{"id":35686,"date":"2020-09-24T00:32:26","date_gmt":"2020-09-23T16:32:26","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35686"},"modified":"2020-12-02T10:09:12","modified_gmt":"2020-12-02T02:09:12","slug":"%e3%80%90%e9%97%9c%e6%96%bc-covid-19-%e7%9a%84%e9%80%99%e5%a4%a7%e5%8d%8a%e5%b9%b4%e3%80%91%e5%85%8d%e7%96%ab%e7%b3%bb%e7%b5%b1%ef%bc%9f%e4%b9%9f%e4%b8%8d%e6%98%af%e7%9c%81%e6%b2%b9%e7%9a%84%e7%87%88","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35686","title":{"rendered":"\u3010\u95dc\u65bc COVID-19 \u7684\u9019\u5927\u534a\u5e74\u3011\u514d\u75ab\u7cfb\u7d71\uff1f\u4e5f\u4e0d\u662f\u7701\u6cb9\u7684\u71c8\uff01"},"content":{"rendered":"

COVID-19 \u75ab\u60c5\u6301\u7e8c\u81f3\u4eca\uff0c\u6700\u88ab\u95dc\u6ce8\u7684\u8ab2\u984c\u4e4b\u4e00\uff0c\u5927\u6982\u5c31\u662f\u514d\u75ab\u7cfb\u7d71\u5c0d\u65bc SARS-CoV-2 \u9019\u6b79\u300c\u6bd2\u300d\uff0c\u662f\u4e0d\u662f\u6709\u61c9\u5c0d\u7b56\u7565\u3002\u9019\u554f\u984c\u4e4b\u6240\u4ee5\u5982\u6b64\u95dc\u9375\uff0c\u662f\u56e0\u70ba\u4e4b\u65bc\u6b64\u554f\u984c\u7684\u7b54\u6848\u6703\u76f4\u63a5\u5f71\u97ff\u5230\u6211\u5011\u91dd\u5c0d SARS-CoV-2 \u75c5\u6bd2\u7684\u4f5c\u6230\u8a08\u5283\u3002\u4e5f\u56e0\u70ba SARS-CoV-2 \u662f\u65b0\u578b\u75c5\u6bd2\uff0c\u6211\u5011\u4e5f\u5c31\u53ea\u80fd\u5728\u75ab\u60c5\u88e1\u908a\u8d70\u908a\u770b\uff0c\u908a\u770b\u908a\u5b78\uff0c\u4e26\u4e14\u91dd\u5c0d\u4e0d\u65b7\u6316\u6398\u51fa\u4f86\u7684\u65b0\u8cc7\u8a0a\uff0c\u4e00\u908a\u5f48\u6027\u5730\u8abf\u6574\u4f5c\u6230\u7b56\u7565\u3002<\/strong><\/span><\/p>\n

\u90a3\uff0c\u6211\u5011\u4e00\u8d77\u4f86\u770b\u770b\u5728\u9019\u5927\u534a\u5e74\u88e1\uff0c\u6211\u5011\u65b0\u767c\u73fe\u4e86\u4ec0\u9ebc SARS-CoV-2 \u75c5\u6bd2\u7684\u91cd\u8981\u8cc7\u8a0a\u5427\u3002<\/strong><\/span><\/p>\n

\"\"
Illustration: Perry Tse<\/figcaption><\/figure>\n

\u64b0\u6587\uff0f\u99f1\u5b9b\u7433<\/strong><\/p>\n

SARS-CoV-2 \u7684\u75ab\u60c5\u525b\u7206\u767c\u7684\u6642\u5019\uff0c\u56e0\u70ba\u6575\u60c5\u8cc7\u8a0a\u7684\u5331\u4e4f\uff0c\u5168\u4e16\u754c\u90fd\u77c7\u8457\u773c\u6253\u4ed7\u3002\u4e0d\u904e\uff0c\u5927\u534a\u5e74\u904e\u53bb\u4e86\uff0c\u6211\u5011\u8207 SARS-CoV-2 \u75c5\u6bd2\u7684\u6bcf\u4e00\u5834\u4ea4\u92d2\u5c0d\u8adc\uff0c\u4e5f\u90fd\u8b93\u6211\u5011\u66f4\u4e86\u89e3 SARS-CoV-2 \u4e00\u9ede\uff0c\u800c\u9019\u4e9b\u65b0\u8cc7\u8a0a\uff0c\u4e5f\u90fd\u80fd\u5920\u8b93\u6211\u5011\u5728\u9632\u75ab\u4e4b\u8def\u4e0a\uff0c\u8d70\u5f97\u66f4\u7a69\u7576\u3002<\/p>\n

\u95dc\u65bc SARS-CoV-2 \u7684\u8b0e\u5718\u5f88\u591a\u3002\u4f46\u9996\u8981\u4e4b\u52d9\uff0c\u662f\u63a2\u7a76\u6e05\u695a\u6211\u5011\u662f\u4e0d\u662f\u53ef\u4ee5\u504e\u5411\u514d\u75ab\u7cfb\u7d71\u9019\u9846\u5927\u897f\u74dc\uff0c\u4f86\u4f5c\u70ba\u9632\u6bd2\u5927\u6230\u7684\u5fc5\u6bba\u6280\u3002\u4f9d\u508d\u8457\u514d\u75ab\u7cfb\u7d71\u9019\u9846\u5927\u897f\u74dc\u6709\u4ec0\u9ebc\u597d\u8655\u5462\uff1f\u56e0\u70ba\uff0c\u6211\u5011\u5c31\u53ef\u4ee5\u85c9\u8457\u7814\u767c\u75ab\u82d7\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u7ad9\u5728\u6211\u5011\u9019\u4e00\u908a\uff0c\u4e5f\u5c31\u4e0d\u6703\u50cf\u76ee\u524d\u4e00\u6a23\uff0c\u53ea\u80fd\u88ab SARS-CoV-2 \u75c5\u6bd2\u7aae\u8ffd\u8457\u6253\uff0c\u800c\u53ef\u4ee5\u767c\u52d5\u500b\u9ad4\u7684\u514d\u75ab\u7cfb\u7d71\uff0c\u597d\u597d\u5730\u9084\u624b\u79a6\u6575\u3002<\/p>\n

\u5982\u4eca\u534a\u5e74\u904e\u53bb\u4e86\u3002\u534a\u5e74\u96d6\u77ed\uff0c\u537b\u4e5f\u5920\u9577\u5230\u8b93\u79d1\u5b78\u5bb6\u5c0d\u65bc SARS-CoV-2 \u6240\u6fc0\u767c\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u6478\u7d22\u51fa\u4e86\u5927\u6982\u7684\u8f2a\u5ed3\u3002\u6700\u8fd1\u4e00\u5169\u500b\u6708\u88e1\u982d\uff0c\u4e0d\u5c11\u7684\u7814\u7a76\u4e00\u4e00\u767c\u8868\uff0c\u6211\u5011\u4e5f\u6b63\u597d\u53ef\u4ee5\u85c9\u9019\u500b\u6a5f\u6703\uff0c\u597d\u597d\u6aa2\u8996\u4e00\u756a\u3002<\/p>\n

\u5728\u6211\u5011\u6df1\u5165\u63a2\u7a76\u5404\u500b\u7814\u7a76\u7684\u7d30\u7bc0\u4e4b\u524d\uff0c\u53ef\u4ee5\u628a\u96f7\u5148\u7206\u5728\u524d\u982d\u3002\u76ee\u524d\u770b\u4f86\uff0c\u6211\u5011\u53ef\u4ee5\u671f\u5f85\u7d50\u5c40\u662f\u300cHappy Ending\u300d\u3002 \u5c0d\u65bc SARS-CoV-2 \u75c5\u6bd2\uff0c\u514d\u75ab\u7cfb\u7d71\u53ef\u6c92\u6709\u4e7e\u5750\u8457\u767c\u6123\uff0c\u800c\u662f\u96a8\u5373\u596e\u8d77\u8ffd\u64ca\uff0c\u63a1\u53d6\u4e86\u76f8\u5c0d\u61c9\u7684\u653b\u9632\u3002\u63db\u8a00\u4e4b\uff0c\u5728 SARS-CoV-2 \u75c5\u6bd2\u8ddf\u524d\uff0c\u514d\u75ab\u7cfb\u7d71\u53ef\u4e0d\u662f\u7701\u6cb9\u7684\u71c8\uff1b\u514d\u75ab\u7cfb\u7d71\u53ef\u662f\u5f88\u52aa\u529b\u8a8d\u771f\u5730\u596e\u52c7\u6bba\u6575\u5462\u3002<\/p>\n

\u4e0d\u904e\uff0c\u5373\u4fbf\u6211\u5011\u77e5\u9053\u514d\u75ab\u7cfb\u7d71\u5728\u5c0d\u6230\u75c5\u6bd2\u7684\u524d\u7dda\u76e1\u5fe0\u8077\u5b88\uff0c\u5c0d\u9019\u554f\u984c\u7684\u63a2\u7a76\u537b\u4e0d\u53ea\u662f\u55ae\u7d14\u5730\u8dd1\u4e0a\u53bb\u78ba\u8a8d\u514d\u75ab\u7cfb\u7d71\u6709\u8a8d\u771f\u4e0a\u73ed\u6253\u5361\u3002\u9664\u4e86\u78ba\u8a8d\u514d\u75ab\u7cfb\u7d71\u6709\u5728\u7ad9\u5d17\u9632\u5b88\uff0c\u66f4\u95dc\u9375\u5730\u662f\u6211\u5011\u662f\u4e0d\u662f\u80fd\u5920\u5c0d\u500b\u9ad4\u8207\u500b\u9ad4\u4e4b\u9593\uff0c\u91dd\u5c0d SARS-CoV-2 \u75c5\u6bd2\u6240\u6fc0\u767c\u8d77\u4f86\u7684\u514d\u75ab\u53cd\u61c9\u5dee\u7570\uff0c\u6709\u5168\u76e4\u4e86\u89e3\u3002<\/p>\n

\u9019\u554f\u984c\u4e4b\u6240\u4ee5\u95dc\u9375\uff0c\u662f\u56e0\u70ba\u65e9\u5728\u75ab\u60c5\u4e00\u958b\u59cb\u4e4b\u969b\uff0c\u81e8\u5e8a\u524d\u7dda\u7684\u91ab\u8b77\u4eba\u54e1\u5c31\u767c\u73fe\uff0c\u5728\u611f\u67d3 SARS-CoV-2 \u4e4b\u5f8c\uff0c\u500b\u9ad4\u4e4b\u9593\u7684\u81e8\u5e8a\u75c7\u72c0\u5dee\u7570\u6975\u5927\u3002\u5927\u90e8\u5206\u7684\u75c5\u4eba\u5728\u611f\u67d3\u4e4b\u5f8c\uff0c\u4e0d\u9700\u8981\u5165\u9662\u7167\u8b77\u5c31\u80fd\u5920\u9760\u5404\u81ea\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u75ca\u7652\u597d\u8f49\u3002\u4e5f\u6709\u4e0d\u5bb9\u5ffd\u8996\u7684\u4e00\u7fa4\u4eba\uff0c\u5373\u4fbf\u88ab SARS-CoV-2 \u75c5\u6bd2\u611f\u67d3\uff0c\u537b\u597d\u50cf\u6c92\u4e8b\u4e00\u6a23\uff0c\u6216\u662f\u75c7\u72c0\u8f15\u5fae\u5230\u8b93\u4eba\u7121\u52d5\u65bc\u8877\u3002\u4e0d\u904e\uff0c\u5e73\u5747\u800c\u8ad6\uff0c\u6709\u767e\u5206\u4e4b\u4e94\u5230\u767e\u5206\u4e4b\u5341\u7684\u75c5\u4eba\uff0c\u75c5\u6cc1\u6703\u56b4\u91cd\u60e1\u5316\u3002\u82e5\u653e\u773c\u5168\u7403\uff0c\u6642\u5c46\u516b\u6708\u5e95\u7684\u6b64\u523b\uff0c\u5c07\u8fd1\u4e8c\u5343\u4e94\u767e\u842c\u4eba\u88ab\u611f\u67d3\uff0c\u5df2\u6709\u8d85\u904e\u516b\u5341\u56db\u842c\u4eba\u56e0\u6b64\u6b7b\u4ea1\u3002<\/p>\n

\u70ba\u4ec0\u9ebc\u500b\u9ad4\u4e4b\u9593\u7684\u75c7\u72c0\u5dee\u7570\u6027\u9019\u9ebc\u5927\uff1f\u6211\u5011\u662f\u4e0d\u662f\u53ef\u4ee5\u5728\u75c5\u4eba\u75c7\u72c0\u60e1\u5316\u4e4b\u524d\uff0c\u85c9\u7531\u6aa2\u9a57\u6578\u64da\u7684\u5206\u6790\uff0c\u4e8b\u5148\u9810\u6e2c\u51fa\u75c5\u4eba\u5f8c\u7e8c\u7684\u75c5\u6cc1\u767c\u5c55\uff0c\u7be9\u6aa2\u51fa\u9810\u5f8c\u53ef\u80fd\u4e0d\u4f73\u7684\u75c5\u4eba\uff0c\u5c0d\u5176\u53ca\u65e9\u63a1\u53d6\u76f8\u5c0d\u61c9\u5730\u91ab\u7642\u7b56\u7565\uff0c\u597d\u907f\u514d\u5176\u75c5\u6cc1\u771f\u5f97\u60e1\u5316\u5230\u6700\u7cdf\u7684\u60c5\u6cc1\u5462\uff1f\u9019\u4e9b\u554f\u984c\u4e4b\u8feb\u5207\uff0c\u7814\u7a76\u4eba\u54e1\u8207\u91ab\u7642\u524d\u7dda\u90fd\u6025\u8457\u627e\u5230\u76f8\u95dc\u7dda\u7d22\u3002\u4e5f\u56e0\u6b64\uff0c\u5c0d\u65bc\u514d\u75ab\u7cfb\u7d71\u5982\u4f55\u61c9\u5c0d SARS-CoV-2 \u75c5\u6bd2\u7684\u5165\u4fb5\u611f\u67d3\uff0c\u80fd\u4e86\u89e3\u6108\u5168\u76e4\u8a73\u7d30\u6108\u597d\u3002<\/p>\n

\u6211\u5011\u5148\u4f86\u770b\u770b\u514d\u75ab\u7cfb\u7d71\u5c0d\u65bc SARS-CoV-2 \u75c5\u6bd2\uff0c\u64ec\u5b9a\u4e86\u600e\u6a23\u7684\u4f5c\u6230\u7b56\u7565\u5427\u3002<\/p>\n

\u82f1\u570b\u502b\u6566 The Francis Crick Institute \u8207 Guy\u2019s and St Thomas\u2019 NHS Foundation Trust \u7814\u7a76\u6a5f\u69cb\uff0c\u5728 Adrian Hayday \u535a\u58eb\u8207 Manu Shankar-Hari \u4e3b\u5c0e\u4e0b\uff0c\u5e0c\u671b\u80fd\u5920\u85c9\u8457\u514d\u75ab\u5b78\u7814\u7a76\u8207\u81e8\u5e8a\u524d\u7dda\u7684\u806f\u624b\u5408\u4f5c\uff0c\u5c0d SARS-CoV-2 \u76f8\u95dc\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u597d\u597d\u6aa2\u8996\u4e00\u756a\u3002<\/p>\n

COVID-19 \u7684\u75c7\u72c0\u56e0\u4eba\u800c\u7570\uff0c\u800c\u4e14\u500b\u9ad4\u4e4b\u9593\u5dee\u7570\u5f88\u5927\uff0c\u518d\u52a0\u4e0a\u65cf\u7fa4\u3001\u5e74\u7d00\u3001\u6027\u5225\u3001\u9084\u6709\u500b\u9ad4\u539f\u672c\u7684\u5065\u5eb7\u72c0\u6cc1\u90fd\u53ef\u80fd\u5c0d\u75c5\u60c5\u767c\u5c55\u6709\u8209\u8db3\u8f15\u91cd\u7684\u5f71\u97ff\u3002\u8003\u91cf\u65bc\u6b64\uff0c\u7814\u7a76\u5718\u968a\u5728\u7814\u7a76\u8a2d\u8a08\u4e0a\uff0c\u6c7a\u5b9a\u628a\u7814\u7a76\u76ee\u6a19\u5b9a\u5728\u627e\u51fa\u514d\u75ab\u7cfb\u7d71\u7684\u4f5c\u6230\u300c\u4e3b\u8ef8\u300d\u3002\u9019\u662f\u4ec0\u9ebc\u610f\u601d\u5462\uff1f<\/p>\n

\u5c31\u50cf\u570b\u8ecd\u4f5c\u6230\u9ad4\u7cfb\u6709\u9678\u3001\u6d77\u3001\u7a7a\u4e09\u8ecd\uff0c\u5404\u6709\u5c08\u8077\u80fd\u5920\u62b5\u79a6\u5916\u6575\u4f86\u72af\u3002\u514d\u75ab\u7cfb\u7d71\u5c0d\u65bc\u5165\u4fb5\u7684\u75c5\u539f\u83cc\uff0c\u4e5f\u5728\u9577\u9577\u4e45\u4e45\u7684\u6f14\u5316\u58d3\u529b\u4e0b\uff0c\u91dd\u5c0d\u5404\u7a2e\u4f86\u72af\u7684\u75c5\u539f\u83cc\uff0c\u6f14\u5316\u51fa\u5c08\u9580\u7684\u4f5c\u6230\u65b9\u91dd\u3002\u5de7\u5f97\u662f\uff0c\u514d\u75ab\u7cfb\u7d71\u4e5f\u6709\u4e09\u8ecd\u9ad4\u7cfb\uff0c\u800c\u4e14\u5206\u9580\u5225\u985e\u7684\u540d\u7a31\u975e\u5e38\u7c21\u55ae\u597d\u8a18\uff0c\u5206\u5225\u662f\u7b2c\u4e00\u578b\u3001\u7b2c\u4e8c\u578b\u3001\u8207\u7b2c\u4e09\u578b\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n

\u9019\u4e09\u7a2e\u514d\u75ab\u53cd\u61c9\u7684\u5206\u9580\u5225\u985e\u96d6\u7136\u7565\u986f\u7c97\u7cd9\uff0c\u4f46\u5728\u57fa\u790e\u7814\u7a76\u4e0a\uff0c\u5927\u62b5\u582a\u7528\u3002\u50cf\u5728\u75ab\u82d7\u63a5\u7a2e\uff0c\u6216\u8005\u662f\u985e\u4f3c\u65bc\u6557\u8840\u75c5\uff08sepsis\uff09\u9019\u7a2e\u514d\u75ab\u53cd\u61c9\u56b4\u91cd\u5931\u8abf\u7684\u75be\u60a3\uff0c\u5373\u4f7f\u767e\u6a23\u7c73\u990a\u4e86\u767e\u7a2e\u4eba\uff0c\u4e5f\u90fd\u9084\u662f\u53ef\u4ee5\u5728\u767e\u7a2e\u4eba\u88e1\uff0c\u627e\u5230\u514d\u75ab\u53cd\u61c9\u7684\u4e2d\u5fc3\u300c\u4e3b\u8ef8\u300d\u6a23\u614b\u3002<\/p>\n

\u7b2c\u4e00\u578b\u514d\u75ab\u53cd\u61c9\u901a\u5e38\u91dd\u5c0d\u300c\u611f\u67d3\u7d30\u80de\u5167\u7684\u75c5\u539f\u83cc\u300d\u3002\u50cf\u662f\u75c5\u6bd2\uff0c\u5c31\u662f\u8b93\u7b2c\u4e00\u578b\u514d\u75ab\u53cd\u61c9\u4f5c\u6230\u8b66\u9234\u5927\u97ff\u7684\u4e3b\u8981\u6230\u72af\u3002\u5728\u7b2c\u4e00\u578b\u514d\u75ab\u53cd\u61c9\u88e1\uff0c\u9996\u8981\u4f5c\u6230\u76ee\u6a19\u662f\u628a\u85cf\u533f\u65bc\u7d30\u80de\u5167\u7684\u75c5\u539f\u83cc\u6e05\u9664\u4e7e\u6de8\uff0c\u7aef\u9760\u7684\u662f\u80fd\u5920\u57f7\u884c\u7d30\u80de\u6bd2\u7d20\u514d\u75ab\u7684\u751f\u529b\u8ecd\uff0c\u50cf\u662f\u81ea\u7136\u6bba\u624b\u7d30\u80de\uff08natural killer cells\uff1bNK cells\uff09\u3001\u9084\u6709\u80de\u6bd2\u578b T \u7d30\u80de\uff08cytotoxic T cells\uff09\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u9084\u6709\u7b2c\u4e00\u985e\u5148\u5929\u6027\u6dcb\u5df4\u7d30\u80de\uff08group 1 innate lymphocytes\uff1bILC1\uff09\u4ee5\u53ca\u7b2c\u4e00\u985e\u8f14\u52a9\u578b T \u7d30\u80de\uff08T helper 1 cells\uff1bTh1 cells\uff09\u3002\u9019\u4e9b\u7b2c\u4e00\u578b\u514d\u75ab\u53cd\u61c9\u7684\u4f5c\u6230\u4e3b\u529b\u6709\u500b\u5171\u901a\u9ede\uff0c\u90fd\u64c5\u9577\u4f7f\u7528\u4e19\u578b\u5e72\u64fe\u7d20\uff08interferon gamma\uff09\uff0c\u4f5c\u6230\u7e3d\u6307\u63ee\u5b98\u662f\u6b78 T-bet \u9019\u500b\u8f49\u9304\u56e0\u5b50\u6240\u7ba1\u8f44\u3002<\/p>\n

\u81f3\u65bc\u7b2c\u4e8c\u578b\u514d\u75ab\u53cd\u61c9\uff0c\u4f5c\u6230\u7e3d\u6307\u63ee\u5b98\u662f\u500b\u53eb\u505a GATA-3 \u7684\u8f49\u9304\u56e0\u5b50\u3002\u7b2c\u4e8c\u578b\u514d\u75ab\u53cd\u61c9\u64c5\u9577\u5c0d\u4ed8\u8815\u87f2\uff08helminth\uff09\u4e00\u985e\u7684\u5165\u4fb5\u75c5\u539f\u83cc\uff0c\u79d8\u5bc6\u6b66\u5668\u662f\u4ecb\u767d\u7d20 IL-4\u3001IL-5\u3001\u8207 IL-13 \u7b49\uff0c\u9084\u6709\u6297\u9ad4 IgE\uff0c\u80fd\u5920\u9a45\u52d5\u8868\u76ae\u7d30\u80de\u3001\u80a5\u80d6\u7d30\u80de\uff08mast cell\uff09\u3001\u55dc\u9178\u6027\u7403\uff08eosinophil\uff09\u8207\u55dc\u9e7c\u6027\u7403\uff08basophil \uff09\uff0c\u5c07\u5165\u4fb5\u75c5\u539f\u83cc\u9a45\u9010\u3002<\/p>\n

\u7b2c\u4e09\u578b\u514d\u75ab\u53cd\u61c9\u5247\u662f\u7531  ROR\u0263t \u8f49\u9304\u56e0\u5b50\u6240\u6307\u63ee\uff0c\u6b64\u4e00\u4f5c\u6230\u90e8\u9760\u8457\u7b2c\u4e09\u985e\u5148\u5929\u6027\u6dcb\u5df4\u7d30\u80de\uff08group 3 innate lymphocytes\uff1bILC3\uff09\u4ee5\u53ca\u8f14\u52a9\u578b T \u7d30\u80de 17\uff08T helper 17 cells\uff1bTh17 cells\uff09\u7684\u5408\u529b\uff0c\u85c9\u8457\u5206\u6ccc\u4ecb\u767d\u7d20 IL-22 \u8207 IL-17\uff0c\u5c07\u55dc\u4e2d\u6027\u7403\uff08neutrophil\uff09\u7d0d\u5165\u6297\u6575\u7684\u5927\u65d7\u4e0b\uff0c\u4ee5\u91dd\u5c0d\u771f\u83cc\u3001\u7d30\u80de\u5916\u7d30\u83cc\u70ba\u4e3b\u3002<\/p>\n

\u9019\u4e09\u578b\u6297\u6575\u53cd\u61c9\u5404\u6709\u5404\u81ea\u64c5\u5834\uff0c\u6839\u64da\u9019\u500b\u5927\u898f\u5247\uff0c\u65e2\u7136 SARS-CoV-2 \u662f\u75c5\u6bd2\uff0c\u5f97\u9760\u8457\u611f\u67d3\u7d30\u80de\u800c\u81f4\u75c5\uff0c\u5bb0\u6bba\u8eb2\u5728\u7d30\u80de\u5167\u75c5\u6bd2\u7684\u6700\u597d\u8fa6\u6cd5\uff0c\u4f3c\u4e4e\u4ee5\u7b2c\u4e00\u578b\u514d\u75ab\u53cd\u61c9\u70ba\u6700\u4f73\u89e3\u3002\u90a3\uff0c\u679c\u771f\u5982\u6b64\u55ce\uff1f<\/p>\n

 <\/p>\n

\u6211\u5011\u5148\u4f86\u770b\u770b\u82f1\u570b\u9019\u7d44\u7814\u7a76\u5718\u968a\uff0c\u6240\u627e\u5230\u7684\u514d\u75ab\u7cfb\u7d71\u300c\u4f5c\u6230\u4e3b\u8ef8\u300d\uff0c\u9577\u4ec0\u9ebc\u6a23\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u9996\u5148\u62db\u52df\u4e86 63 \u4f4d\u6536\u6cbb\u65bc Guy\u2019s and St Thomas\u2019 Hospital\uff0c\u78ba\u8a3a\u70ba COVID-19 \u7684\u75c5\u4eba\uff0c\u53e6\u5916\u52a0\u4e0a 55 \u4f4d\u5065\u5eb7\u53d7\u8a66\u8005\uff0c\u4ee5\u53ca 23 \u4f4d\u5148\u524d\u88ab\u611f\u67d3\u904e\u3001\u8840\u6e05\u6aa2\u9a57\u5448\u73fe\u967d\u6027\u7684\u5065\u5eb7\u4eba\u7576\u4f5c\u6bd4\u8f03\u7528\u7684\u63a7\u5236\u7d44\uff0c\u9084\u6709 10 \u4f4d\u300c\u4e0d\u662f\u300d\u56e0\u70ba SARS-CoV-2 \u800c\u5c0e\u81f4\u4e0b\u547c\u5438\u9053\u611f\u67d3\u7684\u4f4f\u9662\u75c5\u60a3\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u5c07\u5206\u6790\u76ee\u6a19\u653e\u5728\u8840\u6db2\u6aa2\u9ad4\u4e0a\uff0c\u56e0\u70ba\u9019\u4e0d\u4f46\u662f\u6700\u5bb9\u6613\u53d6\u5f97\u7684\u6aa2\u9ad4\uff0c\u4e0d\u8ad6\u662f\u5728\u600e\u6a23\u7684\u91ab\u7642\u6a5f\u69cb\uff0c\u5e7e\u4e4e\u90fd\u53ef\u4ee5\u8fa6\u5230\u3002\u800c\u4e14\uff0c\u8840\u6db2\u6aa2\u9ad4\u63a1\u6a23\u9084\u65b9\u4fbf\u9577\u6642\u9593\u8ffd\u8e64\uff0c\u4e5f\u80fd\u5920\u548c\u76ee\u524d\u5176\u4ed6\u75c5\u5fb5\u7684\u81e8\u5e8a\u6aa2\u6e2c\u63a5\u8ecc\uff0c\u514d\u75ab\u7d30\u80de\u66f4\u662f\u5e38\u5e38\u5f97\u85c9\u7531\u8840\u6db2\u5e79\u9053\uff0c\u5faa\u6d41\u5404\u7d44\u7e54\uff0c\u56e0\u6b64\u63d0\u4f9b\u4e86\u7814\u7a76\u4eba\u54e1\u96d6\u4e0d\u5168\u9762\u3001\u4f46\u8db3\u53ef\u582a\u7528\u7684\u300c\u7528\u7ba1\u7aba\u5929\u300d\u4e4b\u6a5f\u3002<\/p>\n

\u6211\u5c24\u5176\u559c\u6b61\u7814\u7a76\u4eba\u54e1\u4e0d\u50c5\u50c5\u6db5\u84cb\u4e86\u5065\u5eb7\u4eba\uff0c\u9084\u540c\u6642\u56ca\u62ec\u4e86\u66fe\u7d93\u611f\u67d3\u904e\u7684\u8840\u6e05\u6aa2\u9a57\u967d\u6027\u7fa4\u773e\uff0c\u4ee5\u53ca\u78ba\u8a3a\u4e0d\u662f SARS-CoV-2 \u611f\u67d3\uff0c\u4f46\u75c7\u72c0\u4e5f\u56b4\u91cd\u5230\u9700\u8981\u4f4f\u9662\u7684\u75c5\u60a3\u3002\u96d6\u7136\u7fa4\u9ad4\u6578\u91cf\u4e0d\u5927\uff0c\u4f46\u9019\u652f\u300c\u5c0f\u7ba1\u300d\uff0c\u5012\u4e5f\u4f54\u5230\u4e86\u4e00\u500b\u597d\u4f4d\u7f6e\uff0c\u80fd\u5920\u5c07 SARS-CoV-2 \u4e4b\u6240\u4ee5\u96e3\u7e8f\u7684\u79d8\u5bc6\uff0c\u597d\u597d\u5be9\u8996\u6e05\u695a\u3002<\/p>\n

\u5927\u62b5\u4f86\u8aaa\uff0c\u7814\u7a76\u767c\u73fe\u4e0d\u8ad6\u662f\u5148\u5929\u514d\u75ab\u53cd\u61c9\uff0c\u9084\u662f\u5f8c\u5929\u514d\u75ab\u53cd\u61c9\uff0c\u5728\u88ab SARS-CoV-2 \u611f\u67d3\u4e4b\u5f8c\uff0c\u90fd\u5168\u8ecd\u52d5\u54e1\u8d77\u4f86\u3002\u4ee5\u5f8c\u5929\u514d\u75ab\u53cd\u61c9\u4f86\u8aaa\uff0c\u5169\u5927\u4e3b\u529b\u8ecd\uff1aB \u7d30\u80de\u8207 T \u7d30\u80de\u5927\u8ecd\u7fa4\u88e1\uff0c\u90fd\u53ef\u4ee5\u627e\u5230\u91dd\u5c0d SARS-CoV-2 \u5927\u6230\u904e\u4e00\u756a\u7684\u4f5c\u6230\u75d5\u8de1\u3002<\/p>\n

\u6176\u5e78\u7684\u662f\uff0c\u5728 COVID-19 \u75c5\u60a3\u8eab\u4e0a\uff0cB \u7d30\u80de\u4e0d\u4f46\u6d3b\u5316\uff0c\u4e5f\u597d\u597d\u5730\u706b\u529b\u5168\u958b\uff0c\u50be\u76e1\u5168\u529b\u88fd\u9020\u6297\u9ad4\u3002\u6297\u9ad4\u529b\u50f9\u4e5f\u96a8\u8457\u611f\u67d3\u65e5\u7a0b\u800c\u4e00\u6b65\u6b65\u63d0\u9ad8\uff0c\u800c\u4e14\u53ef\u4ee5\u627e\u5230\u4ee5\u5c08\u653b SARS-CoV-2 \u53d7\u5668\u7d50\u5408\u57df\uff08receptor-binding domain\uff09\u7684\u6297\u9ad4\u3002\u6211\u5011\u5728\u4e4b\u524d\u7684\u5c08\u6b04\u88e1\uff0c\u66fe\u7d93\u8a0e\u8ad6\u904e\u53d7\u5668\u7d50\u5408\u57df\u662f SARS-CoV-2 \u80fd\u5920\u7d50\u5408\u4e0a\u7d30\u80de\u53d7\u5668 ACE2\uff0c\u800c\u611f\u67d3\u5bbf\u4e3b\u7d30\u80de\u7684\u91cd\u8981\u6b65\u9a5f\u3002\u5982\u4eca\uff0c\u514d\u75ab\u7cfb\u7d71\u80fd\u5920\u91dd\u5c0d SARS-CoV-2 \u4e0d\u53ef\u6216\u7f3a\u7684\u77dc\u8cb4\u5927\u5c07\u70ba\u653b\u64ca\u9776\u9ede\uff0c\u5c31\u662f\u6f02\u4eae\u7684\u56de\u64ca\u3002<\/p>\n

\u4e0d\u904e\uff0c\u6211\u5011\u4e5f\u66fe\u7d93\u8a0e\u8ad6\u904e\uff0cSARS-CoV-2 \u7684\u72e1\u8a50\uff0c\u5728\u65bc\u80fd\u5920\u628a\u53d7\u5668\u7d50\u5408\u57df\u597d\u597d\u4fdd\u8b77\u8d77\u4f86\uff0c\u4f4e\u8abf\u7684\u85cf\u5728\u91cd\u91cd\u91a3\u57fa\u5316\u4fee\u98fe\u5e95\u4e0b\u3002\u4e0d\u904e\uff0c\u5f9e\u4e0d\u4e7e\u5750\u7684\u514d\u75ab\u7cfb\u7d71\uff0c\u4e5f\u5c0d\u6b64\u6709\u53cd\u64ca\u7b56\u7565\u3002\u7814\u7a76\u5718\u968a\u5728\u5206\u6790\u4e86 COVID-19 \u75c5\u4eba\u8840\u6db2\u6aa2\u9ad4\u4e4b\u5f8c\uff0c\u767c\u73fe T \u7d30\u80de\u3001\u81ea\u7136\u6bba\u624b\u7d30\u80de\u3001\u9084\u6709\u5c0d\u65bc\u5bb0\u6bba\u75c5\u6bd2\u611f\u67d3\u7d30\u80de\u7279\u5225\u6709\u4e00\u624b\u7684 d1+<\/sup> gd T \u7d30\u80de\uff0c\u90fd\u8d77\u800c\u6230\u4e4b\u3002<\/p>\n

\u81e8\u5e8a\u91ab\u8b77\u4eba\u54e1\u5f88\u65e9\u5c31\u767c\u73fe\uff0cCOVID-19 \u75c5\u60a3\u5e38\u5e38\u4f34\u96a8\u6709\u6dcb\u5df4\u7403\u6e1b\u5c11\u7684\u75c7\u72c0\uff0c\u800c\u5728\u9019\u8d77\u7814\u7a76\u5206\u6790\u88e1\uff0c\u4e5f\u7684\u78ba\u767c\u73fe\u4e0d\u55ae\u55ae\u662f B \u7d30\u80de\u6e1b\u5c11\uff0cT \u7d30\u80de\u4e5f\u540c\u6a23\u6e1b\u5c11\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u55dc\u9e7c\u6027\u7403\uff0c\u9084\u6709\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u7d30\u80de\uff08plasmacytoid dendritic cell\uff09\u7684\u6578\u91cf\u4e5f\u90fd\u53d7\u5230\u5f71\u97ff\uff0c\u800c\u4e14\u75c5\u6cc1\u8d8a\u56b4\u91cd\u7684\u75c5\u60a3\u8eab\u4e0a\uff0c\u9019\u5169\u7a2e\u7d30\u80de\u7684\u6e1b\u5c11\u8d8a\u662f\u660e\u986f\u3002<\/p>\n

\u53e6\u4e00\u500b\u4e3b\u8981\u7684\u4f5c\u6230\u4e3b\u8ef8\uff0c\u5247\u662f\u7d30\u80de\u6fc0\u7d20\uff08cytokine\uff09\u3002\u5728 COVID-19 \u75c5\u60a3\u88e1\uff0c\u4ecb\u767d\u7d20 IL-10 \u8207 IL-6 \u7684\u5206\u6ccc\uff0c\u5728\u611f\u67d3\u904e\u7a0b\u88e1\u90fd\u4e00\u76f4\u7dad\u6301\u9817\u9ad8\u3002\u6700\u8b93\u4eba\u611f\u8208\u8da3\u7684\u662f\uff0c\u662f IP-10 \u7684\u4e0a\u5347\u4e86\u3002\u5728\u7814\u7a76\u6a23\u672c\u88e1\uff0cIP-10 \u7684\u6fc3\u5ea6\u548c\u75c5\u4eba\u7f79\u75c5\u56b4\u91cd\u7a0b\u5ea6\uff0c\u5448\u73fe\u9ad8\u5ea6\u76f8\u95dc\u3002\u9019\u662f\u4e0d\u662f\u53ef\u4ee5\u7528\u505a\u75be\u75c5\u75c5\u7a0b\u7684\u89c0\u5bdf\u6307\u6a19\uff0c\u975e\u5e38\u503c\u5f97\u5f8c\u7e8c\u7814\u7a76\u7684\u8ddf\u9032\u8207\u5206\u6790\u6bd4\u8f03\u3002<\/p>\n

\u800c\u5728\u7f8e\u570b Yale University\u3001\u6cd5\u570b University de Paris \u7684\u7814\u7a76\u5718\u968a\u4e5f\u6c92\u6709\u9592\u8457\u3002\u5206\u5225\u7531 Akiko Iwasaki \u535a\u58eb\u9084\u6709 Benjamin Terrier \u535a\u58eb\u6240\u4e3b\u5c0e\u7684\u7814\u7a76\u5718\u968a\uff0c\u4e5f\u5728\u81ea\u5bb6\u91ab\u9662\u88e1\uff0c\u6536\u96c6\u5206\u6790\u4e86 COVID-19 \u75c5\u4eba\u6aa2\u9ad4\u3002Akiko Iwasaki \u535a\u58eb\u6240\u4e3b\u5c0e\u7684\u7814\u7a76\u767c\u73fe\uff0c\u65e9\u671f\u7d30\u80de\u6fc0\u7d20\u7684\u88fd\u9020\u5206\u6ccc\u91cf\uff0c\u548c\u9810\u5f8c\u6709\u8457\u6975\u5927\u76f8\u95dc\u3002<\/p>\n

\u5927\u90e8\u5206\u9810\u5f8c\u826f\u597d\u7684\u75c5\u4eba\uff0c\u90fd\u80fd\u5920\u767c\u52d5\u6709\u6548\u7684\u7b2c\u4e00\u578b\u514d\u75ab\u53cd\u61c9\uff08\u5c08\u70ba\u5c0d\u6297\u75c5\u6bd2\uff09\u8207\u7b2c\u4e09\u578b\u514d\u75ab\u53cd\u61c9\uff08\u5c08\u70ba\u5c0d\u6297\u771f\u83cc\uff09\uff0c\u5305\u62ec\u4e86 IL-1\u3001IFNa\u3001IFNg \u3001\u8207IL-17\u3002\u4e0d\u904e\uff0c\u9019\u4e9b\u75c5\u4eba\u75c5\u60c5\u4e0d\u81f3\u65bc\u60e1\u5316\u7684\u95dc\u9375\u5728\u65bc\uff0c\u96a8\u8457\u75c5\u60c5\u9010\u6f38\u597d\u8f49\uff0c\u7d30\u80de\u6fc0\u7d20\u7684\u5206\u6ccc\u4e5f\u80fd\u5920\u96a8\u4e4b\u7de9\u89e3\uff0c\u75c5\u6bd2\u8ca0\u8377\u91cf\u4e5f\u80fd\u5920\u5728\u514d\u75ab\u7cfb\u7d71\u593e\u64ca\u4e4b\u4e0b\uff0c\u6709\u6548\u5730\u88ab\u6e05\u9664\u800c\u6f38\u6e1b\u3002\u76f8\u8f03\u4e4b\u4e0b\uff0c\u75c5\u60c5\u56b4\u91cd\u60e1\u5316\u7684\u75c5\u4eba\u6aa2\u9ad4\u88e1\uff0c\u9019\u4e9b\u7d30\u80de\u6fc0\u7d20\u7684\u88fd\u9020\u5206\u6ccc\u91cf\u4e00\u76f4\u90fd\u8655\u5728\u6975\u9ad8\u7684\u72c0\u614b\uff0c\u800c\u4e14\uff0c\u5176\u4ed6\u7d30\u80de\u6fc0\u7d20 IL-21\u3001IL-23\u3001\u8207 IL-33\uff0c\u4e5f\u90fd\u760b\u72c2\u9ad8\u6f32\u3002\u63db\u8a00\u4e4b\uff0c\u5728\u75c5\u6cc1\u56b4\u91cd\u60e1\u5316\u7684\u75c5\u4eba\u8eab\u4e0a\uff0c\u514d\u75ab\u7cfb\u7d71\u597d\u50cf\u4e82\u69cd\u6253\u9ce5\u4f3c\u5f97\uff0c\u4e0d\u4f46\u4e0d\u53d7\u5230\u63a7\u5236\uff0c\u4e5f\u53ef\u4ee5\u767c\u73fe\u6709\u555f\u52d5\u7b2c\u4e8c\u578b\u514d\u75ab\u53cd\u61c9\u7684\u614b\u52e2\u3002\u9664\u6b64\u4e4b\u5916\uff0cAkiko Iwasaki \u535a\u58eb\u5718\u968a\u4e5f\u767c\u73fe\uff0c\u5982\u679c\u75c5\u60a3\u9ad4\u5167\u80fd\u5920\u6709\u6548\u555f\u52d5\u548c\u7d44\u7e54\u4fee\u5fa9\u6709\u95dc\u7684\u8a0a\u606f\u53cd\u61c9\uff0c\u75c5\u4eba\u9810\u5f8c\u72c0\u6cc1\u5c31\u6703\u6a02\u89c0\u8a31\u591a\u3002<\/p>\n

\u81f3\u65bc\u6cd5\u570b Benjamin Terrier \u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\uff0c\u5247\u767c\u73fe\u56b4\u91cd\u7684\u75c5\u60a3\u8eab\u4e0a\uff0c\u5e72\u64fe\u7d20 IFNa \u8207 IFNb \u7684\u5206\u6ccc\u4f3c\u4e4e\u56b4\u91cd\u53d7\u963b\u3002\u800c\u9019\u5169\u7a2e\u5e72\u64fe\u7d20\u5c0d\u65bc\u75c5\u6bd2\u8ca0\u8f09\u91cf\u7684\u7ba1\u63a7\uff0c\u90fd\u6975\u6709\u8ca2\u737b\u3002\u56e0\u6b64\uff0c\u7576\u5e72\u64fe\u7d20\u5206\u6ccc\u4e0d\u5920\u7684\u6642\u5019\uff0c\u75c5\u4eba\u8840\u6db2\u6aa2\u9ad4\u88e1\u7684\u75c5\u6bd2\u91cf\uff0c\u4e5f\u5c31\u4e00\u76f4\u5c45\u9ad8\u4e0d\u4e0b\u4e86\u3002<\/p>\n

\u5728\u75ab\u60c5\u96aa\u5cfb\u88e1\uff0c\u7814\u7a76\u4eba\u54e1\u5feb\u99ac\u52a0\u97ad\u5730\u60f3\u8b93\u91dd\u5c0d SARS-CoV-2 \u75c5\u6bd2\u611f\u67d3\u800c\u596e\u8d77\u7684\u514d\u75ab\u7cfb\u7d71\u53cd\u61c9\uff0c\u80fd\u5920\u597d\u597d\u5730\u73fe\u51fa\u5eec\u5c71\u771f\u9762\u76ee\u3002\u77e5\u9053\u514d\u75ab\u7cfb\u7d71\u5982\u4f55\u80fd\u5920\u91dd\u5c0d SARS-CoV-2 \u75c5\u6bd2\u5165\u4fb5\uff0c\u800c\u505a\u51fa\u53cd\u61c9\uff0c\u80fd\u5920\u5e6b\u52a9\u6211\u5011\u4e86\u89e3\u8a72\u600e\u6a23\u624d\u80fd\u5920\u6709\u6548\u6e05\u9664\u75c5\u6bd2\u3002\u5f85\u89e3\u7b54\u7684\u554f\u984c\u4f9d\u7136\u5f88\u591a\uff0c\u597d\u5728\uff0c\u76f8\u95dc\u7684\u7814\u7a76\u6210\u679c\u4e5f\u76f8\u7e7c\u767c\u8868\u3002\u5728\u63a5\u4e0b\u4f86\u7684\u7bc7\u7ae0\u88e1\uff0c\u6211\u5011\u518d\u4f86\u597d\u597d\u8a0e\u8ad6\u514d\u75ab\u7cfb\u7d71\u662f\u4e0d\u662f\u771f\u7684\u80fd\u5920\u4fdd\u8b77\u6211\u5011\u514d\u65bc SARS-CoV-2 \u7684\u5a01\u8105\u5427\uff01<\/p>\n

 <\/p>\n

 <\/p>\n

\u539f\u59cb\u7814\u7a76\uff1a<\/strong><\/p>\n

\u4ee5\u82f1\u570b\u70ba\u672c\u7684\u7814\u7a76\uff1a<\/p>\n

Adam G Laing, et al. A dynamic COVID-19 immune signature includes associations with poor prognosis. Nat Med. 2020 Aug 17. doi: 10.1038\/s41591-020-1038-6. Online ahead of print.<\/p>\n

\u4ee5\u7f8e\u570b\u70ba\u672c\u7684\u7814\u7a76\uff1a<\/p>\n

Lucas C, et al. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature. 2020 Aug;584(7821):463-469. doi: 10.1038\/s41586-020-2588-y. Epub 2020 Jul 27.<\/p>\n

\u4ee5\u6cd5\u570b\u70ba\u672c\u7684\u7814\u7a76\uff1a<\/p>\n

Hadjadj J, et al. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science. 2020 Aug 7;369(6504):718-724. doi: 10.1126\/science.abc6027. Epub 2020 Jul 13.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u82f1\u570b\u502b\u6566 The Francis Crick Institute \u8207 Guy\u2019s and St Thomas\u2019 NHS Foundation Trust \u7814\u7a76\u6a5f\u69cb\uff0c\u5728 Adrian Hayday \u535a\u58eb\u8207 Manu Shankar-Hari \u4e3b\u5c0e\u4e0b\uff0c\u5e0c\u671b\u80fd\u5920\u85c9\u8457\u514d\u75ab\u5b78\u7814\u7a76\u8207\u81e8\u5e8a\u524d\u7dda\u7684\u806f\u624b\u5408\u4f5c\uff0c\u5c0d SARS-CoV-2 \u76f8\u95dc\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u597d\u597d\u6aa2\u8996\u4e00\u756a\u3002COVID-19 \u7684\u75c7\u72c0\u56e0\u4eba\u800c\u7570\uff0c\u800c\u4e14\u500b\u9ad4\u4e4b\u9593\u5dee\u7570\u5f88\u5927\uff0c\u518d\u52a0\u4e0a\u65cf\u7fa4\u3001\u5e74\u7d00\u3001\u6027\u5225\u3001\u9084\u6709\u500b\u9ad4\u539f\u672c\u7684\u5065\u5eb7\u72c0\u6cc1\u90fd\u53ef\u80fd\u5c0d\u75c5\u60c5\u767c\u5c55\u6709\u8209\u8db3\u8f15\u91cd\u7684\u5f71\u97ff\u3002\u8003\u91cf\u65bc\u6b64\uff0c\u7814\u7a76\u5718\u968a\u5728\u7814\u7a76\u8a2d\u8a08\u4e0a\uff0c\u6c7a\u5b9a\u628a\u7814\u7a76\u76ee\u6a19\u5b9a\u5728\u627e\u51fa\u514d\u75ab\u7cfb\u7d71\u7684\u4f5c\u6230\u300c\u4e3b\u8ef8\u300d\u3002\u9019\u662f\u4ec0\u9ebc\u610f\u601d\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":35687,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4580,3293,2977],"tags":[],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/09\/cover-1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35686"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35686"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35686\/revisions"}],"predecessor-version":[{"id":35688,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35686\/revisions\/35688"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35687"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}