{"id":35731,"date":"2020-11-04T00:29:19","date_gmt":"2020-11-03T16:29:19","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35731"},"modified":"2020-11-02T14:36:09","modified_gmt":"2020-11-02T06:36:09","slug":"%e8%83%b0%e8%87%9f%e7%99%8c%e8%88%87%e9%ab%98%e7%b3%96%e7%9a%84%e9%97%9c%e4%bf%82","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35731","title":{"rendered":"\u80f0\u81df\u764c\u8207\u9ad8\u7cd6\u7684\u95dc\u4fc2"},"content":{"rendered":"

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\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n

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\u9020\u6210\u80f0\u81df\u764c\u7684\u539f\u56e0\u81f3\u4eca\u4ecd\u4e0d\u660e\u78ba\uff0c\u4f46\u53ef\u80fd\u7684\u5371\u96aa\u56e0\u5b50\u5305\u62ec\u5e74\u9f61\uff08\u5927\u65bc60\u6b72\uff09\u3001\u62bd\u83f8\u3001\u559d\u9152\u3001\u6162\u6027\u80f0\u81df\u708e\u3001\u7cd6\u5c3f\u75c5\u3001\u66fe\u63a5\u53d7\u80c3\u90e8\u5207\u9664\u624b\u8853\u3001\u9577\u6642\u9593\u63a5\u89f8\u5316\u5b78\u54c1\u53ca\u7279\u6b8a\u98f2\u98df\u7fd2\u6163\uff08\u5982\u611b\u5403\u7d05\u8089\u3001\u9ad8\u8102\u53ca\u9ad8\u7cd6\u98df\u54c1\uff09\u7b49\uff0c\u76f8\u95dc\u7814\u7a76\u4ecd\u5728\u6301\u7e8c\u9032\u884c\u4e2d\uff0c\u5176\u4e2d\u4ee5\u9ad8\u7cd6\u8207\u80f0\u81df\u764c\u7684\u95dc\u4fc2\u662f\u8fd1\u4f86\u7814\u7a76\u7684\u91cd\u9ede\u3002<\/p>\n

KRAS<\/em>\u57fa\u56e0\u662f\u4fc3\u9032\u7d30\u80de\u751f\u9577\u8207\u5b58\u6d3b\u7684\u57fa\u56e0\uff0c\u7576\u5176\u767c\u751f\u7a81\u8b8a\u6642\uff0c\u7d30\u80de\u5206\u88c2\u6703\u96e3\u4ee5\u63a7\u5236\u800c\u53ef\u80fd\u9020\u6210\u816b\u7624\u7d30\u80de\u751f\u6210\uff0c\u81e8\u5e8a\u4e0a\u5df2\u767c\u73fe\u8d85\u904e90%\u7684\u80f0\u817a\u764c\u75c5\u4eba\u6aa2\u9ad4\u6709KRAS<\/em>\u57fa\u56e0\u7a81\u8b8a\u3002\u57282019\u5e74\uff0c\u53f0\u7063\u7814\u7a76\u4eba\u54e1\u5728\u52d5\u7269\u5be6\u9a57\u4e2d\uff0c\u767c\u73fe\u82e5\u9577\u671f\u9935\u98df\u5c0f\u9f20\u9ad8\u7cd6\u9ad8\u8102\u7684\u98df\u7269\u9020\u6210\u5176\u9ad8\u8840\u7cd6\u5f8c\uff0c\u5c0f\u9f20\u7684\u4e3b\u8981\u5668\u5b98\u53ea\u6709\u80f0\u81df\u6703\u51fa\u73fe\u660e\u986f\u57fa\u56e0\u7d44\u53d7\u640d\u548cKRAS<\/em>\u57fa\u56e0\u7a81\u8b8a\u7684\u72c0\u6cc1\u3002\u4ed6\u5011\u518d\u7528\u6b63\u5e38\u7684\u80f0\u81df\u7d30\u80de\u4f5c\u5be6\u9a57\uff0c\u6295\u8207\u9ad8\u6fc3\u5ea6\u7684\u7cd6\u3001\u86cb\u767d\u8cea\u53ca\u8102\u80aa\u4f5c\u70ba\u57f9\u990a\u57fa\uff0c\u7d50\u679c\u986f\u793a\u53ea\u6709\u9ad8\u7cd6\u6703\u8b93\u80f0\u81df\u7d30\u80de\u7522\u751f\u57fa\u56e0\u7684\u8b8a\u7570\u3002\u9032\u4e00\u6b65\u7814\u7a76\u66f4\u767c\u73fe\u5728\u9ad8\u7cd6\u74b0\u5883\u4e0b\uff0c\u7d30\u80de\u5167\u7684O-GlcNAcylation\u4f5c\u7528\u986f\u8457\u63d0\u9ad8\uff0c\u9019\u7a2e\u8f49\u8b6f\u5f8c\u4fee\u98fe\u6703\u964d\u4f4e\u6838\u7cd6\u6838\u82f7\u9178\u9084\u539f\u9176\uff08ribonucleotide reductase, RNR\uff09\u7684\u6d3b\u6027\uff0c\u4f7f\u5f97\u5408\u6210\u57fa\u56e0\u751f\u6210\u548c\u8907\u88fd\u6240\u9700\u7684\u56db\u7a2e\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u4e09\u78f7\u9178\uff08deoxy-ribonucleoside triphosphate, dNTP\uff09\u7684\u91cf\u5747\u660e\u986f\u964d\u4f4e\u3002\u751f\u7522dNTP\u7684\u88fd\u7a0b\u88ab\u904e\u591a\u7684\u7cd6\u6240\u64fe\u4e82\uff0c\u9020\u6210\u4e86dNTP\u7684\u77ed\u7f3a\uff0c\u4f7f\u5f97\u5728\u80f0\u81df\u7d30\u80de\u7684\u57fa\u56e0\u7d44\u8907\u88fd\u904e\u7a0b\u4e2d\uff0c\u7576\u6709\u640d\u50b7\u9700\u8981\u4fee\u88dc\u6642\uff0c\u56e0\u539f\u6599\u4e0d\u8db3\u800c\u767c\u751f\u932f\u8aa4\uff0c\u5c0e\u81f4KRAS<\/em>\u57fa\u56e0\u7a81\u8b8a\uff0c\u5f15\u767c\u80f0\u81df\u7d30\u80de\u7684\u764c\u5316\u3002<\/p>\n

\u753e\u9187\u8abf\u7bc0\u5143\u4ef6\u7d50\u5408\u86cb\u767d1\uff08sterol regulatory element binding protein 1, SREBP1\uff09\u662f\u53c3\u8207\u8102\u8cea\u4ee3\u8b1d\u548c\u816b\u7624\u64f4\u5c55\u7684\u91cd\u8981\u8f49\u9304\u56e0\u5b50\uff08transcription factor\uff09\uff0c\u4f46\u662f\u5728\u9ad8\u7cd6\u5fae\u74b0\u5883\uff08high glucose microenvironment\uff09\u4e0b\uff0cSREBP1\u548c\u80f0\u817a\u764c\u7684\u95dc\u4fc2\u4ecd\u6709\u5f85\u4e86\u89e3\u3002\u57282019\u5e74\uff0c\u4e2d\u570b\u7814\u7a76\u4eba\u54e1\u5728\u7279\u5b9a\u57f9\u990a\u57fa\u4e2d\u57f9\u990a\u80f0\u81df\u764c\u7d30\u80de\uff0c\u4f7f\u7528\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u6cd5\uff08mmunohistochemistry\uff09\u548c\u897f\u65b9\u58a8\u9ede\u6cd5\uff08\u86cb\u767d\u8cea\u8f49\u6f2c\u6cd5\uff0cWestern blotting\uff09\u4f86\u6aa2\u6e2cSREBP1\u7684\u8868\u73fe\u3002\u4ed6\u5011\u767c\u73fe\u9ad8\u8840\u7cd6\u6c34\u5e73\u8207\u80f0\u817a\u764c\u60a3\u8005\u7684\u9810\u5f8c\u4e0d\u826f\u6709\u5bc6\u5207\u95dc\u4fc2\uff0cSREBP1\u5728\u80f0\u817a\u764c\u7d44\u7e54\u548c\u7d30\u80de\u4e2d\u5747\u8868\u73fe\u904e\u91cf\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\u9ad8\u7cd6\u5fae\u74b0\u5883\u6703\u85c9\u7531\u589e\u5f37SREBP1\u7684\u8868\u73fe\uff0c\u4f86\u4fc3\u9032\u816b\u7624\u589e\u6b96\u3001\u6291\u5236\u7d30\u80de\u51cb\u4ea1\uff08apoptosis\uff09\u53ca\u964d\u4f4e\u81ea\u566c\uff08autophagy\uff09\u6c34\u5e73\u3002\u6b64\u5916\uff0c\u81ea\u566c\u7684\u6fc0\u6d3b\uff08activation\uff09\u6703\u52a0\u901fSREBP1\u7684\u8868\u73fe\uff0c\u4e26\u6291\u5236\u7d30\u80de\u51cb\u4ea1\uff0c\u9019\u610f\u5473\u8457SREBP1\u53ef\u80fd\u662f\u80f0\u817a\u764c\u9810\u9632\u548c\u6cbb\u7642\u7684\u65b0\u76ee\u6a19\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Zhou C, Qian W, Li J, Ma J, Chen X, Jiang Z, Cheng L, Duan W, Wang Z, Wu Z, Ma Q, Li X. High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer. J Exp Clin Cancer Res. 2019 Jul 11;38(1):302. doi: 10.1186\/s13046-019-1288-7.<\/li>\n
  2. Hu CM, Tien SC, Hsieh PK, Jeng YM, Chang MC, Chang YT, Chen YJ, Chen YJ, Lee EYP, Lee WH. High glucose triggers nucleotide imbalance through O-GlcNAcylation of key enzymes and induces KRAS mutation in pancreatic cells. Cell Metab. 2019 Jun 4;29(6):1334-1349.e10. doi: 10.1016\/j.cmet.2019.02.005. Epub 2019 Mar 7.<\/li>\n<\/ol>\n
      \n
    1. Ansari D, Tingstedt B, Andersson B, Holmquist F, Sturesson C, Williamsson C, Sasor A, Borg D, Bauden M, Andersson R. Pancreatic cancer yesterday, today and tomorrow. Future Oncol. 2016 Aug;12(16):1929-46. doi: 10.2217\/fon-2016-0010. Epub 2016 Jun 1.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      \u96a8\u8457\u4eba\u53e3\u8001\u5316\u53ca\u98f2\u98df\u897f\u5316\uff0c\u8fd1\u5e74\u570b\u5167\u80f0\u81df\u764c\u60a3\u8005\u6709\u9010\u6f38\u589e\u52a0\u7684\u8da8\u52e2\u3002\u80f0\u81df\u764c\u662f\u4e00\u7a2e\u60e1\u6027\u6975\u9ad8\u7684\u764c\u75c7\u4e26\u6709\u300c\u764c\u738b\u300d\u4e4b\u7a31\uff0c\u6709\u8d85\u904e85 %\u7684\u60a3\u8005\u7121\u6cd5\u4ee5\u624b\u8853\u9032\u884c\u6cbb\u7642\uff0c\u4e94\u5e74\u7684\u5b58\u6d3b\u7387\u5e73\u5747\u66f4\u662f\u4f4e\u65bc5%\u3002\u7136\u800c\uff0c\u81f4\u764c\u5371\u96aa\u56e0\u5b50\u7684\u7814\u7a76\u6709\u52a9\u65bc\u80f0\u81df\u764c\u7684\u9810\u9632\u53ca\u6cbb\u7642\uff0c\u6211\u5011\u5728\u672c\u6587\u5c07\u5f15\u9818\u8b80\u8005\u8a8d\u8b58\u80f0\u81df\u764c\uff0c\u4e26\u63a2\u7d22\u80f0\u81df\u764c\u8207\u9ad8\u7cd6\u7684\u95dc\u4fc2\u3002<\/p>\n","protected":false},"author":20,"featured_media":35734,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4733,4734,4735,4731],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/7986464.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35731"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35731"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35731\/revisions"}],"predecessor-version":[{"id":35735,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35731\/revisions\/35735"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35734"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}