{"id":36154,"date":"2021-02-10T00:33:23","date_gmt":"2021-02-09T16:33:23","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=36154"},"modified":"2021-02-05T10:08:32","modified_gmt":"2021-02-05T02:08:32","slug":"%e6%ad%90%e7%be%8ecovid-19%e7%96%ab%e8%8b%97%e7%9a%84%e6%9c%80%e6%96%b0%e7%99%bc%e5%b1%95","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=36154","title":{"rendered":"\u6b50\u7f8eCOVID-19\u75ab\u82d7\u7684\u6700\u65b0\u767c\u5c55"},"content":{"rendered":"

\u56b4\u91cd\u7684\u6025\u6027\u547c\u5438\u7cfb\u7d71\u75c7\u5019\u7fa4\u51a0\u72c0\u75c5\u6bd22\uff08SARS-CoV-2\uff09\u9020\u6210\u7684\u51a0\u72c0\u75c5\u6bd2\u611f\u67d3\u75c72019\uff08Covid-19\uff09\uff0c\u5728\u8fd12\u5e74\u7684\u5168\u7403\u5927\u6d41\u884c\u4e2d\u5df2\u611f\u67d3\u4e86\u6578\u5343\u842c\u4eba\uff0c\u4e26\u9020\u6210\u8d85\u904e\u5169\u767e\u842c\u4eba\u6b7b\u4ea1\uff0c\u6240\u4ee5\u5b89\u5168\u4e14\u6709\u6548\u7684\u75ab\u82d7\u986f\u5f97\u8feb\u5207\u9700\u8981\u3002\u6700\u8fd1\u4e00\u5e74\u591a\u4f86\u4e16\u754c\u5404\u570b\u7af6\u76f8\u7814\u767c\u75ab\u82d7\uff0c\u76ee\u524d\u6b50\u7f8e\u570b\u5bb6\u5df2\u958b\u767c\u6210\u529f\u4e26\u5be6\u969b\u7528\u65bc\u63a5\u7a2e\u7684\u75ab\u82d7\u4e3b\u8981\u6709\u8f1d\u745e\u75ab\u82d7\u3001\u83ab\u5fb7\u7d0d\u75ab\u82d7\u53ca\u725b\u6d25\u75ab\u82d7\u4e09\u7a2e\u3002\u6211\u5011\u5728\u672c\u6587\u5c07\u7c21\u4ecb\u9019\u4e09\u7a2e\u75ab\u82d7\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u4e26\u5c0d\u5176\u7814\u767c\u904e\u7a0b\u3001\u6548\u529b\uff08\u4fdd\u8b77\u529b\uff09\u53ca\u5b89\u5168\u6027\u9032\u884c\u63a2\u8a0e\u53ca\u6bd4\u8f03\u3002<\/strong><\/span><\/p>\n

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\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cfCOVID <\/strong>\u75ab\u82d7\u7814\u767c<\/strong><\/span><\/p>\n

\u6b50\u7f8e\u570b\u5bb6\u5165\u79cb\u5f8c\u98fd\u53d7COVID-19\u75ab\u60c5\u53cd\u64b2\u4e4b\u82e6\uff0c\u53f0\u7063\u8fd1\u65e5\u4ea6\u7206\u767c\u91ab\u8b77\u4eba\u54e1\u9662\u5167\u611f\u67d3\u6848\u4f8b\uff0c\u6240\u4ee5\u4e9f\u9700\u958b\u767c\u75ab\u82d7\u4ee5\u4fdd\u8b77\u9ad8\u98a8\u96aa\u7684\u4eba\uff0c\u4e16\u754c\u5404\u570b\u83ab\u4e0d\u5e0c\u671b\u75ab\u82d7\u76e1\u5feb\u4e0a\u5e02\u4ee5\u9054\u9810\u9632Covid-19\u7684\u6548\u679c\u3002\u6839\u64daCOVID-19\u75ab\u82d7\u7814\u767c\u8ffd\u8e64\u7d71\u8a08\uff0c\u5168\u7403\u7814\u88fd\u4e2d\u7684\u75ab\u82d7\u591a\u905478\u7a2e\uff0c\u76ee\u524d\u897f\u65b9\u570b\u5bb6\u7814\u767c\u9032\u5ea6\u6700\u5feb\u7684\u662f\u8f1d\u745e\uff08Pfizer\uff09\u3001\u83ab\u5fb7\u7d0d\uff08Moderna\uff09\u53ca\u725b\u6d25\u75ab\u82d7\uff0c\u5df2\u5728\u7f8e\u570b\u53ca\u6b50\u6d32\u7533\u8acb\u7dca\u6025\u6388\u6b0a\uff0c\u82f1\u570b\u5247\u5df2\u6838\u51c6\u8f1d\u745e\u75ab\u82d7\u7dca\u6025\u4f7f\u7528\uff08\u8868\u4e00\uff09\u3002<\/p>\n

\"\"
\u8868\u4e00\uff1a\u4e09\u7a2e\u897f\u65b9\u570b\u5bb6\u7814\u767c\u4e0a\u5e02\u7684\u75ab\u82d7<\/figcaption><\/figure>\n

 <\/p>\n

\u25cf\u8f1d\u745e\u75ab\u82d7<\/span><\/strong><\/p>\n

\u57282020\u5e74\uff0c\u7f8e\u570b\u8f1d\u745e\u85e5\u5ee0\u8207\u5fb7\u570b\u751f\u6280\u516c\u53f8BioNTech\u5408\u4f5c\u9032\u884c\u4e00\u9805\u5b89\u6170\u5291\u5c0d\u7167\uff08placebo control\uff09\u53ca\u89c0\u5bdf\u8005\u76f2\u76ee\uff08observer-blinded\uff09\u7684\u95dc\u9375\u7642\u6548\u8a66\u9a57\u4e2d\uff0c\u4ee51\uff1a1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u914d16\u6b72\u4ee5\u4e0a\u7684\u4eba\uff0c\u5171\u670943548\u540d\u53c3\u8207\u8005\u9032\u884c\u4e86\u96a8\u6a5f\u5206\u7d44\uff0c\u5171\u670943448\u4eba\u63a5\u53d7\u4e86\u63a5\u7a2e\uff0c\u5176\u4e2d21720\u4eba\u6ce8\u5c04BNT162b2\u5019\u9078\u75ab\u82d7\uff08\u8f1d\u745e\u75ab\u82d7\uff09\uff0cBNT162b2\u75ab\u82d7\u662f\u4e00\u7a2e\u7d93\u904e\u4fee\u98fe\u7684mRNA\u75ab\u82d7\uff0c\u53ef\u7de8\u78bc\u878d\u5408\u524d\u7a69\u5b9a\u7684SARS-CoV-2\u5168\u9577\u68d8\u7a81\u86cb\u767d\uff08spike protein\uff0c\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u5c0d\u6297\u51a0\u72c0\u75c5\u6bd2\u7684\u4e3b\u8981\u9776\u6a19\uff09\uff0c\u7528\u65bc\u78ba\u8a8d\u5c0d\u6297Covid-19\u7684\u6548\u529b\uff08efficacy\uff09\u548c\u5b89\u5168\u6027\uff08safety\uff09\uff1b\u53e6\u5916\u768421728\u4eba\u6ce8\u5c04\u5b89\u6170\u5291\uff08placebo\uff09\u3002\u53d7\u8a66\u8005\u9593\u969421\u5929\u63a5\u53d7\u5169\u5291\u8102\u8cea\u5948\u7c73\u9846\u7c92\uff08lipid nanoparticle\uff09\u914d\u88fd\u7684BNT162b2\u75ab\u82d7\uff0830 \u03bcg\/dose\uff09\u6216\u5b89\u6170\u5291\u3002\u7814\u7a76\u4eba\u54e1\u767c\u73fe\u5728\u7b2c\u4e8c\u6b21\u63a5\u7a2eBNT162b2\u75ab\u82d7\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u81f3\u5c11\u67097\u4f8b\u5728\u7b2c\u4e8c\u6b21\u7d66\u85e5\u5f8c\uff0c7\u5929\u5167\u51fa\u73fe\u4e86Covid-19\u75c7\u72c0\uff1b\u800c\u5728\u63a5\u53d7\u5b89\u6170\u5291\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u5247\u6709162\u4f8b\u3002\u7814\u7a76\u7d50\u679c\u986f\u793aBNT162b2\u75ab\u82d7\u9810\u9632Covid-19\u7684\u6548\u529b\u70ba95\uff05\uff08\u53ef\u4fe1\u5ea6\u5340\u9593[confidence interval, CI]\u70ba95\uff05\uff0c\u5f9e90.3\u81f397.6\uff09\u3002\u5728\u6839\u64da\u5e74\u9f61\u3001\u6027\u5225\u3001\u7a2e\u65cf\u3001\u8eab\u9ad4\u8cea\u91cf\u6307\u6578\uff08body mass index\uff09\u53ca\u5171\u5b58\u689d\u4ef6\u800c\u5b9a\u7fa9\u7684\u4e9e\u7d44\uff08subgroup\uff09\u4e2d\uff0c\u89c0\u5bdf\u5230\u76f8\u4f3c\u7684\u75ab\u82d7\u6548\u529b\uff08\u901a\u5e38\u70ba90-100\uff05\uff09\u3002\u5728\u63a5\u7a2e\u9996\u5291\u75ab\u82d7\u5f8c\u768410\u4f8bCovid-19\u56b4\u91cd\u60a3\u8005\u4e2d\uff0c\u5b89\u6170\u5291\u63a5\u53d7\u8005\u4f549\u4f8b\uff0c\u800cBNT162b2\u75ab\u82d7\u63a5\u53d7\u8005\u5247\u50c5\u67091\u4f8b\u3002BNT162b2\u75ab\u82d7\u7684\u526f\u4f5c\u7528\u901a\u5e38\u50c5\u65bc\u6ce8\u5c04\u90e8\u4f4d\u6709\u77ed\u671f\u3001\u8f15\u5ea6\u81f3\u4e2d\u5ea6\u75bc\u75db\u53ca\u982d\u75db\u3001\u75b2\u52de\u7b49\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5f88\u5c11\u767c\u751f\uff0c\u800c\u4e14\u8207\u5b89\u6170\u5291\u7d44\u767c\u751f\u7387\u63a5\u8fd1\u3002\u8a66\u9a57\u7d50\u679c\u5f97\u77e5 BNT162b2\u75ab\u82d7\u7684\u5169\u5291\u65b9\u6848\u53ef\u70ba16\u6b72\u4ee5\u4e0a\u7684\u4eba\u63d0\u4f9b\u91dd\u5c0dSARS-CoV-2\u611f\u67d3\u7d0495\uff05\u7684\u4fdd\u8b77\u529b\u3002<\/p>\n

\u25cf\u83ab\u5fb7\u7d0d\u75ab\u82d7<\/strong><\/span><\/p>\n

\u57282020\u5e74\uff0c\u7f8e\u570b\u83ab\u5fb7\u7d0d\u516c\u53f8\u8207\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\uff08National Institute of Health, NIH\uff09\u5408\u4f5c\u958b\u767c\u4e00\u7a2e\u8102\u8cea\u5948\u7c73\u9846\u7c92\u5305\u88f9\u7684mRNA-1273\u75ab\u82d7\uff08\u83ab\u5fb7\u7d0d\u75ab\u82d7\uff09\uff0c\u53ef\u7de8\u78bcSARS-CoV-2\u7684\u5168\u9577\u68d8\u7a81\u86cb\u767d\u3002\u8a72\u75ab\u82d7\u7b2c\u4e09\u671f\u89c0\u5bdf\u8005\u76f2\u76ee\u53ca\u5b89\u6170\u5291\u5c0d\u7167\u7684\u81e8\u5e8a\u8a66\u9a57\u5728\u7f8e\u570b99\u500b\u4e2d\u5fc3\u9032\u884c\uff0c\u5171\u62db\u52df\u4e8630420\u540d\u5fd7\u9858\u53d7\u8a66\u8005\uff0c\u4ee51\uff1a1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u914d\u4ee5\u63a5\u53d7\u75ab\u82d7\u6216\u5b89\u6170\u5291\uff08\u6bcf\u7d4415210\u540d\u53d7\u8a66\u8005\uff09\u3002\u8d85\u904e96\uff05\u7684\u53d7\u8a66\u8005\u63a5\u53d7\u4e86\u4ee5\u4e0a\u5169\u7a2e\u6ce8\u5c04\uff0c\u4e26\u4e14\u67092.2\uff05\u7684\u53d7\u8a66\u8005\u5728\u57fa\u7dda\uff08baseline\uff09\u6642\u6709SARS-CoV-2\u611f\u67d3\u7684\u8b49\u64da\uff08\u8840\u6e05\u5b78\u3001\u75c5\u6bd2\u5b78\u6216\u5169\u8005\u517c\u6709\uff09\u3002\u5c07SARS-CoV-2\u611f\u67d3\u8005\u6216\u5176\u4f75\u767c\u75c7\u7684\u60a3\u8005\u4ee51\uff1a1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u914d\uff0c\u9593\u969428\u5929\u63a5\u53d7\u5169\u6b21\u808c\u8089\u6ce8\u5c04mRNA-1273\u75ab\u82d7\uff08100 \u03bcg\/dose\uff09\u6216\u5b89\u6170\u5291\u3002\u5728\u5b89\u6170\u5291\u7d44\u7684185\u540d\u53c3\u8207\u8005\uff08\u6bcf\u5343\u4eba56.5\/\u5e74\uff0c95\uff05CI\u5f9e48.7\u81f365.3\uff09\u548c\u5728mRNA-1273\u7d44\u768411\u540d\u53c3\u8207\u8005\uff08\u6bcf\u5343\u4eba3.3\/\u5e74\uff0c95\uff05CI\uff0c\u5f9e1.7\u81f36.0\uff09\u4e2d\u8b49\u5be6\u6709\u4e86Covid-19\u7684\u75c7\u72c0\u3002\u75ab\u82d7\u6548\u529b\u70ba94.1\uff05\uff0895\uff05CI\uff0c89.3\u81f396.8\uff05\uff0cP <0.001\uff09\u3002\u5728\u9996\u6b21\u63a5\u7a2e\u5f8c14\u5929\u7684\u8a55\u4f30\uff0c\u5206\u6790\u57fa\u7dda\u6642\u6709SARS-CoV-2\u611f\u67d3\u53ca65\u6b72\u4ee5\u4e0a\u7684\u53d7\u8a66\u8005\uff0c\u7642\u6548\u5747\u76f8\u4f3c\u3002\u56b4\u91cd\u7684Covid-19\u75c7\u72c0\u767c\u751f\u572830\u540d\u53c3\u8207\u8005\uff08\u5176\u4e2d1\u540d\u6b7b\u4ea1\uff09\uff0c\u4f46\u6240\u670930\u4f4d\u60a3\u8005\u5747\u5c6c\u65bc\u5b89\u6170\u5291\u7d44\uff0c\u4e2d\u5ea6\u3001\u77ed\u66ab\u7684\u4e0d\u826f\u53cd\u61c9\u96d6\u7136\u6642\u5e38\u5728mRNA-1273\u75ab\u82d7\u7d44\u767c\u751f\uff0c\u53ef\u662f\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5f88\u5c11\u898b\uff0c\u800c\u4e14\u8207\u5b89\u6170\u5291\u7d44\u767c\u751f\u7387\u63a5\u8fd1\u3002<\/p>\n

\u25cf\u725b\u6d25\u75ab\u82d7<\/strong><\/span><\/p>\n

\u57282020\u5e74\uff0c\u82f1\u570b\u725b\u6d25\u5927\u5b78\uff08Oxford University\uff09\u548c\u963f\u65af\u7279\u6377\u5229\u5eb7\uff08AstraZeneca\uff09\u88fd\u85e5\u516c\u53f8\u81ea\u9ed1\u7329\u7329\u7684\u7cde\u4fbf\u4e2d\u5206\u96e2\u51fa\u817a\u75c5\u6bd2\uff08adenovirus\uff09\uff0c\u6b64\u75c5\u6bd2\u5728\u6539\u9020\u5f8c\u88fd\u6210\u725b\u6d25\u75ab\u82d7\u3002\u6539\u9020\u5f8c\u7684\u817a\u75c5\u6bd2\u96d6\u7136\u5728\u7d30\u80de\u4e2d\u4e0d\u6703\u8907\u88fd\uff0c\u4f46\u6ce8\u5c04\u5f8c\u6703\u8a98\u767c\u4eba\u985e\u7d30\u80de\u7522\u751fSARS-CoV-2\u68d8\u7a81\u86cb\u767d\u3002\u6839\u64da\u5728\u82f1\u570b\u548c\u5df4\u897f\u768411000\u591a\u540d\u53d7\u8a66\u8005\u4e2d\u7684131\u500bCOVID-19\u75c5\u4f8b\uff0c\u7814\u7a76\u4eba\u54e1\u5728\u53d7\u8a66\u8005\u63a5\u53d7\u7b2c\u4e8c\u5291\u75ab\u82d72\u9031\u5f8c\u6e2c\u5b9a\u6548\u529b\uff0c\u767c\u73fe\u9019\u5169\u5291\u75ab\u82d7\u7684\u6548\u529b\u7d04\u70ba70\uff05\u3002\u521d\u6b65\u5206\u6790\u81e8\u5e8a\u8a66\u9a57\u7b2c\u4e09\u671f\u7684\u6578\u64da\uff0c\u5e73\u5747\u6709\u6548\u7387\u7d04\u70ba70\uff05\uff0c\u6b64\u6578\u64da\u662f\u5169\u7a2e\u63a5\u7a2e\u65b9\u6848\u4e2d62\uff05\u548c90\uff05\u6548\u529b\u7684\u5e73\u5747\u503c\uff0c\u7d10\u7d04\u5e02\u897f\u5948\u5c71\u91ab\u5b78\u9662\u7684\u75c5\u6bd2\u5b78\u5bb6\u5f17\u6d1b\u91cc\u5b89\uff08Florian Krammer\uff09\u8a8d\u70ba90\uff05\u7684\u6548\u529b\u76f8\u7576\u4e0d\u932f\uff0c\u4f46\u662f\u7b2c\u4e8c\u7a2e\u6e2c\u8a66\u65b9\u6848\u768462\uff05\u7684\u6548\u529b\u4e26\u4e0d\u7406\u60f3\u3002\u7136\u800c\uff0c\u7814\u7a76\u4eba\u54e1\u9032\u4e00\u6b65\u5206\u6790\u7d50\u679c\u5f8c\u767c\u73fe\uff0c\u6839\u64da\u905e\u9001\u7d66\u53d7\u8a66\u8005\u7684\u75ab\u82d7\u6578\u91cf\uff0c\u6548\u529b\u5b58\u5728\u986f\u8457\u5dee\u7570\u3002\u5728\u76f8\u96941\u500b\u6708\u5169\u500b\u5168\u5291\u91cf\u65b9\u6848\u4e2d\uff0c\u767c\u73fe\u53ea\u670962\uff05\u6709\u6548\uff0c\u4f46\u8207\u5b89\u6170\u5291\u7d44\u7684\u53d7\u8a66\u8005\u76f8\u6bd4\uff0c\u986f\u73fe\u5728\u7b2c\u4e00\u5291\u4e2d\u63a5\u53d7\u8f03\u4f4e\u5291\u91cf\u7684\u75ab\u82d7\u7136\u5f8c\u5728\u7b2c\u4e8c\u5291\u4e2d\u63a5\u53d7\u5168\u5291\u91cf\u75ab\u82d7\u7684\u53d7\u8a66\u8005\uff0c\u4ed6\u5011\u611f\u67d3SARS-CoV-2\u7684\u53ef\u80fd\u6027\u964d\u4f4e\u7d0490\uff05\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Schaefer GO, Tam CC, Savulescu J, Voo TC. COVID-19 vaccine development: Time to consider SARS-CoV-2 challenge studies? Vaccine. 2020 Jul 14;38(33):5085-5088. doi: 10.1016\/j.vaccine.2020.06.007. Epub 2020 Jun 4.<\/li>\n
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  5. Why Oxford\u2019s positive COVID vaccine results are puzzling scientists. Nature news. 2020 Nov. 23. doi: https:\/\/doi.org\/10.1038\/d41586-020-03326-w<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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