{"id":35261,"date":"2020-05-15T00:26:02","date_gmt":"2020-05-14T16:26:02","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35261"},"modified":"2020-05-11T11:41:09","modified_gmt":"2020-05-11T03:41:09","slug":"%e4%bb%a3%e7%b3%96%e9%a8%99%e5%be%97%e4%ba%86%e8%88%8c%e9%a0%ad%e5%91%b3%e8%a6%ba%ef%bc%8c%e5%8d%bb%e9%a8%99%e4%b8%8d%e9%81%8e%e8%85%b8%ef%bc%8d%e8%85%a6%e8%bb%b8%e7%b7%9a-gut-brain-axis","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35261","title":{"rendered":"\u4ee3\u7cd6\u9a19\u5f97\u4e86\u820c\u982d\u5473\u89ba\uff0c\u537b\u9a19\u4e0d\u904e\u8178\uff0d\u8166\u8ef8\u7dda (gut-brain axis)"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u4eba\u5011\u5634\u4e0a\u4e0d\u8aaa\uff0c\u8eab\u9ad4\u537b\u5f88\u8aa0\u5be6\uff0c\u5f80\u5f80\u96e3\u4ee5\u62b5\u6297\u542b\u7cd6\u98f2\u6599\u7684\u8a98\u60d1\u3002\u60f3\u559d\u6709\u751c\u7684\u98f2\u6599\u4f46\u53c8\u4e0d\u60f3\u7372\u5f97\u71b1\u91cf\uff0c\u4f7f\u7528\u96f6\u71b1\u91cf\u7684\u300c\u4ee3\u7cd6\u300d\u662f\u98df\u54c1\u696d\u88e1\u5e38\u898b\u7684\u624b\u6bb5\u3002\u7136\u800c\uff0c\u8a34\u6c42\u5065\u5eb7\u7684\u7121\u7cd6\u53ef\u6a02\uff0c\u4e26\u6c92\u6709\u50cf\u539f\u672c\u53ef\u6a02\u90a3\u822c\u53d7\u5230\u6d88\u8cbb\u8005\u9752\u775e\u30022020 \u5e74 4 \u6708\u5728\u570b\u969b\u77e5\u540d\u671f\u520a <em>Nature<\/em> \u767c\u8868\u7684\u4e00\u9805\u7814\u7a76\uff0c\u5c0d\u6b64\u884c\u70ba\u73fe\u8c61\u63d0\u4f9b\u4e86\u4e00\u7a2e\u53ef\u80fd\u7684\u79d1\u5b78\u89e3\u91cb\uff1a\u4ee3\u7cd6\u96d6\u7136\u80fd\u9a19\u820c\u982d\u5473\u89ba\uff0c\u537b\u7121\u6cd5\u6eff\u8db3\u5927\u8166\uff0c\u539f\u56e0\u662f\u53ea\u6709\u300c\u771f\u6b63\u7684\u7cd6\u300d\u624d\u6703\u555f\u52d5\u300c\u8178\uff0d\u8166\u8ef8\u7dda (gut-brain axis)\u300d\u7684\u795e\u7d93\u8ff4\u8def\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_35266\" aria-describedby=\"caption-attachment-35266\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-35266\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/05\/561513.jpg\" alt=\"\" width=\"450\" height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/05\/561513.jpg 827w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/05\/561513-300x200.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/05\/561513-768x512.jpg 768w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-35266\" class=\"wp-caption-text\">\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n<p><strong>\u6587\uff0f\u694a\u671d\u5091<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u4ee3\u7cd6\u96d6\u6709\u751c\u5473\uff0c\u4f46\u52d5\u7269\u4f9d\u7136\u5b58\u5728\u504f\u611b\u771f\u7cd6\u7684\u884c\u70ba<\/strong><\/span><\/p>\n<p>\u5927\u5403\u751c\u98df\u6216\u5927\u53e3\u559d\u542b\u7cd6\u98f2\u6599\u4e4b\u5f8c\uff0c\u4e0d\u5c11\u4eba\u6703\u64d4\u6182\u767c\u80d6\u800c\u7f6a\u60e1\u611f\u5341\u8db3\u3002\u80fd\u5920\u8ce6\u4e88\u98df\u54c1\u751c\u5473\u7684\u4ee3\u7cd6\uff0c\u4e5f\u88ab\u7a31\u70ba\u4eba\u5de5\u751c\u5473\u5291\uff0c\u56e0\u70ba\u50c5\u542b\u6709\u6975\u4f4e\u6216\u751a\u81f3\u4e0d\u542b\u4efb\u4f55\u71b1\u91cf\uff0c\u6240\u4ee5\u5e38\u5e38\u88ab\u6dfb\u52a0\u5230\u9700\u8981\u6e1b\u5c11\u71b1\u91cf\u7684\u98df\u7269\u4e2d\u3002\u6700\u8fd1\uff0c\u7531\u7f8e\u570b\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78 (Columbia University) \u7684\u795e\u7d93\u79d1\u5b78\u5bb6 Charles S. Zuker \u6559\u6388\u6240\u9818\u5c0e\u7684\u5718\u968a\uff0c\u5c0d\u65bc\u5927\u8166\u5982\u4f55\u7406\u89e3\u5473\u89ba\u6709\u4e86\u65b0\u7684\u9032\u5c55\uff0c\u4ed6\u5011\u767c\u73fe\u4ee3\u7cd6\u96d6\u7136\u80fd\u9a19\u904e\u820c\u982d\u5473\u857e\u7684\u751c\u5473\u53d7\u9ad4\uff0c\u4f46\u5927\u8166\u88e1\u5f97\u5230\u7684\u53cd\u994b\u6548\u679c\u537b\u4e0d\u80fd\u5b8c\u5168\u5730\u4ee3\u66ff\u300c\u771f\u7cd6\u300d\u3002\u7cd6\u662f\u6240\u6709\u52d5\u7269\u7684\u91cd\u8981\u57fa\u672c\u80fd\u91cf\u4f86\u6e90\uff0c\u5927\u591a\u6578\u7269\u7a2e\u5305\u62ec\u4eba\u985e\u90fd\u5df2\u9032\u5316\u51fa\u5c08\u9580\u7684\u5927\u8166\u8ff4\u8def\u4f86\u611f\u77e5\u7cd6\u985e\uff0c\u63a5\u8457\u4f86\u770b\u770b\u79d1\u5b78\u5bb6\u5011\u662f\u600e\u9ebc\u900f\u904e\u5be6\u9a57\uff0c\u5256\u6790\u52d5\u7269\u504f\u611b\u771f\u7cd6\u7684\u795e\u7d93\u8ff4\u8def\u3002<\/p>\n<p>\u7b2c\u4e00\u500b\u5be6\u9a57\u662f\u5728\u5c0f\u9f20\u7684\u7c60\u5b50\u88e1\uff0c\u653e\u4e86\u5169\u74f6\u5206\u5225\u6dfb\u52a0\u4e86\u8461\u8404\u7cd6 (\u771f\u7cd6) \u548c\u4eba\u5de5\u751c\u5473\u5291 (\u6b64\u8655\u4f7f\u7528 Acesulfame K) \u7684\u6eb6\u6db2\uff0c\u525b\u958b\u59cb\u5c0f\u9f20\u7684\u884c\u70ba\u8868\u73fe\u51fa\u96a8\u6a5f\u9078\u64c7\uff0c\u7136\u800c\u7d93\u904e 24 \u5c0f\u6642\u5f8c\uff0c\u5c0f\u9f20\u9010\u6f38\u66f4\u504f\u611b\u65bc\u8461\u8404\u7cd6\u6eb6\u6db2\u3002\u4e0d\u50c5\u5982\u6b64\uff0c\u5373\u4f7f\u662f\u5c07\u5c0f\u9f20\u7684\u5473\u89ba\u53d7\u9ad4\u5254\u9664 (knockout)\uff0c\u5c0f\u9f20\u820c\u982d\u4e0a\u5690\u4e0d\u51fa\u751c\u5473\u5f8c\uff0c\u9019\u7a2e\u504f\u611b\u771f\u7cd6\u7684\u884c\u70ba\u6163\u6027\u4f9d\u7136\u5b58\u5728\u3002\u54ea\u9ebc\u554f\u984c\u4f86\u4e86\uff0c\u70ba\u4ec0\u9ebc\u52d5\u7269\u5011\u559c\u611b\u651d\u53d6\u771f\u7cd6\u800c\u975e\u4eba\u5de5\u751c\u5473\u5291\uff0c\u5176\u4e2d\u4f3c\u4e4e\u6709\u8457\u7121\u6cd5\u6291\u5236\u7684\u9a45\u52d5\u529b\uff1f<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u7368\u7acb\u65bc\u5473\u89ba\u7cfb\u7d71\u4e4b\u5916\uff0c\u8178\uff0d\u8166\u8ef8\u7dda\u8def\u5f91\u53ea\u5c0d\u771f\u7cd6\u6709\u53cd\u61c9<\/strong><\/span><\/p>\n<p>\u6839\u64da\u4e0a\u8ff0\u5be6\u9a57\u7d50\u679c\uff0c\u4e5f\u6697\u793a\u8457\u5728\u5473\u89ba\u7cfb\u7d71\u4e4b\u5916\uff0c\u53ef\u80fd\u5b58\u5728\u53e6\u4e00\u7a2e\u7368\u7acb\u7684\u7cd6\u985e\u611f\u77e5\u6a5f\u5236\u3002\u56e0\u6b64\uff0c\u79d1\u5b78\u5bb6\u9032\u4e00\u6b65\u5206\u6790\u5c0f\u9f20\u5728\u559d\u6c34\u3001\u771f\u7cd6\u6eb6\u6db2\u3001\u4eba\u5de5\u751c\u5473\u5291\u6eb6\u6db2\u6642\uff0c\u89c0\u5bdf\u53ca\u6bd4\u8f03\u5927\u8166\u7684\u6d3b\u52d5\u5dee\u7570\u3002\u79d1\u5b78\u5bb6\u767c\u73fe\u8166\u90e8\u4e2d\u6709\u4e00\u584a\u5340\u57df\u50c5\u50c5\u5c0d\u771f\u7cd6\u6709\u53cd\u61c9\uff0c\u9019\u500b\u5340\u57df\u4f4d\u5728\u5c3e\u5074\u5b64\u675f\u6838 (caudal nucleus of the solitary tract, cNST)\uff0c\u6709\u8da3\u7684\u662f\u5b83\u4e26\u4e0d\u5728\u5c0f\u9f20\u8655\u7406\u5473\u89ba\u7684\u8166\u5340\u88e1\uff0c\u800c\u662f\u85cf\u5728\u88ab\u8996\u70ba\u6700\u539f\u59cb\u5927\u8166\u69cb\u9020\u7684\u300c\u8166\u5e79\u300d\u4e4b\u5167\u3002<\/p>\n<p>\u9019\u88e1\u53c8\u51fa\u73fe\u4e00\u500b\u554f\u984c\uff0c\u8eab\u9ad4\u5403\u9032\u771f\u7cd6\u7684\u8a0a\u865f\u662f\u901a\u904e\u90a3\u689d\u795e\u7d93\u8ff4\u8def\u4f86\u6d3b\u5316\u4e86 cNST \u8166\u5340\uff1f\u79d1\u5b78\u5bb6\u5c07\u76ee\u5149\u8f49\u79fb\u5230\u4e86\u9023\u63a5\u8178\u9053\u8207\u8166\u90e8\u7684\u300c\u8ff7\u8d70\u795e\u7d93\u300d\u4e0a\uff0c\u79d1\u5b78\u5bb6\u958b\u767c\u4e86\u76e3\u6e2c\u8ff7\u8d70\u795e\u7d93\u53ca cNST \u5be6\u6642\u6d3b\u52d5\u53cd\u61c9\u7684\u6280\u8853\uff0c\u4e26\u6e2c\u8a66\u5c07\u771f\u7cd6\u6216\u4eba\u5de5\u751c\u5473\u5291\u76f4\u63a5\u9001\u9032\u5c0f\u9f20\u7684\u8178\u9053\u5f8c\uff0c\u89c0\u5bdf\u9019\u4e9b\u795e\u7d93\u7d30\u80de\u7684\u6d3b\u6027\u5982\u4f55\u8b8a\u5316\u3002\u503c\u5f97\u6ce8\u610f\u7684\u767c\u73fe\u662f\uff0c\u9019\u4e9b\u795e\u7d93\u5143\u50c5\u53d7\u5230\u771f\u7cd6\u7684\u523a\u6fc0\uff0c\u800c\u5c0d\u4eba\u5de5\u751c\u5473\u5291\u7121\u53cd\u61c9\u3002\u672c\u7bc7\u7814\u7a76\u7684\u4f5c\u8005 Alexander C. Sisti \u4e5f\u8868\u793a\ufe55\u300c\u9019\u662f\u6211\u5011\u7b2c\u4e00\u6b21\u767c\u73fe\uff0c\u6709\u4e00\u689d\u5f9e\u8178\u5230\u8166\uff0c\u80fd\u611f\u77e5\u7cd6\u985e\u7684\u76f4\u63a5\u8def\u5f91\u3002\u300d\u9019\u689d\u7531\u300c\u8178\u2192\u8ff7\u8d70\u795e\u7d93\u2192\u8166\u300d\u6240\u5f62\u6210\u7684\u8def\u5f91\uff0c\u4e5f\u5c31\u662f\u8178\uff0d\u8166\u8ef8\u7dda (gut-brain axis) \u7684\u795e\u7d93\u8ff4\u8def\uff0c\u800c\u4e14\u8207\u820c\u982d\u5473\u857e\u7684\u751c\u5473\u8def\u5f91\u7121\u95dc\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u4e86\u89e3\u751c\u5473\u53ca\u8178\uff0d\u8166\u8ef8\u7dda\u7684\u96d9\u8def\u5f91\uff0c\u6709\u52a9\u65bc\u958b\u767c\u65b0\u7684\u7cd6\u985e\u66ff\u4ee3\u54c1<\/strong><\/span><\/p>\n<p>\u77e5\u9053\u4e86\u9019\u689d\u611f\u77e5\u7cd6\u985e\u7684\u7368\u7acb\u8def\u5f91\uff0c\u79d1\u5b78\u5bb6\u4e5f\u8a66\u5716\u6291\u5236\u6b64\u8def\u5f91\uff0c\u60f3\u5f9e\u6839\u672c\u4e0a\u6e1b\u5c11\u52d5\u7269\u504f\u611b\u771f\u7cd6\u7684\u672c\u80fd\u885d\u52d5\u3002\u79d1\u5b78\u5bb6\u8a66\u8457\u5c0d\u5be6\u9a57\u5c0f\u9f20\u9032\u884c\u57fa\u56e0\u6539\u9020\uff0c\u4f7f\u5176\u8178\uff0d\u8166\u8ef8\u7dda\u7684\u795e\u7d93\u6d3b\u52d5\u5728\u57fa\u56e0\u5c64\u9762\u4e0a\u53d7\u5230\u6291\u5236\uff0c\u7d50\u679c\u80fd\u6210\u529f\u963b\u6b62\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c0d\u771f\u7cd6\u504f\u597d\u7684\u884c\u70ba\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u79d1\u5b78\u5bb6\u9084\u767c\u73fe\u8178\u9053\u88e1\u95dc\u9375\u5f71\u97ff\u7cd6\u8a0a\u865f\u7684\u8461\u8404\u7cd6\u8f49\u904b\u86cb\u767d\uff0c\u540d\u7a31\u70ba\u9209-\u8461\u8404\u7cd6\u5354\u540c\u8f49\u904b\u9ad4 (sodium\u2013glucose-linked transporter-1, SGLT1)\uff0c\u53ea\u8981\u4f7f\u7528 SGLT1 \u963b\u65b7\u5291 (blocker) \u5c31\u53ef\u6d88\u9664\u6b64\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u7684\u795e\u7d93\u5143\u53cd\u61c9\u3002<\/p>\n<p>\u9019\u9805\u7814\u7a76\u8b93\u6211\u5011\u7406\u89e3\u5230\uff0c\u539f\u4f86\u52d5\u7269\u5c0d\u771f\u7cd6\u7684\u504f\u597d\u884c\u70ba\uff0c\u662f\u540d\u7b26\u5176\u5be6\u7684\u300c\u53e3\u8179\u4e4b\u617e\u300d\uff0c\u5473\u89ba\u8207\u8178\u9053\u9019\u5169\u500b\u96d9\u7cfb\u7d71\u90fd\u9a45\u52d5\u8457\u5403\u7cd6\u7684\u617e\u671b\uff0c\u9019\u9805\u65b0\u767c\u73fe\u6216\u8a31\u6703\u4fc3\u9032\u79d1\u5b78\u754c\uff0c\u767c\u5c55\u51fa\u66f4\u70ba\u6709\u6548\u7684\u300c\u6212\u7cd6\u300d\u7b56\u7565\uff0c\u5e6b\u52a9\u4eba\u5011\u6e1b\u5c11\u5c0d\u7cd6\u4e4b\u9700\u6c42\uff0c\u6216\u662f\u6253\u9020\u51fa\u66f4\u63a5\u8fd1\u771f\u7cd6\u5c0d\u5927\u8166\u4f5c\u7528\u7684\u66ff\u4ee3\u54c1\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Tan HE, et al. Nature. 2020 Apr;580(7804):511-516. <a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2199-7\">The gut-brain axis mediates sugar preference.<\/a><\/li>\n<li>EurekAlert 15-APR-2020. <a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2020-04\/tzia-hds041020.php\">How does sugar drive consumption? Scientists discover gut-brain sugar sensor in mice.<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u4eba\u5011\u5634\u4e0a\u4e0d\u8aaa\uff0c\u8eab\u9ad4\u537b\u5f88\u8aa0\u5be6\uff0c\u5f80\u5f80\u96e3\u4ee5\u62b5\u6297\u542b\u7cd6\u98f2\u6599\u7684\u8a98\u60d1\u3002\u60f3\u559d\u6709\u751c\u7684\u98f2\u6599\u4f46\u53c8\u4e0d\u60f3\u7372\u5f97\u71b1\u91cf\uff0c\u4f7f\u7528\u96f6\u71b1\u91cf\u7684\u300c\u4ee3\u7cd6\u300d\u662f\u98df\u54c1\u696d\u88e1\u5e38\u898b\u7684\u624b\u6bb5\u3002\u7136\u800c\uff0c\u8a34\u6c42\u5065\u5eb7\u7684\u7121\u7cd6\u53ef\u6a02\uff0c\u4e26\u6c92\u6709\u50cf\u539f\u672c\u53ef\u6a02\u90a3\u822c\u53d7\u5230\u6d88\u8cbb\u8005\u9752\u775e\u30022020 \u5e74 4 \u6708\u5728\u570b\u969b\u77e5\u540d\u671f\u520a Nature \u767c\u8868\u7684\u4e00\u9805\u7814\u7a76\uff0c\u5c0d\u6b64\u884c\u70ba\u73fe\u8c61\u63d0\u4f9b\u4e86\u4e00\u7a2e\u53ef\u80fd\u7684\u79d1\u5b78\u89e3\u91cb\uff1a\u4ee3\u7cd6\u96d6\u7136\u80fd\u9a19\u820c\u982d\u5473\u89ba\uff0c\u537b\u7121\u6cd5\u6eff\u8db3\u5927\u8166\uff0c\u539f\u56e0\u662f\u53ea\u6709\u300c\u771f\u6b63\u7684\u7cd6\u300d\u624d\u6703\u555f\u52d5\u300c\u8178\uff0d\u8166\u8ef8\u7dda (gut-brain axis)\u300d\u7684\u795e\u7d93\u8ff4\u8def\u3002<\/p>\n","protected":false},"author":20,"featured_media":35266,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4635,4633,4632,4634],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/05\/561513.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35261"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35261"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35261\/revisions"}],"predecessor-version":[{"id":35267,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35261\/revisions\/35267"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35266"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}