{"id":36654,"date":"2021-07-08T00:13:36","date_gmt":"2021-07-07T16:13:36","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=36654"},"modified":"2021-06-23T11:45:51","modified_gmt":"2021-06-23T03:45:51","slug":"%e8%9b%ad%e9%a1%9e%e7%9a%84%e9%86%ab%e7%99%82%e7%94%a8%e9%80%94%ef%bc%88%e5%9b%9b%ef%bc%89%ef%bc%9a%e8%9b%ad%e9%a1%9e%e6%8a%97%e5%87%9d%e8%a1%80%e7%9a%84%e4%b8%bb%e8%a6%81%e6%88%90%e4%bb%bd%e6%8e%a2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=36654","title":{"rendered":"\u86ed\u985e\u7684\u91ab\u7642\u7528\u9014\uff08\u56db\uff09\uff1a\u86ed\u985e\u6297\u51dd\u8840\u7684\u4e3b\u8981\u6210\u4efd\u63a2\u7a76"},"content":{"rendered":"<p><strong>\u64b0\u6587\uff0f\u8cf4\u4ea6\u5fb7<\/strong><\/p>\n<p><strong><span style=\"color: #008080;\">\u25cf\u86ed\u985e\u6297\u51dd\u8840\u6210\u4efd\u8403\u53d6<\/span><\/strong><\/p>\n<p>\u7121\u8ad6\u662f\u6d3b\u9ad4\u5916\u7528\u6216\u662f\u85e5\u6750\u5167\u670d\uff0c\u91cd\u9ede\u9084\u662f\u86ed\u985e\u9ad4\u5167\u7684\u529f\u80fd\u6027\u56e0\u5b50\u9032\u5165\u4eba\u9ad4\u5f8c\u7522\u751f\u4f5c\u7528\u3002\u82e5\u662f\u80fd\u5920\u5c07\u86ed\u985e\u9ad4\u5167\u7684\u6709\u6548\u6210\u4efd\u7d14\u5316\u8403\u53d6\u751a\u81f3\u5927\u91cf\u88fd\u9020\uff0c\u4ee5\u6ce8\u5c04\u6216\u53e3\u670d\u65b9\u5f0f\u76f4\u63a5\u9032\u5165\u8840\u6db2\u6216\u60a3\u8655\u767c\u63ee\u6548\u679c\uff0c\u4f3c\u4e4e\u90fd\u80fd\u66f4\u52a0\u8fc5\u901f\u800c\u6709\u6548\u3002\u56e0\u6b64\uff0c\u904e\u53bb\u4e00\u767e\u591a\u5e74\u4f86\uff0c\u6771\u897f\u65b9\u7684\u5b78\u8005\u90fd\u8017\u8cbb\u4e0d\u5c11\u5fc3\u8840\uff0c\u52aa\u529b\u5f9e\u6c34\u86ed\u8eab\u4e0a\u8403\u53d6\u51fa\u5404\u5f0f\u5404\u6a23\u7684\u6709\u6548\u6210\u4efd\uff0c\u800c\u9019\u4e00\u5207\u7684\u6feb\u89f4\u7576\u7136\u975e\u86ed\u7d20\uff08Hirudin\uff09\u83ab\u5c6c\u3002<\/p>\n<figure id=\"attachment_36655\" aria-describedby=\"caption-attachment-36655\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-36655\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/PDB_1dwc_EBI.jpg\" alt=\"\" width=\"500\" height=\"375\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/PDB_1dwc_EBI.jpg 800w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/PDB_1dwc_EBI-300x225.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/PDB_1dwc_EBI-768x576.jpg 768w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-36655\" class=\"wp-caption-text\">\u86ed\u7d20\u7684\u5206\u5b50\u7d50\u69cb\u793a\u610f\u5716\uff08\u4f86\u81ea\u7dad\u57fa\u767e\u79d1\uff09<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_36672\" aria-describedby=\"caption-attachment-36672\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"wp-image-36672\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/Hirudin_in_complex_with_thrombin.png\" alt=\"\" width=\"500\" height=\"361\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/Hirudin_in_complex_with_thrombin.png 1251w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/Hirudin_in_complex_with_thrombin-300x216.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/Hirudin_in_complex_with_thrombin-768x554.png 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/Hirudin_in_complex_with_thrombin-1024x738.png 1024w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-36672\" class=\"wp-caption-text\">\u86ed\u7d20\uff08\u5e36\u72c0\u7d50\u69cb\uff09\u8207\u51dd\u8840\u9176\uff08\u679d\u72c0\u7d50\u69cb\uff09\u7d50\u5408\u5f8c\u7684\u8907\u5408\u9ad4\u793a\u610f\u5716\uff08\u4f86\u81ea\u7dad\u57fa\u767e\u79d1\uff09<\/figcaption><\/figure>\n<p>\u5341\u4e5d\u4e16\u7d00\u672b\uff0c\u96d6\u7136\u86ed\u985e\u653e\u8840\u7642\u6cd5\u5728\u897f\u65b9\u91ab\u5b78\u4e2d\u4e0d\u518d\u53d7\u6b61\u8fce\uff0c\u79d1\u5b78\u754c\u5c0d\u86ed\u985e\u7684\u6297\u51dd\u8840\u80fd\u529b\u537b\u4f9d\u7136\u8208\u5473\u76ce\u7136\u30021809\u5e74\u4fc4\u7f85\u65af\u6559\u6388\u8fea\u4e9e\u79d1\u8afe\u592b\uff08Diakonov\uff09\u5728\u8457\u4f5c\u4e2d\u63d0\u53ca\u6b50\u6d32\u91ab\u86ed\u8178\u9053\u5167\u7684\u8840\u6db2\u4e26\u4e0d\u6703\u51dd\u56fa\uff0c\u56e0\u6b64\u63a8\u6e2c\u5176\u4e2d\u5fc5\u6709\u6eb6\u89e3\u8840\u6db2\u7684\u56e0\u5b50\uff1b1884\u5e74\uff0c\u82f1\u570b\u5b78\u8005\u6d77\u514b\u62c9\u592b\u7279\uff08John Berry Haycraft\uff09\u767c\u73fe\u6b50\u6d32\u91ab\u86ed\u553e\u6db2\u4e2d\u6709\u4e00\u7a2e\u6297\u51dd\u8840\u56e0\u5b50\uff0c\u5fb7\u570b\u5b78\u8005\u96c5\u5404\u6bd4\uff08Jacobj\uff09\u57281904\u5e74\u5c07\u6b64\u6297\u51dd\u8840\u56e0\u5b50\u6fc3\u7e2e\u4e26\u547d\u540d\u70ba\u86ed\u7d20\uff08Hirudin\uff09\u3002\u4f46\u4e00\u76f4\u5230\u534a\u4e16\u7d00\u5f8c\u76841955\u5e74\uff0c\u5fb7\u570b\u5b78\u8005\u99ac\u514b\u6c83\u5fb7\u7279\uff08Markwardt\uff09\u624d\u5c07\u86ed\u7d20\u5f9e\u6b50\u6d32\u91ab\u86ed\u553e\u817a\u4e2d\u8403\u53d6\u7d14\u5316\u51fa\u4f86\uff0c\u4e26\u5c55\u73fe\u5176\u6297\u51dd\u8840\u6d3b\u6027\uff0c\u65bc\u662f\u958b\u555f\u4e86\u86ed\u985e\u6297\u51dd\u8840\u7269\u8cea\u7684\u73fe\u4ee3\u7814\u7a76\u30021986\u5e74\uff0c\u54c8\u7dad\uff08Harvey\uff09\u89e3\u958b\u86ed\u7d20\u7684cDNA\u5e8f\u5217\uff0c\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u6280\u8853\u5c07\u6b64\u5e8f\u5217\u8f49\u6b96\u5927\u8178\u687f\u83cc\uff0c\u9996\u6b21\u91cf\u7522\u4eba\u5de5\u91cd\u7d44\u86ed\u7d20\u3002\u4e0d\u904e\uff0c\u7531\u65bc\u91cd\u7d44\u86ed\u7d20\u5728\u7b2c63\u4f4d\u7684\u916a\u6c28\u9178\u6b98\u57fa\u4e26\u672a\u786b\u9178\u5316\uff0c\u56e0\u6b64\u6297\u51dd\u8840\u6d3b\u6027\u6bd4\u8d77\u5929\u7136\u86ed\u7d20\u6709\u6240\u4e0b\u964d\uff0c\u5373\u4f7f\u5982\u6b64\uff0c\u91cd\u7d44\u86ed\u7d20\u4e5f\u65e9\u5df2\u5546\u54c1\u5316\u70baLepirudin\u548cDesirudin\u5169\u7a2e\u6297\u51dd\u8840\u5291\u4e0a\u5e02\u30021998\u5e74\uff0c\u86ed\u7d20\u901a\u904e\u7f8e\u570bFDA\u8a8d\u53ef\uff0c\u53ef\u505a\u70ba\u809d\u7d20\u8a98\u767c\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u548c\u9aa8\u79d1\u624b\u8853\u5f8c\u9810\u9632\u8840\u6813\u7684\u6cbb\u7642\u85e5\u7269\uff0c\u800c\u4e14\u4e5f\u662f\u552f\u4e00\u4e00\u500bFDA\u901a\u904e\u81e8\u5e8a\u4f7f\u7528\u8a8d\u53ef\u4e14\u63d0\u53d6\u81ea\u5438\u8840\u52d5\u7269\u7684\u6297\u51dd\u8840\u56e0\u5b50\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u86ed\u7d20\u8207\u5176\u4ed6\u6297\u51dd\u8840\u56e0\u5b50<\/strong><\/span><\/p>\n<p>\u86ed\u7d20\u8eab\u70ba\u81f3\u4eca\u4ee5\u4f86\u6700\u5f37\u6548\u7684\u5929\u7136\u51dd\u8840\u9176\u6291\u5236\u5291\uff0c\u5176\u6297\u51dd\u8840\u80fd\u529b\u4f86\u81ea\u65bc\u86ed\u7d20\u8207\u51dd\u8840\u9176\u80fd\u5920\u76f4\u63a5\u7d50\u5408\uff0c\u4f7f\u8840\u6db2\u7684\u51dd\u8840\u6a5f\u5236\u7121\u6cd5\u904b\u4f5c\u3002\u540c\u6a23\u5177\u6709\u6297\u51dd\u8840\u529f\u80fd\u7684\u5e38\u898b\u85e5\u7269\u809d\u7d20\uff0c\u5176\u6297\u51dd\u8840\u6a5f\u5236\u5247\u662f\u7d50\u5408\u4e26\u6d3b\u5316\u6297\u51dd\u8840\u9176III\uff0c\u6d3b\u5316\u5f8c\u7684\u6297\u51dd\u8840\u9176III\u518d\u9032\u4e00\u6b65\u5f71\u97ff\u6291\u5236\u51dd\u8840\u9176\u548c\u51dd\u8840\u56e0\u5b50Xa\u53ca\u5176\u4ed6\u86cb\u767d\u9176\u3002\u76f8\u8f03\u4e4b\u4e0b\uff0c\u86ed\u7d20\u7684\u6297\u51dd\u8840\u529f\u80fd\u4e0d\u4f9d\u8cf4\u51dd\u8840\u9176III\u3001\u7279\u7570\u6027\u5f37\u5927\u3001\u4e0d\u548c\u5167\u76ae\u7d30\u80de\u7d50\u5408\u3001\u7528\u91cf\u8207\u6297\u51dd\u8840\u6548\u679c\u7684\u76f8\u95dc\u6027\u8f03\u597d\u3001\u4e0d\u6703\u8a98\u767c\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u3001\u4e5f\u4e0d\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\u3002\u9664\u4e86\u6297\u51dd\u8840\u529f\u80fd\u5916\uff0c\u86ed\u7d20\u4e5f\u6709\u6297\u8840\u6813\u529f\u80fd\u3002\u86ed\u7d20\u76f4\u63a5\u91dd\u5c0d\u51dd\u8840\u9176\u7d50\u5408\uff0c\u4e0d\u50c5\u963b\u65b7\u4e86\u8840\u6db2\u51dd\u56fa\uff0c\u4e5f\u6291\u5236\u4e86\u8840\u6db2\u51dd\u56fa\u5f8c\u89f8\u767c\u7684\u7e96\u7dad\u86cb\u767d\u51dd\u56fa\u548c\u8840\u5c0f\u677f\u805a\u96c6\uff0c\u56e0\u6b64\u5177\u6709\u9632\u6b62\u8840\u7ba1\u8840\u6813\u751f\u6210\u7684\u80fd\u529b\u3002\u53c8\u56e0\u70ba\u86ed\u7d20\u4e0d\u50c5\u80fd\u5920\u8ddf\u6e38\u96e2\u51dd\u8840\u9176\u7d50\u5408\u4e5f\u80fd\u5920\u548c\u8840\u584a\u4e0a\u7684\u51dd\u8840\u9176\u7d50\u5408\uff0c\u56e0\u6b64\u9632\u6b62\u8840\u6813\u5f62\u6210\u548c\u5ef6\u4f38\u7684\u80fd\u529b\u6bd4\u809d\u7d20\u66f4\u5f37\u5927\u3002\u6b64\u5916\uff0c\u86ed\u7d20\u4e5f\u5177\u6709\u6297\u767c\u708e\u529f\u6548\uff0c\u800c\u4e14\u5728\u5fc3\u8166\u8840\u7ba1\u75be\u75c5\u3001\u6025\u6027\u7030\u6f2b\u6027\u8840\u7ba1\u5167\u51dd\u8840\u3001\u814e\u81df\u75be\u75c5\u7684\u81e8\u5e8a\u61c9\u7528\u8207\u57fa\u790e\u7814\u7a76\uff0c\u751a\u81f3\u662f\u76ae\u819a\u75a4\u75d5\u548c\u91ab\u6750\u5857\u5e03\u7814\u7a76\u4e0a\u90fd\u6301\u7e8c\u5c55\u73fe\u5f71\u97ff\u529b\u3002<\/p>\n<p>\u9664\u4e86\u86ed\u7d20\u4e4b\u5916\uff0c\u6578\u5341\u5e74\u4f86\u79d1\u5b78\u5bb6\u9678\u7e8c\u53c8\u627e\u5230\u8a31\u591a\u6297\u51dd\u8840\u56e0\u5b50\u4ee5\u53ca\u5404\u7a2e\u529f\u80fd\u6027\u56e0\u5b50\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u7531\u65bc\u86ed\u985e\u7684\u7956\u5148\u4ee5\u8840\u6db2\u70ba\u98df\uff0c\u56e0\u6b64\u5373\u4f7f\u4e0d\u662f\u5438\u8840\u7dad\u751f\u7684\u7a2e\u985e\uff0c\u8a31\u591a\u86ed\u985e\u9ad4\u5167\u4f9d\u7136\u6703\u5206\u6ccc\u5c11\u91cf\u6216\u8f03\u539f\u59cb\u7684\u6297\u51dd\u8840\u56e0\u5b50\uff0c\u9019\u4e5f\u662f\u70ba\u4ec0\u9ebc\u6355\u98df\u6027\u7684\u5bec\u9ad4\u91d1\u7dda\u86ed\u548c\u5c16\u7d30\u91d1\u7dda\u86ed\u9ad4\u5167\u4e5f\u53ef\u4ee5\u6e2c\u5230\u6297\u51dd\u8840\u6d3b\u6027\u7684\u539f\u56e0\u3002\u4ee5\u4e0b\u6574\u7406\u51fa\u5728\u5438\u8840\u8207\u975e\u5438\u8840\u86ed\u985e\u4e0a\u627e\u5230\u8f03\u77e5\u540d\u7684\u6297\u51dd\u8840\u56e0\u5b50\u548c\u5176\u4ed6\u529f\u80fd\u6027\u56e0\u5b50\u3002<\/p>\n<p><strong><em>\u6291\u5236\u51dd\u8840\u9176\uff1a<\/em><\/strong><\/p>\n<p>\u8403\u53d6\u81ea\u6b50\u6d32\u91ab\u86ed\u8207\u83f2\u64ec\u91ab\u86ed\u7684Hirudin\uff08\u86ed\u7d20\uff09\u3001\u8403\u53d6\u81ea\u83f2\u64ec\u91ab\u86ed\u7684Bufrudin\u3001\u8403\u53d6\u81ea\u65e5\u672c\u91ab\u86ed\u7684Grabulin\u3001\u8403\u53d6\u81ea\u68ee\u6797\u5c71\u86ed\uff08<em>Haemadipsa sylvestris<\/em>\uff09\u7684Haemadin\u3001\u4ee5\u53ca\u8403\u53d6\u81ea\u6574\u5d4c\u6676\u86ed\uff08<em>Theromyzon tessulatum<\/em>\uff09\u7684Theromin\uff0cCytin\u53ef\u80fd\u4e5f\u6709\u985e\u4f3c\u529f\u80fd\u3002<\/p>\n<p><strong><em>\u4f5c\u7528\u65bc\u51dd\u8840\u56e0\u5b50Xa<\/em><em>\u963b\u6b62\u51dd\u8840\uff0c\u7d93\u5e38\u4e5f\u80fd\u5c0d\u6297\u816b\u7624\u8f49\u79fb\u6216\u6297\u767c\u708e\uff1a<\/em><\/strong><\/p>\n<p>\u8403\u53d6\u81ea\u6b50\u6d32\u91ab\u86ed\u548c<em>Haemanteria officinalis<\/em>\u7684Antistasin\u3001\u8403\u53d6\u81ea<em>Haemanteria ghillianii<\/em>\u7684Ghilanten\u3001\u8403\u53d6\u81ea<em>Haemanteria depressa<\/em>\u7684Lefaxin\u3001\u8403\u53d6\u81ea\u6574\u5d4c\u6676\u86ed\u7684Therostasin\u3001Tessulin\u548cTherin\u3001\u8403\u53d6\u81ea\u6b50\u6d32\u91ab\u86ed\u7684Bdellastasin\u548cHirustasin\u3001\u8403\u53d6\u81ea\u65e5\u672c\u91ab\u86ed\u7684Piguamerin\u548c\u672a\u77e5\u91d1\u7dda\u86ed\u7684Guamerin\u3001\u8403\u53d6\u81ea\u83f2\u64ec\u91ab\u86ed\u7684Gelin\u3002<\/p>\n<p><strong><em>\u6291\u5236\u8840\u5c0f\u677f\u805a\u96c6\uff1a<\/em><\/strong><\/p>\n<p>\u8403\u53d6\u81ea<em>Macrobdella decora<\/em>\u7684Decorsin\u3001\u8403\u53d6\u81ea<em>Placobdella ornata<\/em>\u7684Ornatin\u3001\u8403\u53d6\u81ea\u6b50\u6d32\u91ab\u86ed\u7684Calin\u548c\u4ea6\u53ef\u6297\u767c\u708e\u7684Bdellin\u3001\u8403\u53d6\u81ea<em>Haementeria of<\/em><em>\ufb01cinalis<\/em>\u7684Saratin\u3001\u8403\u53d6\u81ea<em>Haemanteria officinalis<\/em>\u7684Leech Anti-Platelet Protein\uff08LAPP\uff09\u3001\u8403\u53d6\u81ea<em>Haemanteria ghillianii<\/em>\u7684Tridegin\u3001\u4ee5\u53ca\u8403\u53d6\u81ea\u672a\u77e5\u7a2e\u91ab\u86ed\uff0c\u5c0d\u4eba\u9ad4\u70ba\u904e\u654f\u539f\u4ea6\u53ef\u6297\u767c\u708e\u7684Eglin\u3002<\/p>\n<p><strong><em>\u5176\u4ed6\u529f\u80fd\uff1a<\/em><\/strong><\/p>\n<p>\u5438\u8840\u86ed\u985e\u7684\u553e\u817a\u80fd\u5206\u6ccc\u985e\u7d44\u7e54\u80fa\uff0c\u80fd\u5920\u4fc3\u9032\u5c40\u90e8\u8840\u7ba1\u8207\u7d44\u7e54\u901a\u900f\u6027\uff0c\u9019\u4e5f\u662f\u86ed\u985e\u5438\u8840\u5f8c\u7684\u50b7\u53e3\u6703\u6578\u5341\u5206\u9418\u751a\u81f3\u6578\u5c0f\u6642\u4e0d\u65b7\u6ef2\u8840\uff0c\u4e14\u50b7\u53e3\u5468\u570d\u5728\u7652\u5408\u904e\u7a0b\u4e2d\u7d93\u5e38\u8f15\u5fae\u816b\u8139\u7684\u4e3b\u8981\u539f\u56e0\u3002\u8403\u53d6\u81ea<em>Haemanteria ghillianii<\/em>\u7684Hementin\uff0c\u80fd\u6291\u5236\u7e96\u7dad\u86cb\u767d\u539f\u88ab\u5207\u5272\u800c\u963b\u6b62\u51dd\u8840\uff0c\u4e5f\u80fd\u6eb6\u89e3\u8840\u6813\uff1b\u8403\u53d6\u81ea\u6b50\u6d32\u91ab\u86ed\u7684Destabilase\uff0c\u80fd\u5207\u65b7\u7e96\u7dad\u86cb\u767d\u7684\u4ea4\u4e92\u9023\u7d50\uff0c\u4e5f\u80fd\u6eb6\u89e3\u8840\u6813\uff1b\u8403\u53d6\u81ea<em>Haementeria lutzi<\/em>\u7684Hementerin\uff0c\u80fd\u6d3b\u5316\u4eba\u9ad4\u8840\u6f3f\u4e2d\u7684\u7e96\u7dad\u86cb\u767d\u6eb6\u89e3\u7cfb\u7d71\uff1b\u8403\u53d6\u81ea\u6b50\u6d32\u91ab\u86ed\u7684LDTI\uff0c\u5177\u6709\u985e\u80f0\u86cb\u767d\u9176\u7684\u529f\u80fd\uff1b\u8403\u53d6\u81ea\u6b50\u6d32\u91ab\u86ed\u7684Hyaluronidase\uff0c\u53ef\u964d\u89e3\u7d30\u80de\u9593\u806f\u7e6b\u8b93\u7d44\u7e54\u901a\u900f\u6027\u589e\u52a0\uff0c\u4ea6\u6709\u6297\u83cc\u529f\u80fd\uff0c\u64da\u7a31\u53ef\u6cbb\u7642\u9752\u5149\u773c\uff0c\u4e14\u5df2\u7d93\u5546\u54c1\u5316\u70baOrgelase\u4e0a\u5e02\u3002<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u96d6\u7136\u86ed\u985e\u553e\u817a\u6703\u5206\u6ccc\u9ebb\u9189\u7269\u8cea\u6240\u4ee5\u54ac\u4eba\u4e0d\u75db\u7684\u8aaa\u6cd5\u6b77\u4e45\u4e0d\u8870\uff0c\u4e14\u597d\u4e9b\u7814\u7a76\u4e5f\u6307\u51fa\u86ed\u985e\u7642\u6cd5\u5728\u67d0\u7a2e\u7a0b\u5ea6\u4e0a\u6709\u52a9\u6b62\u75db\uff0c\u4f46\u76ee\u524d\u5728\u5404\u7a2e\u86ed\u985e\u7684\u553e\u817a\u5206\u6ccc\u7269\u4e2d\uff0c\u4f9d\u7136\u5f9e\u672a\u627e\u5230\u5177\u9ebb\u9189\u4f5c\u7528\u7684\u6210\u4efd\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u53c3\u8003\u6587\u737b\uff1a<br \/>\nJ.Malcolm Elliott1 and Ulrich Kutschera. 2011. Medicinal leeches: historical use, ecology, genetics and conservation. Freshwater Reviews 4: 21-41<br \/>\nJun-Gu Kang, Sohyun Won, Hye-Won Kim, Baek-Jun Kim, Bae-Keun Park, Tae-Seo Park, Hong-Yul Seo and Joon-Seok Chae. 2016. Molecular detection of Bartonella spp. in terrestrial leeches (Haemadipsa rjukjuana) feeding on human and animal blood in Gageo-do, Republic of Korea. Parasites &amp; Vectors 9: 326-331<br \/>\nU. Kutschera. 2012. The Hirudo medicinalis species complex. Naturwissenschaften 99: 433\u2013434<br \/>\nSebastian Kvist, Gi-Sik Min &amp; Mark E Siddall. 2013. Diversity and selective pressures of anticoagulants in three medicinal leeches (Hirudinida: Hirudinidae, Macrobdellidae). Ecology and Evolution 3: 918\u2013933<br \/>\nSebastian Kvist, Indra Neil Sarkar and Mark E. Siddall. 2011. Genome-wide search for leech antiplatelet proteins in the non-blood-feeding leech Helobdella robusta (Rhyncobdellida: Glossiphoniidae) reveals evidence of secreted anticoagulants. Invertebrate Biology 130: 344-350<br \/>\nGi-Sik Min, Indra Neil Sarkar, and Mark E. Siddall. 2010. Salivary Transcriptome of the North American Medicinal Leech, Macrobdella decora. Journal of Parasitology 96: 1211-1221<br \/>\nMark E. Siddall, Peter Trontelj, Serge Y. Utevsky, Mary Nkamany and Kenneth S. Macdonald III. 2007. Diverse molecular data demonstrate that commercially available medicinal leeches are not Hirudo medicinalis. Proc. R. Soc. B 274: 1481\u20131487<br \/>\nSawyer, R.T. 1986. Leech Biology and Behaviour. Oxford University Press, New York, USA<br \/>\nMichel Salzet. 2001. Minireview Anticoagulants and inhibitors of platelet aggregation derived from leeches. FEBS Letters 492: 187-192<br \/>\nMichel Salzet. 2002. Leech Thrombin Inhibitors. Current Pharmaceutical Design 8: 493-503<br \/>\n\u5f20\u548c\u97e1\uff0c\u738b\u4e3d\u840d\u30022013\u3002\u6c34\u86ed\u7d20\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u4e2d\u56fd\u4e2d\u897f\u533b\u7ed3\u5408\u80be\u75c5\u6742\u5fd7\uff0c14: 76-78<\/p>\n<p>&nbsp;<\/p>\n<p>--<br \/>\n<strong>\u672c\u7cfb\u5217\u5176\u4ed6\u6587\u7ae0\uff1a<br \/>\n<\/strong><a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=36572\">\u86ed\u985e\u7684\u91ab\u7642\u7528\u9014\uff08\u4e00\uff09\uff1a\u50b3\u7d71\u7684\u6d3b\u9ad4\u5916\u7528\u6cd5<\/a><br \/>\n<a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=36584\">\u86ed\u985e\u7684\u91ab\u7642\u7528\u9014\uff08\u4e8c\uff09\uff1a\u73fe\u4ee3\u7684\u6d3b\u9ad4\u5916\u7528\u6cd5<\/a><br \/>\n<a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=36644\">\u86ed\u985e\u7684\u91ab\u7642\u7528\u9014\uff08\u4e09\uff09\uff1a\u6c34\u86ed\u5167\u670d\u85e5\u6750\u7684\u6b77\u53f2<\/a><br \/>\n<a href=\"http:\/\/case.ntu.edu.tw\/blog\/?p=36654\">\u86ed\u985e\u7684\u91ab\u7642\u7528\u9014\uff08\u56db\uff09\uff1a\u86ed\u985e\u6297\u51dd\u8840\u7684\u4e3b\u8981\u6210\u4efd\u63a2\u7a76<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7121\u8ad6\u662f\u6d3b\u9ad4\u5916\u7528\u6216\u662f\u85e5\u6750\u5167\u670d\uff0c\u91cd\u9ede\u9084\u662f\u86ed\u985e\u9ad4\u5167\u7684\u529f\u80fd\u6027\u56e0\u5b50\u9032\u5165\u4eba\u9ad4\u5f8c\u7522\u751f\u4f5c\u7528\u3002\u82e5\u662f\u80fd\u5920\u5c07\u86ed\u985e\u9ad4\u5167\u7684\u6709\u6548\u6210\u4efd\u7d14\u5316\u8403\u53d6\u751a\u81f3\u5927\u91cf\u88fd\u9020\uff0c\u4ee5\u6ce8\u5c04\u6216\u53e3\u670d\u65b9\u5f0f\u76f4\u63a5\u9032\u5165\u8840\u6db2\u6216\u60a3\u8655\u767c\u63ee\u6548\u679c\uff0c\u4f3c\u4e4e\u90fd\u80fd\u66f4\u52a0\u8fc5\u901f\u800c\u6709\u6548\u3002\u56e0\u6b64\uff0c\u904e\u53bb\u4e00\u767e\u591a\u5e74\u4f86\uff0c\u6771\u897f\u65b9\u7684\u5b78\u8005\u90fd\u8017\u8cbb\u4e0d\u5c11\u5fc3\u8840\uff0c\u52aa\u529b\u5f9e\u6c34\u86ed\u8eab\u4e0a\u8403\u53d6\u51fa\u5404\u5f0f\u5404\u6a23\u7684\u6709\u6548\u6210\u4efd\uff0c\u800c\u9019\u4e00\u5207\u7684\u6feb\u89f4\u7576\u7136\u975e\u86ed\u7d20\uff08Hirudin\uff09\u83ab\u5c6c\u3002<\/p>\n","protected":false},"author":20,"featured_media":36672,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2021\/06\/Hirudin_in_complex_with_thrombin.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36654"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36654"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36654\/revisions"}],"predecessor-version":[{"id":36677,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36654\/revisions\/36677"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/36672"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}