a3\u985e\u7d44\u6210\u7684\u7d30\u80de\u74a7\u5916\u90e8\u7d68\u6bdb\u72c0\u7684\u7d30\u80de\u5916\u805a\u5408\u7269\uff08extracellular polymeric substance\uff09\uff0c\u6709\u52a9\u65bc\u7d30\u83cc\u9ecf\u9644\u5728\u7269\u9ad4\u8868\u9762\u3001\u6fc3\u7e2e\u990a\u5206\u53ca\u5f62\u6210\u5171\u751f\u9ad4\u7cfb\uff0c\u7d30\u83cc\u4ea6\u53ef\u80fd\u6703\u85c9\u7531\u751f\u7269\u819c\u9003\u907f\u5bbf\u4e3b\u7684\u9632\u79a6\uff0c\u4e26\u5c0d\u6bba\u83cc\u5291\u7522\u751f\u8010\u53d7\u6027\uff0c\u9019\u4f7f\u5f97\u5177\u6709\u751f\u7269\u819c\u7684\u7d30\u83cc\u611f\u67d3\u7279\u5225\u96e3\u4ee5\u6839\u9664\u3002\u6b64\u5916\uff0c\u7f3a\u4e4f\u5c0d\u751f\u7269\u819c\u5177\u6709\u7279\u7570\u6027\u7684\u751f\u7269\u6a19\u8a8c\u7269\uff08biomarker\uff09\u4f7f\u5f97\u9019\u7a2e\u611f\u67d3\u7684\u6aa2\u6e2c\u548c\u8a3a\u65b7\u5341\u5206\u56f0\u96e3\u3002\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u56e0\u5177\u6709\u6297\u751f\u7d20\u6297\u85e5\u6027\u548c\u8868\u73fe\u578b\u9069\u61c9\u6027\uff08phenotypic adaptation\uff09\u800c\u5e38\u5f15\u8d77\u96e3\u4ee5\u6cbb\u7652\u7684\u6162\u6027\u6301\u7e8c\u611f\u67d3\uff0c\u9019\u5169\u8005\u90fd\u4f86\u81ea\u5176\u5f62\u6210\u751f\u7269\u819c\u7684\u80fd\u529b\u3002\u56e0\u70ba\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u662f\u5e38\u898b\u6703\u7522\u751f\u751f\u7269\u819c\u7684\u7d30\u83cc\uff0c\u50b3\u7d71\u6297\u751f\u7d20\u5c0d\u9019\u7a2e\u7d30\u83cc\u4e26\u6c92\u6709\u6548\u679c\uff0c\u6240\u4ee5\u60a3\u8005\u53ea\u80fd\u9760\u983b\u7e41\u66f4\u63db\u4fb5\u5165\u5f0f\u91ab\u7642\u5668\u6750\u4ee5\u907f\u514d\u611f\u67d3\uff0c\u4e14\u76f8\u8f03\u4e00\u822c\u7d30\u83cc\uff0c\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u7522\u751f\u6297\u85e5\u6027\u7684\u6a5f\u7387\u8981\u9ad81000 \u500d\u3002\u56e0\u6b64\uff0c\u958b\u767c\u91dd\u5c0d\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u7684\u751f\u7269\u819c\u611f\u67d3\u662f\u6709\u9700\u8981\u7684\uff0c\u5c0d\u6297\u611f\u67d3\u7b56\u7565\u5305\u62ec\uff1a(1)\u9810\u9632\u65b9\u6cd5\uff0c\u958b\u767c\u6297\u751f\u7269\u819c\u8868\u9762\u5857\u5c64\uff0c\u5305\u542b\u751f\u7269\u819c\u7279\u7570\u6027\u75ab\u82d7\u6297\u539f\uff1b(2)\u6839\u9664\u65b9\u6cd5\uff0c\u4e86\u89e3\u751f\u7269\u819c\u7522\u751f\u548c\u81f4\u75c5\u6a5f\u5236\u7684\u7279\u6027\uff0c\u767c\u5c55\u9776\u5411\u5c0d\u6297\u751f\u7269\u819c\u611f\u67d3\u7684\u7b56\u7565\u3002<\/p>\n

\u5229\u7528\u7d30\u83cc\u8f09\u9ad4\u653b\u7834\u751f\u7269\u819c<\/strong><\/span><\/p>\n

\u80ba\u708e\u9ef4\u6f3f\u83cc \uff08Mycoplasma pneumoniae<\/em>\uff09\u662f\u4e00\u7a2e\u7279\u6027\u4ecb\u65bc\u7d30\u83cc\u548c\u75c5\u6bd2\u7684\u5fae\u751f\u7269\uff0c\u7d30\u80de\u7d50\u69cb\u53ca\u57fa\u56e0\u7d44\u8207\u4e00\u822c\u7d30\u83cc\u8ff4\u7570\uff0c\u4e26\u4e0d\u5177\u6709\u7d30\u80de\u58c1\uff0c\u4e3b\u8981\u751f\u5b58\u5728\u4eba\u9ad4\u547c\u5438\u9053\uff0c\u611f\u67d3\u6642\u6703\u5f15\u767c\u80ba\u708e\uff0c\u4f46\u662f\u4f5c\u70ba\u8f09\u9ad4\u537b\u6709\u5169\u500b\u4e3b\u8981\u512a\u52e2\uff1a(1)\u907a\u50b3\u5bc6\u78bc\u7279\u6b8a\uff0c\u53ef\u964d\u4f4e\u5728\u9020\u6210\u57fa\u56e0\u8f49\u79fb\u5230\u5176\u4ed6\u7d30\u83cc\u7684\u98a8\u96aa\uff1b(2)\u96d6\u7136\u6c92\u6709\u7d30\u80de\u58c1\uff0c\u4f46\u662f\u80fd\u5920\u5206\u6ccc\u53ef\u9776\u5411\u5206\u89e3\u751f\u7269\u819c\u7684\u86cb\u767d\u8cea\u56e0\u5b50\u3002<\/p>\n

\u57282021\u5e74\uff0c\u897f\u73ed\u7259\u7814\u7a76\u4eba\u54e1\u5c07\u6539\u9020\u904e\u7684\u80ba\u708e\u9ef4\u6f3f\u83cc\u6ce8\u5165\u5c0f\u9f20\u9ad4\u5167\u5f8c\uff0c\u958b\u767c\u51fa\u4e00\u7a2e\u80fd\u5920\u7834\u89e3\u751f\u7269\u819c\u9632\u8b77\u7f69\u7684\u6280\u8853\uff0c\u7814\u7a76\u7d50\u679c\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u300aMolecular Systems Biology\u300b\u3002\u4ed6\u5011\u5148\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u6280\u8853\u964d\u4f4e\u80ba\u708e\u9ef4\u6f3f\u83cc\u7684\u81f4\u75c5\u529b\uff0c\u4e26\u63d0\u5347\u5176\u5206\u6ccc\u53ef\u5206\u89e3\u751f\u7269\u819c\u86cb\u767d\u8cea\u56e0\u5b50\u7684\u80fd\u529b\uff0c\u518d\u4f7f\u7528\u9019\u9805\u300c\u6d3b\u91ab\u7642\u8f09\u9ad4\uff08living medicine vector\uff09\u300d\u653b\u64ca\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u3002\u7d50\u679c\u986f\u793a\u5728\u5c0f\u9f20\u9ad4\u5167\u6ce8\u5c04\u6539\u826f\u5f8c\u7684\u80ba\u708e\u9ef4\u6f3f\u83cc\uff0c\u80fd\u4f7f\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u611f\u67d3\u7684\u767c\u751f\u7387\u964d\u4f4e\u4e86 82%\u3002\u6b64\u9805\u7814\u7a76\u63d0\u51fa\u4e86\u53ef\u4ee5\u6539\u5584\u4fb5\u5165\u5f0f\u91ab\u7642\u5668\u6750\u9020\u6210\u7d30\u83cc\u611f\u67d3\u7684\u65b9\u6cd5\uff0c\u7d30\u83cc\u8f09\u9ad4\u4e0d\u50c5\u8f03\u6297\u751f\u7d20\u6216\u6bba\u83cc\u5291\u66f4\u70ba\u6709\u6548\u3001\u4fbf\u5b9c\u53ca\u5b89\u5168\uff0c\u800c\u4e14\u7d30\u83cc\u7684\u57fa\u56e0\u9ad4\u8f03\u5c0f\uff0c\u4fbf\u65bc\u9032\u884c\u57fa\u56e0\u6539\u9020\uff0c\u50b3\u9001\u9032\u5165\u751f\u7269\u9ad4\u5f8c\u4e5f\u80fd\u6301\u7e8c\u5206\u6ccc\u6cbb\u7642\u5206\u5b50\uff08\u53ef\u5206\u89e3\u751f\u7269\u819c\u7684\u86cb\u767d\u8cea\u56e0\u5b50\uff09\u3002\u9019\u9805\u6280\u8853\u53ef\u4ee5\u6709\u6548\u6291\u5236\u91d1\u9ec3\u8272\u8461\u8404\u7403\u83cc\u7684\u751f\u9577\uff0c\u9019\u4e5f\u662f\u5c07\u4f86\u80fd\u61c9\u7528\u6539\u5584\u6162\u6027\u75be\u75c5\u6cbb\u7642\u7684\u65b9\u5411\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u5718\u968a\u9810\u8a08\u5728 2023 \u5e74\u555f\u52d5\u4eba\u9ad4\u8a66\u9a57\u9032\u884c\u9a57\u8b49\u3002<\/p>\n

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 <\/strong><\/p>\n

\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

    \n
  1. Garrido V, Pi\u00f1ero-Lambea C, Rodriguez-Arce I, Paetzold B, Ferrar T, Weber M, Garcia-Ramallo E, Gallo C, Collantes M, Pe\u00f1uelas I, Serrano L, Grill\u00f3 MJ, Lluch-Senar M. Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo. Mol Syst Biol. 2021 Oct;17(10): e10145. doi: 10.15252\/msb.202010145.<\/li>\n
  2. Suresh MK, Biswas R, Biswas L. An update on recent developments in the prevention and treatment of Staphylococcus aureus biofilms. Int J Med Microbiol. 2019 Jan;309(1):1-12. doi: 10.1016\/j.ijmm.2018.11.002. Epub 2018 Nov 27.<\/li>\n
  3. Bhattacharya M, Wozniak DJ, Stoodley P, Hall-Stoodley L. Prevention and treatment of Staphylococcus aureus biofilms.<\/a> Expert Rev Anti Infect Ther. 2015;13(12):1499-516. doi: 10.1586\/14787210.2015.1100533. Epub 2015 Nov 13.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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