{"id":36019,"date":"2020-12-29T00:49:14","date_gmt":"2020-12-28T16:49:14","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=36019"},"modified":"2020-12-23T10:54:51","modified_gmt":"2020-12-23T02:54:51","slug":"%e8%aa%8d%e8%ad%98%e5%8f%b2%e8%92%82%e8%8a%ac%e5%bc%b7%e6%a3%ae%e7%97%87%e5%80%99%e7%be%a4%ef%bc%88steven-johnson-syndrome%ef%bc%89","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=36019","title":{"rendered":"\u8a8d\u8b58\u53f2\u8482\u82ac\u5f37\u68ee\u75c7\u5019\u7fa4\uff08Steven-Johnson Syndrome\uff09"},"content":{"rendered":"

\u53f2\u8482\u82ac\u5f37\u751f\u75c7\u5019\u7fa4\uff08Stevens Johnson Syndrome\uff0cSJS\uff09\u662f\u6307\u56b4\u91cd\u85e5\u7269\u904e\u654f\u75c7\u72c0\uff0c\u7279\u5fb5\u662f\u5148\u51fa\u73fe\uf9d0\u4f3c\uf9ca\u611f\u7684\u75c7\uf9fa\uff0c\u63a5\u8457\u76ae\u819a\u51fa\u73fe\u591a\u578b\u6027\u74b0\uf9fa\u7d0b\u3001\u7d05\u6591\u53ca\u75b9\u5b50\uff0c\u9762\u7a4d\u9010\u6f38\u64f4\u5927\uff0c\u96a8\u5f8c\u51fa\u73fe\u6c34\u76b0\uff0c\u56b4\u91cd\u6642\u9020\u6210\u4eba\u9ad4\u9ecf\u819c\u53d7\u640d\uff0c\u751a\u81f3\u591a\u91cd\u5668\u5b98\u8870\u7aed\u800c\u6b7b\u4ea1\uff0c\u81f4\u6b7b\u7387\u53ef\u905430%\u4ee5\u4e0a\uff0c\u96d6\u5c6c\u7f55\u898b\u75be\u75c5\uff0c\u4f46\u4ecd\u4ee4\u4eba\u805e\u4e4b\u8272\u8b8a\u3002\u76ee\u524d\u5f15\u8d77SJS\u7684\u539f\u56e0\u5c1a\u672a\u5341\u5206\u6e05\u695a\uff0c\u771f\u6b63\u75c5\u56e0\u4ecd\u5728\u6301\u7e8c\u7814\u7a76\u4e2d\uff0c\u6211\u5011\u5c07\u5728\u672c\u6587\u4e2d\u5f15\u5c0e\u8b80\u8005\u8a8d\u8b58SJS\u7684\u75c7\u72c0\u3001\u6210\u56e0\u53ca\u6cbb\u7642\uff0c\u4e26\u63a2\u8a0e\u5176\u5f15\u767c\u6bd2\u6027\u8868\u76ae\u6eb6\u89e3\u4e4b\u6a5f\u8f49\u3002<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u767c\u73fe\u6b77\u53f2<\/strong><\/span><\/p>\n

\u57281922\u5e74\uff0c\u5169\u4f4d\u7f8e\u570b\u5c0f\u5152\u79d1\u91ab\u751fAlbert Mason Stevens\u53caFrank Chambliss Johnson\u9996\u5148\u89c0\u5bdf\u4e26\u63cf\u8ff0\u53f2\u5e1d\u82ac\u5f37\u751f\u75c7\u5019\u7fa4\uff08Steven-Johnson Syndrome, SJS\uff09\uff0c\u7576\u6642\u4ed6\u5011\u767c\u73fe2\u4f4d7~8\u6b72\u5c0f\u670b\u53cb\u7686\u6709\u767c\u71b1\u3001\u76ae\u75b9\u3001\u9830\u819c\u708e\u75c7\u53ca\u56b4\u91cd\u7d50\u819c\u708e\u7b49\u75c7\u72c0\uff08an extraordinary, generalized eruption with continued fever, inflamed buccal mucosa, and severe purulent conjunctivitis\uff09\uff0c\u56e0\u800c\u88ab\u547d\u540d\u70ba SJS\uff0c\u4f46\u7576\u6642\u5169\u4f4d\u60a3\u8005\u88ab\u8aa4\u8a3a\u70ba\u51fa\u8840\u6027\u75f2\u75b9\uff08hemorrhagic measles\uff09\u3002<\/p>\n

\u25cf\u767c\u75c5\u53ca\u75c7\u72c0<\/strong><\/span><\/p>\n

SJS\u662f\u4e00\u7a2e\u56e0\u76ae\u819a\u8207\u9ecf\u819c\u56b4\u91cd\u904e\u654f\u53cd\u61c9\uff08an immune-complex\u2013mediated hypersensitivity complex that typically involves the skin and the mucous membranes\uff09\u800c\u9020\u6210\u7684\u81f4\u547d\u6027\u75be\u75c5\uff0c\u81e8\u5e8a\u4e0a\u76ae\u819a\u525d\u843d\u7a0b\u5ea6\u8d85\u904e30%\u8005\uff0c\u7a31\u70ba\u6bd2\u6027\u8868\u76ae\u6eb6\u89e3\uff08toxic epidermal necrolysis\uff09\uff0c\u81f4\u6b7b\u7387\u53ef\u9ad8\u905430%\u3002\u60a3\u8005\u767c\u75c5\u521d\u671f\u6703\u5148\u51fa\u73fe\u985e\u4f3c\u6d41\u611f\u7684\u5178\u578b\u524d\u9a45\u75c7\u72c0\uff08prodromal symptom)\uff0c\u5305\u62ec\u54b3\u55fd\u3001\u591a\u75f0\u3001\u4e4f\u529b\u3001\u982d\u75db\u53ca\u95dc\u7bc0\u75db\u7b49\uff0c\u63a5\u8457\u5728\u9762\u90e8\u8207\u8ec0\u5e79\u4e0a\u534a\u90e8\u4f4d\u76ae\u819a\u6703\u51fa\u73fe\u5c0d\u7a31\u6027\u76ae\u75b9\uff08burning rash that begins symmetrically on the face and the upper part of the torso\uff09\uff0d\u9776\u5fc3\uf9fa\u75c5\u7076\uff08target lesion\uff09\uff0c\u9762\u7a4d\u9010\u6f38\u64f4\u5927\uff0c\u96a8\u5f8c\u51fa\u73fe\u6c34\u76b0\uff0c\u64f4\u53ca\u5168\u8eab\u9ecf\u819c\u7d44\u7e54\uff0c\u5305\u62ec\u773c\u3001\u9f3b\u3001\u53e3\u3001\u9670\u9053\u3001\u5c3f\u9053\u3001\u80c3\u8178\u9053\u53ca\u4e0b\u547c\u5438\u9053\u7b49\u5404\u90e8\u4f4d\uff0c\u56b4\u91cd\u6642\u6703\u5f15\u8d77\u5168\u8eab\u8868\u76ae\u7d30\u80de\u6b7b\u4ea1\uff0c\u5c0e\u81f4\u8868\u76ae\u8207\u771f\u76ae\u5206\u96e2\uff08detachment\uff09\uff0c\u4f75\u767c\u75c7\u5247\u5305\u62ec\u591a\u91cd\u5668\u5b98\u8870\u7aed<\/a>\u3001\u89d2\u819c\u812b\u843d\u53ca\u5931\u660e<\/a>\u3002\u5f15\u8d77SJS\u7684\u539f\u56e0\u5c1a\u672a\u5b8c\u5168\u91d0\u6e05\uff0c\u4f46\u73fe\u968e\u6bb5\u7814\u7a76\u986f\u793a\u53ef\u80fd\u662f\u85e5\u7269\u904e\u654f\u3001\u5fae\u751f\u7269\u611f\u67d3\u6216\u907a\u50b3\u57fa\u56e0\u6240\u5c0e\u81f4\uff0c\u5176\u4e2d\u4ee5\u85e5\u7269\u904e\u654f\u5360\u6700\u5927\u5b97\uff08\u88681\uff09\u3002<\/p>\n

 <\/p>\n

\u88681\uff1a\u53ef\u80fd\u5f15\u767c\u53f2\u5e1d\u82ac\u5f37\u751f\u75c7\u5019\u7fa4\u7684\u539f\u56e0<\/p>\n\n\n\n\n\n\n
\u539f\u56e0<\/strong><\/td>\n\u8aaa\u660e<\/strong><\/td>\n<\/tr>\n
\u85e5\u7269\u904e\u654f<\/td>\n(1)  \u6297\u751f\u7d20\uff1a\u5982Penicillin\u3001\u78fa\u80fa\u5291<\/a>\u3001Aminoglycoside\u3001Macrolide\u3002<\/p>\n

(2)  \u7cbe\u795e\u79d1\u7528\u85e5\uff1a\u5982Phenytoin\u3001Carbamazepine\u3001Valproic acid\u3001Barbiturate\u3001Phenobarbital\u3001Phenytoin\u3001Valproic acid\u3002<\/p>\n

(3)  \u6297\u7672\u7647\u85e5\uff1a\u5982Psychoepileptic\u3001Phenytoin\u3002<\/p>\n

(4)  \u975e\u985e\u56fa\u9187\u6297\u767c\u708e\u85e5\uff08NSAIDs\uff09\uff1a\u5982Butazone\u985e\u884d\u751f\u7269\u3001Diclofenac\u3001Ketoprofen\u3001Oxicam\u985e\u884d\u751f\u7269\uff08piroxicam, tenoxicam\uff09\u3001Salicylate\u3001Sulpyrin\u3001Sulindac\u3002<\/p>\n

(5)  \u6297\u75db\u98a8\u85e5\uff1a\u5982Allopurinol\u3002<\/p>\n

(6)  \u5176\u4ed6\uff1a\u5982Acetaminophen\u3001Antimalarial\u3001Antiretroviral drug\u3001Aspirin\u3001 Penicillamine\u3002<\/td>\n<\/tr>\n

\u5fae\u751f\u7269\u611f\u67d3<\/td>\n\u7d30\u83cc\u6027\u3001\u75c5\u6bd2\u6027\u75be\u75c5\u6216\u771f\u83cc\u611f\u67d3\u3002<\/td>\n<\/tr>\n
\u907a\u50b3\u57fa\u56e0<\/td>\n\u85e5\u7269\u6fc0\u767c\u514d\u75ab\u53cd\u61c9\uff0c\u7279\u5225\u662f\u7d93\u7531\u4eba\u985e\u767d\u8840\u7403\u6297\u539f\uff08human leucocyte antigen, HLA\uff09\u7684\u4ea4\u4e92\u4f5c\u7528\u800c\u6d3b\u5316\u7d30\u80de\u6bd2\u6027\u6dcb\u5df4\uff08CD8+ T\uff09\u7d30\u80de\uff0c\u91cb\u653e\u5927\u91cf\u7684\u9846\u7c92\u7d20\uff08granulysin\uff09\u3002\u9019\u4e9b\u76f8\u61c9\u7684\u57fa\u56e0\u5305\u62ecHLA-B1502, HLA-B5801, HLA-B44, HLA-A29, HLA-B12, HLA-DR7, HLA-A2, HLA-A0206, HLA-DQB10601<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u25cf\u6cbb\u7642\u53ca\u7167\u8b77<\/span><\/strong><\/p>\n

\u904e\u654f\u53cd\u61c9\uff08allergy\uff09\u5206\u70ba\u4ee5\u4e0b\u56db\u578b\uff1a(1)\u7b2c\u4e00\u578b\uff1a\u5373\u767c\u6027\u904e\u654f\u53cd\u61c9\uff08immediate hypersensitivity\uff09\uff0c\u4ea6\u7a31 IgE\u4ecb\u5c0e\u578b\u904e\u654f\u53cd\u61c9\uff08IgE mediated hypersensitivity\uff09\uff1b(2)\u7b2c\u4e8c\u578b\uff1a\u6297\u9ad4\u4f9d\u8cf4\u578b\u548c\u7d30\u80de\u6bd2\u6bba\u904e\u654f\u53cd\u61c9\uff08antibody-dependent cytotoxic hypersensitivity\uff09\uff1b(3)\u7b2c\u4e09\u578b\uff1a\u514d\u75ab\u8907\u5408\u9ad4\u5a92\u4ecb\u904e\u654f\u53cd\u61c9\uff08immune complex-mediated hypersensitivity\uff09\uff1b(4)\u7b2c\u56db\u578b\uff1a\u9072\u767c\u6027\u904e\u654f\u53cd\u61c9\uff08delayed-type hypersensitivity\uff09\u3002SJS\u901a\u5e38\u662f\u75c5\u60a3\u63a5\u89f8\u5230\u67d0\u4e9b\u85e5\u7269\u8d85\u904e2-3\u5929\uff0c\u6709\u4e9b\u500b\u6848\u751a\u81f3\u8d85\u904e5\u5929\u5f8c\uff0c\u624d\u958b\u59cb\u51fa\u73fe\u75c7\u72c0\uff0c\u6545\u61c9\u5c6c\u65bc\u9072\u767c\u6027\u904e\u654f\u53cd\u61c9\u3002<\/p>\n

SJS\u7684\u6cbb\u7642\u8207\u7167\u8b77\u9996\u61c9\u505c\u7528\u53ef\u80fd\u5f15\u8d77\u6b64\u526f\u4f5c\u7528\u7684\u85e5\u7269\uff0c\u75c5\u4eba\u907f\u514d\u7528\u624b\u6293\u7662\u800c\u5c0e\u81f4\u7834\u76ae\u4ee5\u9810\u9632\u611f\u67d3\uff0c\u56e0\u82e5\u76ae\u819a\u9ecf\u819c\u53d7\u640d\uff0c\u4fbf\u6210\u70ba\u9ad8\u5371\u96aa\u7fa4\uff0c\u56b4\u91cd\u8005\u53ef\u80fd\u56e0\u6557\u8840\u75c7\u800c\u6b7b\u4ea1\uff0c\u6545\u61c9\u6ce8\u610f\u6709\u7121\u53d7\u5230\u611f\u67d3\u7684\u5fb5\u5146\uff08\u5982\u53e3\u8154\u7834\u640d\u3001\u767c\u71d2\u3001\u5c40\u90e8\u50b7\u53e3\u5316\u81bf\u3001\u54b3\u55fd\u3001\u8179\u7009\u6216\u983b\u5c3f\u7b49\uff09\u3002\u985e\u56fa\u9187\uff08corticosteroid\uff09\u53ef\u4ee5\u63a7\u5236\u904e\u654f\u53cd\u61c9\u3001\u6297\u767c\u708e\u4f5c\u7528\u3001\u6cbb\u7642\u7d05\u75b9\u548c\u5176\u4ed6\u76ae\u819a\u75c5\uff0c\u7814\u7a76\u986f\u793a\u5c0d\u6c92\u6709\u7279\u5b9a\u7981\u5fcc\u7684SJS\u60a3\u8005\u800c\u8a00\uff0c\u65e9\u671f\u4f7f\u7528\u9ad8\u5291\u91cf\u985e\u56fa\u9187\u6700\u80fd\u6709\u6548\u963b\u6b62\u75c5\u60c5\u7684\u60e1\u5316\uff0c\u4e26\u589e\u52a0\u5b58\u6d3b\u7387\u3002\u74b0\u5b62\u9748\uff08cyclosporine\uff09\u662f\u76ee\u524d\u4e16\u754c\u7b2c\u4e8c\u7a2e\u5e38\u7528\u65bc\u6cbb\u7642SJS\u7684\u514d\u75ab\u6291\u5236\u85e5\u7269\uff0c\u5df2\u6709\u7814\u7a76\u6307\u51fa\u5176\u53ef\u80fd\u662f\u6cbb\u7642SJS\u7684\u6709\u6548\u85e5\u7269\u4e4b\u4e00\u3002<\/p>\n

\u25cfSJS<\/strong>\u5f15\u767c\u6bd2\u6027\u8868\u76ae\u6eb6\u89e3\u4e4b\u53ef\u80fd\u6a5f\u8f49<\/strong><\/span><\/p>\n

SJS\u88ab\u8a8d\u70ba\u662f\u85c9\u7531CD8+ T\u7d30\u80de\u901a\u904eHLA\u9650\u5236\u6027\u9014\u5f91\u5f15\u767c\u7684\u85e5\u7269\u904e\u654f\u514d\u75ab\u800c\u5c0e\u81f4\u7684\u75be\u75c5\uff0c\u73fe\u5df2\u78ba\u5b9a\u5e7e\u7a2e\u4ecb\u8cea\uff08mediator\uff09\u6703\u4fc3\u6210\u7d30\u80de\u51cb\u4ea1\uff08apoptosis\uff09\uff0c\u5305\u62ec\u9846\u7c92\u7d20\uff08granulysin\uff09\u3001\u53ef\u6eb6\u6027Fas\u914d\u9ad4\uff08soluble Fas ligand\uff09\u3001\u7a7f\u5b54\u7d20\uff08perforin\uff09\/\u9846\u7c92\u9176\uff08granzyme\uff09\u3001\u816b\u7624\u58de\u6b7b\u56e0\u5b50\uff08tumor necrosis factor, TNF\uff09-\u03b1\u53caTNF\u76f8\u95dc\u7684\u7d30\u80de\u51cb\u4ea1\u8a98\u5c0e\u914d\u9ad4\uff08TNF-related apoptosis-inducing ligand\uff09\u3002\u6bd2\u6027\u8868\u76ae\u6eb6\u89e3\u7406\u8ad6\u4e3b\u8981\u6d89\u53ca\u4ee5\u4e0b\u6a5f\u5236\uff1a(1)\u9846\u7c92\u7d20\u662f\u4fc3\u6210\u89d2\u8cea\u5f62\u6210\u7d30\u80de\uff08keratinocyte\uff09\u51cb\u4ea1\u7684\u6700\u4e3b\u8981\u539f\u56e0\u3002(2)\u5728\u6fc0\u6d3b\u7684\u7d30\u80de\u6bd2\u6027T\u7d30\u80de\u4e0a\u8868\u9054\u7684Fas\u2013FasL\u4e5f\u53ef\u4ee5\u901a\u904e\u7522\u751f\u80de\u5167\u80f1\u5929\u86cb\u767d\u9176\uff08caspase\uff09\u4f86\u7834\u58de\u89d2\u8cea\u5f62\u6210\u7d30\u80de\uff08keratinocyte\uff09\u3002(3)CD+T\u7d30\u80de\u7684\u7a7f\u5b54\u7d20\u548c\u9846\u7c92\u9176B\uff0c\u5728\u9776\u7d30\u80de\u819c\uff08target cell membrane\uff09\u4e0a\u5f62\u6210\u6fc0\u6d3b\u80f1\u5929\u86cb\u767d\u9176\uff08caspase\uff09\u7684\u901a\u9053\u3002(4)TNF-\u03b1\u53ef\u80fd\u5f15\u8d77\u7d30\u80de\u51cb\u4ea1\u6216\u5c0d\u5176\u9032\u884c\u4fdd\u8b77\u3002(5)TNF-\u03b1\u548c\u5e72\u64fe\u7d20\uff08interferon, IFN\uff09-\u03b1\u5f15\u8d77\u7684\u4e00\u6c27\u5316\u6c2e\uff08NO\uff09\u53ef\u80fd\u6703\u523a\u6fc0\u80f1\u5929\u86cb\u767d\u9176\u3002<\/p>\n

SJS\u6bd2\u6027\u8868\u76ae\u58de\u6b7b\u6eb6\u89e3\u7684\u521d\u59cb\u6b65\u9a5f\u53ef\u80fd\u662f\u85e5\u7269\u76f8\u95dc\u6297\u539f\u6216\u4ee3\u8b1d\u7522\u7269\u8207\u7b2cI\u578b\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u8907\u5408\u7269\uff08type I major histocompatibility complex, MHC-1\uff09\u6216\u7d30\u80de\u80bd\u76f8\u4e92\u7d50\u5408\u5f8c\u958b\u59cb\u9032\u884c\uff0c\u5f9e\u800c\u5f62\u6210\u514d\u75ab\u539f\u6027\u5316\u5408\u7269\uff0c\u4f46\u78ba\u5207\u7684\u6a5f\u5236\u4ecd\u4e0d\u660e\u6717\u3002CD8 +T\u7d30\u80de\u5b58\u5728\u65bc\u6c34\u76b0\u4e2d\uff0c\u4e26\u53ef\u80fd\u8a98\u5c0e\u89d2\u8cea\u5f62\u6210\u7d30\u80de\u51cb\u4ea1\uff0c\u5148\u5929\u514d\u75ab\u7cfb\u7d71\u7684\u7d30\u80de\u4e5f\u6703\u4f5c\u7528\uff0c\u5305\u62ec\u5de8\u566c\u7d30\u80de\u3001\u55dc\u4e2d\u6027\u7403\uff08neutrophil\uff09\u548c\u81ea\u7136\u6bba\u624b\uff08natural killer\uff09\u7d30\u80de\u3002CD40\u914d\u9ad4\u7d30\u80de\u4e26\u53ef\u80fd\u8a98\u5c0eTNF-\u03b1\u3001NO\u3001\u767d\u4ecb\u7d208\uff08IL-8\uff09\u548c\u7d30\u80de\u7c98\u9644\u6297\u9ad4\u91cb\u653e\uff0cTNF-\u03b1\u4e5f\u6703\u8a98\u5c0e\u7d30\u80de\u51cb\u4ea1\uff0c\u8f14\u52a9T\u7d30\u80de\uff08T helper cells, Th\uff09\u7684Th1\u548cTh2\u7d30\u80de\u56e0\u5b50\u5747\u5b58\u5728\u4e14\u53c3\u8207\u5176\u4e2d\u3002<\/p>\n

\u6709\u95dcSJS\u5f15\u767c\u6bd2\u6027\u8868\u76ae\u6eb6\u89e3\u4e4b\u53ef\u80fd\u4f5c\u7528\u6a5f\u8f49\u4e3b\u8981\u6709\u5169\u7a2e\u8ad6\u8ff0\uff1a\u7b2c\u4e00\u7a2e\u7406\u8ad6\u662f\u85e5\u7269\u8207\u514d\u75ab\u7cfb\u7d71\u7684\u85e5\u7406\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u5c0e\u81f4\u8ca0\u8cac\u85e5\u7269\u8207T\u7d30\u80de\u53d7\u9ad4\u53ca\u5176MHC-1\u7d50\u5408\u800c\u523a\u6fc0\u514d\u75ab\u7cfb\u7d71\uff1b\u53e6\u4e00\u7a2e\u5247\u662f\u534a\u6297\u539f\uff08pro-hapten \uff09\u7684\u6982\u5ff5\uff0c\u8a8d\u70ba\u5176\u4e2d\u7684\u85e5\u7269\u4ee3\u8b1d\u7269\uff08metabolite\uff09\u5177\u6709\u514d\u75ab\u539f\u6027\uff08immunogenicity\uff09\u800c\u523a\u6fc0\u514d\u75ab\u7cfb\u7d71\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Harris V, Jackson C, Cooper A. Review of Toxic Epidermal Necrolysis. Int J Mol Sci. 2016 Dec 18;17(12):2135. doi: 10.3390\/ijms17122135.<\/li>\n
  2. Oakley AM, Krishnamurthy K. Stevens Johnson Syndrome. 2020 Aug 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan\u2013.2020 Aug 11.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u53f2\u8482\u82ac\u5f37\u751f\u75c7\u5019\u7fa4\uff08Stevens\u00a0Johnson\u00a0Syndrome\uff0cSJS\uff09\u662f\u6307\u56b4\u91cd\u85e5\u7269\u904e\u654f\u75c7\u72c0\uff0c\u7279\u5fb5\u662f\u5148\u51fa\u73fe\uf9d0\u4f3c\uf9ca\u611f\u7684\u75c7\uf9fa\uff0c\u63a5\u8457\u76ae\u819a\u51fa\u73fe\u591a\u578b\u6027\u74b0\uf9fa\u7d0b\u3001\u7d05\u6591\u53ca\u75b9\u5b50\uff0c\u9762\u7a4d\u9010\u6f38\u64f4\u5927\uff0c\u96a8\u5f8c\u51fa\u73fe\u6c34\u76b0\uff0c\u56b4\u91cd\u6642\u9020\u6210\u4eba\u9ad4\u9ecf\u819c\u53d7\u640d\uff0c\u751a\u81f3\u591a\u91cd\u5668\u5b98\u8870\u7aed\u800c\u6b7b\u4ea1\uff0c\u81f4\u6b7b\u7387\u53ef\u905430%\u4ee5\u4e0a\uff0c\u96d6\u5c6c\u7f55\u898b\u75be\u75c5\uff0c\u4f46\u4ecd\u4ee4\u4eba\u805e\u4e4b\u8272\u8b8a\u3002\u76ee\u524d\u5f15\u8d77SJS\u7684\u539f\u56e0\u5c1a\u672a\u5341\u5206\u6e05\u695a\uff0c\u771f\u6b63\u75c5\u56e0\u4ecd\u5728\u6301\u7e8c\u7814\u7a76\u4e2d\uff0c\u6211\u5011\u5c07\u5728\u672c\u6587\u4e2d\u5f15\u5c0e\u8b80\u8005\u8a8d\u8b58SJS\u7684\u75c7\u72c0\u3001\u6210\u56e0\u53ca\u6cbb\u7642\uff0c\u4e26\u63a2\u8a0e\u5176\u5f15\u767c\u6bd2\u6027\u8868\u76ae\u6eb6\u89e3\u4e4b\u6a5f\u8f49\u3002<\/p>\n","protected":false},"author":20,"featured_media":36020,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4795,4798,4796,4797,4799],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/12\/641313.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36019"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36019"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36019\/revisions"}],"predecessor-version":[{"id":36023,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/36019\/revisions\/36023"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/36020"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=36019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=36019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}