{"id":36684,"date":"2021-07-22T00:32:31","date_gmt":"2021-07-21T16:32:31","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=36684"},"modified":"2021-06-24T10:05:49","modified_gmt":"2021-06-24T02:05:49","slug":"%e7%b2%be%e5%ad%90%e7%9a%84%e6%aa%a2%e6%b8%ac","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=36684","title":{"rendered":"\u7cbe\u5b50\u7684\u6aa2\u6e2c"},"content":{"rendered":"

\u7cbe\u5b50\u662f\u7537\u6027\u7684\u751f\u6b96\u7d30\u80de\uff0c\u5176\u54c1\u8cea\u5c0d\u65bc\u662f\u5426\u80fd\u8207\u5375\u5b50\u6210\u529f\u7d50\u5408\u800c\u767c\u80b2\u6210\u6b63\u5e38\u80da\u80ce\u95dc\u4fc2\u91cd\u5927\uff0c\u6545\u5fc5\u9808\u6709\u7cbe\u6e96\u7684\u6aa2\u6e2c\u65b9\u6cd5\u4ee5\u78ba\u4fdd\u7cbe\u5b50\u7684\u54c1\u8cea\u3002\u50b3\u7d71\u7684\u65b9\u6cd5\u96d6\u80fd\u521d\u6b65\u6aa2\u6e2c\u7cbe\u5b50\uff0c\u4f46\u5c0d\u65bc\u7cbe\u5b50\u67d3\u8272\u9ad4\u662f\u5426\u6709\u7f3a\u5931\uff0c\u4ecd\u7121\u6cd5\u52a0\u4ee5\u78ba\u8a8d\uff0c\u7279\u5225\u662f\u7570\u5e38\u914d\u5b50\u5c0e\u81f4\u5b50\u4ee3\u767c\u751f\u4e0d\u5e73\u8861\u8f49\u4f4d\u7684\u60c5\u5f62\u3002\u5e78\u904b\u5730\uff0c\u87a2\u5149\u539f\u4f4d\u96dc\u4ea4\uff08FISH\uff09\u5df2\u88ab\u958b\u767c\u51fa\u4f86\u7528\u65bc\u5206\u6790\u67d3\u8272\u9ad4\u7570\u5e38\uff0c\u53ef\u80fd\u6709\u6f5b\u529b\u7528\u65bc\u6aa2\u6e2c\u5e73\u8861\u8f49\u4f4d\u5e36\u56e0\u8005\u7684\u7cbe\u5b50\u67d3\u8272\u9ad4\u7570\u5e38\uff0c\u60df\u4ecd\u9700\u9032\u4e00\u6b65\u9a57\u8b49\uff0c\u624d\u80fd\u958b\u767c\u4f5c\u70ba\u81e8\u5e8a\u61c9\u7528\u3002<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u7cbe\u5b50\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

\u7cbe\u5b50\uff08\u7cbe\u87f2\uff0cspermatozoan\uff09\u7684\u69cb\u9020\u7531\u9802\u9ad4\u3001\u7d30\u80de\u819c\u3001\u7d30\u80de\u6838\u3001\u7c92\u7dda\u9ad4\u53ca\u97ad\u6bdb\u6240\u7d44\u6210\uff0c\u7cbe\u5b50\u904b\u52d5\u6642\u9700\u8981\u5927\u91cf\u7684\u80fd\u91cf\u4f86\u4f7f\u5176\u874c\u86aa\u5c3e\u5df4\u6d3b\u52d5\uff0c\u800c\u6240\u9700\u7684\u71c3\u6599\u4f86\u81ea\u679c\u7cd6\u3002\u7cbe\u5b50\u8207\u5375\u5b50\u7d50\u5408\u524d\u5fc5\u9808\u7d93\u6b77\u300c\u7372\u80fd(capacitation)\u300d\u7684\u91cd\u8981\u968e\u6bb5\u3002\u7cbe\u6db2\u4e2d\u542b\u6709\u6210\u5206\u70ba\u91a3\u86cb\u767d\u7684\u300c\u53bb\u80fd\u56e0\u6578\u300d\uff0c\u53ef\u6291\u5236\u7cbe\u5b50\u7684\u9802\u9ad4\u9176\u7cfb\u7d71\uff08\u5982\u9802\u9ad4\u7d20\u3001\u795e\u7d93\u80fa\u9176\u3001\u786b\u9178\u8102\u9176\u3001\u900f\u660e\u8cea\u9178\u9176\u3001\u653e\u5c04\u51a0\u5206\u6563\u9176\u53ca\u553e\u6db2\u9178\u82f7\u9176\u7b49\uff09\u7684\u6d3b\u6027\uff0c\u6545\u7cbe\u5b50\u539f\u672c\u662f\u8655\u65bc\u4e00\u500b\u300c\u53bb\u80fd(decapacitation)\u300d\u7684\u72c0\u614b\u3002\u7136\u800c\uff0c\u7cbe\u5b50\u9032\u5165\u9670\u9053\u5f8c\uff0c\u9670\u9053\u4e2d\u5b58\u5728\u542b\u6709\u6fb1\u7c89\u9176\u7684\u300c\u7372\u80fd\u56e0\u6578\u300d\uff0c\u53ef\u6c34\u89e3\u53bb\u80fd\u56e0\u6578\uff0c\u4f7f\u7cbe\u5b50\u9032\u5165\u7372\u80fd\u72c0\u614b\uff0c\u4fc3\u6210\u9802\u9ad4\u9176\u7cfb\u7d71\u91cb\u51fa\u6eb6\u89e3\u9175\u7d20\u4ee5\u57f7\u884c\u9802\u9ad4\u53cd\u61c9\uff08\u7a7f\u5b54\u9ad4\u53cd\u61c9\uff0cacrosome reaction\uff09\uff0c\u9032\u800c\u6eb6\u89e3\u5375\u5b50\u7684\u653e\u5c04\u51a0\u548c\u900f\u660e\u5e36(zona pellucida)\uff0c\u7cbe\u5b50\u624d\u80fd\u5728\u8f38\u5375\u7ba1\u8207\u5375\u5b50\u7d50\u5408\u5f62\u6210\u53d7\u7cbe\u5375\uff0c\u9032\u800c\u767c\u80b2\u70ba\u80da\u80ce\uff0c\u9054\u6210\u53d7\u7cbe\u7684\u76ee\u7684\u3002<\/p>\n

\u6b64\u5916\uff0c\u7576\u7cbe\u5b50\u6210\u529f\u9032\u5165\u5375\u5b50\u5f8c\uff0c\u6703\u7acb\u5373\u8207\u900f\u660e\u5e36\u7684\u91a3\u86cb\u767dZP2\u7d50\u5408\u4ee5\u6fc0\u6d3b\u900f\u660e\u5e36\u53cd\u61c9\uff0c\u4f7f\u900f\u660e\u5e36\u767c\u751f\u786c\u5316\uff0c\u540c\u6642\u5375\u5b50\u4ea6\u6703\u767c\u51fa\u6307\u4ee4\u8b93\u5375\u9ec3\u819c\u8b8a\u7dca\u8b8a\u539a\uff0c\u5f62\u6210\u7b2c\u4e8c\u9053\u5c4f\u969c\uff0c\u4ee5\u963b\u64cb\u5176\u4ed6\u7cbe\u5b50\u7e7c\u7e8c\u9032\u5165\uff0c\u78ba\u4fdd\u53ea\u6709\u55ae\u4e00\u7cbe\u5b50\u9032\u5165\u5375\u5b50\u5167\u3002<\/p>\n

\u25cf\u6aa2\u6e2c\u7684\u9805\u76ee\u53ca\u65b9\u6cd5<\/strong><\/span><\/p>\n

\u773e\u6240\u5468\u77e5\uff0c\u7cbe\u5b50\u7684\u54c1\u8cea\u5c0d\u65bc\u662f\u5426\u80fd\u5920\u6210\u529f\u53d7\u5b55\u5341\u5206\u91cd\u8981\uff0c\u4f46\u7cbe\u5b50\u5e38\u56e0\u591a\u7a2e\u56e0\u7d20\u800c\u53d7\u640d\u751a\u81f3\u7a81\u8b8a\uff0c\u5982\u8870\u8001\u3001\u75be\u75c5\uff0c\u85e5\u7269\u3001\u74b0\u5883\u53ca\u66b4\u9732\u65bc\u6709\u6bd2\u7269\u8cea\u7b49\u3002\u56e0\u6b64\uff0c\u7cbe\u5b50\u54c1\u8cea\u7684\u6aa2\u6e2c\u5341\u5206\u91cd\u8981\uff0c\u9805\u76ee\u5305\u542b\u7cbe\u6db2\u91cf\u3001\u9178\u9e7c\u503c\u3001\u6db2\u5316\u6642\u9593\u3001\u984f\u8272\u53ca\u7cbe\u5b50\u6578\u91cf\u3001\u6d3b\u52d5\u529b\u3001\u5f62\u72c0\u3001\u67d3\u8272\u9ad4\u7570\u5e38\u7b49\u3002\u5176\u4e2d\u7cbe\u5b50\u67d3\u8272\u9ad4\u7684\u6aa2\u6e2c\u626e\u6f14\u4e86\u95dc\u9375\u6027\u7684\u89d2\u8272\uff0c\u8f03\u5e38\u7528\u7684\u65b9\u6cd5\u5982\u4e0b\uff1a<\/p>\n

1.\u7cbe\u5b50DNA\u7247\u6bb5\u5206\u6790(Sperm DNA fragmentation index, DFI)\uff1a\u7528\u4ee5\u5206\u6790\u7cbe\u5b50\u67d3\u8272\u9ad4\u7684\u53d7\u640d\u6bd4\u4f8b\u3002\u7576\u7cbe\u5b50\u7684DFI\u503c\u6108\u9ad8\uff0c\u8868\u793a\u67d3\u8272\u9ad4\u53d7\u640d\u7684\u7a0b\u5ea6\u6108\u56b4\u91cd\uff0c\u8d8a\u96e3\u6b63\u5e38\u53d7\u5b55\u3002<\/p>\n

2.\u7cbe\u5b50\u975e\u6574\u500d\u9ad4\u6aa2\u6e2c ( Sperm aneuploidy test, SAT)\uff1a\u7528\u65bc\u8a55\u4f30\u7cbe\u5b50\u4e2d\u7570\u5e38\u6578\u91cf\u7684\u67d3\u8272\u9ad4\uff08\u975e\u6574\u500d\u6027\u548c\u4e8c\u500d\u9ad4\uff09\u7684\u5b58\u5728\u3002<\/p>\n

3.\u7cbe\u5b50\u67d3\u8272\u9ad4\u6838\u578b\u5206\u6790\uff08Sperm karyotyping\uff09\uff1a\u5c07\u7cbe\u5b50\u67d3\u8272\u9ad4\u4f9d\u7167\u5927\u5c0f\u3001\u5f62\u72c0\u4f9d\u5e8f\u6392\u5217\u6574\u5408\uff0c\u6839\u64da\u9577\u5ea6\u3001\u8457\u7d72\u9ede\uff08centrosome\uff09\u53ca\u689d\u7d0b\uff08banding\uff09\u4fbf\u53ef\u5f97\u5230\u7d30\u80de\u7684\u67d3\u8272\u9ad4\u7d44\u578b\u5716\uff0c\u7528\u65bc\u5224\u65b7\u7d30\u80de\u907a\u50b3\u5b78(cytogenetics)\u3002<\/p>\n

4.\u87a2\u5149\u539f\u4f4d\u96dc\u4ea4\uff08Fluorescence in situ <\/em>hybridization, FISH\uff09\uff1a\u5229\u7528\u87a2\u5149\u63a2\u91dd\u8207\u6838\u9178\u5e8f\u5217\u7684\u9ad8\u5ea6\u4e92\u88dc\u6027\u7d50\u5408\uff0c\u9032\u800c\u5728\u7279\u5b9a\u7684\u7cbe\u5b50\u67d3\u8272\u9ad4\u7684\u57fa\u56e0\u4f4d\u9ede\u7522\u751f\u87a2\u5149\u8a0a\u865f\uff0c\u518d\u85c9\u7531\u87a2\u5149\u986f\u5fae\u93e1\u4f86\u5224\u8b80\u8a0a\u865f\u7684\u4f4d\u7f6e\u8207\u6578\u91cf\u3002<\/p>\n

\u25cf\u5e73\u8861\u8f49\u4f4d\u5e36\u56e0\u8005\u7684<\/strong>\u7cbe\u5b50<\/strong>\u67d3\u8272\u9ad4\u6aa2\u6e2c<\/strong><\/span><\/p>\n

\u4eba\u985e\u670923\u5c0d\uff0846\u689d\uff09\u67d3\u8272\u9ad4\uff0c\u82e5\u5176\u4e2d\u5169\u689d\u4e0d\u540c\u5c0d\u67d3\u8272\u9ad4\u767c\u751f\u90e8\u4efd\u7247\u6bb5\u4ea4\u63db\uff0c\u67d3\u8272\u9ad4\u7684\u7e3d\u91cf\u4e26\u672a\u589e\u52a0\u6216\u6e1b\u5c11\uff0c\u7a31\u70ba\u67d3\u8272\u9ad4\uff62\u5e73\u8861\u8f49\u4f4d\uff08balanced translocation\uff09\uff63\u3002\u4eba\u985e\u767c\u751f\u5e73\u8861\u8f49\u4f4d\u7684\u6a5f\u7387\u5176\u5be6\u76f8\u7576\u9ad8\uff08\u7d041\/500\uff09\uff0c\u96d6\u7136\u5927\u591a\u6578\u5e36\u56e0\u8005\u7684\u67d3\u8272\u9ad4\u7e3d\u91cf\u672a\u8b8a\uff0c\u4e14\u65b7\u88c2\u9ede\u4e0a\u4e5f\u6c92\u6709\u91cd\u8981\u57fa\u56e0\uff0c\u6240\u4ee5\u529f\u80fd\u4ecd\u7136\u7dad\u6301\u6b63\u5e38\uff0c\u4f46\u6b63\u5e38\u7d30\u80de\u7d93\u6e1b\u6578\u5206\u88c2\u5f8c\uff0c\u7522\u751f\u7570\u5e38\u751f\u6b96\u7d30\u80de\uff08\u914d\u5b50\uff09\u7684\u6a5f\u7387\u5f88\u9ad8\uff0c\u4e0b\u4e00\u4ee3\u767c\u751f\u4e0d\u5e73\u8861\u8f49\u4f4d\u7684\u6a5f\u7387\u4ea6\u96a8\u4e4b\u589e\u52a0\uff0c\u5e38\u5c0e\u81f4\u7fd2\u6163\u6027\u6d41\u7522\u3002\u4ee5\u5f80\u8981\u5075\u6e2c\u80ce\u5152\u5065\u5eb7\u60c5\u5f62\uff0c\u50c5\u80fd\u5728\u61f7\u5b55\u4e09\u500b\u6708\u4ee5\u4e0a\u6642\uff0c\u85c9\u7531\u9ad8\u5c64\u6b21\u8d85\u97f3\u6ce2\u6216\u7f8a\u819c\u7a7f\u523a\u624d\u80fd\u5f97\u77e5\u80ce\u5152\u67d3\u8272\u9ad4\u662f\u5426\u7570\u5e38\uff0c\u5c0d\u65bc\u60f3\u5148\u671f\u77e5\u9053\u80ce\u5152\u67d3\u8272\u9ad4\u6b63\u5e38\u8207\u5426\u7684\u7236\u6bcd\u800c\u8a00\uff0c\u76ee\u524d\u5247\u4ee5\u4f5c\u8a66\u7ba1\u5b30\u5152\u52a0\u4e0a\u80da\u80ce\u8457\u5e8a\u524d\u57fa\u56e0\u7be9\u6aa2\uff08Preimplantation genetic screening, PGS\uff09\u6700\u5177\u53ef\u884c\u6027\uff0c\u5728\u80da\u80ce\u968e\u6bb5\u5148\u7be9\u6aa2\u51fa\u542b\u6709\u7570\u5e38\u67d3\u8272\u9ad4\u4e4b\u80da\u80ce\uff0c\u518d\u690d\u5165\u6b63\u5e38\u80da\u80ce\uff0c\u53ef\u5927\u5e45\u964d\u4f4e\u6d41\u7522\u7387\u3002\u7136\u800c\uff0cPGS\u4ecd\u6709\u5176\u9650\u5236\uff0c\u82e5\u80da\u80ce\u662f\u5e73\u8861\u8f49\u4f4d\u6216\u50c5\u6709\u5fae\u5c0f\u7247\u6bb5\u4e4b\u57fa\u56e0\u6539\u8b8a\uff0cPGS\u4e26\u4e0d\u80fd\u6aa2\u6e2c\u51fa\u4f86\uff0c\u5728\u61f7\u5b55\u5f8c\u671f\u4ecd\u9808\u4f5c\u7d68\u6bdb\u819c\u53d6\u6a23\u6216\u662f\u7f8a\u819c\u7a7f\u523a\u3002<\/p>\n

\u57282020\u5e7412\u6708\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1Andrew Wyrobek\u7b49\u767c\u8868\u5728\u300a PLOS One\u300b\u7684\u8ad6\u6587\u4e2d\uff0c\u5ba3\u7a31\u6210\u529f\u5730\u63a1\u7528\u4e00\u7a2e\u6210\u719f\u7684\u7d30\u80deDNA\u5206\u6790\u6280\u8853\uff0d\u87a2\u5149\u539f\u4f4d\u96dc\u4ea4\uff08FISH\uff09\u4f86\u63a2\u6e2c\u7cbe\u5b50DNA\u7684\u591a\u7a2e\u67d3\u8272\u9ad4\u7f3a\u5931\uff08\u5982\u975e\u6574\u500d\u6027\u67d3\u8272\u9ad4\u6578\u76ee\u7570\u5e38\u6216\u67d3\u8272\u9ad4\u65b7\u88c2\u3001\u91cd\u6392\uff09\u3002\u4ed6\u5011\u8a8d\u70ba\u8a72\u6e2c\u5b9a\u6cd5\uff08AM8 sperm FISH protocol\uff09\u53ef\u4ee5\u6aa2\u6e2c\u51fa\u5e73\u8861\u8f49\u4f4d\u5e36\u56e0\u8005\u7684\u7cbe\u5b50\u67d3\u8272\u9ad4\u7570\u5e38\uff08chromosomal abnormality\uff09\u3002\u9019\u500b\u7814\u7a76\u9996\u6b21\u61c9\u7528FISH\u6280\u8853\u4f86\u6e2c\u5b9a\u7cbe\u5b50\u7684\u67d3\u8272\u9ad4\u7d50\u69cb\u7570\u5e38\uff08aberration\uff09\uff0c\u5728\u7cbe\u5b50\u66b4\u9732\u6642\u9593\u6709\u9650\u7684\u689d\u4ef6\u4e0b\uff0c\u53ef\u4ee5\u91cd\u8907\u5206\u6790\u7cbe\u6db2\u4ee5\u5340\u5206\u7cbe\u5b50\u662f\u5728\u6613\u611f\u6027\u6216\u5728\u6297\u6027\u7cbe\u5b50\u767c\u751f\uff08spermatogenesis\uff09\u7684\u968e\u6bb5\u3002<\/p>\n

\u81ea2020\u5e74\u8d77\uff0c\u6211\u570b\u5df2\u9032\u5be6\u8cea\u5165\u4eba\u53e3\u8ca0\u6210\u9577\u7684\u968e\u6bb5\uff0c\u5c11\u5b50\u5316\u5df2\u9020\u6210\u5f88\u591a\u6559\u80b2\u3001\u7d93\u6fdf\u53ca\u793e\u6703\u554f\u984c\uff0c\u751a\u81f3\u5f15\u767c\u570b\u5b89\u5371\u6a5f\uff0c\u653f\u5e9c\u8207\u6c11\u9593\u83ab\u4e0d\u5e0c\u671b\u589e\u52a0\u4eba\u53e3\u6210\u9577\u7387\u3002\u76ee\u524d\u4e0d\u5b55\u592b\u5a66\u7684\u6578\u76ee\u76f8\u7576\u591a\uff0c\u7cbe\u5b50\u54c1\u8cea\u4e0d\u4f73\u4e5f\u662f\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\uff0c\u70ba\u63d0\u5347\u7cbe\u5b50\u54c1\u8cea\uff0c\u767c\u5c55\u7cbe\u6e96\u7684\u7cbe\u5b50\u67d3\u8272\u9ad4\u6aa2\u6e2c\u6280\u8853\u5df2\u6210\u70ba\u7576\u52d9\u4e4b\u6025\u3002\u9664\u4e86\u50b3\u7d71\u7684\u65b9\u6cd5\u5916\uff0cFISH\u4e5f\u662f\u826f\u597d\u7684\u9078\u9805\u4e4b\u4e00\uff0c\u4f46\u73fe\u4ecd\u8655\u65bc\u65e9\u671f\u7814\u7a76\u968e\u6bb5\uff0c\u9700\u8981\u66f4\u591a\u7684\u9a57\u8b49\u548c\u5546\u696d\u958b\u767c\u624d\u80fd\u5728\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u3002<\/p>\n

 <\/strong><\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a
\n<\/strong>1.Berkely news center. How to Find Mutated Sperm? Just Go FISH. January 19, 2021. https:\/\/newscenter.lbl.gov\/2021\/01\/19\/finding-mutated-sperm\/<\/a>
\n2. Frias S, Van Hummelen P, Meistrich ML, Wyrobek AJ. Meiotic susceptibility for induction of sperm with chromosomal aberrations in patients receiving combination chemotherapy for Hodgkin lymphoma. PLoS One. 2020 Dec 28;15(12):e0242218. doi: 10.1371\/journal.pone.0242218. eCollection 2020.PMID: 33370316 .
\n3.Rowe M, Rosengrave P. There and back again: A sperm's tale.<\/a> Mol Reprod Dev. 2020 Apr;87(4):395-398. doi: 10.1002\/mrd.23325. Epub 2020 Feb 5.
\n4.Oleszczuk K, Giwercman A, Bungum M. Sperm chromatin structure assay in prediction of in vitro fertilization outcome. Andrology. 2016 Mar;4(2):290-6. doi: 10.1111\/andr.12153. Epub 2016 Jan 12.<\/p>\n","protected":false},"excerpt":{"rendered":"

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