{"id":36797,"date":"2021-08-04T00:13:34","date_gmt":"2021-08-03T16:13:34","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=36797"},"modified":"2021-08-03T09:26:37","modified_gmt":"2021-08-03T01:26:37","slug":"%e8%8e%ab%e5%a5%88%e6%8b%89%e9%9f%8bmolnupiravir%ef%bc%9acovid-19-%e6%b2%bb%e7%99%82%e5%8f%8a%e9%a0%90%e9%98%b2%e7%9a%84%e6%96%b0%e5%b8%8c%e6%9c%9b%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=36797","title":{"rendered":"\u83ab\u5948\u62c9\u97cb(Molnupiravir)\uff1aCOVID-19 \u6cbb\u7642\u53ca\u9810\u9632\u7684\u65b0\u5e0c\u671b\uff1f"},"content":{"rendered":"

\u96a8\u8457\u5404\u570b\u91ab\u7642\u9ad4\u7cfb\u56e0COVID-19\u5927\u6d41\u884c\u9010\u6f38\u7121\u6cd5\u8ca0\u8377\uff0c\u70ba\u9632\u6b62\u56b4\u91cd\u6025\u6027\u547c\u5438\u9053\u75c7\u5019\u7fa4\u51a0\u72c0\u75c5\u6bd2 2 (SARS-CoV-2) \u7684\u6301\u7e8c\u50b3\u64ad\u53caCOVID-19\u60e1\u5316\u70ba\u56b4\u91cd\u75be\u75c5\uff0c\u958b\u767c\u6613\u65bc\u5206\u767c\u53ca\u53ef\u5c0d\u6297\u75c5\u6bd2\u8b8a\u7570\u7a2e\u7684\u53e3\u670d\u85e5\u7269\u523b\u4e0d\u5bb9\u7de9\u3002\u6211\u5011\u5728\u672c\u6587\u5c07\u5f15\u9818\u8b80\u8005\u8a8d\u8b58\u6297COVID-19\u7684\u65b0\u578b\u53e3\u670d\u85e5\u7269\u83ab\u5948\u62c9\u97cb\uff08Molnupiravir\uff09\uff0c\u4e26\u63a2\u7d22\u5176\u7814\u767c\u8a66\u9a57\u73fe\u6cc1\u53ca\u61c9\u7528\u6f5b\u529b\u3002<\/strong><\/span><\/p>\n

\"\"\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u83ab\u5948\u62c9\u97cb<\/strong>\uff08<\/strong>Molnupiravir<\/strong>\uff09<\/strong>\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

Molnupiravir\u662f\u4e00\u7a2e\u5408\u6210\u7684\u6838\u82f7\u9178\u884d\u751f\u7269 N4<\/sup>-\u7fa5\u57fa\u80de\u82f7\uff08N4<\/sup>-hydroxycytidine\uff09\u7684\u524d\u9a45\u85e5\uff08prodrug\uff09\uff0c\u5c6c\u65bc\u5be6\u9a57\u6027\u6297\u75c5\u6bd2\u85e5\u7269\uff0c\u53ef\u53e3\u670d\u4f7f\u7528\uff0c\u4f5c\u7528\u539f\u7406\u662f\u5728\u75c5\u6bd2RNA\u8907\u88fd\u904e\u7a0b\u4e2d\u5c07\u81ea\u8eab\u5d4c\u5165\u75c5\u6bd2\u7684RNA\uff0c\u5c0e\u81f4\u8907\u88fd\u932f\u8aa4\uff0c\u4f7f\u75c5\u6bd2\u7d2f\u7a4d\u8907\u88fd\u8b8a\u7570\uff0c\u85c9\u7531\u8d85\u904e\u8010\u53d7\u95a5\u503c\uff08threshold\uff09\u7684\u8907\u88fd\u8b8a\u7570\u4f86\u7834\u58de\u75c5\u6bd2\uff0c\u539f\u672c\u958b\u767c\u7528\u65bc\u6cbb\u7642\u6d41\u884c\u6027\u611f\u5192\uff0c\u4f46\u5f8c\u4f86\u4e5f\u767c\u73fe\u5176\u5c0d\u591a\u7a2eRNA\u75c5\u6bd2\u5177\u6709\u5ee3\u8b5c\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002<\/p>\n

\u7f8e\u570b\u653f\u5e9c\u57282021\u5e746\u6708\u548c\u9ed8\u6c99\u6771\uff08MSD\uff09\u88fd\u85e5\u516c\u53f8\u9054\u6210\u4e00\u4efd\u6297COVID-19\u53e3\u670d\u85e5\u7269Molnupiravir\u63a1\u8cfc\u5354\u8b70\uff0c\u5ba3\u5e03\u53ea\u8981\u8a72\u85e5\u7269\u53d6\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\uff08EUA\uff09\uff0c\u5c07\u8cfc\u8cb7\u5176\u7642\u7a0b\u3002\u76ee\u524dMSD\u6b63\u5728\u5168\u7403\u9032\u884cMolnupiravir\u53e3\u670d\u6297\u75c5\u6bd2\u85e5\u7269\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u4e9e\u6d32\u9078\u64c7\u5728\u65e5\u672c\u3001\u83f2\u5f8b\u8cd3\u548c\u53f0\u7063\u9032\u884c\u3002\u5728\u9019\u5834\u5c0d\u6297COVID-19\u85e5\u7269\u958b\u767c\u7684\u7af6\u722d\u4e2d\uff0c\u53f0\u7063\u6436\u5f97\u5148\u6a5f\uff0c\u53c3\u8207\u4e86\u81e8\u5e8a\u8a66\u9a57\uff0c\u4e5f\u53d6\u5f97\u512a\u5148\u63a1\u8cfc\u6cbb\u7642COVID-19\u53e3\u670d\u85e5\u7269\u7684\u6a5f\u6703\uff0c\u70ba\u4e0b\u968e\u6bb5\u65b0\u51a0\u80ba\u708e\u75ab\u60c5\u8f49\u70ba\u6d41\u611f\u5316\u5c55\u958b\u8d85\u524d\u90e8\u7f72\u3002<\/p>\n

\u25cfCOVID-19<\/strong>\u53e3\u670d\u6297\u75c5\u6bd2\u85e5\u7269\u7684\u91cd\u8981\u6027<\/strong><\/span><\/p>\n

\u6211\u5011\u60f3\u8981\u6709\u6548\u63a7\u5236COVID-19\uff0c\u5728\u91ab\u85e5\u7684\u958b\u767c\u4e0a\u6709\u5169\u500b\u91cd\u9ede\uff0c\u4e00\u662f\u75ab\u82d7\u3001\u53e6\u4e00\u5247\u662f\u85e5\u7269\u3002\u76ee\u524d\u5df2\u6709\u591a\u6b3e\u75ab\u82d7\u6210\u529f\u4e0a\u5e02\uff0c\u8a31\u591a\u570b\u5bb6\u90fd\u5728\u65bd\u6253\u4ee5\u9810\u9632\u611f\u67d3\uff1b\u81f3\u65bc\u6cbb\u7642\u85e5\u7269\uff0c\u5247\u4ee5\u6838\u82f7\u985e\u4f3c\u7269\u75c5\u6bd2\u8907\u88fd\u6291\u5236\u5291\uff08\u5982\u745e\u5fb7\u897f\u97cbRemdesivir\uff09\u53ca\u55ae\u682a\u6297\u9ad4\uff08\u5982Casirivimab + Imdevimab\u8207Bamlanivimab + Etesevimab\u5169\u7a2e\u7d44\u5408\uff09\u6700\u6709\u6548\u3002\u7136\u800c\uff0c\u524d\u8005\u53e3\u670d\u6548\u679c\u4e26\u4e0d\u7406\u60f3\u4e14\u7642\u6548\u6709\u722d\u8b70\uff0c\u4f8b\u5982\uff1a\u7f8e\u570bFDA\u57282020\u5e7410\u6708\u6b63\u5f0f\u6279\u51c6\u745e\u5fb7\u897f\u97cb\u53ef\u7528\u572812\u6b72\u4ee5\u4e0a\u4f4f\u9662\u75c5\u60a3\uff0c\u662f\u7f8e\u570b\u7b2c\u4e00\u500b\u7372\u5f97\u8a31\u53ef\u7684\u65b0\u51a0\u80ba\u708e\u7528\u85e5\uff0c\u4f46\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09\u537b\u57282020\u5e7411\u6708\u5ba3\u5e03\u4e0d\u5efa\u8b70\u4f4f\u9662\u60a3\u8005\u4f7f\u7528\uff1b\u5f8c\u8005\u4f9b\u61c9\u91cf\u4e0d\u8db3\u3001\u50f9\u683c\u9ad8\u6602\u4e14\u5291\u578b\u70ba\u91dd\u5291\uff0c\u9700\u8981\u5c08\u696d\u91ab\u8b77\u4eba\u54e1\u65bd\u884c\u6ce8\u5c04\u3002\u5982\u679c\u8981\u4f7f\u5f97COVID-19\u50cf\u6d41\u884c\u6027\u611f\u5192\u4e00\u6a23\uff0c\u4e0d\u81f4\u56b4\u91cd\u885d\u64ca\u8eab\u9ad4\u5065\u5eb7\u3001\u7d93\u6fdf\u6d3b\u52d5\u53ca\u65e5\u5e38\u751f\u6d3b\uff0c\u9664\u4e86\u8b93\u4e00\u822c\u6c11\u773e\u6709\u75ab\u82d7\u53ef\u4ee5\u65bd\u6253\u5916\uff0c\u4e5f\u8981\u8b93\u78ba\u8a3a\u8005\u6709\u85e5\u7269\u53ef\u4ee5\u4f7f\u7528\uff0c\u4f7f\u5176\u75c5\u60c5\u63a7\u5236\u5728\u8f15\u3001\u4e2d\u5ea6\uff0c\u6240\u4ee5\u958b\u767c\u4e00\u7a2e\u666e\u53ca\u5316\u53ca\u6295\u4e88\u7c21\u6613\u7684\u85e5\u7269\u4fbf\u986f\u5f97\u5341\u5206\u91cd\u8981\uff0c\u5c31\u50cf\u53e3\u670d\u6297\u6d41\u611f\u85e5\u7269\uff0d\u514b\u6d41\u611f\uff08Tamiflu\u00ae<\/sup>, Oseltamivir\uff09\u4e00\u6a23\u3002<\/p>\n

\u70ba\u4ec0\u9ebcMolnupiravir\u6703\u8b93\u5168\u7403\u91ab\u85e5\u754c\u5145\u6eff\u671f\u5f85\u5462\uff1f\u7b54\u6848\u662f\u56e0\u70baMolnupiravir\u4e3b\u8981\u7528\u65bc\u6cbb\u7642\u8f15\u5ea6\u548c\u4e2d\u5ea6\u7684COVID-19\u7684\u65e9\u671f\u78ba\u8a3a\u75c5\u60a3\uff0c\u70ba\u4e00\u6b3e\u53e3\u670d\u6297\u75c5\u6bd2\u85e5\u7269\uff0c\u800c\u4e14\u6839\u64da\u6700\u8fd1\u91dd\u5c0dCOVID-19\u60a3\u8005\u81e8\u5e8a\u8a66\u9a57\u7684\u7d50\u679c\u986f\u793a\uff0cMolnupiravir\u53ef\u986f\u8457\u6e1b\u5c11SAR-CoV-2\u75c5\u6bd2\u91cf\uff08viral load\uff09\u3002\u75ab\u82d7\u96d6\u7136\u662f\u5c0d\u6297\u75ab\u60c5\u7684\u6838\u5fc3\u6b66\u5668\uff0c\u4f46\u6297\u75c5\u6bd2\u85e5\u7269\u53ef\u9810\u9632\u8f15\u3001\u4e2d\u5ea6\u60a3\u8005\u60e1\u5316\u6210\u91cd\u75c7\u548c\u63d0\u4f9b\u4f4f\u9662\u75c5\u60a3\u91cd\u8981\u7684\u88dc\u7d66\u54c1\u3002\u7814\u7a76\u4eba\u54e1\u6b63\u5728\u6e2c\u8a66\u53e3\u670d\u9014\u5f91\u7684\u6297\u75c5\u6bd2\u85e5\u7269\uff0c\u4ee5\u63d0\u4f9bCOVID-19\u60a3\u8005\u5c45\u5bb6\u6cbb\u7642\u7684\u9078\u64c7\uff0c\u4f7f\u8f15\u3001\u4e2d\u5ea6\u60a3\u8005\u7121\u9808\u4f4f\u9662\u4ea6\u80fd\u53d6\u5f97\u9ad8\u54c1\u8cea\u6cbb\u7642\uff0c\u66f4\u53ef\u5354\u52a9\u6e1b\u8f15\u91ab\u7642\u9ad4\u7cfb\u4e4b\u8ca0\u64d4\uff0c\u91cb\u653e\u8cc7\u6e90\u7d66\u60c5\u6cc1\u6700\u7dca\u6025\u7684\u91cd\u75c7\u60a3\u8005\u3002<\/p>\n

\u25cfMolnupiravir<\/strong>\u7684\u76f8\u95dc\u7814\u7a76<\/strong><\/span><\/p>\n

\u57282020\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u5728\u7d30\u80de\u57f9\u990a\u53ca\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u8b49\u660e\u6838\u7cd6\u6838\u82f7\u985e\u4f3c\u7269\u03b2-D-N4<\/sup>-\u7fa5\u57fa\u80de\u82f7\uff08\u03b2-D-N4<\/sup>-hydroxycytidine, EIDD-1931\uff09\u5c0dSARS-CoV-2\u3001MERS-CoV\u3001SARS-CoV\u53ca\u5f15\u8d77\u4eba\u755c\u5171\u901a\u75be\u75c5\u7684\u51a0\u72c0\u75c5\u6bd2\u5177\u6709\u5ee3\u8b5c\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u5c0d\u5177\u745e\u5fb7\u897f\u97cb\u6297\u6027\u7684\u51a0\u72c0\u75c5\u6bd2\u8b8a\u7570\u7a2e\u5177\u6709\u589e\u5f37\u6548\u529b\u3002\u5728\u611f\u67d3 SARS-CoV\u6216MERS-CoV\u7684\u5c0f\u9f20\u4e2d\uff0c\u4f7f\u7528\u4e00\u7a2e\u53e3\u670d\u751f\u7269\u53ef\u5229\u7528\u7684\u03b2-D-N4<\/sup>-\u7fa5\u57fa\u80de\u82f7-5'-\u7570\u4e19\u916f\uff08\u03b2-D-N4<\/sup>-hydroxycytidine-5\u2032-isopropyl ester, EIDD-2801\uff09\u524d\u9a45\u85e5\u9032\u884c\u9810\u9632\u6027\u548c\u6cbb\u7642\u6027\u7d66\u85e5\uff0c\u767c\u73fe\u6539\u5584\u4e86\u5c0f\u9f20\u7684\u80ba\u529f\u80fd\uff0c\u4e26\u964d\u4f4e\u4e86\u75c5\u6bd2\u6548\u50f9\uff08titer\uff09\u548c\u5ef6\u7de9\u9ad4\u91cd\u7684\u6e1b\u8f15\u3002\u7814\u7a76\u7d50\u679c\u986f\u793aEIDD-2801\u5177\u6709\u5c0d\u6297\u591a\u7a2e\u51a0\u72c0\u75c5\u6bd2\u7684\u6548\u529b\uff0c\u53e3\u670d\u7684\u751f\u7269\u5229\u7528\u5ea6\uff08bioavailability\uff09\u66f4\u7a81\u986f\u4e86\u5176\u5c0d\u6297 SARS-CoV-2\u548c\u5176\u4ed6\u4eba\u755c\u5171\u901a\u51a0\u72c0\u75c5\u6bd2\u7684\u6f5b\u5728\u6548\u7528\u3002<\/p>\n

SARS-CoV-2\u8b8a\u7570\u7a2e\u7684\u51fa\u73fe\u52a0\u5287\u4e86COVID-19\u7684\u5927\u6d41\u884c\uff0c\u76ee\u524d\u53ef\u7528\u7684\u55ae\u682a\u6297\u9ad4\u548c\u75ab\u82d7\u4f3c\u4e4e\u7121\u6cd5\u5c0d\u5176\u4e2d\u4e00\u4e9b\u8b8a\u7570\u7a2e\u7522\u751f\u986f\u8457\u6548\u529b\u3002\u56e0\u70baMolnupiravir\u4f5c\u7528\u65bcSARS-CoV-2\u7684\u4fdd\u5b88\u86cb\u767d\uff0c\u6545\u4e0d\u592a\u53ef\u80fd\u53d7\u5230SARS-CoV-2\u51fa\u73fe\u7a81\u8b8a\u7684\u5f71\u97ff\uff0c\u61c9\u8a72\u4ecd\u5c0d\u65b0\u51fa\u73fe\u7684\u8b8a\u7570\u7a2e\u6709\u6548\u3002\u57282021\u5e74\uff0c\u6bd4\u5229\u6642\u7814\u7a76\u4eba\u54e1\u63a2\u8a0e\u76ee\u524d\u8655\u65bc\u7b2c\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u7684Molnupiravir\u5728\u5009\u9f20\u4e2d\u7684\u7642\u6548\uff0c\u4ed6\u5011\u767c\u73fe\u5728\u611f\u67d3\u4e86SARS-CoV-2\u6b66\u6f22\u83cc\u682aB.1.1.7\u6216B.1.351\u8b8a\u7570\u7a2e\u7684\u5009\u9f20\u9ad4\u5167\uff0cMolnupiravir\u4ecd\u53ef\u6709\u6548\u7684\u5c0d\u6297\u6bcf\u500b\u8b8a\u7570\u7a2e\u7684\u611f\u67d3\uff0c\u8b49\u660e\u5176\u5177\u6709\u5c0d\u6297\u7576\u524d\u548c\u672a\u4f86\u65b0\u8208SARS-CoV-2\u8b8a\u7570\u7a2e\u7684\u6f5b\u529b\u3002<\/p>\n

\u5728 2021\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u5728\u7b2c\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u8a55\u4f30Molnupiravir\u6cbb\u7642 COVID-19 \u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u6297\u75c5\u6bd2\u529f\u6548\u3002\u4ed6\u5011\u767c\u73fe\u5728202\u540d\u63a5\u53d7\u6cbb\u7642\u7684\u53c3\u8207\u8005\u4e2d\uff0c\u5728\u7b2c3\u5929\uff0c\u63a5\u53d7 800 mg molnupiravir\u8207\u63a5\u53d7\u5b89\u6170\u5291\u7684\u53c3\u8207\u8005\u76f8\u8f03\uff0c\u75c5\u6bd2\u5206\u96e2\u91cf\u986f\u8457\u964d\u4f4e(1.9% vs 16.7%)\u3002\u5728\u7b2c 5 \u5929\uff0c\u63a5\u53d7Molnupiravir \u7684\u53c3\u8207\u8005\u5df2\u7121\u6cd5\u5206\u96e2\u51fa\u4efb\u4f55\u75c5\u6bd2\uff0c\u800c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u53c3\u8207\u8005\u5247\u70ba11.1%\u3002\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0c\u670d\u7528Molnupiravir\u7684\u53c3\u8207\u8005\u5c55\u73fe\u51fa\u75c5\u6bd2RNA\u6e05\u9664\u7684\u6642\u9593\u7e2e\u77ed\u53ca\u7e3d\u9ad4\u6e05\u9664\u7387\u66f4\u9ad8\u7684\u6548\u679c\u3002\u6b64\u5916\uff0c Molnupiravir\u901a\u5e38\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e0d\u826f\u4e8b\u4ef6\u767c\u751f\u6578\u91cf\u8207\u5b89\u6170\u5291\u76f8\u4f3c\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0cMolnupiravir\u662f\u7b2c\u4e00\u7a2e\u53e3\u670d\u3001\u76f4\u63a5\u4f5c\u7528\u7684\u6297\u75c5\u6bd2\u85e5\u7269\uff0c\u5728\u6e1b\u5c11\u9f3b\u54bd\u90e8SARS-CoV-2\u75c5\u6bd2\u91cf\u548c\u75c5\u6bd2RNA\u65b9\u9762\u8868\u73fe\u51fa\u9ad8\u6548\u529b\uff0c\u4e26\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

    \n
  1. Sheahan TP, Sims AC, Zhou S, Graham RL, Pruijssers AJ, Agostini ML, Leist SR, Sch\u00e4fer A, Dinnon KH 3rd, Stevens LJ, Chappell JD, Lu X, Hughes TM, George AS, Hill CS, Montgomery SA, Brown AJ, Bluemling GR, Natchus MG, Saindane M, Kolykhalov AA, Painter G, Harcourt J, Tamin A, Thornburg NJ, Swanstrom R, Denison MR, Baric RS. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci Transl Med. 2020 Apr 29;12(541): eabb5883. doi: 10.1126\/scitranslmed.abb5883. Epub 2020 Apr 6.<\/li>\n
  2. Abdelnabi R, Foo CS, De Jonghe S, Maes P, Weynand B, Neyts J. Molnupiravir inhibits the replication of the emerging SARS-CoV-2 variants of concern (VoCs) in a hamster infection model. J Infect Dis. 2021 Jul 9:jiab361. doi: 10.1093\/infdis\/jiab361. Online ahead of print.<\/li>\n
  3. Fischer W, Eron JJ, Holman W, Cohen MS, Fang L, Szewczyk LJ, Sheahan TP, Baric R, Mollan KR, Wolfe CR, Duke ER, Azizad MM, Borroto-Esoda K, Wohl DA, Loftis AJ, Alabanza P, Lipansky F, Painter WP. Molnupiravir, an Oral Antiviral Treatment for COVID-19.<\/a> 2021 Jun 17:2021.06.17.21258639. doi: 10.1101\/2021.06.17.21258639. Preprint.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u96a8\u8457\u5404\u570b\u91ab\u7642\u9ad4\u7cfb\u56e0COVID-19\u5927\u6d41\u884c\u9010\u6f38\u7121\u6cd5\u8ca0\u8377\uff0c\u70ba\u9632\u6b62\u56b4\u91cd\u6025\u6027\u547c\u5438\u9053\u75c7\u5019\u7fa4\u51a0\u72c0\u75c5\u6bd2 2 (SARS-CoV-2) \u7684\u6301\u7e8c\u50b3\u64ad\u53caCOVID-19\u60e1\u5316\u70ba\u56b4\u91cd\u75be\u75c5\uff0c\u958b\u767c\u6613\u65bc\u5206\u767c\u53ca\u53ef\u5c0d\u6297\u75c5\u6bd2\u8b8a\u7570\u7a2e\u7684\u53e3\u670d\u85e5\u7269\u523b\u4e0d\u5bb9\u7de9\u3002\u6211\u5011\u5728\u672c\u6587\u5c07\u5f15\u9818\u8b80\u8005\u8a8d\u8b58\u6297COVID-19\u7684\u65b0\u578b\u53e3\u670d\u85e5\u7269\u83ab\u5948\u62c9\u97cb\uff08Molnupiravir\uff09\uff0c\u4e26\u63a2\u7d22\u5176\u7814\u767c\u8a66\u9a57\u73fe\u6cc1\u53ca\u61c9\u7528\u6f5b\u529b\u3002<\/p>\n","protected":false},"author":20,"featured_media":36799,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4580,3293,1025],"tags":[4577,4951,4612,4953,4952],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/08\/56554757.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36797"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36797"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36797\/revisions"}],"predecessor-version":[{"id":36800,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36797\/revisions\/36800"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/36799"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}