{"id":35434,"date":"2020-07-02T00:13:00","date_gmt":"2020-07-01T16:13:00","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35434"},"modified":"2020-06-30T09:37:17","modified_gmt":"2020-06-30T01:37:17","slug":"%e5%b7%b4%e9%87%91%e6%a3%ae%e6%b0%8f%e7%97%87%e6%97%a9%e6%9c%9f%e8%a8%ba%e6%96%b7%e9%9c%b2%e5%87%ba%e6%9b%99%e5%85%89","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35434","title":{"rendered":"\u5df4\u91d1\u68ee\u6c0f\u75c7\u65e9\u671f\u8a3a\u65b7\u9732\u51fa\u66d9\u5149"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u7814\u7a76\u767c\u73fe\u8166\u90e8\u4e00\u7a2e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0d\uff0d\u8840\u6e05\u7d20\u7684\u8b8a\u5316\u53ef\u4ee5\u4f5c\u70ba\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7 (Parkinson's disease) \u7684\u65e9\u671f\u8a0a\u865f\uff0c\u6bd4\u76ee\u524d\u7528\u4f86\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u6a19\u6e96\u75c7\u72c0\u63d0\u65e9\u5341\u4e94\u5230\u4e8c\u5341\u5e74\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_35435\" aria-describedby=\"caption-attachment-35435\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-35435\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/06\/computer-tomography-62942_640.jpg\" alt=\"\" width=\"450\" height=\"321\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/06\/computer-tomography-62942_640.jpg 640w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/06\/computer-tomography-62942_640-300x214.jpg 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-35435\" class=\"wp-caption-text\">\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff0f\u9673\u6566\u7406<\/strong><\/p>\n<p>\u5df4\u91d1\u68ee\u6c0f\u75c7\u6216\u7a31\u4f5c\u5e15\u91d1\u68ee\u6c0f\u75c7\u662f\u4e00\u7a2e\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u60a3\u8005\u8166\u90e8\u5206\u6ccc\u591a\u5df4\u80fa (dopamine) \u7684\u7d30\u80de\u9010\u6f38\u58de\u6b7b\uff0c\u8b93\u8166\u90e8\u591a\u5df4\u80fa\u7684\u5206\u6ccc\u6e1b\u5c11\uff0c\u4f7f\u5f97\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u591a\u5df4\u80fa\u8207\u4e59\u91af\u81bd\u9e7c\u5354\u8abf\u8eab\u9ad4\u52d5\u4f5c\u7684\u529f\u80fd\u5931\u53bb\u5e73\u8861\uff0c\u9020\u6210\u75c5\u60a3\u6d3b\u52d5\u6108\u4f86\u6108\u56f0\u96e3\u3002\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7\u6240\u9047\u5230\u7684\u6700\u5927\u96e3\u984c\u5728\u65bc\u8a31\u591a\u75be\u75c5\u90fd\u53ef\u80fd\u51fa\u73fe\u985e\u4f3c\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u75c7\u72c0\uff0c\u50cf\u662f\u5931\u667a\u75c7\u3001\u816b\u7624\u3001\u5275\u50b7\u3001\u85e5\u7269\u526f\u4f5c\u7528\u7b49\u3002\u800c\u62bd\u8840\u6aa2\u67e5\u3001\u8166\u90e8\u96fb\u8166\u65b7\u5c64\u6383\u63cf\u3001\u8166\u90e8\u6838\u78c1\u5171\u632f\u6383\u63cf\u90fd\u4e0d\u80fd\u5354\u52a9\u91ab\u5e2b\u5224\u65b7\u60a3\u8005\u662f\u5426\u7f79\u60a3\u5df4\u91d1\u68ee\u6c0f\u75c7\u3002<\/p>\n<p><strong><span style=\"color: #008080;\">\u25cf\u900f\u904e\u5bb6\u65cf\u907a\u50b3\u5df4\u91d1\u68ee\u6c0f\u75c7\u5c0b\u627e\u65e9\u671f\u8a3a\u65b7\u7684\u65b9\u6cd5<\/span><\/strong><\/p>\n<p>\u5148\u524d\u79d1\u5b78\u5bb6\u767c\u73fe\u5728\u4e00\u7a2e\u5bb6\u65cf\u907a\u50b3\u57fa\u56e0\u7a81\u8b8a LRRK2 \u6240\u9020\u6210\u7684\u5df4\u91d1\u68ee\u6c0f\u75c7\u75c5\u60a3\u8166\u90e8\u767c\u73fe\u8840\u6e05\u7d20 (serotonin) \u660e\u986f\u6e1b\u5c11\u3002\u82f1\u570b\u502b\u6566\u570b\u738b\u5b78\u9662 (King\u2019s College London) \u7684\u7814\u7a76\u5718\u968a\u60f3\u8981\u66f4\u6df1\u5165\u63a2\u8a0e\u8840\u6e05\u7d20\u8b8a\u5316\u662f\u5426\u80fd\u4f5c\u70ba\u5df4\u91d1\u68ee\u6c0f\u75c7\u8a3a\u65b7\u7684\u5de5\u5177\uff0c\u65bc\u662f\u6253\u7b97\u5f9e\u53e6\u4e00\u7a2e\u4e5f\u6703\u9020\u6210\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u5bb6\u65cf\u907a\u50b3\u57fa\u56e0\u7a81\u8b8a SNCA\u4e0b\u624b\u3002<\/p>\n<p>\u4ed6\u5011\u5fb5\u6c42\u5230\u5341\u56db\u4f4d\u4f4f\u5728\u5e0c\u81d8\u3001\u7fa9\u5927\u5229\u504f\u9060\u6751\u843d\u7684\u5c45\u6c11\u53c3\u8207\u5be6\u9a57\uff0c\u9019\u4e9b\u6c11\u773e\u90fd\u60a3\u6709\u7f55\u898b\u7684\u57fa\u56e0\u7a81\u8b8a&nbsp; \u03b1-synuclein (SNCA) \u57fa\u56e0 A53T\uff0c\u8166\u4e2d\u03b1-synuclein\u86cb\u767d\u5806\u7a4d\u88ab\u8a3c\u5be6\u662f\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u75c5\u7406\u5b78\u7279\u5fb5\u3002\u5728\u4ed6\u5011\u5e74\u9f61\u4f86\u5230\u56db\u5341\u3001\u4e94\u5341\u6b72\u5c31\u4e00\u5b9a\u6703\u767c\u5c55\u6210\u5df4\u91d1\u68ee\u6c0f\u75c7\u3002\u53e6\u5916\u4e5f\u5fb5\u6c42\u4f4f\u5728\u82f1\u570b\u7684\u81ea\u9858\u6c11\u773e\u53c3\u8207\u5be6\u9a57\uff0c\u5176\u4e2d\u4e8c\u5341\u4e94\u4eba\u8eab\u9ad4\u5065\u5eb7\u3001\u5e74\u9f61\u8207\u5bb6\u65cf\u907a\u50b3\u5df4\u91d1\u68ee\u6c0f\u75c7\u60a3\u8005\u63a5\u8fd1\uff0c\u4f86\u505a\u70ba\u5be6\u9a57\u5c0d\u7167\u7d44\uff0c\u53e6\u5916\u56db\u5341\u4eba\u5df2\u7d93\u78ba\u8a3a\u5df4\u91d1\u68ee\u6c0f\u75c7\u3002\u6240\u6709\u53c3\u8207\u5be6\u9a57\u7684\u6c11\u773e\u90fd\u6703\u63a5\u53d7\u91ab\u5e2b\u6aa2\u67e5\uff0c\u5f9e\u8eab\u9ad4\u52d5\u4f5c\u65b9\u9762\u3001\u8a8d\u77e5\u80fd\u529b\u4f86\u8a55\u4f30\u662f\u5426\u7f79\u60a3\u5df4\u91d1\u68ee\u6c0f\u75c7\uff0c\u4ee5\u53ca\u75c5\u7a0b\u767c\u5c55\u5982\u4f55\u3002\u70ba\u4e86\u8207\u76ee\u524d\u7684\u5df4\u91d1\u68ee\u6c0f\u75c7\u8a3a\u65b7\u3001\u75c5\u7406\u5b78\u6a19\u6e96\u505a\u70ba\u5c0d\u7167\uff0c\u4ed6\u5011\u4e5f\u63a5\u53d7\u591a\u7a2e\u8166\u90e8\u6383\u63cf\u4f86\u4e86\u89e3\u591a\u5df4\u80fa\u5206\u6ccc\u91cf\u3001\u76f8\u95dc\u90e8\u4f4d\u8166\u9ad4\u7a4d\u8b8a\u5316\u60c5\u5f62\u3002\u81f3\u65bc\u8166\u90e8\u8840\u6e05\u7d20\u7684\u8b8a\u5316\u60c5\u5f62\u5247\u662f\u4ee5\u6b63\u5b50\u65b7\u5c64\u9020\u5f71 (PET) \u7684\u8166\u90e8\u6383\u63cf\u4f86\u9032\u884c\u89c0\u5bdf\u3002<\/p>\n<p><strong><span style=\"color: #008080;\">\u25cf\u4ee5\u8166\u90e8\u8840\u6e05\u7d20\u8b8a\u5316\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7<\/span><\/strong><\/p>\n<p>\u6700\u5f8c\u628a\u4e09\u7fa4\u4e0d\u540c\u53d7\u8a66\u6c11\u773e\u7684\u8166\u90e8\u6383\u63cf\u5f71\u50cf\u3001\u795e\u7d93\u5b78\u6aa2\u67e5\u7d50\u679c\u653e\u5728\u4e00\u8d77\u9032\u884c\u5206\u6790\u3002\u7814\u7a76\u767c\u73fe\u8eab\u4e0a\u5e36\u6709\u7f55\u898b\u57fa\u56e0\u7a81\u8b8a\u3001\u537b\u9084\u6c92\u6709\u767c\u5c55\u6210\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u4e03\u4f4d\u6c11\u773e\uff0c \u8166\u90e8\u591a\u5df4\u80fa\u5206\u6ccc\u6b63\u5e38\u3002\u7136\u800c\u8207\u5065\u5eb7\u6c11\u773e\u7684\u8166\u90e8\u6383\u63cf\u5c0d\u7167\uff0c\u624d\u767c\u73fe\u4ed6\u5011\u8166\u90e8\u90a3\u4e9b\u53d7\u5230\u5df4\u91d1\u68ee\u6c0f\u75c7\u5f71\u97ff\u7684\u76f8\u95dc\u5340\u57df\u8840\u6e05\u7d20\u5206\u6ccc\u5df2\u7d93\u8b8a\u5c11\u3002\u8840\u6e05\u7d20\u662f\u8166\u90e8\u4e00\u7a2e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u4e00\u65e6\u8166\u90e8\u76f8\u95dc\u5340\u57df\u7684\u8840\u6e05\u7d20\u6e1b\u5c11\uff0c\u5f88\u53ef\u80fd\u8b93\u60c5\u7dd2\u8b8a\u5f97\u4f4e\u843d\u3002\u800c\u5e36\u6709\u7f55\u898b\u57fa\u56e0\u7a81\u8b8a\u53c8\u5df2\u7d93\u78ba\u8a3a\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u53e6\u5916\u4e03\u4f4d\u6c11\u773e\uff0c\u8840\u6e05\u7d20\u4e0d\u4f46\u660e\u986f\u6e1b\u5c11\u800c\u4e14\u7bc4\u570d\u66f4\u5927\u3002\u5728\u5bb6\u65cf\u907a\u50b3\u5df4\u91d1\u68ee\u6c0f\u75c7\u548c\u4e00\u822c\u4e0d\u660e\u539f\u56e0\u7684\u5df4\u91d1\u68ee\u6c0f\u75c7\u53d7\u8a66\u6c11\u773e\u8eab\u4e0a\u90fd\u767c\u73fe\u8166\u90e8\u8840\u6e05\u7d20\u4e0b\u964d\u6108\u591a\uff0c\u4ed6\u5011\u56db\u80a2\u986b\u6296\u3001\u50f5\u76f4\u7684\u75c7\u72c0\u6108\u56b4\u91cd\uff0c\u53ea\u662f\u5bb6\u65cf\u907a\u50b3\u5df4\u91d1\u68ee\u6c0f\u75c7\u75c5\u60a3\u7684\u75c5\u7a0b\u66f4\u52a0\u5feb\u901f\uff0c\u5f9e\u7b2c\u4e00\u671f\u8eab\u9ad4\u55ae\u5074\u53d7\u5f71\u97ff\u3001\u529f\u80fd\u5927\u81f4\u6b63\u5e38\u5230\u7b2c\u4e94\u671f\u9700\u81e5\u5e8a\u6216\u5750\u8f2a\u6905\uff0c\u65e5\u5e38\u751f\u6d3b\u7121\u6cd5\u81ea\u7406\u7684\u6642\u9593\u7e2e\u77ed\u3002<\/p>\n<p>\u76ee\u524d\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7\u4e3b\u8981\u9084\u662f\u4f9d\u64da\u81e8\u5e8a\u75c7\u72c0\u548c\u795e\u7d93\u5b78\u6aa2\u67e5\uff0c\u50cf\u662f\u75c5\u60a3\u975c\u6b62\u6642\u4e0d\u81ea\u4e3b\u986b\u6296\u3001\u50f5\u76f4\u52a0\u4e0a\u5c0d\u591a\u5df4\u80fa\u6cbb\u7642\u85e5\u7269\u6709\u53cd\u61c9\u7b49\u3002\u53ef\u4ee5\u60f3\u898b\u4e00\u822c\u6c11\u773e\u5f9e\u51fa\u73fe\u76f8\u95dc\u75c7\u72c0\u5230\u78ba\u8a3a\u66e0\u65e5\u8cbb\u6642\uff0c\u5f88\u53ef\u80fd\u5df2\u932f\u904e\u6cbb\u7642\u7684\u6700\u4f73\u6642\u6a5f\u3002\u8840\u6e05\u7d20\u75c5\u7406\u5b78\u6bd4\u76ee\u524d\u7528\u4f86\u986f\u793a\u5df4\u91d1\u68ee\u6c0f\u75c7\u75c5\u7a0b\u7684\u591a\u5df4\u80fa\u75c5\u7406\u5b78\u9084\u8981\u63d0\u65e9\u975e\u5e38\u591a\uff0c\u800c\u4e14\u4e5f\u8207\u75c5\u60a3\u81e8\u5e8a\u75c7\u72c0\u3001\u795e\u7d93\u5b78\u6aa2\u67e5\u7d50\u679c\u4e00\u81f4\uff0c\u53ef\u4ee5\u505a\u70ba\u5df4\u91d1\u68ee\u6c0f\u75c7\u65e9\u671f\u8a3a\u65b7\u7684\u65b0\u65b9\u6cd5\uff0c\u662f\u5341\u5206\u91cd\u8981\u7684\u767c\u73fe\u3002\u4e0d\u904e\u60f3\u8981\u4ee5\u8166\u90e8\u8840\u6e05\u7d20\u8b8a\u5316\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7\u4ecd\u7136\u9762\u81e8\u4e0d\u5c11\u56f0\u96e3\uff0c\u50cf\u662f\u5927\u90e8\u5206\u7684\u5df4\u91d1\u68ee\u6c0f\u75c7\u90fd\u4e0d\u662f\u5bb6\u65cf\u907a\u50b3\u800c\u4e14\u539f\u56e0\u4e0d\u660e\u3001\u7814\u7a76\u75c5\u4f8b\u6578\u9700\u8981\u589e\u52a0\u6703\u66f4\u6709\u4ee3\u8868\u6027\u3001\u8166\u90e8\u6383\u63cf\u8cbb\u7528\u6602\u8cb4\u3001\u5982\u4f55\u627e\u51fa\u5c1a\u672a\u767c\u75c5\u7684\u5df4\u91d1\u68ee\u6c0f\u75c7\u6c11\u773e\u7b49\u3002<\/p>\n<p>\u5df4\u91d1\u68ee\u6c0f\u75c7\u5f9e\u897f\u5143 1817\u5e74\u82f1\u570b\u91ab\u5e2b\u8a79\u59c6\u58eb\u2027\u5df4\u91d1\u68ee (James Parkinson)\u767c\u8868\u4ee5\u4f86\uff0c\u8d85\u904e 200\u5e74\uff0c\u4ecd\u7136\u6c92\u6709\u5b8c\u5168\u6cbb\u7652\u7684\u65b9\u6cd5\u3002\u8166\u90e8\u8840\u6e05\u7d20\u7684\u8b8a\u5316\u8b93\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u8a3a\u65b7\u53ef\u671b\u63d0\u65e9\u4e8c\u5341\u5e74\uff0c\u5728\u591a\u5df4\u80fa\u6d88\u5931\u3001\u80a2\u9ad4\u986b\u6296\u75c7\u72c0\u51fa\u73fe\u4e4b\u524d\u3002\u800c\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u75c7\u72c0\u51fa\u73fe\u6642\uff0c\u8166\u4e2d\u76f8\u95dc\u90e8\u4f4d\u7684\u795e\u7d93\u7d30\u80de\u5df2\u58de\u6b7b 60%\uff0c\u5982\u679c\u80fd\u5728\u795e\u7d93\u7d30\u80de\u58de\u6b7b\u521d\u671f\u5c31\u7a4d\u6975\u6cbb\u7642\uff0c\u53ef\u80fd\u6703\u6709\u5b8c\u5168\u4e0d\u4e00\u6a23\u7684\u7d50\u679c\u3002\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u65e9\u671f\u8a3a\u65b7\u5c07\u70ba\u65b0\u7642\u6cd5\u7684\u767c\u5c55\u958b\u555f\u4eba\u5011\u4e0d\u66fe\u60f3\u904e\u7684\u4e00\u9053\u9580\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599<br \/>\n<\/strong>1\u3001Heather Wilson, George Dervenoulas, Gennaro Pagano, et al. <a href=\"https:\/\/www.thelancet.com\/journals\/laneur\/article\/PIIS1474-4422(19)30140-1\/fulltext\">Serotonergic pathology and disease burden in the premotor and motor phase of A53T \u03b1-synuclein parkinsonism: a cross-sectional study.<\/a> The Lancet Neurology. 2019.<br \/>\n2\u3001\u9673\u57f9\u8c6a\u3002<a href=\"http:\/\/ttw3.mmh.org.tw\/neuroweb\/edu\/edu_neu5.htm\">\u986b\u6296\u7684\u617e\u671b\uff1a\u8d8a\u4f86\u8d8a\u591a\u7684\u5df4\u91d1\u68ee\u6c0f\u75c5<\/a>\u3002\u99ac\u5055\u7d00\u5ff5\u91ab\u9662\u795e\u7d93\u79d1\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u767c\u73fe\u8166\u90e8\u4e00\u7a2e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0d\uff0d\u8840\u6e05\u7d20\u7684\u8b8a\u5316\u53ef\u4ee5\u4f5c\u70ba\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7 (Parkinson's disease) \u7684\u65e9\u671f\u8a0a\u865f\uff0c\u6bd4\u76ee\u524d\u7528\u4f86\u8a3a\u65b7\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u6a19\u6e96\u75c7\u72c0\u63d0\u65e9\u5341\u4e94\u5230\u4e8c\u5341\u5e74\u3002<\/p>\n","protected":false},"author":20,"featured_media":35435,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[2412,4328,268],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/06\/computer-tomography-62942_640.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35434"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35434"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35434\/revisions"}],"predecessor-version":[{"id":35436,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35434\/revisions\/35436"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35435"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}