{"id":36862,"date":"2021-09-17T00:18:11","date_gmt":"2021-09-16T16:18:11","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=36862"},"modified":"2021-08-19T11:45:36","modified_gmt":"2021-08-19T03:45:36","slug":"%e8%85%b8%e9%81%93%e8%8f%8c%e8%83%bd%e5%bd%b1%e9%9f%bf%e8%85%a6%e4%b8%ad%e9%a2%a8%e5%97%8e","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=36862","title":{"rendered":"\u8178\u9053\u83cc\u80fd\u5f71\u97ff\u8166\u4e2d\u98a8\u55ce ?"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u8178\u9053\u83cc\u7684\u7d44\u6210\u8207\u75be\u75c5\u767c\u751f\u6709\u986f\u8457\u95dc\u806f\u6027\uff0c\u75c5\u60a3\u7684\u8178\u9053\u83cc\u76f8\u8207\u5065\u5eb7\u8005\u5fc5\u7136\u6709\u5dee\u7570\uff0c\u6240\u4ee5\u8178\u9053\u83cc\u76f8\u6aa2\u6e2c\u53ef\u6aa2\u8996\u5bbf\u4e3b\u7684\u751f\u7406\u72c0\u614b\u662f\u5426\u8da8\u8fd1\u65bc\u75be\u75c5\u7684\u72c0\u614b\u3002\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624\u53ef\u80fd\u767c\u751f\u5728\u4eba\u9ad4\u5404\u90e8\u4f4d\uff0c\u7576\u5176\u51fa\u73fe\u5728\u8166\u90e8\u6642\u5bb9\u6613\u5c0e\u81f4\u8166\u4e2d\u98a8\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u5df2\u767c\u73fe\u8178\u9053\u83cc\u5931\u8861\u53ef\u80fd\u4e5f\u8207\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624\u7684\u767c\u751f\u6709\u95dc\u806f\u6027\uff0c\u6545\u7279\u7570\u6027\u8178\u9053\u83cc\u6709\u6f5b\u529b\u4f5c\u70ba\u6aa2\u6e2c\u7684\u751f\u7269\u6a19\u8a18\uff0c\u7528\u65bc\u5feb\u901f\u8a3a\u65b7\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624\u53ca\u5176\u4ed6\u8166\u90e8\u76f8\u95dc\u75be\u75c5\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_36880\" aria-describedby=\"caption-attachment-36880\" style=\"width: 400px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-36880\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/08\/14561651.jpg\" alt=\"\" width=\"400\" height=\"473\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/08\/14561651.jpg 766w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/08\/14561651-254x300.jpg 254w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><figcaption id=\"caption-attachment-36880\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u8178\u9053\u83cc\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n<p>\u9664\u4e86\u6b63\u5e38\u7d30\u80de\u5916\uff0c\u4eba\u9ad4\u5167\u9084\u4e92\u5229\u5171\u751f\u8457\u8a31\u591a\u5fae\u751f\u7269\uff0c\u9019\u4e9b\u5fae\u751f\u7269\u7a31\u70ba\u4eba\u9ad4\u5fae\u751f\u7269\u7fa4\u7cfb\uff08human microbiome\uff09\u6216\u6b63\u5e38\u83cc\u53e2\uff08normal flora\uff09\uff0c\u5305\u62ec\u7d30\u83cc\u3001\u771f\u83cc\u53ca\u539f\u87f2\u7b49\uff0c\u5176\u4e2d\u4ee5\u7d30\u83cc\u6240\u4f54\u7684\u6bd4\u4f8b\u6700\u9ad8\uff0c\u800c\u4e14\u53c3\u8207\u8a31\u591a\u751f\u7406\u529f\u80fd\uff0c\u662f\u76ee\u524d\u76f8\u95dc\u7814\u7a76\u7684\u91cd\u9ede\u3002\u4eba\u9ad4\u5167\u7684\u7d30\u83cc\u4f30\u8a08\u7d04\u670940\u5146\u500b\uff0c\u5176\u4e2d70% \u68f2\u606f\u5728\u6d88\u5316\u9053\u4e2d\uff0c\u4e3b\u56e0\u662f\u8178\u9053\u7684\u7121\u6c27\u74b0\u5883\u8207\u5145\u5206\u71df\u990a\u975e\u5e38\u9069\u5408\u751f\u9577\uff0c\u9019\u4e9b\u7d30\u83cc\u7d71\u7a31\u70ba\u8178\u9053\u83cc\u3002\u8178\u9053\u83cc\u7fa4\u843d\uff08gut microbial community\uff09\u662f\u4eba\u9ad4\u5167\u6700\u8907\u96dc\u4e14\u8b8a\u52d5\u6027\u6975\u9ad8\u7684\u751f\u614b\u7cfb\uff0c\u5176\u4e2d\u5169\u5927\u83cc\u7fa4\u70ba\u64ec\u687f\u83cc\u5c6c\uff08<em>Bacteroidetes<\/em>\uff09\u8207\u539a\u58c1\u83cc\u5c6c\uff08<em>Firmicutes<\/em>\uff09\uff0c\u5408\u8a08\u6700\u9ad8\u53ef\u4f5490%\uff0c\u5176\u9918\u5305\u62ec\u653e\u7dda\u83cc\u5c6c\uff08<em>Actinobacteria<\/em>\uff09\u3001\u68ad\u687f\u83cc\u5c6c\uff08<em>Fusobacteria<\/em>\uff09\u3001\u8b8a\u5f62\u83cc\u5c6c\uff08<em>Proteobacteria<\/em>\uff09\u53ca\u75a3\u5fae\u83cc\u5c6c\uff08<em>Verrucomicrobia<\/em>\uff09\u7b49\u3002<\/p>\n<p>\u8178\u9053\u83cc\u53ef\u4ee5\u57f7\u884c\u8a31\u591a\u91cd\u8981\u529f\u80fd\uff0c\u5305\u62ec\u5e6b\u52a9\u6d88\u5316\u3001\u4ee3\u8b1d\u71df\u990a\u7d20\uff08\u91a3\u985e\u3001\u8102\u8cea\u3001\u86cb\u767d\u8cea\u53ca\u7dad\u751f\u7d20\u7b49\uff09\u3001\u5206\u89e3\u6bd2\u7d20\u3001\u62b5\u79a6\u75c5\u539f\u83cc\u53ca\u4fc3\u9032\u514d\u75ab\u7cfb\u7d71\u6210\u719f\u7b49\u3002\u5728\u6b63\u5e38\u60c5\u6cc1\u4e0b\uff0c\u8178\u9053\u83cc\u7684\u7d44\u6210\u4fdd\u6301\u8457\u4e00\u500b\u5e73\u8861\u72c0\u614b\uff0c\u85c9\u7531\u7a69\u5b9a\u7684\u4ee3\u8b1d\u529f\u80fd\u53ca\u62ee\u6297\u81f4\u75c5\u83cc\u7684\u751f\u9577\u4ee5\u7dad\u6301\u4eba\u9ad4\u5065\u5eb7\uff0c\u4f46\u5982\u679c\u8178\u9053\u83cc\u5728\u83cc\u7fa4\u7a2e\u985e\u3001\u7d44\u6210\u6bd4\u4f8b\u53ca\u62ee\u6297\u4f5c\u7528\u7b49\u767c\u751f\u660e\u986f\u6539\u8b8a\uff0c\u7834\u58de\u539f\u672c\u7684\u5e73\u8861\u72c0\u614b\uff0c\u5c31\u6703\u5f15\u8d77\u75be\u75c5\u3002\u8fd1\u4f86\u7814\u7a76\u5df2\u767c\u73fe\uff0c\u4e0d\u540c\u75be\u75c5\u7684\u60a3\u8005\u8207\u5065\u5eb7\u4eba\u7684\u8178\u9053\u83cc\u7d44\u6210\u6709\u986f\u8457\u5dee\u7570\uff0c\u8b49\u660e\u8178\u9053\u83cc\u76f8\u5931\u8861\u8207\u75be\u75c5\u767c\u751f\u7684\u95dc\u4fc2\u5341\u5206\u5bc6\u5207\uff0c\u5305\u62ec\u80a5\u80d6\u3001\u5927\u8178\u6fc0\u8e81\u75c7\u3001\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\uff08\u5982\u904e\u654f\uff09\u3001\u764c\u75c7\uff08\u5982\u5927\u8178\u76f4\u8178\u764c\uff09\u3001\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u53ca\u6162\u6027\u767c\u708e\uff08chronic inflammation\uff09\u7b49\uff0c\u6709\u4e9b\u6587\u737b\u66f4\u6307\u51fa\u8178\u9053\u83cc\u76f8\u7684\u5931\u8861\u8207\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u767c\u751f\u6709\u95dc\u806f\u6027\u3002\u53e4\u5e0c\u81d8\u91ab\u5b78\u4e4b\u7236<u>\u5e0c\u6ce2\u514b\u62c9\u5e95<\/u>\u66fe\u8aaa\uff1a\u300c\u6240\u6709\u75be\u75c5\u90fd\u6e90\u81ea\u65bc\u8178\u9053\uff08All disease begins in the gut\uff09\u300d\uff0c\u8fd1\u5e74\u79d1\u5b78\u754c\u5c0d\u8178\u9053\u83cc\u7684\u7814\u7a76\u6240\u7d2f\u7a4d\u7684\u77e5\u8b58\uff0c\u6b63\u597d\u70ba\u6b64\u8aaa\u5efa\u7acb\u4e86\u66f4\u5b8c\u6574\u7684\u7406\u8ad6\u57fa\u790e\uff0c\u4e5f\u547c\u61c9\u4e86\u8178\u9053\u83cc\u5728\u7dad\u8b77\u8eab\u9ad4\u5065\u5eb7\u7684\u91cd\u8981\u6027\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u4ec0\u9ebc\u662f\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624<\/strong><\/span><\/p>\n<p>\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624 (Cavernous angiomas, CA)\u4e3b\u8981\u7531\u8106\u5316\u7684\u8584\u58c1\u5fae\u8840\u7ba1\u589e\u751f\u805a\u5408\u6210\u5718\u584a\u5f8c\u5f62\u6210\uff0c\u53ef\u80fd\u767c\u751f\u5728\u4eba\u9ad4\u5404\u90e8\u4f4d\uff0c\u5305\u62ec\u5728\u5927\u8166\u548c\u810a\u9ad3\u5f62\u6210\u591a\u7076\u6027\u75c5\u8b8a\uff0c\u7576\u51fa\u73fe\u5728\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u6642\u5f80\u5f80\u5c0e\u81f4\u8166\u4e2d\u98a8\u3002CA\u7684\u7279\u5fb5\u662f\u7578\u5f62\u64f4\u5f35\u7684\u6bdb\u7d30\u8840\u7ba1\uff0c\u5927\u7d0430-40%\u7684CA\u60a3\u8005\u5728\u4e09\u500bCA \u57fa\u56e0\uff08CCM1\/KRIT1\u3001CCM2\/Malcavernin\u548cCCM3\/PDCD10\uff09\u4e4b\u4e00\u7684\u9ad4\u67d3\u8272\u9ad4\u6709\u986f\u6027\u907a\u50b3\u751f\u6b96\u7cfb\u7a81\u8b8a\u3002\u7136\u800c\uff0c\u5373\u4f7f\u6709\u76f8\u540c\u7684\u57fa\u56e0\u7a81\u8b8a\uff0cCA\u60a3\u8005\u7684\u56b4\u91cd\u7a0b\u5ea6\u548c\u81ea\u7136\u75c5\u7a0b\u4e5f\u6709\u5f88\u5927\u5dee\u7570\uff0c\u6b64\u985e\u8b8a\u7570\u5305\u62ec\u5bb6\u65cf\u6027\u75c5\u4f8b\u4e2d\u7684\u75c5\u8b8a\u6578\u91cf\u3001\u9996\u6b21\u51fa\u73fe\u75c7\u72c0\u6642\u7684\u5e74\u9f61\u53ca\u51fa\u73fe\u75c7\u72c0\u6027\u51fa\u8840\u7684\u50be\u5411\u3002<\/p>\n<p>\u9577\u671f\u7684\u4e0d\u826f\u751f\u6d3b\u7fd2\u6163\uff08\u5982\u4e0d\u5747\u8861\u7684\u98f2\u98df\u3001\u4e0d\u6b63\u5e38\u7684\u751f\u6d3b\u578b\u614b\u7b49\uff09\u5df2\u77e5\u5bb9\u6613\u9020\u6210\u8178\u9053\u83cc\u7684\u8178\u9053\u969c\u853d\uff08gut barrier\uff09\u6548\u679c\u8b8a\u5dee\u800c\u5c0e\u81f4\u8178\u6f0f\uff08gut leak\uff09\uff0c\u8b93\u8178\u9053\u5167\u7684\u81f4\u75c5\u83cc\u8207\u5176\u4ee3\u8b1d\u7269\u6709\u6a5f\u6703\u9032\u5165\u8840\u6db2\u5faa\u74b0\uff0c\u5f15\u8d77\u6162\u6027\u767c\u708e\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u66f4\u986f\u793aCA\u75c5\u7a0b\u53ef\u80fd\u53d7\u6162\u6027\u767c\u708e\u904e\u7a0b\u7684\u5f71\u97ff\u3002\u6b64\u5916\uff0c\u5728\u5148\u524d\u7684\u5c0f\u9f20\u5be6\u9a57\u4e2d\uff0c\u5df2\u521d\u6b65\u767c\u73fe\u8178\u9053\u83cc\u53ef\u80fd\u8207\u8166\u90e8CA\u751f\u6210\u6709\u95dc\u806f\u6027\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u8178\u9053\u83cc\u76f8\u53ef\u9810\u6e2c\u8166\u90e8\u8840\u7ba1\u7624<\/strong><strong>\uff0d<\/strong><strong>\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624<\/strong><\/span><\/p>\n<p>\u57282020\u5e74\uff0c\u7f8e\u570b\u829d\u52a0\u54e5\u5927\u5b78\u7814\u7a76\u4eba\u54e1\u5728\u63a5\u7e8c\u7684\u7814\u7a76\u4e2d\u8b49\u660e\u4e86\u8178\u9053\u83cc\u76f8\u8207CA\u751f\u6210\u7684\u95dc\u4fc2\uff0c\u6210\u679c\u5df2\u767c\u8868\u5728\u570b\u969b\u8457\u540d\u671f\u520a\u300c\u81ea\u7136\u901a\u8a0a\uff08Nature Communication\uff09\u300d\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u54e1\u5728\u5148\u5c0e\u7684\u5be6\u9a57\u4e2d\u5229\u752816S rRNA \u57fa\u56e0\u5b9a\u5e8f\u4f86\u6bd4\u5c0dCA\u60a3\u8005\u8207\u5065\u5eb7\u4eba\u7cde\u4fbf\u6aa2\u9ad4\u7684\u5fae\u751f\u7269\u57fa\u56e0\u5dee\u7570\uff0c\u767c\u73fe\u4e86\u8178\u9053\u83cc\u76f8\u78ba\u5be6\u5177\u6709\u5dee\u7570\u6027\uff0c\u63a5\u8457\u5728\u66f4\u5927\u7684\u5be6\u9a57\u7fa4\u7d44\u4e2d\u9032\u884c\u7e3d\u9ad4\u57fa\u56e0\u9ad4\u96a8\u6a5f\u5b9a\u5e8f\uff08metagenomic shotgun sequencing\uff09&nbsp;\u4f86\u63a2\u7d22\u5fae\u751f\u7269\u7fa4\u7cfb\u7684\u5dee\u7570\uff0c\u518d\u8207\u5148\u524d\u7684\u5be6\u9a57\u7d50\u679c\u9032\u884c\u6bd4\u5c0d\u3002\u4ed6\u5011\u7684\u7814\u7a76\u5206\u6790\u51fa\u985e\u687f\u83cc\uff08<em>Bacteroides<\/em>\uff09\u8207\u666e\u62c9\u68ad\u83cc\uff08<em>Faecalibacterium<\/em>\uff09\u5169\u500b\u83cc\u5c6c\u5206\u5225\u5728CA\u60a3\u8005\u8207\u975eCA\u60a3\u8005\u4e2d\u8868\u73fe\u91cf\u8f03\u9ad8\uff0c\u8868\u73fe\u7684\u8da8\u52e2\u8207\u5206\u6790\u65b9\u6cd5\u6216\u6aa2\u9ad4\u4f86\u6e90\u7121\u95dc\uff0c\u8db3\u4ee5\u4f5c\u70ba\u751f\u7269\u6a19\u8a18\uff08biomarker\uff09\u3002<\/p>\n<p>\u4ed6\u5011\u627e\u5230\u4e09\u7a2e\u6a19\u8a8c\u6027\u83cc\u682a\u4e26\u5c07\u4e4b\u6b78\u985e\u70ba\u751f\u7269\u6a19\u8a18\uff0c\u5176\u4e2d\u9769\u862d\u6c0f\u9670\u6027\u7684\u6c23\u5473\u687f\u83cc\uff08<em>Odoribacter splanchnicus<\/em>\uff09\u5728CA\u60a3\u8005\u8eab\u4e0a\u8868\u73fe\u91cf\u6703\u589e\u52a0\uff0c\u9769\u862d\u6c0f\u967d\u6027\u7684\u666e\u62c9\u68ad\u83cc\uff08<em>Faecalibacterium prausnitzii<\/em>\uff09\u53ca\u9752\u6625\u96d9\u6b67\u687f\u83cc\uff08<em>Bifidobacterium adolescentis<\/em>\uff09\u5247\u6e1b\u5c11\uff0c\u5176\u8868\u73fe\u91cf\u8207CA\u751f\u6210\u7684\u7a0b\u5ea6\u986f\u8457\u76f8\u95dc\uff0c\u5177\u6709\u6f5b\u529b\u4f5c\u70ba\u81e8\u5e8a\u4e0a\u8fa8\u8b58CA\u60a3\u8005\u7684\u751f\u7269\u6a19\u8a18\uff0c\u9019\u9805\u7d50\u679c\u660e\u78ba\u95e1\u660e\u4e86\u5728\u4eba\u9ad4\u4e2d\u8178\u9053\u83cc\u76f8\u8207\u8166\u8840\u7ba1\u75be\u75c5\u767c\u751f\u98a8\u96aa\u7684\u76f8\u95dc\u6027\u3002<\/p>\n<p>\u4ed6\u5011\u4e5f\u767c\u73fe CA\u60a3\u8005\u9ad4\u5167\u7684\u9769\u862d\u6c0f\u9670\u6027\u83cc\u6703\u4fc3\u9032\u8102\u591a\u91a3 (lipopolysaccharide, LPS) \u76f8\u95dc\u86cb\u767d\u7684\u6d3b\u5316\u800c\u5f15\u8d77\u767c\u708e\u53cd\u61c9\uff0c\u7b26\u5408\u5148\u524d\u7684\u7d50\u679c\u3002\u6b64\u5916\uff0c\u4ed6\u5011\u7684\u7814\u7a76\u986f\u793a\uff0c\u8207\u5065\u5eb7\u7684\u500b\u9ad4\u76f8\u6bd4\uff0cCA\u60a3\u8005\u5177\u6709\u7279\u6b8a\u7684\u8178\u9053\u83cc\u76f8\u3002\u751f\u7269\u5408\u6210\u548c\u57fa\u56e0\u6c34\u5e73\u7684\u5206\u6790\u8b49\u660e\u4e86LPS\u6703\u9a45\u52d5CA\u7684\u767c\u751f\u3002\u4e0d\u540c\u75be\u75c5\u7279\u5fb5\u7684CA\u60a3\u8005\u542b\u6709\u4e0d\u540c\u7684\u5fae\u751f\u7269\u7fa4\u7cfb\uff0c\u672a\u4f86\u5e0c\u671b\u9032\u4e00\u6b65\u900f\u904e\u5fae\u751f\u7269\u6aa2\u6e2c\u52a0\u4e0a\u8840\u6db2\u6aa2\u9ad4\u5206\u6790\uff0c\u5e6b\u52a9\u5feb\u901f\u8a3a\u65b7CA\u8207\u5176\u4ed6\u8166\u90e8\u76f8\u95dc\u75be\u75c5\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n<ol>\n<li>Saxena R., Sharma V.K. A Metagenomic Insight into Human Microbiome: Its Implications in Health and Disease. In book: Medical and Health Genomics, Chapter 9 (p.107-117), Edition: 1, Publisher: Elsevier, Editors: Dhavendra Kumar, Stylianos Antonarakis, <a href=\"https:\/\/doi.org\/10.1016\/B978-0-12-420196-5.00009-5\">https:\/\/doi.org\/10.1016\/B978-0-12-420196-5.00009-5<\/a><\/li>\n<li>Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Carri\u00f3n-Penagos J, Girard R, Koskim\u00e4ki J, Zhang D, Stadnik A, Romanos SG, Lyne SB, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA. Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Nat Commun. 2020 May 27;11(1):2659. doi: 10.1038\/s41467-020-16436-w.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u8178\u9053\u83cc\u7684\u7d44\u6210\u8207\u75be\u75c5\u767c\u751f\u6709\u986f\u8457\u95dc\u806f\u6027\uff0c\u75c5\u60a3\u7684\u8178\u9053\u83cc\u76f8\u8207\u5065\u5eb7\u8005\u5fc5\u7136\u6709\u5dee\u7570\uff0c\u6240\u4ee5\u8178\u9053\u83cc\u76f8\u6aa2\u6e2c\u53ef\u6aa2\u8996\u5bbf\u4e3b\u7684\u751f\u7406\u72c0\u614b\u662f\u5426\u8da8\u8fd1\u65bc\u75be\u75c5\u7684\u72c0\u614b\u3002\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624\u53ef\u80fd\u767c\u751f\u5728\u4eba\u9ad4\u5404\u90e8\u4f4d\uff0c\u7576\u5176\u51fa\u73fe\u5728\u8166\u90e8\u6642\u5bb9\u6613\u5c0e\u81f4\u8166\u4e2d\u98a8\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u5df2\u767c\u73fe\u8178\u9053\u83cc\u5931\u8861\u53ef\u80fd\u4e5f\u8207\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624\u7684\u767c\u751f\u6709\u95dc\u806f\u6027\uff0c\u6545\u7279\u7570\u6027\u8178\u9053\u83cc\u6709\u6f5b\u529b\u4f5c\u70ba\u6aa2\u6e2c\u7684\u751f\u7269\u6a19\u8a18\uff0c\u7528\u65bc\u5feb\u901f\u8a3a\u65b7\u6d77\u7dbf\u72c0\u8840\u7ba1\u7624\u53ca\u5176\u4ed6\u8166\u90e8\u76f8\u95dc\u75be\u75c5\u3002<\/p>\n","protected":false},"author":20,"featured_media":36880,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4983,4984,4985,1792],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/08\/14561651.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36862"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36862"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36862\/revisions"}],"predecessor-version":[{"id":36881,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36862\/revisions\/36881"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/36880"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}