{"id":35545,"date":"2020-08-13T00:23:26","date_gmt":"2020-08-12T16:23:26","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35545"},"modified":"2023-06-06T10:54:03","modified_gmt":"2023-06-06T02:54:03","slug":"35545","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35545","title":{"rendered":"\u3010\u79d1\u5b78\u53f2\u6c99\u9f8d\u3011\u3008\u300c\u767c\u751f\u300d\u842c\u842c\u6b72\u3009&#038;\u3008\u8840\u7ba1\u7684\u751f\u6210\uff1a\u591a\u7d30\u80de\u751f\u7269\u9ad4\u5167\u9ad8\u901f\u516c\u8def\u7684\u69cb\u7bc9\u904e\u7a0b\u3009"},"content":{"rendered":"<p style=\"text-align: center;\"><iframe src=\"https:\/\/www.youtube.com\/embed\/Tfi6prAipDw\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"color: 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#800080;\">\u3008\u8840\u7ba1\u7684\u751f\u6210\uff1a\u591a\u7d30\u80de\u751f\u7269\u9ad4\u5167\u9ad8\u901f\u516c\u8def\u7684\u69cb\u7bc9\u904e\u7a0b\u3009<\/span><\/strong><\/p>\n<p><strong>\u591a\u7d30\u80de\u751f\u7269\u7684\u9589\u9396\u5f0f\u5faa\u74b0\u7cfb\u7d71\uff0c\u662f\u6975\u6709\u6548\u7387\u7684\u6f14\u5316\u6210\u679c\uff0c\u800c\u9019\u6975\u5ea6\u4ef0\u8cf4\u6709\u5982\u9ad4\u5167\u9ad8\u901f\u516c\u8def\u7cfb\u7d71\u7684\u8840\u7ba1\u751f\u6210\uff0c\u4fc3\u9032\u7269\u8cea\u4ea4\u63db\u7684\u901f\u5ea6\u8207\u6548\u7387\u3002\u8fd1\u5e74\u7684\u7814\u7a76\u767c\u73fe\uff0c\u764c\u7d30\u80de\u7684\u751f\u9577\u4e5f\u9700\u8981\u4f9d\u8cf4\u65b0\u751f\u8840\u7ba1\u7684\u751f\u6210\uff0c\u56e0\u6b64\u5c0d\u8840\u7ba1\u751f\u6210\u8abf\u63a7\u7684\u5145\u5206\u7406\u89e3\u8207\u63a7\u5236\uff0c\u53ef\u80fd\u662f\u6cbb\u7642\u8a31\u591a\u75be\u75c5\u7684\u6377\u5f91\u3002<\/strong><\/p>\n<p><strong>\u8b1b\u5e2b\uff1a\u674e\u5fc3\u4e88\u2502\u81fa\u5927\u751f\u547d\u79d1\u5b78\u7cfb\u6559\u6388<\/strong><\/p>\n<p>\u8840\u7ba1\u7531\u5167\u76ae\u7d30\u80de\u3001\u5e73\u6ed1\u808c\u8089\u7d30\u80de\u3001\u4ee5\u53ca\u7e96\u7dad\u7d30\u80de\u69cb\u6210\u3002\u5167\u76ae\u7d30\u80de\u662f\u8840\u7ba1\u6700\u57fa\u672c\u7684\u69cb\u9020\uff0c\u5fae\u8840\u7ba1\u57fa\u672c\u4e0a\u5c31\u662f\u55ae\u7d14\u7531\u5167\u76ae\u7d30\u80de\u6240\u69cb\u6210\uff0c\u4e0d\u4f46\u7269\u8cea\u901a\u900f\u8840\u7ba1\u5167\u5916\u5b8c\u5168\u9760\u5167\u76ae\u7d30\u80de\u638c\u63a7\uff0c\u8840\u7ba1\u65b0\u751f\u4e5f\u8207\u5167\u76ae\u7d30\u80de\u6709\u9ad8\u5ea6\u76f8\u95dc\u3002<\/p>\n<p>\u6b63\u5e38\u7684\u80da\u80ce\u8840\u7ba1\u65b0\u751f\uff0c\u9700\u8981\u5927\u91cf\u990a\u5206\u53ca\u4ee3\u8b1d\uff0c\u8840\u7ba1\u751f\u6210\u624d\u8db3\u4ee5\u4f9b\u61c9\u5feb\u901f\u767c\u5c55\u7684\u80da\u80ce\u751f\u9577\u6240\u9700\u3002\u764c\u7d30\u80de\u5728\u5f62\u6210\u60e1\u6027\u816b\u7624\u6642\uff0c\u540c\u6a23\u6703\u5206\u6ccc\u523a\u6fc0\u8840\u7ba1\u65b0\u751f\u7684\u7269\u8cea\uff0c\u523a\u6fc0\u5bbf\u4e3b\u65b0\u751f\u8840\u7ba1\uff0c\u4ee5\u4f9b\u61c9\u5176\u589e\u751f\u6240\u9700\u990a\u5206\u3002\u764c\u7d30\u80de\u85c9\u7531\u8840\u7ba1\u9019\u689d\u9ad8\u901f\u516c\u8def\uff0c\u5728\u9ad4\u5167\u9032\u884c\u8f49\u79fb\u3002\u9019\u8207\u7d30\u80de\u7684\u5927\u5c0f\u53ca\u5176\u64f4\u6563\u4f5c\u7528\u6709\u95dc\uff0c\u7d30\u80de\u5fc5\u9808\u5927\u5230\u8db3\u4ee5\u5bb9\u7d0d\u5404\u7a2e\u5fc5\u8981\u7684\u80de\u5668\uff0c\u4f46\u53c8\u4e0d\u80fd\u5927\u5230\u8d85\u51fa\u64f4\u6563\u4f5c\u7528\u7684\u754c\u7dda\uff0c\u8b93\u7d30\u80de\u7121\u6cd5\u4f9d\u8cf4\u64f4\u6563\u4f5c\u7528\u4ea4\u63db\u7269\u8cea\uff1b\u7136\u800c\u82e5\u80fd\u85c9\u7531\u8840\u7ba1\u8f38\u9001\u990a\u5206\uff0c\u5176\u589e\u751f\u5c31\u53ef\u7a81\u7834\u5176\u81ea\u7136\u5927\u5c0f\u9650\u5236\u3002<\/p>\n<p>\u764c\u7d30\u80de\u7684\u751f\u6210\u8207\u81f4\u764c\u57fa\u56e0\u6709\u95dc\uff0c\u7136\u800c\u81f4\u764c\u57fa\u56e0\u7684\u5019\u9078\u4eba\u65cf\u7e41\u4e0d\u53ca\u5099\u8f09\uff0c\u6bcf\u500b\u7d30\u80de\u5206\u88c2\u7684\u56e0\u5b50\u53ea\u8981\u5728\u7a81\u8b8a\u4e4b\u5f8c\uff0c\u6703\u5f71\u97ff\u6b63\u5e38\u7684\u7d30\u80de\u5206\u88c2\uff0c\u5b83\u5c31\u7b97\u662f\u81f4\u764c\u57fa\u56e0\u3002\u9664\u4e86\u81f4\u764c\u57fa\u56e0\u4ee5\u5916\uff0c\u764c\u7d30\u80de\u751f\u6210\u8ddf\u53e6\u4e00\u7a2e\u300c\u816b\u7624\u6291\u5236\u57fa\u56e0\u300d\u4e5f\u6709\u95dc\u4fc2\u3002\u816b\u7624\u6291\u5236\u57fa\u56e0\u7684\u529f\u80fd\uff0c\u662f\u5728\u7d30\u80de\u5b8c\u6210\u6240\u6709\u67d3\u8272\u9ad4\u8907\u88fd\u4e4b\u524d\uff0c\u6291\u5236\u7d30\u80de\u5206\u88c2\u7684\u52d5\u4f5c\uff1b\u816b\u7624\u6291\u5236\u57fa\u56e0\u82e5\u662f\u767c\u751f\u7a81\u8b8a\uff0c\u5931\u53bb\u6291\u5236\u7d30\u80de\u5206\u88c2\u7684\u529f\u80fd\uff0c\u7d30\u80de\u5c31\u6709\u53ef\u80fd\u5728\u5b8c\u6210\u6b63\u5e38\u7684\u67d3\u8272\u9ad4\u8907\u88fd\u524d\u9015\u884c\u5206\u88c2\uff0c\u5f9e\u800c\u7522\u751f\u816b\u7624\u7d30\u80de\u3002\u816b\u7624\u7d30\u80de\u6709\u826f\u6027\u8ddf\u60e1\u6027\u4e4b\u5206\uff0c\u816b\u7624\u662f\u5426\u6703\u6210\u70ba\u60e1\u6027\u7684\u764c\u7d30\u80de\uff0c\u7aef\u770b\u8a72\u7d30\u80de\u5718\u662f\u5426\u80fd\u5920\u7a81\u7834\u7d30\u80de\u4e0b\u57fa\u5e95\u8cea\u5c64\uff0c\u9032\u5165\u4e0b\u5c64\u7d44\u7e54\u800c\u5b9a\u3002<\/p>\n<p>\u65e2\u7136\u764c\u7d30\u80de\u589e\u751f\u8207\u8840\u7ba1\u65b0\u751f\u6709\u9ad8\u5ea6\u76f8\u95dc\uff0c\u5c31\u53ef\u4ee5\u5f9e\u8840\u7ba1\u751f\u6210\u8abf\u63a7\u7684\u6a5f\u5236\u8457\u624b\uff0c\u9032\u884c\u6291\u5236\u764c\u7d30\u80de\u589e\u751f\u7684\u6cbb\u7642\u3002\u9019\u500b\u6a5f\u5236\u662f\u7531\u8840\u7ba1\u751f\u6210\u6291\u5236\u7269\u8207\u4fc3\u9032\u7269\u7684\u76f8\u5c0d\u5e73\u8861\u6240\u6c7a\u5b9a\uff0c\u7576\u8840\u7ba1\u751f\u6210\u6291\u5236\u7269\u6fc3\u5ea6\u76f8\u5c0d\u9ad8\uff0c\u4fc3\u9032\u7269\u6fc3\u5ea6\u76f8\u5c0d\u4f4e\u6642\uff0c\u7d30\u80de\u5206\u88c2\u7684\u983b\u7387\u5c31\u4f4e\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002\u76ee\u524d\u5df2\u77e5\u6709\u591a\u7a2e\u7269\u8cea\u5177\u6709\u4fc3\u9032\u8840\u7ba1\u751f\u6210\u7684\u80fd\u529b\uff0c\u5176\u4e2d\u7684 VEGF \u5206\u5b50\u8207\u764c\u7d30\u80de\u751f\u6210\u6709\u95dc\uff0c\u50b3\u7d71\u7684\u764c\u75c7\u6cbb\u7642\u85e5\u7269\u5c31\u662f\u91dd\u5c0d VEGF \u958b\u767c\u7684\u6297\u9ad4\u85e5\uff1b\u4e0d\u904e\u73fe\u5728\u6709\u85c9\u7531\u751f\u7269\u5206\u5b50\u4ea4\u4e92\u4f5c\u7528\u5206\u6790\u7cfb\u7d71 (Biacore) \uff0c\u958b\u767c\u51fa\u4f86\u7684\u7d50\u6676\u7e5e\u5c04 (Crystalgraphy) \u4ee5\u53ca\u9ad8\u901a\u91cf\u7be9\u9078 (High Throughput Screening) 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