{"id":35326,"date":"2020-06-10T00:32:51","date_gmt":"2020-06-09T16:32:51","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35326"},"modified":"2020-06-10T08:44:24","modified_gmt":"2020-06-10T00:44:24","slug":"%e5%b7%a8%e7%b4%b0%e8%83%9e%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e5%bc%95%e8%b5%b7%e7%9a%84%e8%85%a6%e9%83%a8%e7%96%be%e7%97%85","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35326","title":{"rendered":"\u5de8\u7d30\u80de\u75c5\u6bd2\u611f\u67d3\u5f15\u8d77\u7684\u8166\u90e8\u75be\u75c5"},"content":{"rendered":"

\u8166\u90e8\u75be\u75c5\u662f\u5168\u7403\u6027\u4eba\u985e\u5065\u5eb7\u554f\u984c\uff0c\u901a\u5e38\u662f\u8907\u96dc\u3001\u56b4\u91cd\u3001\u4e0d\u53ef\u9006\u3001\u6301\u7e8c\u4e14\u96e3\u6cbb\u7684\uff0c\u800c\u5de8\u7d30\u80de\u75c5\u6bd2\uff08cytomegalovirus, CMV\uff09\u662f\u53ef\u80fd\u5c0e\u81f4\u8166\u90e8\u75be\u75c5\uff08\u4f8b\u5982\uff1a\u5fc3\u667a\u9072\u920d\u548c\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u7684\u98a8\u96aa\u56e0\u5b50\u4e4b\u4e00\u3002\u672c\u6587\u5c07\u4ecb\u7d39\u8207CMV\u611f\u67d3\u76f8\u95dc\u7684\u8166\u90e8\u75be\u75c5\uff0c\u63a2\u8a0e\u5176\u5c0d\u4eba\u9ad4\u7684\u5f71\u97ff\u3001\u75c5\u56e0\u53ca\u53ef\u80fd\u7684\u81f4\u75c5\u4f5c\u7528\u6a5f\u8f49\u3002<\/strong><\/span><\/p>\n

\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u8166\u90e8\u75be\u75c5\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

\u5927\u8166\u662f\u4eba\u9ad4\u7684\u63a7\u5236\u4e2d\u5fc3\uff0c\u4e3b\u5c0e\u601d\u60f3\u3001\u8a18\u61b6\u3001\u5b78\u7fd2\u3001\u8a00\u8a9e\u53ca\u904b\u52d5\u7b49\u6d3b\u52d5\uff0c\u4e26\u8abf\u7bc0\u8a31\u591a\u5668\u5b98\u7684\u529f\u80fd\u3002\u5927\u8166\u5065\u5eb7\u6642\u6703\u5feb\u901f\u3001\u81ea\u52d5\u5730\u5de5\u4f5c\uff0c\u4f7f\u4eba\u9ad4\u7dad\u6301\u6b63\u5e38\uff0c\u4f46\u7576\u5927\u8166\u53d7\u640d\u6642\u6703\u5f71\u97ff\u601d\u8003\u3001\u611f\u89ba\u3001\u5fc3\u667a\u53ca\u8eab\u9ad4\u72c0\u614b\u751a\u81f3\u4eba\u683c\u7b49\u3002\u8166\u90e8\u75be\u75c5\u4e3b\u8981\u5305\u62ec\u8166\u640d\u50b7\uff08brain injury\uff09\u3001\u7cbe\u795e\u969c\u7919\uff08mental disorder\uff09\u3001\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff08neurodegenerative disease\uff09\u3001\u5fc3\u667a\u9072\u920d\uff08mental retardation\uff09\u548c\u8166\u7624\uff08brain tumor\uff09\uff0c\u5176\u4e2d\u5fc3\u667a\u9072\u920d\u548c\u8166\u7624\u7684\u767c\u751f\u8207CMV\u611f\u67d3\u6709\u5bc6\u5207\u76f8\u95dc\u6027\uff08\u88681\uff09\u3002<\/p>\n

\"\"<\/p>\n

\u25cf\u8166\u90e8\u75be\u75c5\u8207<\/strong>CMV<\/strong>\u611f\u67d3\u7684\u95dc\u806f\u6027<\/strong><\/span><\/p>\n

1.\u5fc3\u667a\u9072\u920d<\/p>\n

CMV\u7684\u5148\u5929\u6027\u611f\u67d3\uff08congenital infection\uff09\u662f\u9020\u6210\u65b0\u751f\u5152\u5fc3\u667a\u9072\u920d\u7684\u4e3b\u56e0\u4e4b\u4e00\uff0c\u800c\u901a\u904e\u6bcd\u4e73\u6216\u5782\u76f4\u611f\u67d3\uff08\u901a\u904e\u80ce\u76e4\u76f4\u63a5\u611f\u67d3\u80ce\u5152\uff09\u50b3\u67d3\u662f\u5148\u5929\u6027\u611f\u67d3\u7684\u4e3b\u8981\u65b9\u5f0f\u3002\u5982\u679c\u6bcd\u89aa\u5728\u598a\u5a20\u4e2d\u9996\u6b21\u88abCMV\u611f\u67d3\uff08\u539f\u767c\u611f\u67d3\uff09\uff0c\u56e0\u70ba\u5979\u5011\u6c92\u6709CMV\u6297\u9ad4\uff0c\u4fbf\u53ef\u80fd\u6703\u767c\u751f\u5b50\u5bae\u5167\u611f\u67d3\uff08intrauterine infection\uff09\u800c\u50b3\u67d3\u7d66\u80ce\u5152\uff1b\u7136\u800c\uff0c\u4e5f\u6709\u53ef\u80fd\u6bcd\u89aa\u5df2\u5e36\u6709CMV\u6297\u9ad4\uff0c\u4f46\u56e0\u5148\u524dCMV\u7684\u91cd\u65b0\u6fc0\u6d3b\uff08reactivation\uff09\u6216\u4e0d\u540c\u75c5\u6bd2\u682a\u7684\u611f\u67d3\uff08\u975e\u539f\u767c\u6027\u611f\u67d3\uff09\u800c\u5f15\u8d77\u7684\u3002\u96d6\u7136\u5927\u591a\u6578\u5148\u5929\u6027\u611f\u67d3\u662f\u7121\u75c7\u72c0\u7684\uff0885\u201390\uff05\uff09\uff0c\u4f46\u7d0410-15\uff05 \u7684\u5148\u5929\u6027\u611f\u67d3\u7684\u65b0\u751f\u5152\u53ef\u80fd\u6703\u6709\u5f8c\u907a\u75c7\uff0c\u5982\u795e\u7d93\u767c\u80b2\u7de9\u6162\u3001\u5fc3\u667a\u9072\u920d\u3001\u9ec3\u75b8\u3001\u809d\u813e\u816b\u5927\u3001\u5c0f\u982d\u7578\u5f62\u3001\u807d\u529b\u969c\u7919\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u7b49\uff0c\u5176\u4e2d\u6700\u5177\u7834\u58de\u6027\u7684\u662f\u8207\u795e\u7d93\u767c\u80b2\u6709\u95dc\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u5f8c\u907a\u75c7\u3002\u56e0\u70ba\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u640d\u50b7\u662f\u4e0d\u53ef\u9006\u7684\u4e14\u5177\u6301\u7e8c\u6027\uff0c\u53ef\u80fd\u5f15\u8d77\u5fc3\u667a\u9072\u920d\u3001\u7672\u7647\u3001\u807d\u529b\u55aa\u5931\u3001\u8996\u529b\u53d7\u640d\u53ca\u8a8d\u77e5\u969c\u7919\u7b49\uff0c\u986f\u793a\u5148\u5929\u6027\u611f\u67d3\u7684\u7121\u75c7\u72c0\u65b0\u751f\u5152\u5177\u6709\u9577\u671f\u5f8c\u907a\u75c7\u7684\u98a8\u96aa\uff0c\u5c24\u5176\u662f\u5fc3\u667a\u9072\u920d\u548c\u611f\u89ba\u795e\u7d93\u6027\u807d\u529b\u55aa\u5931\uff08sensorineural hearing loss\uff09\u3002<\/p>\n

2.\u81a0\u8cea\u6bcd\u7d30\u80de\u7624<\/p>\n

\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff08glioblastoma, GBM\uff09\u662f\u6210\u4eba\u4e2d\u6700\u5e38\u898b\u548c\u6700\u5177\u7834\u58de\u6027\u7684\u8166\u7624\u4e4b\u4e00\uff0c\u4f46\u767c\u75c5\u6a5f\u8f49\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\uff0c\u5df2\u77e5\u7684\u5371\u96aa\u56e0\u7d20\u5305\u62ec\u907a\u50b3\u6027\u764c\u75c7\u5fb5\u5019\u7fa4\u3001\u96fb\u96e2\u8f3b\u5c04\u548c\u8077\u696d\u6027\u5316\u5b78\u66b4\u9732\uff0c\u53e6\u767c\u73feCMV\u4e5f\u53ef\u80fd\u662f\u4e00\u7a2e\u81f4\u75c5\u56e0\u5b50\u3002\u5f9e\u5df2\u767c\u8868\u6587\u737b\u53ef\u77e5\u67d0\u4e9b\u60e1\u6027GBM\u6703\u8868\u9054CMV\u76f8\u95dc\u86cb\u767d\uff0c\u5305\u62ec\u7acb\u5373\u65e9\u671f\u7684\u57fa\u56e01\uff08immediately early gene-1\uff09\u7522\u7269\u548cunique long 83\uff08UL83\uff09\u57fa\u56e0\u8868\u73fe\u7684\u4e0b\u57fa\u8cea\u78f7\u86cb\u767d65\uff08lower matrix phosphoprotein 65, pp65\uff09\uff0c\u986f\u793aCMV\u53ef\u80fd\u5728GBM\u7684\u7522\u751f\u4e2d\u767c\u63ee\u4e86\u4f5c\u7528\u3002\u96d6\u7136\u57282017\u5e74\u7684\u7814\u7a76\u5df2\u767c\u73feCMV\u53ef\u4ee5\u5728\u9ad4\u5916\u548c\u7570\u7a2e\u79fb\u690d\uff08xenograft\uff09\u6a21\u578b\u4e2d\u8a98\u5c0eGBM\u5f62\u6210\uff0c\u5f9e\u75c5\u60a3\u9ad4\u5167\u5206\u96e2\u51fa\u7684GBM\u4e2d\u4ea6\u53ef\u6aa2\u6e2c\u5230CMV\uff0c\u986f\u793aCMV\u53ef\u80fd\u9a45\u52d5\u816b\u7624\u767c\u751f\u6216\u5728\u816b\u7624\u4e2d\u88ab\u91cd\u65b0\u6fc0\u6d3b\uff0c\u4f46\u5c1a\u7121\u660e\u78ba\u8b49\u64da\u8b49\u660e\u9019\u7a2e\u73fe\u8c61\u666e\u904d\u5b58\u5728\u65bc GBM\u5f62\u6210\u904e\u7a0b\u3002<\/p>\n

\u57282019\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u4ee5\u5c0f\u9f20CMV\uff08murine CMV, MCMV\uff09\u611f\u67d3\u5728\u51fa\u751f\u524d\u5f8c\u7684\u570d\u7522\u671f\uff08perinatal\uff09\u5c0f\u9f20\u800c\u5efa\u7acb\u540c\u57fa\u56e0\uff08syngeneic\uff09GBM\u6a21\u578b\uff0c\u7528\u4f86\u89c0\u5bdfMCMV\u5c0d\u5c0f\u9f20GBM\u751f\u9577\u7684\u5f71\u97ff\u3002\u4ed6\u5011\u767c\u73fe\u88abMCMV\u611f\u67d3\u7684\uff08MCMV +\uff09\u5c0f\u9f20\u8207\u672a\u88ab\u611f\u67d3\u7684\uff08MCMV-\uff09\u7684\u5c0d\u7167\u7d44\u76f8\u6bd4\uff0cMCMV +\u5c0f\u9f20\u816b\u7624\u751f\u9577\u660e\u986f\u589e\u52a0\uff0c\u7e3d\u9ad4\u5b58\u6d3b\u7387\u986f\u8457\u964d\u4f4e\uff08P <0.001\uff09\uff0c\u4e26\u767c\u73feMCMV +\u5c0f\u9f20\u8840\u7ba1\u751f\u6210\uff08angiogenesis\uff09\u548c\u816b\u7624\u8840\u6d41\u91cf\uff08tumor blood flow\uff09\u660e\u986f\u589e\u52a0\u3002\u6b64\u5916\uff0c\u5728\u5c0f\u9f20\u548c\u4eba\u7684GBM\u6aa2\u9ad4\u4e2d\uff0c\u89c0\u5bdf\u5230\u5728\u816b\u7624\u5167\u8840\u7ba1\u5468\u7d30\u80de\uff08intratumoral perivascular pericytes\uff09\u548c\u816b\u7624\u7d30\u80de\u4e2d\u7684MCMV\u5df2\u7d93\u6fc0\u6d3b\uff0cMCMV +\u5c0f\u9f20\u4e2d\u816b\u7624\u8840\u7ba1\u7684\u5468\u7d30\u80de\u8986\u84cb\u7387\u986f\u8457\u589e\u52a0\uff0c\u4e26\u78ba\u5b9a\u8840\u5c0f\u677f\u884d\u751f\u7684\u751f\u9577\u56e0\u5b50D \uff08platelet-derived growth factor D\uff09\u662f\u7531CMV\u8a98\u5c0e\u7522\u751f\u7684\u56e0\u5b50\uff0c\u5c0d\u5468\u7d30\u80de\u805a\u96c6\uff08pericyte recruitment\uff09\u3001\u8840\u7ba1\u751f\u6210\u53ca\u816b\u7624\u751f\u9577\u975e\u5e38\u91cd\u8981\u3002\u5be6\u9a57\u7d50\u679c\u986f\u793aMCMV\u6703\u85c9\u7531\u589e\u52a0\u5468\u7d30\u80de\u805a\u96c6\u548c\u8840\u7ba1\u751f\u6210\u800c\u589e\u5f37GBM\u7684\u751f\u9577\uff0c\u9019\u6b78\u56e0\u65bc\u88ab\u611f\u67d3\u7d30\u80de\u5206\u6ccc\u7684\u86cb\u767d\u8cea\uff08secretome\uff09\u767c\u751f\u6539\u8b8a\u3002\u6b64\u52d5\u7269\u6a21\u578b\u63d0\u4f9b\u4e86CMV\u8207GBM\u589e\u9577\u6709\u76f8\u95dc\u6027\u7684\u8b49\u64da\uff0c\u4e26\u652f\u6301\u6297CMV\u7684\u65b9\u6cd5\u61c9\u53ef\u7528\u65bcGBM\u6cbb\u7642\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Wang SC<\/a>, Chen SJ<\/a>, Chen YC<\/a>. Potential Therapeutic Approaches Against Brain Diseases Associated with Cytomegalovirus Infections.<\/a> Int J Mol Sci. 2020 Feb 18;21(4). pii: E1376. doi: 10.3390\/ijms21041376. Review.<\/li>\n
  2. Cobbs CS<\/a>, Harkins L<\/a>, Samanta M<\/a>, Gillespie GY<\/a>, Bharara S<\/a>, King PH<\/a>, Nabors LB<\/a>, Cobbs CG<\/a>, Britt WJ<\/a>. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res.<\/a>2002 Jun 15;62(12):3347-3350.<\/li>\n
  3. McFaline-Figueroa JR, Wen PY. The viral connection to glioblastoma. Curr Infect Dis Rep. 2017 Feb;19(2):5. doi: 10.1007\/s11908-017-0563-z. Review.<\/li>\n
  4. Krenzlin H, Behera P, Lorenz V, Passaro C, Zdioruk M, Nowicki MO, Grauwet K, Zhang H, Skubal M, Ito H, Zane R, Gutknecht M, Griessl MB, Ricklefs F, Ding L, Peled S, Rooj A, James CD, Cobbs CS, Cook CH, Chiocca EA, Lawler SE. Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis.<\/a> J Clin Invest. 2019 Mar 11;130:1671-1683. doi: 10.1172\/JCI123375. eCollection 2019 Mar 11.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u8166\u90e8\u75be\u75c5\u662f\u5168\u7403\u6027\u4eba\u985e\u5065\u5eb7\u554f\u984c\uff0c\u901a\u5e38\u662f\u8907\u96dc\u3001\u56b4\u91cd\u3001\u4e0d\u53ef\u9006\u3001\u6301\u7e8c\u4e14\u96e3\u6cbb\u7684\uff0c\u800c\u5de8\u7d30\u80de\u75c5\u6bd2\uff08cytomegalovirus, CMV\uff09\u662f\u53ef\u80fd\u5c0e\u81f4\u8166\u90e8\u75be\u75c5\uff08\u4f8b\u5982\uff1a\u5fc3\u667a\u9072\u920d\u548c\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u7684\u98a8\u96aa\u56e0\u5b50\u4e4b\u4e00\u3002\u672c\u6587\u5c07\u4ecb\u7d39\u8207CMV\u611f\u67d3\u76f8\u95dc\u7684\u8166\u90e8\u75be\u75c5\uff0c\u63a2\u8a0e\u5176\u5c0d\u4eba\u9ad4\u7684\u5f71\u97ff\u3001\u75c5\u56e0\u53ca\u53ef\u80fd\u7684\u81f4\u75c5\u4f5c\u7528\u6a5f\u8f49\u3002<\/p>\n","protected":false},"author":20,"featured_media":35377,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4652,4654,4287,4653,4655],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/06\/4131313.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35326"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35326"}],"version-history":[{"count":4,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35326\/revisions"}],"predecessor-version":[{"id":35332,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35326\/revisions\/35332"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35377"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}