{"id":37467,"date":"2021-11-19T00:56:35","date_gmt":"2021-11-18T16:56:35","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=37467"},"modified":"2023-06-05T16:44:43","modified_gmt":"2023-06-05T08:44:43","slug":"%ef%bc%9c%e8%aa%b0%e6%98%af%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e7%96%ab%e8%8b%97%e9%bb%91%e9%a6%ac%e8%83%8c%e5%be%8c%e7%9a%84%e6%8e%a8%e6%89%8b%ef%bc%9f%ef%bc%9e%ef%bc%9c%e5%a4%a9%e8%8a%b1%e7%96%ab","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=37467","title":{"rendered":"\u3010\u79d1\u5b78\u53f2\u6c99\u9f8d\u3011\u3008\u8ab0\u662f\u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u9ed1\u99ac\u80cc\u5f8c\u7684\u63a8\u624b\uff1f\u3009&#038;\u3008\u5929\u82b1\u75ab\u82d7\u7684\u5168\u7403\u5316\u3009"},"content":{"rendered":"<p><iframe title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/OKBHbenwVLQ\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"color: #993300;\"><strong>\u3008\u8ab0\u662f\u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u9ed1\u99ac\u80cc\u5f8c\u7684\u63a8\u624b\uff1f\u3009<\/strong><\/span><\/p>\n<p><span style=\"color: #800080;\"><strong>\u4eba\u985e\u88fd\u4f5c\u75ab\u82d7\u6709\u597d\u5e7e\u7a2e\u6210\u719f\u7684\u50b3\u7d71\u4f5c\u6cd5\uff0c\u7136\u800c\u9019\u6b21\u5728\u7814\u767c\u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u7684\u52aa\u529b\u4e2d\u62d4\u5f97\u982d\u7c4c\u7684\u9ed1\u99ac\uff0c\u537b\u662f mRNA \u75ab\u82d7\u6a6b\u7a7a\u51fa\u4e16\u3002 mRNA \u75ab\u82d7\u5982\u4f55\u5f9e\u4e00\u500b\u6982\u5ff5\u7814\u767c\u6210\u70ba\u7522\u54c1\uff0c\u5176\u80cc\u5f8c\u6709\u4f4d\u767e\u6298\u4e0d\u6493\u7684\u63a8\u624b\uff0c\u672c\u8b1b\u6b21\u5c07\u8207\u807d\u773e\u5206\u4eab\u5979\u7684\u6545\u4e8b\u3002<\/strong><\/span><\/p>\n<p><strong>\u8b1b\u5e2b\uff1a\u5468\u6210\u529f\uff5c\u967d\u660e\u4ea4\u901a\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u66a8\u57fa\u56e0\u9ad4\u79d1\u5b78\u7814\u7a76\u6240\u517c\u4efb\u6559\u6388<\/strong><\/p>\n<p>\u51a0\u72c0\u75c5\u6bd2\u5165\u4fb5\u4eba\u9ad4\u7684\u6a5f\u5236\uff0c\u662f\u4ee5\u75c5\u6bd2\u8868\u9762\u7684\uff33\u86cb\u767d\uff0c\u8207\u4eba\u9ad4\u7d30\u80de\u819c\u4e0a\u7684 ACE2 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mRNA \u75ab\u82d7\u300d\uff0c\u5176\u904b\u4f5c\u6a5f\u5236\u672c\u8eab\u4e26\u7121\u751a\u7a00\u5947\uff0c\u5229\u7528\u7684\u662f\u4eba\u9ad4\u7d30\u80de\u4f9d\u64da DNA \u8f49\u9304\u6210 RNA \u7684\u907a\u50b3\u8cc7\u8a0a\uff0c\u7522\u751f\u86cb\u767d\u8cea\u7684\u5206\u5b50\u751f\u7269\u5b78\u57fa\u672c\u539f\u7406\uff0c\u5c07 mRNA \u6ce8\u5165\u4eba\u9ad4\u5f8c\uff0c\u4fc3\u4f7f\u7d30\u80de\u7522\u751f\u75c5\u6bd2\u7684\u8868\u9762\uff33\u86cb\u767d\uff0c\u9032\u800c\u8a98\u767c\u4eba\u9ad4\u514d\u75ab\u53cd\u61c9\u3002\u7136\u800c\u76f8\u8f03\u65bc\u50b3\u7d71\u7684\u75ab\u82d7\u6280\u8853\uff0c mRNA \u75ab\u82d7\u7684\u7814\u767c\u901f\u5ea6\u76f8\u7576\u5feb\uff0c\u56e0\u6b64\u5728\u5206\u79d2\u5fc5\u722d\u7684\u75ab\u60c5\u5a01\u8105\u4e0b\u7387\u5148\u554f\u4e16\uff0c\u6210\u70ba\u75ab\u82d7\u7814\u767c\u7684\u5927\u9ed1\u99ac\u3002<\/p>\n<p>\u65e2\u7136 mRNA \u75ab\u82d7\u7684\u904b\u4f5c\u6a5f\u5236\u4e26\u7121\u7a00\u5947\u4e4b\u8655\uff0c\u70ba\u4f55\u5148\u524d\u90fd\u6c92\u4eba\u60f3\u5230\u53ef\u7528 mRNA \u88fd\u4f5c\u75ab\u82d7\uff1f\u9019\u5c31\u8981\u63d0\u5230\u751f\u5316\u5b78\u5bb6\u8003\u91cc\u79d1\u00b7\u5361\u5854\u6797 (Karik\u00f3 Katalin) \u4ee5\u53ca\u514d\u75ab\u5b78\u5bb6\u5fb7\u9b6f\u00b7\u97cb\u65af\u66fc (Drew Weissman) \u4e86\uff0c\u4ed6\u5011\u5169\u4f4d\u662f mRNA \u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u7684\u5e55\u5f8c\u63a8\u624b\u3002 RNA \u4f5c\u70ba\u85e5\u7269\u53ca\u57fa\u56e0\u6cbb\u7642\uff0c\u6703\u5f15\u767c\u7d30\u80de\u5f37\u70c8\u7684\u5148\u5929\u514d\u75ab\u53cd\u61c9\uff0c\u5728\u52d5\u7269\u5be6\u9a57\u4e2d\u5f80\u5f80\u4e00\u6ce8\u5165\u9ad4\u5167\u5c31\u9020\u6210\u5be6\u9a57\u9ad4\u6b7b\u4ea1\uff1b\u4ed6\u5011\u5076\u7136\u7d50\u8b58\u5f8c\uff0c\u91dd\u5c0d\u9019\u500b\u74f6\u9838\u9032\u884c\u7814\u7a76\uff0c\u767c\u73fe\u5f9e\u7d30\u83cc\u5206\u96e2\u51fa\u4f86\u7684 RNA \u6703\u9020\u6210\u5f37\u70c8\u514d\u75ab\u53cd\u61c9\uff0c\u4f46\u662f\u5f9e\u54fa\u4e73\u985e\u5206\u96e2\u51fa\u4f86\u7684 RNA \uff0c\u5176\u9e7c\u57fa\u7d93\u904e\u4fee\u98fe\uff0c\u4e26\u4e0d\u6703\u9020\u6210\u5f37\u70c8\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n<p>\u8003\u91cc\u79d1\u5f8c\u4f86\u5230 BioNTech SE \u4efb\u8077\u9ad8\u7d1a\u526f\u7e3d\u88c1\uff0c\u5979\u8207\u97cb\u65af\u66fc\u7814\u767c\u51fa\u4f86\u7684 RNA \u9e7c\u57fa\u4fee\u98fe\u6280\u8853\uff0c\u6210\u70ba\u958b\u767c COVID-19 \u75ab\u82d7\u7684\u57fa\u672c\u539f\u7406\u3002\u7136\u800c\u5373\u4fbf\u8003\u91cc\u79d1\u5728 mRNA \u75ab\u82d7\u9818\u57df\u6700\u95dc\u9375\u7684\u5169\u7bc7\u8ad6\u6587\uff0c\u540c\u6642\u5217\u540d\u7b2c\u4e00\u4f5c\u8005\u4ee5\u53ca\u901a\u8a0a\u4f5c\u8005\uff0c\u6709\u5145\u8db3\u7684\u8b49\u64da\u986f\u793a\u5979\u662f\u7814\u7a76\u7684\u4e3b\u5c0e\u8005\uff0c\u7136\u800c\u5230\u4e86 mRNA \u75ab\u82d7\u554f\u4e16\u6642\uff0c\u5a92\u9ad4\u98a8\u5411\u537b\u662f\u4e3b\u5ba2\u6613\u4f4d\uff0c\u628a\u8f14\u52a9\u7814\u7a76\u7684\u97cb\u65af\u66fc\u6367\u4e0a\u4e86\u75ab\u82d7\u767c\u660e\u4eba\u7684\u5bf6\u5ea7\u3002\u5973\u6027\u79d1\u5b78\u5bb6\u53d7\u5230\u6b67\u8996\u7684\u73fe\u8c61\uff0c\u8fc4\u4eca\u4f3c\u4e4e\u4f9d\u7136\u96e3\u4ee5\u6839\u9664\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #993300;\"><strong>\u3008\u5929\u82b1\u75ab\u82d7\u7684\u5168\u7403\u5316\u3009<\/strong><\/span><\/p>\n<p><span style=\"color: #800080;\"><strong>\u6b50\u6d32\u767d\u4eba\u5f81\u670d\u65b0\u4e16\u754c\uff0c\u4e3b\u8981\u4f9d\u8cf4\u5728\u820a\u4e16\u754c\u8086\u8650\u5df2\u4e45\u7684\u50b3\u67d3\u75c5\uff0c\u4f8b\u5982\u6d41\u611f\u3001\u50b7\u5bd2\u3001\u5929\u82b1\u7b49\u3002\u5929\u82b1\u75ab\u60c5\u6bcf\u6bcf\u9020\u6210\u7576\u5730\u4eba\u53e3\u7d50\u69cb\u6539\u8b8a\uff0c\u751a\u81f3\u751a\u81f3\u53ef\u80fd\u6539\u8b8a\u6b77\u53f2\u884c\u9032\u7684\u8ecc\u8de1\uff0c\u800c\u4eba\u985e\u4ee5\u75ab\u82d7\u63a5\u7a2e\u7684\u65b9\u5f0f\uff0c\u7d93\u904e\u9577\u4e45\u7684\u52aa\u529b\uff0c\u7d42\u65bc\u5728 1980 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