{"id":35262,"date":"2020-05-12T00:26:03","date_gmt":"2020-05-11T16:26:03","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35262"},"modified":"2020-05-11T11:49:09","modified_gmt":"2020-05-11T03:49:09","slug":"%e5%b7%a8%e7%b4%b0%e8%83%9e%e7%97%85%e6%af%92%e7%96%ab%e8%8b%97%e7%9a%84%e7%99%bc%e5%b1%95","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35262","title":{"rendered":"\u5de8\u7d30\u80de\u75c5\u6bd2\u75ab\u82d7\u7684\u767c\u5c55"},"content":{"rendered":"

\"\"<\/strong><\/p>\n

\u4eba\u985e\u5de8\u7d30\u80de\u75c5\u6bd2\uff08human cytomegalovirus, HCMV\uff09\u5f15\u767c\u7684\u6a5f\u6703\u6027\u611f\u67d3\u53ca\u5148\u5929\u6027\u611f\u67d3\u4ecd\u662f\u5168\u7403\u6027\u7684\u4eba\u985e\u5065\u5eb7\u91cd\u5927\u5a01\u8105\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u514d\u75ab\u529b\u8f03\u5f31\u7684\u5b30\u5e7c\u5152\u3001\u8001\u5e74\u4eba\u53ca\u75c5\u4eba\u3002\u57fa\u65bcHCMV\u7368\u7279\u751f\u6d3b\u53f2\u53ca\u6f5b\u4f0f\u7684\u7279\u6027\uff0c\u6709\u6642\u75be\u75c5\u6cbb\u7642\u7684\u6548\u679c\u4e26\u4e0d\u986f\u8457\uff0c\u56e0\u6b64\u6709\u6548\u7684\u75ab\u82d7\u662f\u8feb\u5207\u9700\u8981\uff0c\u5176\u4e2d\u5c0d\u80b2\u9f61\u5a66\u5973\u800c\u8a00\uff0c\u5b55\u5a66\u7684HCMV\u5782\u76f4\u611f\u67d3\u8207\u80ce\u5152\u6703\u5c0e\u81f4\u6d41\u7522\u6216\u65b0\u751f\u5152\u6b98\u75be\u3002HCMV\u75ab\u82d7\u7684\u958b\u767c\u9664\u4e86\u53ef\u907f\u514d\u5065\u5eb7\u4eba\u53d7\u5230\u75c5\u6bd2\u7684\u611f\u67d3\u5916\uff0c\u4e26\u6709\u52a9\u65bc\u9810\u9632\u5148\u5929\u6027\u611f\u67d3\u53ca\u5f88\u591a\u7684\u65b0\u751f\u5152\u7684\u6b98\u75be\u3002<\/strong><\/span><\/p>\n

 <\/strong>\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u4eba\u985e\u5de8\u7d30\u80de\u75c5\u6bd2\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

HCMV\u5c6c\u65bc\u76b0\u75b9\u75c5\u6bd2\u79d1\u7684\u4e00\u500b\u5c6c\uff0c\u57fa\u56e0\u7d44\u662f\u5927\u5c0f\u7d04230 kb\u7684\u96d9\u93c8DNA\uff0c\u75c5\u6bd2\u9846\u7c92\uff08virion\uff09\u76f4\u5f91\u7d04\u70ba180 nm\u3002HCMV\u7684\u7d50\u69cb\u7531\u5167\u5230\u5916\u5206\u5225\u662fDNA\u6838\u5fc3\uff08core\uff09\u3001\u8863\u6bbc\uff08capsid\uff09\u3001\u76ae\u5957\uff08tugument\uff09\u548c\u5916\u819c\u5305\u88ab\uff08envelope\uff09\u3002DNA\u57fa\u56e0\u7d44\u88ab\u7531162\u500bcapsomere\u7d44\u6210\u7684\u8863\u6bbc\u6240\u5305\u88f9\uff0c\u76ae\u5957\u88ab\u69cb\u9020\u662f\u8102\u8cea\u96d9\u5c64\uff08lipid biolayer\uff09\u7684\u5916\u819c\u5305\u88ab\u5305\u570d\uff0c\u5916\u819c\u5305\u88ab\u542b\u670920\u591a\u7a2e\u53c3\u8207\u5c0d\u5bbf\u4e3b\u7d30\u80de\u7684\u9644\u8457\u548c\u7a7f\u900f\u7684\u7cd6\u86cb\u767d\uff08glycoprotein\uff09\u3002\u8207\u6240\u6709\u76b0\u75b9\u75c5\u6bd2\u4e00\u6a23\uff0cHCMV\u57fa\u56e0\u6309\u4ee5\u4e0b\u9806\u5e8f\u9032\u884c\u8868\u9054\uff1a\uff081\uff09\u7acb\u5373\u65e9\u671f\u57fa\u56e0\uff08immediately early gene\uff09\uff1a\u7de8\u78bc\u8abf\u7bc0\u86cb\u767d\uff08regulatory protein\uff09\uff082\uff09\u65e9\u671f\u57fa\u56e0\uff08early gene\uff09\uff1a\u7de8\u78bc\u7528\u65bc\u8907\u88fd\u75c5\u6bd2DNA\u7684\u9175\u7d20\uff083\uff09\u665a\u671f\u57fa\u56e0\uff08late gene\uff09\uff1a\u7de8\u78bc\u7528\u65bc\u88dd\u914d\u611f\u67d3\u6027\u75c5\u6bd2\u9846\u7c92\u7684\u7d50\u69cb\u86cb\u767d\uff08structural protein\uff09\u3002<\/p>\n

\u25cfHCMV<\/strong>\u611f\u67d3\u5f15\u8d77\u75be\u75c5<\/strong><\/span><\/p>\n

HCMV\u4e3b\u8981\u900f\u904e\u8840\u6db2\u3001\u553e\u6db2\u3001\u7cbe\u6db2\u3001\u5c3f\u6db2\u3001\u4e73\u6c41\u53ca\u5782\u76f4\u611f\u67d3\u4f86\u50b3\u64ad\uff0c\u611f\u67d3\u7684\u4e3b\u8981\u6a19\u7684\u7d30\u80de\u662f\u55ae\u6838\u7d30\u80de\uff08monocyte\uff09\u3001\u6dcb\u5df4\u7d30\u80de\uff08lymphocyte\uff09\u53ca\u4e0a\u76ae\u7d30\u80de\uff08epithelial cell\uff09\uff0c\u4e3b\u8981\u7684\u6f5b\u4f0f\u90e8\u4f4d\u5728\u5916\u570d\u55ae\u6838\u7d30\u80de\uff08peripheral monocyte\uff09\u53caCD34 +\u524d\u9a45\u7d30\u80de\uff08progenitor cell\uff09\u3002\u5728\u5065\u5eb7\u6210\u5e74\u4eba\u9ad4\u5167\uff0cHCMV\u56e0\u70ba\u53d7\u5230\u514d\u75ab\u7cfb\u7d71\u7684\u63a7\u5236\uff0c\u901a\u5e38\u4e0d\u6703\u5f15\u8d77\u4efb\u4f55\u75c7\u72c0\u6216\u50c5\u80fd\u9020\u6210\u8f15\u5ea6\u75be\u75c5\u3002\u7136\u800c\uff0cHCMV\u611f\u67d3\u5f8c\u6709\u80fd\u529b\u9577\u671f\u5728\u9ad4\u5167\u6f5b\u4f0f\uff08latency\uff09\uff0c\u4e26\u5728\u500b\u9ad4\u7684\u514d\u75ab\u529f\u80fd\u4e0d\u6210\u719f\uff08\u5982\u5b30\u5e7c\u5152\uff09\u6216\u514d\u75ab\u7cfb\u7d71\u8001\u5316\u3001\u640d\u50b7\u3001\u53d7\u6291\u5236\uff08\u5982\u8001\u5e74\u4eba\u3001\u75c5\u4eba\u3001\u5f8c\u5929\u514d\u75ab\u7f3a\u4e4f\u75c7\u5019\u7fa4\u60a3\u8005\u53ca\u5668\u5b98\u79fb\u690d\u8005\u7b49\uff09\u6642\u5fa9\u767c\uff0c\u6f5b\u4f0f\u7684HCMV\u91cd\u65b0\u6d3b\u5316\uff08reactivation\uff09\u6703\u7834\u58de\u60a3\u8005\u7684\u7d44\u7e54\u800c\u5c0e\u81f4\u5668\u5b98\u75be\u75c5\uff0c\u4e26\u53ef\u80fd\u89f8\u767c\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\uff0c\u6b64\u7a2e\u6f5b\u4f0f\u6027\u611f\u67d3\uff08latent infection\uff09\u5f62\u6210\u7684\u6a5f\u6703\u6027\u611f\u67d3\uff08opportunistic infection\uff09\u53ef\u5f15\u767c\u591a\u7a2e\u75be\u75c5\uff0c\u5982\u80ba\u708e\uff0c\u8996\u7db2\u819c\u708e\uff0c\u80c3\u8178\u9053\u75be\u75c5\uff0c\u5fc3\u667a\u9072\u7de9\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\uff0c\u56b4\u91cd\u6642\u751a\u81f3\u6703\u9020\u6210\u6b7b\u4ea1\u3002\u6b64\u5916\uff0c\u7d93\u7531\u61f7\u5b55\u5a66\u5973\u50b3\u67d3\u7d66\u80ce\u5152\u7684\u5148\u5929\u6027\u611f\u67d3\uff08congenital infection\uff09\u662fHCMV\u7684\u4e3b\u8981\u554f\u984c\uff0c\u5168\u7403\u7f79\u60a3\u7387\u4f30\u8a08\u7d04\u70ba0.64\uff05\uff0c\u5176\u4e2d17-20\uff05\u88ab\u611f\u67d3\u7684\u5b30\u5152\u5c07\u906d\u53d7\u5404\u7a2e\u7a0b\u5ea6\u7684\u6b98\u75be\uff0c\u5305\u62ec\u807d\u529b\u640d\u5931\u3001\u8996\u529b\u969c\u7919\u3001\u7cbe\u795e\u904b\u52d5\u529f\u80fd\u969c\u7919\u53ca\u5b78\u7fd2\u969c\u7919\u7b49\u3002<\/p>\n

\u25cf\u9810\u9632\u75ab\u82d7\u7684\u7814\u767c<\/strong><\/span><\/p>\n

HCMV\u7684\u611f\u67d3\u53ef\u80fd\u9020\u6210\u4eba\u985e\u56b4\u91cd\u75be\u75c5\uff0c\u800c\u4e14\u521d\u4f30\u5e36\u539f\u8005\u4eba\u6578\u5f88\u591a\uff0c\u50b3\u64ad\u7bc4\u570d\u4e5f\u76f8\u7576\u5ee3\u6cdb\uff0c\u57fa\u65bc\u75be\u75c5\u7684\u9810\u9632\u91cd\u65bc\u6cbb\u7642\uff0c\u75ab\u82d7\u7684\u958b\u767c\u6709\u5176\u5fc5\u8981\u6027\uff0c\u4f46HCMV\u7684\u75ab\u82d7\u5fc5\u9808\u5177\u6709\u7279\u7570\u6027\u5f37\u7684\u9ad4\u6db2\u514d\u75ab\u53cd\u61c9\uff08humoral immunity\uff09\uff0c\u4e26\u5f15\u767c\u7d30\u80de\u4ecb\u5c0e\u7684\u514d\u75ab\u53cd\u61c9\uff08cell-mediated immunity\uff09\uff0c\u624d\u80fd\u63d0\u4f9b\u5b8c\u6574\u4fdd\u8b77\u3002\u591a\u5e74\u4f86\uff0c\u5118\u7ba1\u6709\u6301\u7e8c\u4e0d\u65b7\u7684\u75ab\u82d7\u7814\u767c\u5de5\u4f5c\uff0c\u4f46\u5c1a\u7121\u6279\u51c6\u7528\u65bc\u9810\u9632HCMV\u611f\u67d3\u7684\u75ab\u82d7\u4e0a\u5e02\uff0c\u53ef\u80fd\u662f\u7531\u65bc\u5c0d\u5176\u611f\u67d3\u9632\u8b77\u6240\u9700\u7684\u514d\u75ab\u53cd\u61c9\u4ecd\u672a\u5341\u5206\u660e\u77ad\u3002\u7136\u800c\uff0c\u8fd1\u5e74\u5df2\u6709\u4ee5\u4e0b\u7814\u767c\u6210\u679c\uff0c\u70baHCMV\u75ab\u82d7\u7684\u4e0a\u5e02\u958b\u555f\u4e00\u7dda\u66d9\u5149\uff1a<\/p>\n

\u57282019\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\u5929\u7afa\u9f20\u505a\u70ba\u52d5\u7269\u6a21\u5f0f\u958b\u767cCMV\u75ab\u82d7\u3002\u8207HCMV\u4e00\u6a23\uff0c\u5929\u7afa\u9f20\u5de8\u7d30\u80de\u75c5\u6bd2\uff08guinea pig cytomegalovirus, GPCMV\uff09\u4e5f\u9700\u8981\u5929\u7afa\u9f20\u7684\u7279\u7570\u6027\u7d30\u80de\u53d7\u9ad4\uff0d\u8840\u5c0f\u677f\u6e90\u6027\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u03b1\uff08platelet-derived growth factor receptor \u03b1\uff09\u624d\u80fd\u9032\u5165\u6210\u7e96\u7dad\u7d30\u80de\uff08fibroblast cell\uff09\uff0c\u4f46\u8981\u9032\u5165\u975e\u6210\u7e96\u7dad\u7d30\u80de\uff08non-fibroblast cell\uff09\u5247\u9700\u8981\u5176\u4ed6\u53d7\u9ad4\uff0c\u800c\u5df2\u77e5GPCMV\u7de8\u78bc\u7684\u4e94\u805a\u9ad4\u8907\u5408\u7269\uff08pentamer complex\uff09\uff08\u4e00\u7a2e\u4f4d\u65bc\u5916\u819c\u5305\u88ab\u4e0a\u7684\u7cd6\u86cb\u767d\uff09\u662f\u4f7f\u75c5\u6bd2\u9032\u5165\u5929\u7afa\u9f20\u7684\u975e\u6210\u7e96\u7dad\u7d30\u80de\u7684\u95dc\u9375\u56e0\u5b50\u3002\u4ed6\u5011\u4f7f\u7528\u5931\u53bb\u529f\u80fd\u7684\u55ae\u5faa\u74b0\u50b3\u67d3\u6027\uff08disabled infectious single-cycle\uff09GPCMV\u75ab\u82d7\u682a\u63a5\u7a2e\u5230\u5929\u7afa\u9f20\uff0c\u8a98\u5c0e\u5bbf\u4e3b\u7522\u751f\u91dd\u5c0d\u75c5\u6bd2\u4e94\u805a\u9ad4\u8907\u5408\u7269\u7684\u9ad4\u6db2\u514d\u75ab\u53cd\u61c9\uff0c\u4ee5\u589e\u5f37\u975e\u6210\u7e96\u7dad\u7d30\u80de\u7684\u4e2d\u548c\u4f5c\u7528\uff0c\u56e0\u800c\u4fdd\u8b77\u5929\u7afa\u9f20\u514d\u53d7\u5230GPCMV\u7684\u611f\u67d3\u3002\u6b64\u52d5\u7269\u5be6\u9a57\u7d50\u679c\u767c\u73fe\uff0c\u5229\u7528\u4e94\u805a\u9ad4\u8907\u5408\u7269\u4f5c\u70ba\u75ab\u82d7\u4e00\u90e8\u5206\u7684\u8a2d\u8a08\u53ef\u4ee5\u986f\u8457\u63d0\u9ad8\u75ab\u82d7\u7684\u529f\u6548\uff0c\u8b49\u660e\u91dd\u5c0d\u4e94\u805a\u9ad4\u8907\u5408\u7269\u7684\u514d\u75ab\u53cd\u61c9\u5728\u5c0d\u6297\u5148\u5929\u6027CMV\u611f\u67d3\u7684\u91cd\u8981\u6027\u3002<\/p>\n

\u57282019\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u5728\u4eba\u9ad4\u8a66\u9a57\u4e2d\uff0c\u4f7f\u7528\u7f3a\u4e4f\u5728\u6d3b\u9ad4\u5167\u8907\u88fd\u80fd\u529b\u7684\u7f3a\u9677\u75c5\u6bd2V160\u4f5c\u70ba\u5019\u9078\u75ab\u82d7\uff0c\u7d50\u679c\u986f\u793a\u5728HCMV\u8840\u6e05\u9670\u6027\u7684\u4eba\u9ad4\u4e2d\u662f\u5b89\u5168\u7684\u4e14\u5177\u514d\u75ab\u539f\u6027\uff08immunogenicity\uff09\uff0c\u4e26\u53ef\u8a98\u5c0e\u5bbf\u4e3b\u7522\u751f\u9ad4\u6db2\u514d\u75ab\u53cd\u61c9\u53ca\u7d30\u80de\u4ecb\u5c0e\u7684\u514d\u75ab\u53cd\u61c9\uff0c\u800c\u4e14\u53cd\u61c9\u5f37\u5927\u3001\u6301\u4e45\u4e14\u5177\u6709\u9577\u671f\u8a18\u61b6\u6027\u3002\u4ed6\u5011\u66f4\u9032\u4e00\u6b65\u8b49\u660e\u4f86\u81eaV160\u514d\u75ab\u63a5\u7a2e\u7684HCMV\u8840\u6e05\u9670\u6027\u53d7\u8a66\u8005\u7684\u8840\u6e05\u8207\u4f86\u81ea\u8840\u6e05\u967d\u6027\u53d7\u8a66\u8005\u6709\u76f8\u4f3c\u7684\u5c6c\u6027\uff0c\u5305\u62ec\u91dd\u5c0dHCMV\u6297\u539f\u7684\u9ad8\u89aa\u548c\u529b\u6297\u9ad4\uff0c\u56e0\u598a\u5a20\u524d\u8840\u6e05\u53cd\u61c9\u967d\u6027\u7684\u5a66\u5973\u6240\u751f\u7684\u5b69\u5b50\u53d7\u5148\u5929\u6027HCMV\u611f\u67d3\u7684\u53ef\u80fd\u6027\u8f03\u5c0f\uff0c\u6545\u53ef\u8a98\u5c0e\u8840\u6e05\u53cd\u61c9\u9670\u6027\u7684\u5a66\u5973\u7522\u751f\u985e\u4f3c\u8840\u6e05\u53cd\u61c9\u967d\u6027\u7684\u5a66\u5973\u7684\u514d\u75ab\u53cd\u61c9\u7684\u75ab\u82d7\u53ef\u80fd\u662f\u6709\u6548\u7684\u3002\u672c\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0cV160\u96d6\u7136\u662f\u8907\u88fd\u7f3a\u9677\u578b\u75c5\u6bd2\uff0c\u4f46\u8a98\u5c0e\u7684\u6297\u9ad4\u53ef\u4e2d\u548c\u4e00\u7d44\u907a\u50b3\u4e0a\u4e0d\u540c\u7684\u81e8\u5e8a\u5206\u96e2\u682a\uff0c\u53ef\u4ee5\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u9632\u6b62\u75c5\u6bd2\u611f\u67d3\u5e7e\u7a2e\u4e0d\u540c\u985e\u578b\u7684\u4eba\u985e\u7d30\u80de\uff0c\u4e26\u53ef\u5728\u4eba\u9ad4\u4e2d\u6709\u6548\u5730\u8a98\u5c0e\u985e\u4f3c\u65bcHCMV\u8840\u6e05\u53cd\u61c9\u967d\u6027\u60a3\u8005\u7684\u6297\u9ad4\u7522\u751f\uff0c\u662f\u4e00\u7a2e\u80fd\u4fdd\u8b77\u8840\u6e05\u53cd\u61c9\u9670\u6027\u7684\u80b2\u9f61\u5a66\u5973\u514d\u53d7HCMV\u611f\u67d3\u7684\u6f5b\u5728\u5019\u9078\u75ab\u82d7\uff0c\u4f46\u4ecd\u9700\u5728\u81e8\u5e8a\u4e0a\u8a55\u4f30\u5176\u9810\u9632\u5148\u5929\u6027\u611f\u67d3\u7684\u6548\u80fd\uff08efficacy\uff09\uff0c\u4ee5\u78ba\u4fdd\u75ab\u82d7\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n

 <\/strong><\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Krishna BA, Wills MR, Sinclair JH. Advances in the treatment of cytomegalovirus. Br. Med. Bull. 2019, Sep 19;131(1):5-17. doi: 10.1093\/bmb\/ldz031.<\/li>\n
  2. Choi KY, El-Hamdi NS, McGregor A. Inclusion of the viral pentamer complex in a vaccine design greatly improves protection against congenital cytomegalovirus in the guinea pig model. J Virol.<\/a> 2019 Oct 29;93(22). pii: e01442\u2013e014519. doi: 10.1128\/JVI.01442-19. Print 2019 Nov 15.<\/li>\n
  3. Liu Y, Freed DC, Li L, Tang A, Li F, Murray, EM, Adler SP, McVoy MA, Rupp RE, Barrett D, Ye X<\/a>, Zhang N<\/a>, Beck K<\/a>, Culp T<\/a>, Das R<\/a>, Song L<\/a>, Vora K<\/a>, Zhu H<\/a>, Wang D<\/a>, Espeseth AS<\/a>, An Z<\/a>, Musey L<\/a>, Fu TM<\/a>,<\/sup>. A replication defective human cytomegalovirus vaccine elicits humoral immune responses analogous to those with natural infection. J. Virol. 2019 Nov 13;93(23). pii: e00747-19. doi: 10.1128\/JVI.00747-19. Print 2019 Dec 1.<\/li>\n
  4. Chen SJ, Wang SC, Chen YC. Antiviral agents as therapeutic strategies against cytomegalovirus
    \n<\/a> Viruses. 2019 Dec 23;12(1). pii: E21. doi: 10.3390\/v12010021. Review.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u4eba\u985e\u5de8\u7d30\u80de\u75c5\u6bd2\uff08human cytomegalovirus, HCMV\uff09\u5f15\u767c\u7684\u6a5f\u6703\u6027\u611f\u67d3\u53ca\u5148\u5929\u6027\u611f\u67d3\u4ecd\u662f\u5168\u7403\u6027\u7684\u4eba\u985e\u5065\u5eb7\u91cd\u5927\u5a01\u8105\uff0c\u7279\u5225\u662f\u5c0d\u65bc\u514d\u75ab\u529b\u8f03\u5f31\u7684\u5b30\u5e7c\u5152\u3001\u8001\u5e74\u4eba\u53ca\u75c5\u4eba\u3002\u57fa\u65bcHCMV\u7368\u7279\u751f\u6d3b\u53f2\u53ca\u6f5b\u4f0f\u7684\u7279\u6027\uff0c\u6709\u6642\u75be\u75c5\u6cbb\u7642\u7684\u6548\u679c\u4e26\u4e0d\u986f\u8457\uff0c\u56e0\u6b64\u6709\u6548\u7684\u75ab\u82d7\u662f\u8feb\u5207\u9700\u8981\uff0c\u5176\u4e2d\u5c0d\u80b2\u9f61\u5a66\u5973\u800c\u8a00\uff0c\u5b55\u5a66\u7684HCMV\u5782\u76f4\u611f\u67d3\u8207\u80ce\u5152\u6703\u5c0e\u81f4\u6d41\u7522\u6216\u65b0\u751f\u5152\u6b98\u75be\u3002HCMV\u75ab\u82d7\u7684\u958b\u767c\u9664\u4e86\u53ef\u907f\u514d\u5065\u5eb7\u4eba\u53d7\u5230\u75c5\u6bd2\u7684\u611f\u67d3\u5916\uff0c\u4e26\u6709\u52a9\u65bc\u9810\u9632\u5148\u5929\u6027\u611f\u67d3\u53ca\u5f88\u591a\u7684\u65b0\u751f\u5152\u7684\u6b98\u75be\u3002<\/p>\n","protected":false},"author":20,"featured_media":35269,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4639,4636,4638,4637],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/05\/511-1.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35262"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35262"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35262\/revisions"}],"predecessor-version":[{"id":35270,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35262\/revisions\/35270"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35269"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}