{"id":35198,"date":"2020-04-30T00:21:48","date_gmt":"2020-04-29T16:21:48","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35198"},"modified":"2020-04-24T11:21:34","modified_gmt":"2020-04-24T03:21:34","slug":"%e5%9a%b4%e9%87%8d%e7%89%b9%e6%ae%8a%e5%82%b3%e6%9f%93%e6%80%a7%e8%82%ba%e7%82%8e%ef%bc%88covid-19%ef%bc%89%e6%b2%bb%e7%99%82%e8%97%a5%e7%89%a9%e5%8f%8a%e9%a0%90%e9%98%b2%e7%96%ab%e8%8b%97%e7%9a%84","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35198","title":{"rendered":"\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\uff08COVID-19\uff09\u6cbb\u7642\u85e5\u7269\u53ca\u9810\u9632\u75ab\u82d7\u7684\u7814\u767c\u6709\u4f55\u6311\u6230\uff1f"},"content":{"rendered":"
\"\"
\u5716\u7247\u4f86\u6e90: pixabay<\/figcaption><\/figure>\n

\u51a0\u72c0\u75c5\u6bd2 2019-nCoV\uff08SARS-CoV-2\uff09\u5f15\u767c\u7684\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\uff08COVID-19\uff09\u5df2\u5728\u5168\u7403\u5927\u898f\u6a21\u6d41\u884c\uff0c\u78ba\u8a3a\u53ca\u6b7b\u4ea1\u4eba\u6578\u4e0d\u65b7\u6500\u5347\uff0c\u4f46\u8fc4\u7121\u6b63\u5f0f\u7372\u5f97\u6838\u51c6\u4e0a\u5e02\u7684\u6709\u6548\u6cbb\u7642\u85e5\u7269\u53ca\u9810\u9632\u75ab\u82d7\u3002\u70ba\u89e3\u6c7a\u6b64\u4eba\u985e\u672c\u4e16\u7d00\u6700\u5927\u516c\u5171\u885b\u751f\u53ca\u5065\u5eb7\u5371\u6a5f\uff0c\u5404\u570b\u79d1\u5b78\u5bb6\u83ab\u4e0d\u7af6\u76f8\u7814\u767c\u76f8\u95dc\u85e5\u7269\u53ca\u75ab\u82d7\uff0c\u6709\u7684\u5df2\u5b8c\u6210\u6d3b\u9ad4\u5916\u5be6\u9a57\u3001\u9032\u5165\u52d5\u7269\u5be6\u9a57\u6216\u6b63\u9032\u884c\u4eba\u9ad4\u8a66\u9a57\u4e2d\uff0c\u671f\u671b\u5728\u6700\u77ed\u6642\u9593\u5167\u5b8c\u6210\u6e2c\u8a66\u63d0\u4f9b\u81e8\u5e8a\u4f7f\u7528\u3002\u76ee\u524d\uff0c\u96d6\u5df2\u6709\u591a\u7a2e\u5019\u9078\u85e5\u7269\u53ef\u4f9b\u60a3\u8005\u4f7f\u7528\uff0c\u4ea6\u6709\u5f88\u591a\u75ab\u82d7\u6b63\u5728\u9032\u884c\u8a66\u9a57\u4e2d\uff0c\u4f46\u4ecd\u6709\u8af8\u591a\u6311\u6230\u6709\u5f85\u514b\u670d\u3002<\/span><\/strong><\/p>\n

\u64b0\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u6f5b\u5728\u6709\u6548\u6cbb\u7642\u85e5\u7269<\/strong>\uff1a<\/strong><\/span><\/p>\n

1. \u85e5\u54c1\uff1a\u5f59\u6574\u570b\u5167\u5916\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\uff08Coronavirus disease 2019, COVID-19\uff09\u7684\u76f8\u95dc\u7814\u7a76\u5831\u544a\uff0c\u767c\u73fe\u8a31\u591a\u5316\u5b78\u54c1\u3001\u7d30\u80de\u6fc0\u7d20\uff08cytokine\uff09\u53ca\u6297\u9ad4\uff08antibody\uff09\u53ef\u80fd\u662f\u6cbb\u7642COVID-19\u7684\u6f5b\u5728\u5019\u9078\u85e5\u54c1\uff08\u88681\uff09\u3002<\/p>\n

\u88681. \u6f5b\u5728\u5019\u9078\u85e5\u54c1\u6e05\u55ae<\/p>\n

\"\"<\/p>\n

\u7814\u767c\u4e0a\u7684\u4e3b\u8981\u6311\u6230\uff1a<\/p>\n

\uff0e\u5927\u591a\u50c5\u9032\u884c\u6d3b\u9ad4\u5916\u53ca\u52d5\u7269\u5be6\u9a57\uff0c\u5c1a\u672a\u5b8c\u6210\u81e8\u5e8a\u8a66\u9a57\u4e09\u671f\uff0c\u81e8\u5e8a\u61c9\u7528\u6548\u679c\u53ca\u53ef\u80fd\u7684\u4e0d\u826f\u53cd\u61c9\uff08\u526f\u4f5c\u7528\uff09\u4e26\u672a\u5145\u5206\u8a55\u4f30\u3002<\/p>\n

\uff0eCOVID-19\u60a3\u8005\u7684\u75c7\u72c0\u53ef\u5927\u81f4\u5206\u6210\u7121\u75c7\u72c0\u3001\u8f15\u75c7\u53ca\u91cd\u75c7\u4e09\u7a2e\uff0c\u4e26\u672a\u8a55\u4f30\u500b\u5225\u85e5\u54c1\u5c0d\u4e0d\u540c\u7a0b\u5ea6\u75c7\u72c0\u60a3\u8005\u7684\u9069\u7528\u6027\uff0c\u4f8b\u5982\uff1aChloroquine\u53caHydroxychloroquine\u9069\u7528\u65bc\u8f15\u75c7\uff0cRemdesivir \u9069\u7528\u65bc\u91cd\u75c7\u3002<\/p>\n

\uff0eSARS-CoV-2 \u7684RNA\u57fa\u56e0\u7d44\u7a81\u8b8a\u7387\u9ad8\uff0c\u5df2\u767c\u73fe\u6709\u591a\u7a2e\u8b8a\u7570\u682a\u7522\u751f\uff0c\u6050\u6015\u6703\u6709\u6297\u85e5\u6027\u75c5\u6bd2\u682a\u51fa\u73fe\u7684\u53ef\u80fd\u3002<\/p>\n

2. \u7279\u6b8a\u751f\u7269\u88fd\u5291\uff08\u75ca\u7652\u8005\u7684\u8840\u6f3f\uff09<\/p>\n

\u57282020\u5e74\uff0c\u4e2d\u570b\u91ab\u5e2b\u62bd\u53d65\u4f4dCOVID-19\u75ca\u7652\u8005\u7684\u8840\u6f3f\uff08convalescent plasma\uff09\uff0c\u8840\u6f3f\u4e2d\u7684SARS-CoV-2\u7279\u7570\u6027\u6297\u9ad4\uff08IgG\uff09\u7d50\u5408\u6548\u50f9\uff08binding titer\uff09\u5927\u65bc1\uff1a1000\uff0c\u4e2d\u548c\u6548\u50f9\uff08neutralization titer\uff09\u5927\u65bc40\uff0c\u8f38\u8840\u7d66\u5448\u73fe\u56b4\u91cd\u6025\u6027\u547c\u5438\u7d9c\u5408\u75c7\u5019\u7fa4\uff08severe acute respiratory syndrome, ARDS\uff09\u7684COVID-19\u91cd\u75c7\u75c5\u4eba\uff0c\u572810\u81f322\u5929\u7d66\u4e88\u75ca\u7652\u8005\u7684\u8840\u6f3f\uff0c\u767c\u73fe\u57285\u4f8b\u60a3\u8005\u4e2d\u67094\u4f8b\u57283\u5929\u5167\u9ad4\u6eab\u6062\u5fa9\u6b63\u5e38\uff0c\u75c5\u6bd2\u8ca0\u8f09\u91cf\u4e5f\u4e0b\u964d\uff1b\u8f38\u8840\u5f8c\u7b2c12\u5929\uff0c\u67094\u4f8b\u60a3\u8005\u7684ARDS\u6d88\u5931\uff1b\u5728\u6cbb\u764214\u5929\u5167\uff0c\u67093\u4f8b\u60a3\u8005\u4e0d\u518d\u9700\u8981\u4f7f\u7528\u547c\u5438\u5668\u3002\u57285\u540d\u60a3\u8005\u4e2d\uff0c\u67093\u540d\u53ef\u5206\u5225\u5728\u4f4f\u966253\u300151\u548c55\u5929\u5f8c\u51fa\u9662\uff0c\u9084\u67092\u540d\u5728\u8f38\u8840\u5f8c\u7b2c37\u5929\u75c5\u60c5\u7a69\u5b9a\uff0c\u986f\u793a\u7d66\u4e88\u5305\u542b\u4e2d\u548c\u6297\u9ad4\u7684\u75ca\u7652\u8005\u7684\u8840\u6f3f\u53ef\u6539\u5584\u75c5\u4eba\u7684\u81e8\u5e8a\u75c7\u72c0\u3002<\/p>\n

\u7814\u767c\u4e0a\u7684\u4e3b\u8981\u6311\u6230\uff1a<\/p>\n

\uff0e\u6848\u4f8b\u6578\u50c5\u67095\u4f8b\u5448\u73feARDS\u7684COVID-19\u91cd\u75c7\u60a3\u8005\uff0c\u672c\u7814\u7a76\u61c9\u50c5\u70ba\u6848\u4f8b\u5831\u544a\uff08case report\uff09\uff0c\u4e26\u672a\u5b8c\u6210\u5168\u90e8\u81e8\u5e8a\u8a66\u9a57\uff0c\u6b64\u7a2e\u7642\u6cd5\u53ef\u80fd\u50c5\u9069\u7528\u65bc\u7015\u5371\u7684\u91cd\u75c7\u60a3\u8005\u3002<\/p>\n

\uff0e\u672a\u8a55\u4f30\u63a5\u53d7\u75ca\u7652\u8005\u8840\u6f3f\u7684COVID-19\u60a3\u8005\u662f\u5426\u6709\u6392\u65a5\u53ca\u904e\u654f\u7684\u73fe\u8c61\uff0c\u9810\u5f8c\uff08prognosis\uff09\u60c5\u6cc1\u4ea6\u7121\u6301\u7e8c\u8ffd\u8e64\u8a55\u4f30\u4e4b\u5831\u544a\uff0c\u3002<\/p>\n

\uff0e\u672a\u8003\u91cf\u75ca\u7652\u8005\u662f\u5426\u60a3\u6709\u5176\u4ed6\u75be\u75c5\uff0c\u5176\u8840\u6f3f\u4e2d\u9664\u6709\u6297\u9ad4\u5916\uff0c\u53ef\u80fd\u9084\u542b\u6709\u5176\u4ed6\u7269\u8cea\u751a\u81f3\u5fae\u751f\u7269\uff0c\u672a\u9032\u884c\u6cbb\u7642\u5229\u76ca\u53ca\u98a8\u96aa\u8a55\u4f30\u3002<\/p>\n

\u25cf\u9810\u9632\u75ab\u82d7\u7684\u7814\u767c<\/strong><\/span><\/p>\n

\u57282020\u5e74\uff0c\u9999\u6e2f\u7814\u7a76\u4eba\u54e1\u57fa\u65bcSARS-CoV-2\u8207SARS-CoV\u5177\u6709\u9ad8\u5ea6\u907a\u50b3\u76f8\u4f3c\u6027\uff0c\u5229\u7528\u73fe\u6709\u7684SARS-CoV\u514d\u75ab\u5b78\u7814\u7a76\u8cc7\u6599\uff0c\u4ee5\u8a2d\u8a08\u5c0d\u6297SARS-CoV-2\u7684\u75ab\u82d7\u3002\u4ed6\u5011\u9451\u5b9a\u4e86\u4e00\u7d44\u5f97\u81ea\u75c5\u6bd2\u68d8\u7a81\u86cb\u767d\uff08spike protein\uff09\u548c\u6838\u6bbc\u86cb\u767d\uff08nucleocapsid protein\uff09\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u6297\u539f\u8868\u4f4d\uff08epitope\uff09\uff0c\u5728120\u500b\u53ef\u7528\u7684SARS-CoV-2\u5e8f\u5217\u4e2d\uff0c\u4e26\u672a\u89c0\u5bdf\u5230\u5728\u5df2\u78ba\u5b9a\u7684\u6297\u539f\u8868\u4f4d\u767c\u751f\u7a81\u8b8a\uff0c\u6240\u4ee5\u75ab\u82d7\u82e5\u514d\u75ab\u6a19\u9776\u4f5c\u7528\u65bc\u9019\u4e9b\u6297\u539f\u8868\u4f4d\uff0c\u61c9\u53ef\u63d0\u4f9b\u4eba\u9ad4\u4fdd\u8b77\u4ee5\u5c0d\u6297SARS-CoV-2\u3002<\/p>\n

\u7814\u767c\u4e0a\u7684\u4e3b\u8981\u6311\u6230\uff1a<\/p>\n

\uff0e\u75ab\u82d7\u4e43\u63d0\u4f9b\u8207\u5065\u5eb7\u4eba\u4f5c\u75be\u75c5\u9810\u9632\u4e4b\u7528\uff0c\u5b89\u5168\u6027\u8981\u6c42\u6a19\u6e96\u6975\u9ad8\uff0c\u50c5\u6709\u6d3b\u9ad4\u5916\u5be6\u9a57\u6210\u529f\uff0c\u8b49\u64da\u4ecd\u986f\u4e0d\u8db3\uff0c\u9808\u7d93\u9577\u671f\u53ca\u5927\u91cf\u7684\u52d5\u7269\u5be6\u9a57\u53ca\u5065\u5eb7\u81ea\u9858\u8005\u8a66\u9a57\u65b9\u80fd\u5b8c\u6210\u5b89\u5168\u6027\u53ca\u6709\u6548\u6027\u6e2c\u8a66\u3002<\/p>\n

\uff0e\u75c5\u6bd2\u7a81\u8b8a\u7387\u9ad8\uff0c\u68d8\u7a81\u86cb\u767d\u548c\u6838\u6bbc\u86cb\u767d\u7684\u4fdd\u5b88\u6027\uff08conservation\uff09\u672a\u4f5c\u8a73\u7d30\u8a55\u4f30\uff0c\u75ab\u82d7\u6709\u6548\u6027\uff08effectiveness\uff09\u53ca\u6548\u671f\uff08expiration\uff09\u53ef\u80fd\u5747\u76f8\u7576\u6709\u9650\u3002<\/p>\n

\uff0e\u6839\u64da\u73fe\u6709\u81e8\u5e8a\u8cc7\u6599\u986f\u793a\uff0c\u75c5\u6bd2\u682a\u5df2\u767c\u751f\u7a81\u8b8a\u800c\u53ef\u80fd\u662f\u5169\u7a2e\u4ee5\u4e0a\u7684\u6df7\u5408\u682a\uff08mixed population\uff09\uff0c\u91dd\u5c0d\u55ae\u4e00\u75c5\u6bd2\u682a\u6297\u539f\u7814\u767c\u7684\u75ab\u82d7\u6050\u7121\u6cd5\u63d0\u4f9b\u4eba\u9ad4\u5b8c\u6574\u514d\u75ab\u529b\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Singh AK, Singh A, Shaikh A, Singh R, Misra A. Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries.<\/a> Diabetes Metab Syndr. 2020 Mar 26;14(3):241-246. doi: 10.1016\/j.dsx.2020.03.011. [Epub ahead of print]<\/li>\n
  2. Shen C<\/a>, Wang Z<\/a>, Zhao F<\/a>, Yang Y<\/a>, Li J<\/a>, Yuan J<\/a>, Wang F<\/a>, Li D<\/a>, Yang M<\/a>, Xing L<\/a>, Wei J<\/a>, Xiao H<\/a>, Yang Y<\/a>, Qu J<\/a>, Qing L<\/a>, Chen L<\/a>, Xu Z<\/a>, Peng L<\/a>, Li Y<\/a>, Zheng H<\/a>, Chen F<\/a>, Huang K<\/a>, Jiang Y<\/a>, Liu D<\/a>, Zhang Z<\/a>, Liu Y<\/a>, Liu L<\/a>. Treatment of 5 critically Ill patients with COVID-19 with convalescent plasma. JAMA.<\/a> 2020 Mar 27. doi: 10.1001\/jama.2020.4783. [Epub ahead of print]<\/li>\n
  3. Wang M<\/a>, Cao R<\/a>, Zhang L<\/a>, Yang X<\/a>, Liu J<\/a>, Xu M<\/a>, Shi Z<\/a>, Hu Z<\/a>, Zhong W<\/a>, Xiao G<\/a>. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res.<\/a> 2020 Mar; 30(3):269-271. doi: 10.1038\/s41422-020-0282-0. Epub 2020 Feb 4.<\/li>\n
  4. Du YX<\/a>, Chen XP<\/a>. Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV infection. Clin Pharmacol Ther.<\/a>2020 Apr 4. doi: 10.1002\/cpt.1844. [Epub ahead of print]<\/li>\n
  5. Ahmed SF<\/a>, Quadeer AA<\/a>, McKay MR<\/a>. Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies. Viruses.<\/a> 2020 Feb 25;12(3). pii: E254. doi: 10.3390\/v12030254.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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