{"id":35592,"date":"2020-08-31T00:47:04","date_gmt":"2020-08-30T16:47:04","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35592"},"modified":"2020-08-24T14:59:27","modified_gmt":"2020-08-24T06:59:27","slug":"%e6%93%8d%e6%8e%a7%e7%b4%b0%e8%83%9e%e8%80%81%e5%8c%96%e3%80%81%e6%88%90%e5%8a%9f%e5%bb%b6%e9%95%b7%e9%85%b5%e6%af%8d%e5%a3%bd%e5%91%bd","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35592","title":{"rendered":"\u64cd\u63a7\u7d30\u80de\u8001\u5316\u3001\u6210\u529f\u5ef6\u9577\u9175\u6bcd\u58fd\u547d"},"content":{"rendered":"<figure id=\"attachment_35593\" aria-describedby=\"caption-attachment-35593\" style=\"width: 640px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-35593\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/08\/cells-1872666_640.jpg\" alt=\"\" width=\"640\" height=\"320\" 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#008080;\">\u64cd\u63a7\u7d30\u80de\u8001\u5316\u3001\u6210\u529f\u5ef6\u9577\u58fd\u547d<\/span><\/strong><\/p>\n<p>\u5148\u524d\u7814\u7a76\u7d30\u80de\u8001\u5316\u7684\u7126\u9ede\u4e3b\u8981\u96c6\u4e2d\u5728\u907a\u50b3\u7269\u8cea\u7a81\u8b8a\u5f8c\u5982\u4f55\u6539\u8b8a\u751f\u7269\u58fd\u547d\uff0c\u4ee5\u53ca\u627e\u51fa\u76f8\u95dc\u7684\u57fa\u56e0\u8207\u5176\u4ed6\u91cd\u8981\u56e0\u7d20\uff0c\u537b\u5c0d\u65bc\u7d30\u80de\u5982\u4f55\u63a7\u5236\u3001\u8abf\u7bc0\u8001\u5316\u7684\u904e\u7a0b\u77ad\u89e3\u4e0d\u591a\u3002\u70ba\u4e86\u66f4\u6df1\u5165\u5f04\u6e05\u695a\u7d30\u80de\u600e\u9ebc\u6c7a\u5b9a\u8d70\u4e0a\u4e0d\u540c\u7684\u8001\u5316\u8def\u7dda\uff0c\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u8056\u5730\u7259\u54e5\u5206\u6821 (University of California San Diego) \u5206\u5b50\u751f\u7269\u5b78\u8207\u751f\u7269\u5de5\u7a0b\u5b78\u7684\u79d1\u5b78\u5bb6\u904b\u7528\u55ae\u7d30\u80de\u651d\u5f71\u3001\u5ef6\u6642\u651d\u5f71 (time-lapse imaging)\u3001\u5fae\u6d41\u63a7 (microfluidics) 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DNA\uff0c\u8b93\u9175\u6bcd\u8d70\u4e00\u689d\u65b0\u7684\u8001\u5316\u8def\u7dda\uff0c\u6210\u529f\u8b93\u58fd\u547d\u53ef\u4ee5\u8b8a\u5f97\u5f88\u9577\u3002<\/p>\n<p><span style=\"color: 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(nucleolus) \uff0c\u4e00\u534a\u7d30\u80de\u8001\u5316\u662f\u56e0\u70ba\u7d30\u80de\u6838\u7684\u6838\u4ec1\u6108\u4f86\u6108\u4e0d\u7a69\u5b9a\uff0c\u800c\u6838\u4ec1\u662f\u86cb\u767d\u8cea\u7684\u4e0a\u6e38\u5de5\u5ee0\u3002\u53e6\u5916\u4e00\u689d\u662f\u7c92\u817a\u9ad4 (mitochondria) \u8def\u7dda\uff0c\u6709\u53e6\u5916\u4e00\u534a\u7d30\u80de\u8001\u5316\u5247\u662f\u56e0\u70ba\u6709\u7d30\u80de\u767c\u96fb\u5834\u4e4b\u7a31\u3001\u7522\u751f\u80fd\u91cf\u7684\u7c92\u817a\u9ad4\u9010\u6f38\u5931\u53bb\u529f\u80fd\u3002\u6709\u8da3\u7684\u662f\u5728\u7d30\u80de\u751f\u547d\u7684\u65e9\u671f\u5c31\u5df2\u7d93\u6c7a\u5b9a\u5c07\u4f86\u662f\u900f\u904e\u7c92\u817a\u9ad4\u8def\u7dda\u3001\u9084\u662f\u6838\u4ec1\u8def\u7dda\u8001\u5316\u3002<\/p>\n<p>\u7d30\u80de\u6838\u907a\u50b3\u7269\u8cea\u7d50\u69cb\u4e0d\u7a69\u5b9a\u8207\u7c92\u817a\u9ad4\u6e1b\u5c11\uff0c\u5169\u7a2e\u73fe\u8c61\u5c0d\u7d30\u80de\u8001\u5316\u6709\u91cd\u8981\u7684\u5f71\u97ff\uff0c\u96d6\u7136\u9019\u65b9\u9762\u5df2\u6709\u4e0d\u5c11\u7814\u7a76\uff0c\u537b\u4ecd\u7136\u4e0d\u6e05\u695a\u5728\u7d30\u80de\u8001\u5316\u6642\uff0c\u90a3\u4e00\u7a2e\u624d\u626e\u6f14\u6c7a\u5b9a\u6027\u89d2\u8272\u3002\u79d1\u5b78\u5bb6\u80fd\u5920\u64cd\u63a7\u7d30\u80de\u8001\u5316\u3001\u6210\u529f\u5ef6\u9577\u58fd\u547d\u662f\u56e0\u70ba\u767c\u73fe\u57fa\u56e0\u95dc\u9589\u8207\u7c92\u817a\u9ad4\u8def\u5f91\u4e0d\u662f\u7368\u7acb\u767c\u751f\uff0c\u800c\u662f\u6709\u4ea4\u4e92\u4f5c\u7528\uff0c\u5c0e\u81f4\u9175\u6bcd\u5728\u5206\u88c2\u3001\u8001\u5316\u6642\u6703\u5f62\u6210\u591a\u91cd\u5e73\u8861\u72c0\u614b\u3002\u56e0\u6b64\u7d30\u80de\u9700\u8981\u65e9\u65e9\u6c7a\u5b9a\u8001\u5316\u8def\u7dda\uff0c\u5728\u5206\u88c2\u3001\u8001\u5316\u6642\u53ea\u6703\u63a1\u53d6\u5176\u4e2d\u4e00\u7a2e\u72c0\u614b\u3002\u9019\u7a2e\u8a08\u756b\u6027\u7684\u8001\u5316\u7167\u8868\u64cd\u8ab2\uff0c\u4e0d\u6703\u53d7\u5230\u7d30\u80de\u5167\u5206\u5b50\u3001\u69cb\u9020\u3001\u751f\u7406\u74b0\u5883\u8b8a\u5316\u7684\u5f71\u97ff\u3002\u6240\u4ee5\u907a\u50b3\u8207\u74b0\u5883\u5169\u8005\u90fd\u6703\u5f71\u97ff\u7d30\u80de\u6c7a\u5b9a\u8001\u5316\u8def\u7dda\uff0c\u6709\u7d30\u80de\u6838\u7684\u771f\u6838\u751f\u7269\u90fd\u6709\u9019\u7a2e\u6a5f\u5236\uff0c\u5305\u62ec\u4eba\u985e\u3002<\/p>\n<p>\u79d1\u5b78\u5bb6\u64cd\u63a7\u7d30\u80de\u8001\u5316\u3001\u6210\u529f\u5ef6\u9577\u58fd\u547d\u7684\u4e0b\u4e00\u6b65\uff0c\u6703\u628a\u76f8\u540c\u7684\u6a21\u5f0f\u904b\u7528\u5728\u6bd4\u8f03\u8907\u96dc\u7684\u591a\u7d30\u80de\u751f\u7269\u4f86\u505a\u5be6\u9a57\u3002\u7814\u7a76\u591a\u7d30\u80de\u751f\u7269\u6bd4\u8d77\u55ae\u7d30\u80de\u7684\u9175\u6bcd\u96e3\u5ea6\u66f4\u9ad8\uff0c\u96d6\u7136\u6709\u540c\u6a23\u7684\u57fa\u56e0\uff0c\u58fd\u547d\u9577\u77ed\u537b\u5dee\u5f88\u591a\u3002\u4e0d\u540c\u7d30\u80de\u6703\u5c08\u9580\u8ca0\u8cac\u7279\u6b8a\u7684\u4efb\u52d9\u3001\u7d30\u80de\u9593\u9084\u6703\u5206\u5de5\u5408\u4f5c\u3001\u806f\u7d61\u3001\u4ea4\u4e92\u4f5c\u7528\u7b49\u3002\u5e0c\u671b\u6709\u4e00\u5929\u80fd\u5920\u91cd\u65b0\u7de8\u5beb\u4eba\u985e\u7d30\u80de\u8001\u5316\u7684\u85cd\u5716\u4f86\u5ef6\u9577\u58fd\u547d\uff0c\u540c\u6642\u4e5f\u9700\u8981\u975e\u5e38\u5c0f\u5fc3\u5982\u4f55\u9632\u6b62\u7d93\u904e\u6539\u9020\u7684\u9577\u58fd\u7d30\u80de\u6709\u4e00\u5929\u4e0d\u53d7\u63a7\u5236\uff0c\u5982\u764c\u7d30\u80de\u539f\u672c\u90fd\u662f\u4eba\u9ad4\u7684\u6b63\u5e38\u7d30\u80de\uff0c\u5728\u75c5\u8b8a\u4e4b\u5f8c\u4e0d\u53d7\u63a7\u5236\u4e0d\u65b7\u5206\u88c2\u7e41\u6b96\u5230\u8655\u7834\u58de\u3002\u5957\u7528\u76f8\u540c\u6a21\u5f0f\u770b\u4f3c\u7c21\u55ae\uff0c\u4ecd\u7136\u6709\u8a31\u591a\u6311\u6230\u9700\u8981\u514b\u670d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n<p>1\u3001Yang Li, Yanfei Jiang, Julie Paxman et al. <a href=\"https:\/\/science.sciencemag.org\/content\/369\/6501\/325\">A programmable fate decision landscape underlies single-cell aging in yeast.<\/a> Science. 2020.<\/p>\n<p>2\u3001Meng Jin, Yang Li, Richard O\u2019Laughlin et al. <a href=\"https:\/\/www.cell.com\/cell-systems\/supplemental\/S2405-4712(19)30036-5\">Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics.<\/a> Cell Systems. 2019.<\/p>\n<p>3\u3001Yang Li, Meng Jin, Richard O\u2019Laughlin, Philip Bittihn et al. <a href=\"https:\/\/www.pnas.org\/content\/114\/42\/11253\">Multigenerational silencing dynamics control cell aging.<\/a> Proceedings of the National Academy of Sciences. 2017.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6b77\u53f2\u4e0a\u4eba\u5011\u7aae\u76e1\u4e00\u751f\u5c0b\u627e\u6771\u65b9\u9577\u751f\u4e0d\u8001\u85e5\u3001\u897f\u65b9\u7684\u9752\u6625\u4e4b\u6cc9\uff0c\u5230\u73fe\u4ee3\u4eba\u751f\u6d3b\u4e2d\u7433\u7405\u6eff\u76ee\u7684\u5316\u599d\u54c1\u3001\u77ac\u9593\u79d2\u6bba\u984d\u6eff\u7684\u91cd\u91cf\u8a13\u7df4\u8ab2\u7a0b\u3002\u4eba\u985e\u7e3d\u662f\u60f3\u76e1\u8fa6\u6cd5\u60f3\u8981\u5e38\u4fdd\u9752\u6625\uff0c\u60f3\u8981\u627e\u56de\u6c38\u6046\u7684\u751f\u547d\u3002\u8fd1\u671f\u7814\u7a76\u767c\u73fe\uff0c\u79d1\u5b78\u5bb6\u80fd\u900f\u904e\u96fb\u8166\u6a21\u64ec\u3001\u57fa\u56e0\u5de5\u7a0b\u4f86\u4fee\u6539\u9175\u6bcd\u7684\u907a\u50b3\u7269\u8cea 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