{"id":35730,"date":"2020-10-13T00:29:18","date_gmt":"2020-10-12T16:29:18","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35730"},"modified":"2020-10-08T10:12:18","modified_gmt":"2020-10-08T02:12:18","slug":"%e8%82%ba%e7%99%8c%e6%9c%89%e5%8f%af%e8%83%bd%e6%98%af%e5%90%83%e5%87%ba%e4%be%86%e7%9a%84%e5%97%8e","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35730","title":{"rendered":"\u80ba\u764c\u6709\u53ef\u80fd\u662f\u5403\u51fa\u4f86\u7684\u55ce ?"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u6839\u64da\u885b\u751f\u798f\u5229\u90e8\u7684\u7d71\u8a08\uff0c\u80ba\u764c\u5df2\u8e8d\u5c45\u6211\u570b\u7537\u5973\u6027\u764c\u75c7\u6b7b\u4ea1\u4eba\u6578\u7684\u7b2c\u4e00\u4f4d\uff0c\u4e00\u822c\u8a8d\u70ba\u5176\u767c\u751f\u8207\u5438\u83f8\uff08\u542b\u4e8c\u3001\u4e09\u624b\u83f8\uff09\u3001\u7a7a\u6c23\u6c59\u67d3\uff08\u542b\u5eda\u623f\u6cb9\u7159\uff09\u3001\u80ba\u90e8\u6162\u6027\u767c\u708e\u75be\u75c5\u3001\u907a\u50b3\u53ca\u9577\u671f\u66b4\u9732\u65bc\u81f4\u764c\u74b0\u5883\uff08 \u5982\u51b6\u91d1\u696d\u3001\u63a1\u7926\u696d\u53ca\u77f3\u7dbf\u3001\u653e\u5c04\u7dda\u63a5\u89f8\u8005\uff09\u6709\u5bc6\u5207\u76f8\u95dc\u6027\u3002\u5728\u53f0\u7063\uff0c\u8d85\u904e50\uff05\u7684\u60a3\u8005\u4e26\u672a\u62bd\u83f8\uff0c\u5176\u4e2d 93\uff05\u662f\u5973\u6027\uff0c\u50b3\u7d71\u4e0a\u8a8d\u70ba\u662f\u7a7a\u6c59\u53ca\u6cb9\u7159\u5c0e\u81f4\u7684\u3002\u4f46\u6700\u8fd1\u7684\u7814\u7a76\u986f\u793a\u9019\u4e9b\u4e0d\u5438\u83f8\u65cf\u7fa4\u7f79\u60a3\u80ba\u764c\u53ef\u80fd\u548c\u9ad4\u5167\u7684APOBEC\u57fa\u56e0\u767c\u751f\u7a81\u8b8a\u6709\u95dc\uff0c\u70ba\u80ba\u764c\u7684\u75c5\u56e0\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u65b9\u5411\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_35732\" aria-describedby=\"caption-attachment-35732\" style=\"width: 350px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-35732\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/94413.jpg\" alt=\"\" width=\"350\" height=\"464\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/94413.jpg 966w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/94413-226x300.jpg 226w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/94413-768x1018.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/94413-773x1024.jpg 773w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><figcaption id=\"caption-attachment-35732\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90: Pixabay<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u80ba\u764c\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n<p><a href=\"https:\/\/thebetteraging.businesstoday.com.tw\/article\/detail\/201907140003\/157885\/%E7%A2%BA%E8%A8%BA%E8%82%BA%E7%99%8C%E6%99%9A%E6%9C%9F%EF%BC%8C%E9%86%AB%E5%B8%AB%E5%AE%A3%E5%88%A4%E6%B4%BB%E4%B8%8D%E5%88%B0%E4%B8%80%E5%B9%B4%EF%BC%8173%E6%AD%B2%E9%98%BF%E5%AC%A4%E9%9D%A0%E9%80%991%E6%8B%9B%EF%BC%8C%E5%A4%9A%E6%B4%BB%E5%B9%BE%E5%B9%B4%E9%82%84%E8%83%BD%E5%87%BA%E9%96%80%E8%B6%B4%E8%B6%B4%E8%B5%B0\">\u80ba\u764c<\/a>\u53ef\u5206\u6210\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08Non-small-cell lung carcinoma, NSCLC, 85%\uff09\u53ca\u5c0f\u7d30\u80de\u80ba\u764c\uff08small-cell lung carcinoma, SCLC, 15%\uff09\u5169\u7a2e\uff0c\u524d\u8005\u4e3b\u8981\u5305\u62ec\u80ba\u817a\u764c\uff08adenocarcinomas\uff09\u3001\u9e9f\u72c0\u7d30\u80de\u80ba\u764c&nbsp;\uff08<a href=\"https:\/\/en.wikipedia.org\/wiki\/Squamous-cell_carcinoma\">squamous cell carcinoma<\/a>\uff09\u53ca\u5927\u7d30\u80de\u80ba\u764c\uff08large-cell carcinoma\uff09\uff0c\u5176\u4e2d\u4ee5\u80ba\u817a\u764c\u6700\u5e38\u898b\uff0c\u7d04\u4f5490%\u4ee5\u4e0a\u3002\u80ba\u764c\u65e9\u671f\u6c92\u6709\u75c7\u72c0\uff0c\u81e8\u5e8a\u4e0a\u6aa2\u6e2c\u80ba\u764c\u7684\u65b9\u6cd5\u6700\u5e38\u5229\u7528\u50b3\u7d71\u80ba\u90e8X\u5149\u6aa2\u67e5\uff0c\u4f46\u56e0\u654f\u611f\u6027\u4f4e\uff0c\u5f80\u5f80\u4e0d\u5bb9\u6613\u767c\u73fe\u5c0f\u65bc1\u516c\u5206\u7684\u816b\u7624\u3002\u7814\u7a76\u986f\u793a\u80ba\u764c\u57281\u516c\u5206\u5de6\u53f3\u4ee5\u624b\u8853\u5207\u9664\u7684\u6cbb\u7652\u7387\u7d04\u70ba85%~90% (\u4e94\u5e74\u4e0d\u5fa9\u767c)\uff0c\u800c\u4f4e\u5291\u91cf\u96fb\u8166\u65b7\u5c64\u6383\u63cf\uff08low dose computed tomography\uff09\u70ba\u76ee\u524d\u5c0d\u80ba\u764c\u6aa2\u67e5\u6700\u9748\u654f\u7684\u65b9\u6cd5\uff0c\u53ef\u5075\u6e2c\u5c0f\u81f30.3\u516c\u5206\u7684\u80ba\u90e8\u75c5\u8b8a\uff0c\u6709\u52a9\u65bc\u65e9\u671f\u8a3a\u65b7\u4e26\u8ffd\u8e64\u6cbb\u7642\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u4e0d\u5438\u83f8\u80ba\u764c\u60a3\u8005\u7684\u7814\u7a76<\/strong><\/span><\/p>\n<p>\u57282020\u5e74\uff0c\u53f0\u7063\u7814\u7a76\u4eba\u54e1\u4ee5\u86cb\u767d\u57fa\u56e0\u9ad4\uff08proteogenomic\uff09\u6280\u8853\u5206\u6790103\u540d\u4e0d\u5438\u83f8\u80ba\u817a\u764c\u60a3\u8005\uff0c\u5efa\u7acb\u65e9\u671f\u80ba\u764c\u75c5\u4eba\u7684\u751f\u7269\u5206\u6790\u6cd5\u5927\u6578\u64da\u3002\u4ed6\u5011\u7814\u7a76\u80ba\u817a\u764c\u4e94\u5927\u764c\u7d30\u80de\u57fa\u56e0\u7a81\u8b8a\u6027\u7279\u5fb5\uff08mutational signature\uff09\uff0c\u767c\u73fe\u767c\u751f\u7a81\u8b8a\u6700\u986f\u8457\u7684\u662fAPOBEC\uff08apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like\uff09\u7279\u5fb5\uff0c\u5b8c\u5168\u8207\u5438\u83f8\u7121\u95dc\u3002\u65e9\u671f\u8a8d\u70ba\u80ba\u764c\u767c\u75c5\u8207\u4e3b\u8981\u7684\u8868\u9762\u751f\u9577\u56e0\u5b50\u63a5\u53d7\u9ad4\uff08epidermal growth factor receptor, EGFR\uff09\u57fa\u56e0\u767c\u751f\u7a81\u8b8a\u6709\u95dc\uff0c\u70ba\u4e86\u95e1\u660e\u9019\u7a2e\u4eba\u53e3\u7d71\u8a08\u5b78\u4e0a\u4e0d\u540c\u7684\u75be\u75c5\u7684\u5206\u5b50\u8868\u578b\uff0c\u4ed6\u5011\u9032\u884c\u4e00\u500b\u524d\u77bb\u6027\u968a\u5217\uff08prospective cohort\uff09\u7684\u7814\u7a76\uff0c\u8a72\u968a\u5217\u4ee3\u8868\u65e9\u671f\u3001\u4ee5\u5973\u6027\u70ba\u4e3b\u53ca\u4e0d\u5438\u7159\u7684\u80ba\u817a\u764c\u60a3\u8005\u3002\u4ed6\u5011\u6574\u5408\u57fa\u56e0\u9ad4\u5b78\uff0c\u86cb\u767d\u8cea\u9ad4\u5b78\u548c\u78f7\u9178\u86cb\u767d\u8cea\u9ad4\u5b78\u4ee5\u5206\u6790\u4eba\u53e3\u7d71\u8a08\u5b78\u4e0a\u4e0d\u540c\u7684\u5206\u5b50\u5c6c\u6027\uff08molecular attribute\uff09\u548c\u816b\u7624\u9032\u5c55\u7684\u6a19\u8a8c\uff08hallmark\uff09\uff0c\u57fa\u56e0\u9ad4\u5206\u6790\u63ed\u793a\u4e86\u8207\u5e74\u9f61\u3001\u6027\u5225\u53ca\u74b0\u5883\u81f4\u764c\u7269\u76f8\u95dc\u7684\u7a81\u8b8a\u6a5f\u5236\uff0c\u5177\u9ad4\u8868\u73fe\u5728\u5e74\u8f15\u5973\u6027APOBEC&nbsp;\u7a81\u8b8a\u6027\u7279\u5fb5\u7684\u9ad8\u5ea6\u6d41\u884c\u7387\u53ca\u8001\u5e74\u5973\u6027\u66dd\u9732\u65bc\u74b0\u5883\u81f4\u764c\u7269\u800c\u5c0e\u81f4\u7a81\u8b8a\u6848\u4f8b\u7684\u589e\u591a\uff0c\u7814\u7a76\u7d50\u679c\u986f\u793a\u5c0f\u65bc\u516d\u5341\u6b72\u7684\u5973\u6027\u53d7APOBEC\u5f71\u97ff\u8f03\u5927\uff0c\u4f46\u9ad8\u65bc\u516d\u5341\u6b72\u5973\u6027\u5247\u53d7\u5230\u9577\u671f\u7d2f\u7a4d\u7684\u74b0\u5883\u56e0\u5b50\uff08\u5982\u7a7a\u6c59\u3001\u4e8c\u624b\u83f8\u7b49\uff09\u5f71\u97ff\u8f03\u5927\uff0c\u4ea6\u5373\u6e1b\u5c11\u63a5\u89f8<a href=\"https:\/\/health.udn.com\/health\/search\/%E8%87%B4%E7%99%8C%E7%89%A9\">\u81f4\u764c\u7269<\/a>\uff0c\u61c9\u662f\u9810\u9632\u80ba\u764c\u7684\u6709\u6548\u7b56\u7565\u4e4b\u4e00\u3002\u86cb\u767d\u8cea\u7d44\u5b78\u5206\u985e\u6709\u52a9\u65bc\u5340\u5206\u65e9\u671f\u60a3\u8005\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u81e8\u5e8a\u7279\u5fb5\uff1b\u6574\u5408\u7684\u86cb\u767d\u8cea\u7db2\u7d61\u5206\u6790\u5247\u63ed\u793a\u7d30\u80de\u91cd\u69cb\u7684\u57fa\u790e\uff0c\u5354\u52a9\u9451\u5225\u816b\u7624\u5f62\u6210\u7684\u6a19\u8a8c\u3001\u751f\u7269\u6a19\u8a18\u7269\uff08biomarker\uff09\u53ca\u4f5c\u70ba\u85e5\u7269\u4f5c\u7528\u7684\u6a19\u9776\u4f4d\u7f6e \uff08druggable target\uff09\uff0c\u53ef\u7528\u65bc\u60a3\u8005\u5206\u7d1a\u53ca\u63d0\u4f9b\u6cbb\u7642\u7684\u81e8\u5e8a\u65b9\u6cd5\u3002\u9019\u7a2e\u591a\u7d44\u5b78\u5206\u5b50\u7d50\u69cb\uff08multi-omic molecular architecture\uff09\u53ef\u80fd\u6709\u52a9\u65bc\u5236\u5b9a\u7b56\u7565\u4ee5\u7ba1\u7406\u4e0d\u5438\u7159\u8005\u7684\u65e9\u671f\u80ba\u817a\u764c\u3002<\/p>\n<p>\u57282020\u5e74\uff0c\u6bd4\u5229\u6642\u7814\u7a76\u4eba\u54e1\u6536\u96c6\u4e8646\u500b\u4e0d\u5438\u7159NSCLC\u60a3\u8005\u7684\u524d\u77bb\u6027\u968a\u5217\uff0c\u4e26\u5c0d\u80ba\u90e8\u816b\u7624\u548c\u5339\u914d\u7684\u7a2e\u7cfbDNA\u9032\u884c\u4e86\u5168\u5916\u986f\u5b50\u7d44\uff08whole exome\uff09\u548c\u4f4e\u8986\u84cb\u7387\u5168\u57fa\u56e0\u7d44\u5b9a\u5e8f\u3002\u8207\u5438\u7159\u8005\u76f8\u6bd4\uff0c\u4ed6\u5011\u89c0\u5bdf\u5230\u672a\u5438\u83f8\u8005\u7684\u80ba\u90e8\u816b\u7624\u8f03\u5c11\u767c\u751f\u9ad4\u7d30\u80de\u7a81\u8b8a\uff08somatic mutation\uff09\u3001\u8f03\u5c11\u7684\u57fa\u56e0\u7d44\u65b7\u88c2\u9ede\uff08genomic breakpoint\uff09\u53ca\u8f03\u5c0f\u90e8\u5206\u7684\u57fa\u56e0\u7d44\u67d3\u8272\u9ad4\u4e0d\u7a69\u5b9a\uff08chromosomal instability\uff09\uff0c\u4f7f\u5176\u80fd\u5920\u9451\u5225TSC22D1\uff08TSC22 domain family member 1\uff09\u70baNSCLC\u6f5b\u5728\u7684\u9a45\u52d5\u57fa\u56e0\u3002\u53e6\u5916\uff0c\u8207\u5438\u7159\u8005\u76f8\u6bd4\uff0c\u672a\u5438\u83f8\u8005\u7684EGFR\u548cERBB2\uff08receptor tyrosine-protein kinase\uff09\u7b49\u53ef\u64cd\u4f5c\u57fa\u56e0\u7684\u7a81\u8b8a\u7387\u53caMET\uff08mesenchymal-epithelial transition factor, which codes for a transmembrane tyrosine kinase known as an oncoprotein\uff09\u7684\u64f4\u589e\uff08amplification\uff09\u8f03\u9ad8\uff0c\u800cTP53\uff08\u4e00\u7a2e\u9810\u5f8c\u7684\u8ca0\u9762\u56e0\u5b50\uff09\u57fa\u56e0\u7684\u7a81\u8b8a\u7387\u5247\u8f03\u4f4e\uff0c\u7d50\u679c\u986f\u793a\u672a\u5438\u7159\u7684NSCLC\u60a3\u8005\u7684\u9810\u5f8c\u8f03\u597d\u3002\u9ad4\u7d30\u80de\u7a81\u8b8a\u5206\u70ba\u516d\u7a2e\u66ff\u4ee3\u985e\u578b\u6a21\u5f0f\uff08type pattern\uff09\u621696\u500b\u66ff\u4ee3\u985e\u578b\u7279\u5fb5\uff08type signature\uff09\u986f\u793a\u5438\u7159\u8005\u8207\u4e0d\u5438\u7159\u8005\u4e4b\u9593\u6709\u660e\u986f\u7684\u5340\u5225\uff0c\u7279\u5225\u662f\u4ed6\u5011\u9451\u5225\u51fa\u4f86\u672a\u5438\u7159\u8005\u7684\u8001\u5316\u3001\u540c\u6e90\u91cd\u7d44\u640d\u50b7\uff08homologous recombination damage\uff09\u53caAPOBEC \/ AID\uff08a family of cytidine deaminases that mutate RNA and DNA at distinct preferred nucleotide contexts \u201chotspots\u201d\uff09\u6d3b\u6027\u662f\u5c0e\u81f4NSCLC\u6700\u91cd\u8981\u7684\u539f\u56e0\uff0c\u800c\u4e14\u4e8c\u624b\u7159\u4e26\u4e0d\u662f\u672a\u5438\u83f8\u8005\u7f79\u60a3NSCLC\u7684\u81f4\u75c5\u56e0\u5b50\u3002\u5c0d\u672a\u5438\u7159\u8005\u8207\u5438\u7159\u8005\u7684NSCLC\u9032\u884c\u6bd4\u8f03\uff0c\u7e3d\u7d50\u7d50\u679c\u5982\u4e0b\uff1a\uff081\uff09\u986f\u8457\u8f03\u5c11\u7684\u7a81\u8b8a\u3001\u65b7\u88c2\u9ede\u548c\u62f7\u8c9d\u6578\uff08copy number\uff09\u4e0d\u7a69\u5b9a\uff1b\uff082\uff09\u9ad4\u7d30\u80de\u7a81\u8b8a\u4e0d\u540c\u7684\u516d\u7a2e\u66ff\u4ee3\u985e\u578b\u6a21\u5f0f\u548c96\u500b\u66ff\u4ee3\u985e\u578b\u7279\u5fb5\u53ef\u4ee5\u5340\u5206\u51fa\u4f86\uff0c\u4e26\u6307\u51fa\u4e0d\u540c\u7684\u75c5\u56e0\uff1b\uff083\uff09EGFR\u3001ERBB2\u53caTP53\u7b49\u57fa\u56e0\u7684\u7a81\u8b8a\u7387\u4e0d\u540c\uff1b\uff084\uff09TSC22D1\u53ef\u4ee5\u8a8d\u70ba\u662f\u975e\u5438\u7159NSCLC\u60a3\u8005\u7684\u65b0\u9a45\u52d5\u7a81\u8b8a\uff08driver mutation\uff09\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u7d50\u8ad6<\/strong><\/span><\/p>\n<p>\u80ba\u764c\u5df2\u9023\u7e8c\u591a\u5e74\u5728\u4e16\u754c\u4e0a\u4f4d\u5c45\u5169\u6027\u5341\u5927\u764c\u75c7\u6b7b\u56e0\u4e4b\u9996\uff0c\u5176\u4e2d\u6771\u4e9e\u7684\u80ba\u764c\u66f4\u88ab\u8a8d\u70ba\u662f\u4e0d\u540c\u7684\u75be\u75c5\uff0c\u56e0\u70ba\u6709\u9ad8\u905460%\u75c5\u60a3\u6709EGFR\u7a81\u8b8a\u4e14\u4e26\u672a\u5438\u83f8\uff0c\u800c\u5728\u897f\u65b9\u570b\u5bb6\u5247\u50c5\u6709\u4e0d\u523020\uff05\u6709EGFR\u7a81\u8b8a\u4e14\u591a\u70ba\u5438\u83f8\u6240\u5f15\u8d77\u3002\u5728\u53f0\u7063\uff0c\u4e0d\u5438\u83f8\u7f79\u60a3\u80ba\u764c\u7684\u60a3\u8005\u6bd4\u5438\u83f8\u8005\u9084\u591a\uff0c\u4e14\u78ba\u8a3a\u4eba\u6578\u4e0d\u65b7\u6500\u5347\uff0c\u66f4\u6709\u5e74\u8f15\u5316\u53ca\u5973\u6027\u6bd4\u4f8b\u589e\u52a0\u7684\u73fe\u8c61\u3002\u53f0\u7063\u7814\u7a76\u4eba\u54e1\u5c07\u767c\u73fe\u7684\u4e94\u7a2e\u764c\u7d30\u80de\u7a81\u8b8a\u7279\u5fb5\uff0c\u8207\u570b\u5916\u7684\u81f4\u764c\u7a81\u8b8a\u7279\u5fb5\u8cc7\u6599\u5eab\u6bd4\u5c0d\uff0c\u767c\u73fe\u80ba\u764c\u7684\u5371\u96aa\u56e0\u5b50\u4e0d\u53ea\u662f\u83f8\u5bb3\u53ca\u7a7a\u6c23\u6c59\u67d3\uff0c\u4ea6\u53ef\u80fd\u8207\u98df\u54c1\u6dfb\u52a0\u7269\u6216\u9632\u8150\u5291\u76f8\u95dc\uff0c\u986f\u793a\u80ba\u764c\u4e0d\u50c5\u53ef\u7531\u80ba\u90e8\u5438\u5165\u7684\u7269\u8cea\u6240\u5f15\u8d77\uff0c\u66f4\u53ef\u80fd\u8207\u98f2\u98df\u3001\u74b0\u5883\u3001\u57fa\u56e0\u3001\u85e5\u7269\u3001\u8001\u5316\u53ca\u751f\u6d3b\u7fd2\u6163\u6709\u95dc\u806f\u6027\u3002\u56e0\u6b64\uff0c\u9664\u4e86\u5438\u83f8\u548c\u7a7a\u6c23\u6c59\u67d3\u4e4b\u5916, \u80ba\u764c\u78ba\u5be6\u6709\u53ef\u80fd\u662f\u5403\u51fa\u4f86\u7684\uff0c\u4f46\u4ecd\u6709\u5f85\u9032\u4e00\u6b65\u7814\u7a76\u624d\u80fd\u78ba\u8a8d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Boeckx B, Shahi RB, Smeets D, De Brakeleer S, Decoster L, Van Brussel T, Galdermans D, Vercauter P, Decoster L, Alexander P, Berchem G, Ocak S, Vuylsteke P, Deschepper K, Lambrechts M, Cappoen N, Teugels E, Lambrechts D, De Greve J. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31745979\/\">The genomic landscape of nonsmall&nbsp;cell&nbsp;lung&nbsp;carcinoma in never smokers.<\/a> Int J Cancer. 2020 Jun 1;146(11):3207-3218. doi: 10.1002\/ijc.32797. Epub 2019 Dec 10.<\/li>\n<li>Chen YJ, Roumeliotis TI, Chang YH, Chen CT, Han CL, Lin MH, Chen HW, Chang GC, Chang YL, Wu CT, Lin MW, Hsieh MS, Wang YT, Chen YR, Jonassen I, Ghavidel FZ, Lin ZS, Lin KT, Chen CW, Sheu PY, Hung CT, Huang KC, Yang HC, Lin PY, Yen TC, Lin YW, Wang JH, Raghav L, Lin CY, Chen YS, Wu PS, Lai CT, Weng SH, Su KY, Chang WH, Tsai PY, Robles AI, Rodriguez H, Hsiao YJ, Chang WH, Sung TY, Chen JS, Yu SL, Choudhary JS, Chen HY, Yang PC, Chen YJ. Proteogenomics of Non-smoking&nbsp;Lung&nbsp;Cancer&nbsp;in East Asia Delineates Molecular Signatures of Pathogenesis and Progression. Cell. 2020 Jul 9;182(1):226-244.e17. doi: 10.1016\/j.cell.2020.06.012.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u6839\u64da\u885b\u751f\u798f\u5229\u90e8\u7684\u7d71\u8a08\uff0c\u80ba\u764c\u5df2\u8e8d\u5c45\u6211\u570b\u7537\u5973\u6027\u764c\u75c7\u6b7b\u4ea1\u4eba\u6578\u7684\u7b2c\u4e00\u4f4d\uff0c\u4e00\u822c\u8a8d\u70ba\u5176\u767c\u751f\u8207\u5438\u83f8\uff08\u542b\u4e8c\u3001\u4e09\u624b\u83f8\uff09\u3001\u7a7a\u6c23\u6c59\u67d3\uff08\u542b\u5eda\u623f\u6cb9\u7159\uff09\u3001\u80ba\u90e8\u6162\u6027\u767c\u708e\u75be\u75c5\u3001\u907a\u50b3\u53ca\u9577\u671f\u66b4\u9732\u65bc\u81f4\u764c\u74b0\u5883\uff08 \u5982\u51b6\u91d1\u696d\u3001\u63a1\u7926\u696d\u53ca\u77f3\u7dbf\u3001\u653e\u5c04\u7dda\u63a5\u89f8\u8005\uff09\u6709\u5bc6\u5207\u76f8\u95dc\u6027\u3002\u5728\u53f0\u7063\uff0c\u8d85\u904e50\uff05\u7684\u60a3\u8005\u4e26\u672a\u62bd\u83f8\uff0c\u5176\u4e2d 93\uff05\u662f\u5973\u6027\uff0c\u50b3\u7d71\u4e0a\u8a8d\u70ba\u662f\u7a7a\u6c59\u53ca\u6cb9\u7159\u5c0e\u81f4\u7684\u3002\u4f46\u6700\u8fd1\u7684\u7814\u7a76\u986f\u793a\u9019\u4e9b\u4e0d\u5438\u83f8\u65cf\u7fa4\u7f79\u60a3\u80ba\u764c\u53ef\u80fd\u548c\u9ad4\u5167\u7684APOBEC\u57fa\u56e0\u767c\u751f\u7a81\u8b8a\u6709\u95dc\uff0c\u70ba\u80ba\u764c\u7684\u75c5\u56e0\u63d0\u4f9b\u4e86\u65b0\u7684\u7814\u7a76\u65b9\u5411\u3002<\/p>\n","protected":false},"author":20,"featured_media":35732,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/94413.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35730"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35730"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35730\/revisions"}],"predecessor-version":[{"id":35733,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35730\/revisions\/35733"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35732"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}