{"id":36847,"date":"2021-08-17T11:48:47","date_gmt":"2021-08-17T03:48:47","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=36847"},"modified":"2021-08-25T15:52:18","modified_gmt":"2021-08-25T07:52:18","slug":"%e4%bb%80%e9%ba%bc%e6%98%af%e3%80%8c%e7%aa%81%e7%a0%b4%e6%80%a7%e6%84%9f%e6%9f%93%e3%80%8d%ef%bc%9f%e8%ae%8a%e7%a8%ae%e7%97%85%e6%af%92%e6%9c%89%e5%a4%9a%e5%a4%a7%e7%9a%84%e5%a8%81%e8%84%85%e5%91%a2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=36847","title":{"rendered":"\u4ec0\u9ebc\u662f\u300c\u7a81\u7834\u6027\u611f\u67d3\u300d\uff1f\u8b8a\u7a2e\u75c5\u6bd2\u6709\u591a\u5927\u7684\u5a01\u8105\u5462\uff1f"},"content":{"rendered":"

\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u7a81\u8b8a\u901f\u5ea6\u9a5a\u4eba\uff0c\u9020\u6210\u591a\u7a2e\u8b8a\u7a2e\u75c5\u6bd2\u751f\u6210\uff0c\u6210\u70ba\u6240\u8b02\u7a81\u7834\u6027\u611f\u67d3\u7684\u4e3b\u56e0\uff0c\u4e26\u5f15\u8d77\u5168\u7403\u53e6\u4e00\u6ce2\u75ab\u60c5\uff0c\u800c\u4e14\u6709\u4e9b\u8b8a\u7a2e\u75c5\u6bd2\u5df2\u88ab\u8b49\u5be6\u53ef\u6291\u5236\u6838\u51c6\u75ab\u82d7\u8207\u6cbb\u7642\u65b9\u6cd5\u7684\u6709\u6548\u6027\uff0c\u5c0d\u73fe\u884c\u7684 COVID-19\u7684\u9810\u9632\u53ca\u6cbb\u7642\u7b56\u7565\u5f62\u6210\u56b4\u5cfb\u7684\u6311\u6230\u3002\u5728\u672c\u6587\uff0c\u6211\u5011\u5c07\u5f15\u9818\u8b80\u8005\u4e86\u89e3\u7a81\u7834\u6027\u611f\u67d3\u3001\u8a8d\u8b58\u8b8a\u7a2e\u75c5\u6bd2\u53ca\u5176\u5a01\u8105\u6027\uff0c\u4e26\u63a2\u7d22\u56e0\u61c9\u4e4b\u9053\u3002<\/strong><\/span><\/p>\n

\"\"\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u7a81\u7834\u6027\u611f\u67d3<\/strong>\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

\u5f88\u591a\u570b\u5bb6\u90fd\u5728\u52aa\u529b\u63d0\u9ad8COVID-19\u75ab\u82d7\u65bd\u6253\u7387\uff0c\u4f46\u4ecd\u767c\u73fe\u6709\u5c11\u6578\u5b8c\u5168\u63a5\u7a2e\u8005\uff08\u63a5\u7a2e\u5b8c\u5169\u5291\u75ab\u82d7\u8d85\u904e14\u5929\u4ee5\u4e0a\uff09\u4ecd\u78ba\u8a3aCOVID-19\uff0c\u4f8b\u5982\uff1a\u7f8e\u570b\u7684\u5967\u904b\u4ee3\u8868\u968a\u81f3\u5c112\u4f4d\u5df2\u5b8c\u5168\u63a5\u7a2e\u904b\u52d5\u54e1\u5c31\u56e0\u6b64\u4e0d\u80fd\u53c3\u52a0\u6bd4\u8cfd\uff1b\u5168\u7403\u75ab\u82d7\u63a5\u7a2e\u7387\u6700\u9ad8\u7684\u4ee5\u8272\u5217\uff08\u65bd\u6253\u8f1d\u745e\/BNT\u75ab\u82d7\u5169\u5291\u8986\u84cb\u7387\u7d0460%\uff09\u73fe\u5df2\u8003\u616e\u63a5\u7a2e\u7b2c\u4e09\u5291\u4e86\u3002\u65bd\u6253\u75ab\u82d7\u4e0d\u662f\u5c31\u514d\u75ab\u4e86\u55ce\uff1f\u70ba\u4f55 COVID-19 \u80fd\u7a81\u7834\u75ab\u82d7\u7684\u9632\u8b77\u7db2\uff1f\u9019\u7a2e\u72c0\u6cc1\u7a31\u70ba\u7a81\u7834\u6027\u611f\u67d3\uff08Breakthrough infection\uff09\uff0c\u4e5f\u5c31\u662f\u65bd\u6253\u75ab\u82d7\u5f8c\u4ecd\u78ba\u8a3a\u50b3\u67d3\u75c5\u7684\u60c5\u6cc1\u3002\u7f8e\u570b\u75be\u75c5\u7ba1\u5236\u8207\u9810\u9632\u4e2d\u5fc3\uff08Center for Disease Control, CDC\uff09 \u5b9a\u7fa9\u7a81\u7834\u6027\u611f\u67d3\u70ba\uff1a\u300c\u5b8c\u5168\u63a5\u7a2e\u65b0\u51a0\u75ab\u82d7\u5f8c\u81f3\u5c1114\u5929\uff0c\u7d93\u904e\u63a1\u6aa2\u5f8c\u78ba\u8a3a COVID-19\u300d\u3002\u6b64\u5916\uff0c\u7a81\u7834\u6027\u611f\u67d3\u4e0d\u662f\u53ea\u767c\u751f\u5728\u65b0\u51a0\u75c5\u6bd2\uff08SARS-CoV-2\uff09\uff0c\u4e5f\u51fa\u73fe\u65bc\u5176\u4ed6\u75c5\u539f\u9ad4\u4e0a\uff0c\u53ef\u80fd\u7684\u539f\u56e0\u5982\u4e0b\uff1a<\/p>\n

1.\u75ab\u82d7\u4fdd\u8b77\u529b\u4e26\u975e100%\uff1a\u96d6\u7136\u7372\u5f97WHO\u6216\u5404\u570b\u5b98\u65b9\u8a8d\u8b49\u6216\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\uff08EUA\uff09\u7684COVID-19\u75ab\u82d7\u54c1\u724c\u53ca\u985e\u578b\u5f88\u591a\uff0c\u4f46\u5ba3\u7a31\u4fdd\u8b77\u529b\u5747\u4ecb\u65bc60~95% \u5de6\u53f3\uff0c\u6c92\u6709\u4e00\u6b3e\u75ab\u82d7\u53ef\u4ee5\u8b49\u660e\u5176\u4fdd\u8b77\u529b\u662f100%\uff0c\u6240\u4ee5\u4e0d\u4ee3\u8868\u65bd\u6253\u75ab\u82d7\u5c31\u6703\u7d55\u5c0d\u514d\u75ab\u3002<\/p>\n

2.\u5728\u672a\u7372\u5b8c\u6574\u4fdd\u8b77\u529b\u524d\u5df2\u53d7\u5230\u611f\u67d3\uff1a\u5927\u591a\u6578COVID-19\u75ab\u82d7\uff08\u5982\u8f1d\u745e\/BNT\u3001\u83ab\u5fb7\u7d0d\u3001AZ\u75ab\u82d7\u7b49\uff0c\u5b0c\u751f\u75ab\u82d7\u9664\u5916\uff09\u7686\u9808\u63a5\u7a2e 2 \u5291\u624d\u80fd\u9054\u5230\u5b8c\u6574\u4fdd\u8b77\u529b\uff0c\u800c\u65bd\u6253\u5f8c\u4e5f\u9700\u89812\u9031\u624d\u80fd\u7522\u751f\u6297\u9ad4\uff0c\u7a81\u7834\u6027\u611f\u67d3\u6848\u4f8b\u53ef\u80fd\u662f\u5728\u75ab\u82d7\u65bd\u6253\u524d\u6216\u5728\u8eab\u9ad4\u6b63\u5728\u7522\u751f\u6297\u9ad4\u6642\u53d7\u5230\u75c5\u6bd2\u611f\u67d3\uff0c\u6240\u4ee5\u624d\u6703\u5728\u75ab\u82d7\u63a5\u7a2e\u5b8c\u6210\u5f8c\u4ecd\u78ba\u8a3a\u3002<\/p>\n

3.\u75ab\u82d7\u63a5\u7a2e\u8005\u9ad4\u8cea\u5dee\u7570\uff1a\u75ab\u82d7\u4e43\u85c9\u7531\u5f15\u767c\u63a5\u7a2e\u8005\u514d\u75ab\u7cfb\u7d71\u7522\u751f\u53cd\u61c9\u5c0d\u6297\u75c5\u539f\u9ad4\uff0c\u8207\u4e00\u822c\u85e5\u54c1\u76f4\u63a5\u6cbb\u7642\u75be\u75c5\u7684\u539f\u7406\u5dee\u8ddd\u8f03\u5927\uff0c\u6545\u7522\u751f\u7684\u6548\u7528\u53ca\u4fdd\u8b77\u529b\u5e38\u56e0\u500b\u4eba\u9ad4\u8cea\u800c\u6709\u5dee\u7570\uff0c\u5982\u7522\u751f\u7684\u6297\u9ad4\u6548\u50f9\u53ca\u514d\u75ab\u53cd\u61c9\u7684\u5f37\u5ea6\u7b49\u3002\u56e0\u6b64\uff0c\u514d\u75ab\u7cfb\u7d71\u8f03\u5f31\u7684\u65cf\u7fa4\u53ef\u80fd\u56e0\u514d\u75ab\u53cd\u61c9\u6216\u6297\u9ad4\u4e0d\u8db3\uff0c\u800c\u518d\u6b21\u53d7\u5230\u611f\u67d3\u3002<\/p>\n

4.\u8b8a\u7a2e\u75c5\u6bd2\u51fa\u73fe\uff1aSARS-CoV-2\u70baRNA\u75c5\u6bd2\uff0c\u56e0\u5176\u8907\u88fd\u6240\u7528\u7684RNA dependent RNA polymerase \u7684\u6821\u8b80\u80fd\u529b\u8f03\u5dee\uff0c\u672c\u4f86\u7a81\u8b8a\u7387\u4fbf\u8f03\u9ad8\uff0c\u800c\u75c5\u6bd2\u8207\u85e5\u7269\u6216\u75ab\u82d7\u63a5\u89f8\u904e\u5f8c\uff0c\u57fa\u65bc\u751f\u7269\u81ea\u6211\u8abf\u7bc0\u4ee5\u9069\u61c9\u74b0\u5883\u3001\u6301\u7e8c\u751f\u5b58\u7684\u672c\u80fd\uff0c\u4e5f\u6709\u53ef\u80fd\u8a98\u767c\u5176\u767c\u751f\u7a81\u8b8a\u4ee5\u5c0d\u6297\u75ab\u82d7\u53ca\u85e5\u7269\uff0c\u4f8b\u5982\uff1a\u67d0\u4e9b\u75c5\u6bd2\u8b8a\u7570\u682a\u5df2\u8b49\u5be6\u53ef\u6291\u5236\u6838\u51c6\u75ab\u82d7\u8207\u6cbb\u7642\u7684\u6709\u6548\u6027\uff0c\u96d6\u5c1a\u7121\u5be6\u8cea\u8b49\u64da\uff0c\u4f46\u79d1\u5b78\u5bb6\u61f7\u7591\u53ef\u80fd\u63a8\u5347\u7a81\u7834\u6027\u611f\u67d3\u7684\u6578\u91cf\uff0c\u672a\u4f86\u4ea6\u53ef\u80fd\u6703\u51fa\u73fe\u53ef\u5c0d\u6297\u4eba\u985e\u514d\u75ab\u7cfb\u7d71\u6216\u75ab\u82d7\u7684\u65b0\u8b8a\u7a2e\u3002<\/p>\n

\u25cf\u8b8a\u7a2e\u75c5\u6bd2\u7684\u5206\u985e<\/strong><\/span><\/p>\n

\u57282021\u5e743\u6708\uff0c\u7f8e\u570bCDC\u548c\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09\u5c0dSARS-CoV-2\u8b8a\u7a2e\u75c5\u6bd2\u7684\u5206\u985e\u5236\u5b9a\u4e86\u65b0\u6a19\u6e96\uff0c\u5206\u70ba\u300c\u503c\u5f97\u95dc\u6ce8\u7684\u8b8a\u7570\u300d\uff08variant of interest\uff0cVOI\uff09\u3001\u300c\u4ee4\u4eba\u64d4\u6182\u7684\u8b8a\u7570\u300d\uff08variant of concern\uff0cVOC\uff09\u53ca\u300c\u56b4\u91cd\u6027\u9ad8\u7684\u8b8a\u7570\uff08variant of high consequence\uff0cVOHC\uff09\u300d\uff0c\u4e3b\u65e8\u5728\u95e1\u660e\u8b8a\u7a2e\u75c5\u6bd2\u8b8a\u5316\u7684\u7a0b\u5ea6\u3001\u50b3\u64ad\u7684\u98a8\u96aa\u53ca\u5c0d\u516c\u5171\u885b\u751f\u7684\u5a01\u8105\u56b4\u91cd\u6027\u3002<\/p>\n

1.\u503c\u5f97\u95dc\u6ce8\u7684\u8b8a\u7570\uff08VOI\uff09\uff1a\u75c5\u6bd2\u57fa\u56e0\u5e8f\u5217\u51fa\u73fe\u8b8a\u7570\u800c\u6539\u8b8a\u4e86\u5c0d\u7d30\u80de\u53d7\u9ad4\u7d50\u5408\u7684\u80fd\u529b\uff0c\u4e5f\u964d\u4f4e\u4e86\u611f\u67d3\u6216\u63a5\u7a2e\u75ab\u82d7\u5f8c\u6240\u7522\u751f\u7684\u6297\u9ad4\u4e2d\u548c\u6548\u679c\u3001\u6cbb\u7642\u529f\u6548\u53ca\u8a3a\u65b7\uff0c\u751a\u81f3\u53ef\u80fd\u589e\u52a0\u50b3\u64ad\u6027\u6216\u75be\u75c5\u56b4\u91cd\u6027\uff0c\u53ef\u80fd\u6703\u9020\u6210\u78ba\u8a3a\u75c5\u4f8b\u6fc0\u589e\u6216\u7fa4\u7a81\u767c\uff0c\u53ef\u540c\u6642\u5728\u591a\u500b\u570b\u5bb6\u5f15\u8d77\u6709\u9650\u5ea6\u7684\u6d41\u884c\u3002<\/p>\n

2.\u4ee4\u4eba\u64d4\u6182\u7684\u8b8a\u7570\uff08VOC\uff09\uff1a\u5df2\u6709\u8b49\u64da\u986f\u793a\u75c5\u6bd2\u6709\u66f4\u5f37\u7684\u50b3\u67d3\u6027\u6216\u5c0e\u81f4\u66f4\u56b4\u91cd\u7684\u611f\u67d3\uff08\u4f8b\u5982\u4f4f\u9662\u6216\u6b7b\u4ea1\u4eba\u6578\u589e\u52a0\uff09\u3001\u5148\u524d\u611f\u67d3\u6216\u75ab\u82d7\u63a5\u7a2e\u5f8c\u7522\u751f\u7684\u6297\u9ad4\u4e2d\u548c\u4f5c\u7528\u986f\u8457\u964d\u4f4e\u3001\u6cbb\u7642\u6216\u75ab\u82d7\u7684\u6709\u6548\u6027\u6e1b\u5c11\u6216\u5c0e\u81f4\u6aa2\u6e2c\u5931\u6557\u3002<\/p>\n

3.\u56b4\u91cd\u6027\u9ad8\u7684\u8b8a\u7a2e\uff08VOHC\uff09\uff1a\u75c5\u6bd2\u5df2\u986f\u8457\u964d\u4f4e\u75ab\u82d7\u3001\u85e5\u7269\u7b49\u9810\u9632\u53ca\u6cbb\u7642\u65b9\u6cd5\u7684\u6709\u6548\u6027\uff0c\u5373\u4f7f\u63a5\u7a2e\u75ab\u82d7\u5f8c\uff0c\u767c\u751f\u7a81\u7834\u6027\u611f\u67d3\u7684\u75c5\u4f8b\u4ecd\u6fc0\u589e\uff0c\u5c0d\u91cd\u75c7\u7684\u4fdd\u8b77\u529b\u4e5f\u5f88\u4f4e\uff0c\u9020\u6210\u66f4\u591a\u75c5\u4eba\u51fa\u73fe\u56b4\u91cd\u7684\u75c7\u72c0\u548c\u9700\u8981\u4f4f\u9662\u6cbb\u7642\u3002<\/p>\n

\u25cf\u8b8a\u7a2e\u75c5\u6bd2\u7684\u5a01\u8105\u6027<\/strong><\/span><\/p>\n

SARS-CoV-2\u80fd\u5728\u77ed\u6642\u9593\u5167\u51fa\u73fe\u591a\u500b\u8b8a\u7a2e\uff0c\u800c\u5728\u7279\u5b9a\u4f4d\u9ede\u7684\u7a81\u8b8a\u5c07\u964d\u4f4e\u6838\u51c6\u7642\u6cd5\u7684\u529f\u6548\uff0c\u4e26\u4f7f\u5176\u8eb2\u907f\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u80fd\u529b\u53ca\u50b3\u67d3\u529b\u5927\u5e45\u63d0\u5347\uff0cWHO\u5df2\u8a3b\u8a18Alpha\u3001Beta\u3001Gamma\u3001Delta \u56db\u7a2e\u8b8a\u7570\u7a2e\u5c6c\u65bc\u4ee4\u4eba\u64d4\u6182\u7684\u8b8a\u7570\uff08VOC\uff09\u3002\u5176\u4e2dDelta\u662f\u76ee\u524d\u50b3\u67d3\u529b\u6700\u5f37\u7684\u8b8a\u7a2e\u75c5\u6bd2\uff0c\u57fa\u672c\u50b3\u67d3\u6578\uff08Basic reproduction number, R0\uff09\u521d\u4f30\u53ef\u9ad8\u90549\u3002<\/p>\n

Alpha\u3001Beta\u3001Gamma\u90fd\u6709N501Y\u4f4d\u9ede\u7a81\u8b8a\u6703\u4f7f\u50b3\u67d3\u529b\u63d0\u5347\uff0c\u53e6\u5747\u6709E484K\u4f4d\u9ede\u7a81\u8b8a\u53ef\u964d\u4f4e\u6838\u51c6\u75ab\u82d7\u8207\u6cbb\u7642\u7684\u4e2d\u548c\u6297\u9ad4\u6548\u529b\uff0c\u800cDelta\u64c1\u6709\u7684L452R\u4f4d\u9ede\u7a81\u8b8a\u5247\u53ef\u5f37\u5316\u50b3\u67d3\u529b\u53ca\u9003\u907f\u514d\u75ab\u7cfb\u7d71\u7684\u653b\u64ca\u3002\u76ee\u524d Delta\u8b8a\u7a2e\u75c5\u6bd2\u5df2\u5165\u4fb5\u8d85\u904e85\u500b\u570b\u5bb6\uff0c\u4f8b\u5982\uff1a\u82f1\u570b90% \u65b0\u6848\u4f8b\u7686\u70baDelta\u8b8a\u7a2e\u611f\u67d3\uff1b\u4ee5\u8272\u5217\u7684\u521d\u671f\u7814\u7a76\u6307\u51fa50%\u65b0\u6210\u5e74\u6848\u4f8b\u662f\u5df2\u65bd\u62532\u5291\u75ab\u82d7\u7684\u6c11\u773e\uff1b\u5728\u7f8e\u570b\uff0cDelta\u8207Gamma \u9010\u6f38\u53d6\u4ee3\u5176\u4ed6\u8b8a\u7a2e\u6210\u70ba\u4e3b\u6d41\uff0c\u6700\u8fd1Delta\u6848\u4f8b\u7684\u6210\u9577\u6578\u5df2\u8d85\u904e Gamma\u800c\u6210\u70ba\u6700\u5927\u5b97\uff1b\u5728\u53f0\u7063\uff0c\u524d\u4e9b\u6642\u5019\u7684Delta\u6848\u4f8b\uff0c\u4f7f\u4e2d\u592e\u75ab\u60c5\u6307\u63ee\u4e2d\u5fc3\u5982\u81e8\u5927\u6575\uff0c\u6c11\u773e\u805e\u4e4b\u8272\u8b8a\u3002<\/p>\n

\u8fd1\u671f\u53f0\u7063COVID-19\u75ab\u60c5\u5347\u6eab\uff0c\u5f15\u767c\u5927\u773e\u64d4\u6182\u82e5\u8b8a\u7a2e\u75c5\u6bd2\u5165\u4fb5\u53f0\u7063\uff0c\u662f\u5426\u53ef\u80fd\u5f15\u767c\u66f4\u5ee3\u6cdb\u800c\u5f37\u70c8\u7684\u50b3\u64ad\u53ca\u61f7\u7591\u75ab\u82d7\u662f\u5426\u6703\u56e0\u800c\u5931\u53bb\u4fdd\u8b77\u529b\uff0c\u95dc\u5207\u5f15\u767c\u7a81\u7834\u6027\u611f\u67d3\u7684\u8b8a\u7a2e\u75c5\u6bd2\u6848\u4f8b\u6578\u591a\u55ce\uff1f\u50b3\u67d3\u529b\u5982\u4f55\u5462\uff1f\u75ab\u60c5\u56b4\u5cfb\u55ce\uff1f \u7e3d\u4e4b\uff0c\u6211\u5011\u9762\u5c0d\u75c5\u6bd2\u4e0d\u65b7\u51fa\u73fe\u65b0\u8b8a\u7a2e\u7684\u5a01\u8105\uff0c\u56e0\u61c9\u4f5c\u70ba\u9664\u4e86\u6301\u7e8c\u52a0\u5f37\u75c5\u6bd2\u8b8a\u7570\u7684\u76e3\u6e2c\u5916\uff0c\u4e0d\u8ad6\u662f\u5426\u63a5\u7a2e\u75ab\u82d7\u4ecd\u61c9\u843d\u5be6\u6234\u53e3\u7f69\u3001\u52e4\u6d17\u624b\u53ca\u4fdd\u6301\u793e\u4ea4\u8ddd\u96e2\uff0c\u6aa2\u75ab\u53ca\u9694\u96e2\u7b49\u9632\u75ab\u5de5\u4f5c\u4e0d\u80fd\u9b06\u61c8\uff0c\u4e26\u63d0\u9ad8\u75ab\u82d7\u7684\u63a5\u7a2e\u7387\uff0c\u540c\u6642\u76e3\u6e2c\u75ab\u82d7\u5c0d\u8b8a\u7a2e\u75c5\u6bd2\u7684\u4fdd\u8b77\u529b\uff0c\u4e00\u65e6\u51fa\u73fe\u56b4\u91cd\u6027\u9ad8\u7684\u8b8a\u7a2e\uff08VOHC\uff09\u75c5\u6bd2\u6642\uff0c\u4fbf\u61c9\u7814\u767c\u65b0\u7684\u75ab\u82d7\uff0c\u624d\u80fd\u9632\u6b62\u4e0b\u4e00\u6ce2\u7684\u5927\u6d41\u884c\u3002<\/p>\n

 <\/strong><\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a
\n<\/strong>1.Cherian, S., Potdar, V., Jadhav, S., et al 2021. Convergent evolution of SARS-CoV-2 spike mutations, L452R, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India. bioRxiv. doi:<\/strong>org\/10.1101\/2021.04.22.440932
\n2.Yadav, P.D., Mohandas, S., Shete, A.M., et al 2021. SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant. bioRxiv. doi:org\/10.1101\/2021.05.05.442760
\n3.Edara, V.V., Lai, L., Sahoo, M., et al. Infection
\n4.van Dorp L, Acman M, Richard D, Shaw LP, Ford CE, Ormond L, Owen CJ, Pang J, Tan CCS, Boshier FAT, Ortiz AT, Balloux F. Emergence of genomic diversity and recurrent mutations in SARS-CoV-2.<\/a> Infect Genet Evol. 2020 Sep; 83:104351. doi: 10.1016\/j.meegid.2020.104351. Epub 2020 May 5.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\uff08SARS-CoV-2\uff09\u7a81\u8b8a\u901f\u5ea6\u9a5a\u4eba\uff0c\u9020\u6210\u591a\u7a2e\u8b8a\u7a2e\u75c5\u6bd2\u751f\u6210\uff0c\u6210\u70ba\u6240\u8b02\u7a81\u7834\u6027\u611f\u67d3\u7684\u4e3b\u56e0\uff0c\u4e26\u5f15\u8d77\u5168\u7403\u53e6\u4e00\u6ce2\u75ab\u60c5\uff0c\u800c\u4e14\u6709\u4e9b\u8b8a\u7a2e\u75c5\u6bd2\u5df2\u88ab\u8b49\u5be6\u53ef\u6291\u5236\u6838\u51c6\u75ab\u82d7\u8207\u6cbb\u7642\u65b9\u6cd5\u7684\u6709\u6548\u6027\uff0c\u5c0d\u73fe\u884c\u7684 COVID-19\u7684\u9810\u9632\u53ca\u6cbb\u7642\u7b56\u7565\u5f62\u6210\u56b4\u5cfb\u7684\u6311\u6230\u3002\u5728\u672c\u6587\uff0c\u6211\u5011\u5c07\u5f15\u9818\u8b80\u8005\u4e86\u89e3\u7a81\u7834\u6027\u611f\u67d3\u3001\u8a8d\u8b58\u8b8a\u7a2e\u75c5\u6bd2\u53ca\u5176\u5a01\u8105\u6027\uff0c\u4e26\u63a2\u7d22\u56e0\u61c9\u4e4b\u9053\u3002<\/p>\n","protected":false},"author":20,"featured_media":36856,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4580,3293,3005,1025],"tags":[4577,4612,4970,3716,4971],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/08\/16641009_MotionElements_covid-19-coronavirus.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36847"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36847"}],"version-history":[{"count":2,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36847\/revisions"}],"predecessor-version":[{"id":36858,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36847\/revisions\/36858"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/36856"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}