{"id":35889,"date":"2020-12-10T00:45:23","date_gmt":"2020-12-09T16:45:23","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35889"},"modified":"2020-11-24T11:16:10","modified_gmt":"2020-11-24T03:16:10","slug":"c-%e5%9e%8b%e8%82%9d%e7%82%8e%e7%97%85%e6%af%92%e7%9a%84%e7%99%bc%e7%8f%be%e6%ad%b7%e7%a8%8b%e5%8f%8a%e8%87%b4%e7%97%85%e6%a9%9f%e8%bd%89","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35889","title":{"rendered":"C \u578b\u809d\u708e\u75c5\u6bd2\u7684\u767c\u73fe\u6b77\u7a0b\u53ca\u81f4\u75c5\u6a5f\u8f49"},"content":{"rendered":"

2020\u5e74\u5ea6\u8afe\u8c9d\u723e\u751f\u7406\u91ab\u5b78\u734e\u5df2\u63ed\u66c9\u7531\u767c\u73feC\u578b\u809d\u708e\u75c5\u6bd2\uff08hepatitis C virus, HCV\uff09\u7684\u963f\u7279\u723e\uff08Harvey Alter\uff09\u3001\u8cc0\u9813\uff08Michael Houghton\uff09\u53ca\u840a\u65af\uff08Charles Rice\uff09\u4e09\u4f4d\u5b78\u8005\u5171\u540c\u7372\u5f97\u6b8a\u69ae\u3002\u85c9\u7531\u8840\u6db2\u50b3\u64ad\uff08blood-borne\uff09\u7684C\u578b\u809d\u708e\u5bb9\u6613\u8f49\u8b8a\u6210\u6162\u6027\u809d\u708e\u3001\u809d\u786c\u5316\u53ca\u809d\u764c\uff0c\u767c\u75c5\u7387\u53ca\u81f4\u6b7b\u7387\u5747\u6975\u9ad8\uff0c\u6bcf\u5e74\u5728\u5168\u4e16\u754c\u596a\u8d70\u4e0a\u767e\u842c\u689d\u4eba\u547d\u3002HCV\u7684\u767c\u73fe\u5c0dC\u578b\u809d\u708e\u7684\u6d41\u884c\u6027\u3001\u81f4\u75c5\u6027\u53ca\u6cbb\u7642\u7684\u7814\u7a76\u6975\u70ba\u95dc\u9375\uff0c\u6211\u5011\u5c07\u5728\u672c\u6587\u4e2d\u63a2\u7d22HCV\u767c\u73fe\u7684\u6b77\u7a0b\u3001\u53ef\u80fd\u7684\u81f4\u75c5\u6a5f\u8f49\u53ca\u85e5\u7269\u3001\u75ab\u82d7\u958b\u767c\u4e4b\u6311\u6230\u3002<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n

C<\/strong>\u578b\u809d\u708e\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

C\u578b\u809d\u708e\u662f\u7531HCV\uff08\u57fa\u56e0\u9ad4\u70ba\u7d049.5 kb\u5927\u5c0f\u7684RNA\uff09\u611f\u67d3\u6240\u5f15\u8d77\u7684\uff0c\u611f\u67d3\u5f8c\u7d0420-30%\u60a3\u8005\u53ef\u80fd\u51fa\u73fe\u3001\u5641\u5fc3\u3001\u5614\u5410\u3001\u75b2\u5026\u3001\u53ad\u98df\u3001\u767c\u71d2\u6216\u9ec3\u75b8\u7b49\u75c7\u72c0\uff0c\u75be\u75c5\u56b4\u91cd\u5ea6\u53ef\u5f9e\u96b1\u7d04\u7684\u75c7\u72c0\u5230\u81f4\u547d\u7684\u731b\u7206\u6027\u809d\u708e\u3002\u7576\u8840\u6db2\u4e2dHCV\u6297\u9ad4(anti-HCV)\u5448\u73fe\u967d\u6027\u6301\u7e8c6\u500b\u6708\u4ee5\u4e0a\uff0c\u4e14\u53ef\u5728\u8840\u6db2\u6aa2\u9a57\u5230HCV\uff0c\u8868\u793a\u70ba\u6162\u6027C\u578b\u809d\u708e\u611f\u67d3\u8005\uff0c\u5176\u4e2d\u7d0470-80\uff05\u53ef\u80fd\u9032\u4e00\u6b65\u60e1\u5316\u6210\u809d\u786c\u5316\u6216\u809d\u764c\u3002HCV\u4e3b\u8981\u662f\u7d93\u7531\u8840\u6db2\u50b3\u67d3\uff0c\u6545\u8207\u4ed6\u4eba\u5171\u7528\u6ce8\u5c04\u5668\u3001\u63a5\u53d7\u6c61\u67d3\u4e4b\u8840\u6db2\uff08\u6216\u8840\u6db2\u88fd\u5291\uff09\u53ca\u4f7f\u7528\u6ec5\u83cc\u4e0d\u5b8c\u5168\u4e4b\u5668\u68b0\u5747\u53ef\u80fd\u53d7\u5230\u611f\u67d3\uff0c\u800c\u8207C\u578b\u809d\u708e\u611f\u67d3\u8005\u767c\u751f\u6027\u63a5\u89f8\u6216\u7d93\u7531\u6bcd\u5b50\u7684\u5782\u76f4\u611f\u67d3\u4ea6\u70ba\u53ef\u80fd\u7684\u611f\u67d3\u9014\u5f91\u3002HCV\u662f\u8207B\u578b\u809d\u708e\u75c5\u6bd2\uff08hepatitis B virus, HBV\uff09\u540c\u70ba\u4e3b\u8981\u7d93\u7531\u8840\u6db2\u50b3\u67d3\u7684\u75c5\u6bd2\uff0c\u4f46\u76ee\u524dC\u578b\u809d\u708e\u5df2\u9010\u6f38\u53d6\u4ee3B\u578b\u809d\u708e\uff0c\u6210\u70ba\u6162\u6027\u809d\u708e\u7684\u4e3b\u8981\u539f\u56e0\uff0c1999\u5e74\u7684\u79d1\u5b78\uff08Science\uff09\u96dc\u8a8c\u751a\u81f3\u5c07HCV\u5c0d\u65bc\u5168\u4e16\u754c\u4eba\u985e\u7684\u5065\u5eb7\u5a01\u8105\uff0c\u6bd4\u55bb\u70ba\u53e6\u4e00\u7a2e\u611b\u6ecb\u75c5\u6bd2\uff08human immunodeficient virus\uff09\uff0c\u53ef\u898b\u5176\u9020\u6210\u7684\u885d\u64ca\u975e\u5e38\u91cd\u5927\u3002<\/p>\n

HCV<\/strong>\u7684\u767c\u73fe<\/strong><\/span><\/p>\n

\u57281940\u5e74\u4ee3\uff0c\u4eba\u985e\u4fbf\u5c07\u50b3\u67d3\u6027\u809d\u708e\u5340\u5206\u70ba\u5169\u5927\u985e\uff1a(1)A\u578b\u809d\u708e\uff1a\u50b3\u67d3\u6e90\u70ba\u906d\u611f\u67d3\u8005\u6c61\u67d3\u7684\u98df\u7269\u3001\u98f2\u6c34\u6216\u5176\u6392\u6cc4\u7269\uff1b(2)\u8840\u6e90\u6027\u809d\u708e\uff1a\u85c9\u7531\u8840\u6db2\u6216\u9ad4\u6db2\u50b3\u64ad\u7684\u809d\u708e\uff0c\u5c0e\u81f4\u6162\u6027\u809d\u708e\uff0c\u751a\u81f3\u767c\u5c55\u70ba\u809d\u786c\u5316\u3001\u809d\u764c\uff0c\u5728\u56b4\u91cd\u4f75\u767c\u75c7\u51fa\u73fe\u524d\uff0c\u5e7e\u7121\u4efb\u4f55\u75c7\u72c0\u3002\u57281960\u5e74\u4ee3\uff0c\u7f8e\u570b\u5b78\u8005\u5e03\u9686\u4f2f\u683c\uff08Baruch Blumberg\uff09\u78ba\u7acb\u4e86\u90e8\u5206\u8840\u6e90\u6027\u809d\u708e\u7684\u75c5\u539f\u70baHBV\uff0c\u4fc3\u9032\u8840\u6db2\u6aa2\u6e2c\u548cB\u578b\u809d\u708e\u75ab\u82d7\u7684\u767c\u5c55\uff0c\u4e26\u57281976\u5e74\u88ab\u6388\u4e88\u8afe\u8c9d\u723e\u91ab\u5b78\u734e\u6b8a\u69ae\u3002\u7136\u800c\uff0c\u5728\u5df2\u77e5\u7684A\u578b\u548cB\u578b\u809d\u708e\u4e4b\u5916\uff0c\u53e6\u6709\u4e00\u7a2e\u75c5\u539f\u9ad4\u4e0d\u660e\u7684\u809d\u708e\u5c1a\u672a\u88ab\u91d0\u6e05\u800c\u7a31\u4e4b\u70ba\u300c\u975eA\u975eB\u578b\u809d\u708e\u300d\u30022020\u5e743\u4f4d\u8afe\u8c9d\u723e\u91ab\u5b78\u734e\u5f97\u4e3b\u7684\u958b\u5275\u6027\u767c\u73fe\uff0c\u5373\u70ba\u9996\u5ea6\u767c\u73fe\u6b64\u7a2e\u4e0d\u660e\u75c5\u539f\u9ad4\u70baHCV\u3002HCV\u548c\u5176\u4ed6\u5df2\u77e5\u7684\u809d\u708e\u75c5\u6bd2\u6bd4\u8f03\u5982\u4e0b\u8868\u3002<\/p>\n

\"\"<\/p>\n

HCV<\/strong>\u611f\u67d3\u53ef\u80fd\u7684\u81f4\u75c5\u6a5f\u8f49\u8207\u85e5\u7269<\/strong>\u3001<\/strong>\u75ab\u82d7\u958b\u767c\u4e4b\u6311\u6230<\/strong><\/span><\/p>\n

HCV\u662f\u4e00\u7a2e\u975e\u7d30\u80de\u75c5\u8b8a\u6027\u75c5\u6bd2\uff08non-cytopathic virus\uff09\uff0c\u81f4\u75c5\u6a5f\u8f49\u53d7\u5bbf\u4e3b\u7684\u514d\u75ab\u529b\u548c\u4ee3\u8b1d\u8b8a\u5316\u7684\u8abf\u7bc0\uff0c\u5305\u62ec\u6c27\u5316\u523a\u6fc0\uff08oxidative stress\uff09\u3001\u80f0\u5cf6\u7d20\u62b5\u6297\uff08insulin resistance\uff09\u548c\u809d\u8102\u80aa\u8b8a\u6027\uff08hepatic steatosis\uff09\u3002\u5148\u5929\u6027\u514d\u75ab\u548c\u9069\u61c9\u6027\u514d\u75ab\u5747\u6703\u5728HCV\u81f4\u75c5\u6a5f\u8f49\u4e2d\u5f15\u8d77\u91cd\u8981\u4f5c\u7528\uff0c\u7d30\u80de\u6bd2\u6027\u6dcb\u5df4\u7d30\u80de\u5728\u75c5\u6bd2\u6d88\u9664\uff08eradication\uff09\u6216\u6301\u7e8c\uff08persistence\uff09\u904e\u7a0b\u4e2d\u986f\u793a\u51fa\u81f3\u95dc\u91cd\u8981\u7684\u6d3b\u6027\uff0c\u4e26\u53d7\u5230\u75c5\u6bd2\u86cb\u767d\u3001HCV\u6e96\u7a2e\uff08quasispecies\uff09\u548c\u8abf\u7bc0\u809d\u81df\u4ee3\u8b1d\u7684\u591a\u7a2e\u56e0\u5b50\u5f71\u97ff\u3002HCV\u611f\u67d3\u4e4b\u81f4\u75c5\u6a5f\u8f49\u4ecd\u672a\u5341\u5206\u6e05\u695a\uff0c\u4f46\u5927\u591a\u6578\u79d1\u5b78\u5bb6\u8a8d\u70ba\u5176\u4e26\u975e\u76f4\u63a5\u7d30\u80de\u6bd2\u6027\u4e4b\u75c5\u6bd2\uff0c\u800c\u61c9\u8207\u809d\u7d30\u80de\u53d7\u5230\u50b7\u5bb3\u548c\u5bbf\u4e3b\u514d\u75ab\u653b\u64ca\u6709\u95dc\u3002\u56e0\u6b64\uff0cHCV\u81f4\u75c5\u6a5f\u8f49\u975e\u5e38\u8907\u96dc\uff0c\u4ecd\u9700\u9032\u4e00\u6b65\u7814\u7a76\u4ee5\u78ba\u5b9a\u5176\u6d89\u53ca\u7684\u56e0\u7d20\u3002<\/p>\n

\u8207HBV\u76f8\u6bd4\uff0cHCV\u9032\u5165\u809d\u7d30\u80de\u662f\u4e00\u500b\u9ad8\u5ea6\u7cbe\u5fc3\u7b56\u5283\u7684\u904e\u7a0b\uff0c\u6d89\u53ca\u75c5\u6bd2\u548c\u5bbf\u4e3b\u7d30\u80de\u56e0\u5b50\uff0c\u5305\u62ec\u75c5\u6bd2\u5916\u5957\u819c\u91a3\u86cb\u767d\uff08envelope glycoprotein\uff09E1\u548cE2\u3001CD81\u3001\u6e05\u9053\u592b\u53d7\u9ad4\uff08scavenger receptor\uff09B\u53ca\u7dca\u5bc6\u9023\u63a5\u86cb\u767d\uff08tight junction protein\uff09claudin-1\u548coccludin\u3002\u81e8\u5e8a\u524d\u6a21\u578b\u548c\u611f\u67d3\u60a3\u8005\u7684\u7814\u7a76\u986f\u793a\uff0cHCV\u5df2\u767c\u5c55\u51fa\u591a\u7a2e\u7b56\u7565\u4f86\u9003\u907f\u5bbf\u4e3b\u514d\u75ab\u53cd\u61c9\uff0c\u5176\u4e2d\u5305\u62ec\u907f\u514d\u4e2d\u548c\u6297\u9ad4\u7684\u4f5c\u7528\u53ca\u7d93\u7531\u7d30\u80de\u9593\u4f86\u50b3\u64ad\uff08cell-cell transmission\uff09\u3002HCV\u53ef\u85c9\u7531\u7279\u6b8a\u7684\u6a5f\u5236\u5c07\u91cd\u8981\u7684\u57fa\u56e0\u96b1\u85cf\u8d77\u4f86\uff0c\u4e26\u4fdd\u6301\u5176\u76f8\u5c0d\u7a69\u5b9a\uff0c\u800c\u628a\u514d\u75ab\u7cfb\u7d71\u53ef\u4ee5\u767c\u63ee\u4f5c\u7528\u7684\u6297\u539f\uff08\u5982\u5916\u5957\u819c\u91a3\u86cb\u767dE2\uff09\u5448\u73fe\u5728\u5bb9\u6613\u767c\u751f\u8b8a\u7570\u7684\u4f4d\u7f6e\uff0c\u5f62\u6210\u4e00\u500b\u9ad8\u5ea6\u8b8a\u7570\u5340\u3002HCV\u5728\u8907\u88fd\u904e\u7a0b\u6642\u5e38\u767c\u751f\u8b8a\u7570\uff0c\u4f7f\u5f97\u5bbf\u4e3b\u5c0d\u539f\u75c5\u6bd2\u6297\u539f\u7522\u751f\u7684\u6297\u9ad4\u5f88\u5feb\u4fbf\u5931\u6548\uff0c\u5f9e\u800c\u9003\u907f\u514d\u75ab\u7cfb\u7d71\u7684\u653b\u64ca\uff0c\u9020\u6210\u75c5\u6bd2\u611f\u67d3\u4eba\u9ad4\u5f8c\u96e3\u4ee5\u6e05\u9664\uff0c\u6210\u70ba\u6162\u6027\u611f\u67d3\u8005\u3002\u56e0\u6b64\uff0c\u81f3\u4eca\u5c1a\u7121HCV\u75ab\u82d7\uff0c\u5b8c\u5168\u6709\u6548\u6cbb\u7642C\u578b\u809d\u708e\u7684\u65b9\u6cd5\u4ecd\u5728\u6301\u7e8c\u958b\u767c\u4e2d\u3002<\/p>\n

HCV\u611f\u67d3\u809d\u7d30\u80de\u5f8c\u7684\u6eb6\u7d30\u80de\u4f5c\u7528\uff08cytolysis\uff09\u662f\u7531\u5bbf\u4e3b\u7684\u6bd2\u6027T\u6dcb\u5df4\u7d30\u80de\uff08cytotoxic T lymphocyte, CTL\uff09\u548c\u81ea\u7136\u6bba\u624b\uff08natural killer, NK\uff09\u7d30\u80de\u5206\u6ccc\u7684\u7a7f\u5b54\u7d20\uff08perforin\uff09\u548c\u9846\u7c92\u9176\uff08granzyme\uff09\u8abf\u63a7\u7684\uff0c\u800c\u975e\u6eb6\u7d30\u80de\u6027\u7684HCV\u6e05\u9664\u662f\u7531CTL\u548cNK\u7d30\u80de\u5206\u6ccc\u7684\u5e72\u64fe\u7d20\u03b3\uff08interferon -\u03b3\uff09\u8abf\u63a7\u7684\u3002\u5bbf\u4e3b\u8207HCV\u7684\u76f8\u4e92\u4f5c\u7528\u6c7a\u5b9a\u4e86\u611f\u67d3\u7684\u6025\u6027\u671f\u662f\u5426\u6703\u5b8c\u5168\u6d88\u9000\u6216\u6210\u70ba\u6301\u4e45\u6027\u75c5\u6bd2\u611f\u67d3\uff0c\u9032\u800c\u767c\u5c55\u70ba\u6162\u6027HCV\u611f\u67d3\u3002\u6b64\u5916\uff0c\u9019\u4e9b\u5bbf\u4e3b\u8207HCV\u7684\u76f8\u4e92\u4f5c\u7528\u6703\u9020\u6210\u6e05\u9664\u75c5\u6bd2\u611f\u67d3\u7684\u514d\u75ab\u53cd\u61c9\u5931\u6557\u53ca\u4fc3\u9032\u75c5\u6bd2\u6301\u4e45\u6027\u7684\u611f\u67d3\uff0c\u4ea6\u53ef\u80fd\u5c0dHCV\u75ab\u82d7\u7684\u958b\u767c\u69cb\u6210\u6311\u6230\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

1. Georgel P, Schuster C, Zeisel MB, Stoll-Keller F, Berg T, Bahram S, Baumert TF. Virus-host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies. Trends Mol Med. 2010 Jun;16(6):277-86. doi: 10.1016\/j.molmed.2010.04.003. Epub 2010 May 25.<\/p>\n

    \n
  1. Irshad M, Mankotia DS, Irshad K. An insight into the diagnosis and pathogenesis of hepatitis C virus infection.<\/a> World J Gastroenterol. 2013 Nov 28;19(44):7896-909. doi: 10.3748\/wjg.v19.i44.7896.<\/li>\n
  2. Pol S, Lagaye S. The remarkable history of the hepatitis C virus. Genes Immun. 2019 May;20(5):436-446. doi: 10.1038\/s41435-019-0066-z. Epub 2019 Apr 25.<\/li>\n
  3. Chigbu DI, Loonawat R, Sehgal M, Patel D, Jain P. Hepatitis C virus infection: Host\u2013virus interaction and mechanisms of viral persistence. Cells. 2019 Apr 25;8(4):376. doi: 10.3390\/cells8040376.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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