{"id":35133,"date":"2020-03-17T00:40:30","date_gmt":"2020-03-16T16:40:30","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35133"},"modified":"2020-10-23T12:49:36","modified_gmt":"2020-10-23T04:49:36","slug":"%e6%96%b0%e4%b8%96%e4%bb%a3%e6%b5%81%e8%a1%8c%e6%80%a7%e6%84%9f%e5%86%92%e7%96%ab%e8%8b%97%e7%9a%84%e7%99%bc%e5%b1%95%e5%89%8d%e6%99%af","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35133","title":{"rendered":"\u65b0\u4e16\u4ee3\u6d41\u884c\u6027\u611f\u5192\u75ab\u82d7\u7684\u767c\u5c55\u524d\u666f"},"content":{"rendered":"

\u5b63\u7bc0\u6027\u6d41\u611f\u75ab\u82d7\u5c0d\u65bc\u8b8a\u7570\u6027\u6216\u5168\u7403\u6027\u6d41\u611f\u75c5\u6bd2\u682a\u7684\u529f\u6548\u6709\u9650\uff0c\u6545\u958b\u767c\u5177\u6709\u5ee3\u6cdb\u9069\u7528\u6027\u514d\u75ab\u529b\u7684\u6539\u826f\u75ab\u82d7\u4ecd\u662f\u516c\u5171\u885b\u751f\u7684\u91cd\u9ede\u3002\u7576\u524d\u75ab\u82d7\u7684\u514d\u75ab\u53cd\u61c9\u96c6\u4e2d\u5728\u8840\u7403\u51dd\u96c6\u7d20\uff08hemagglutinin, HA\uff09\u7684\u982d\u90e8\uff08head\uff09\u5340\u57df\uff0c\u800c\u65b0\u4e16\u4ee3\u75ab\u82d7\u7684\u958b\u767c\u76ee\u6a19\u5247\u5728\u53ef\u8b8a\u6027\u8f03\u5c0f\u7684\u75c5\u6bd2\u7d50\u69cb\uff0c\u5982HA\u57fa\u90e8\uff08stem\uff09\u3002\u7528\u4ee5\u63d0\u9ad8\u75ab\u82d7\u6709\u6548\u6027\u7684\u7b56\u7565\u5305\u62ec\u4f7f\u7528\u5948\u7c73\u7c92\u5b50\u3001\u589e\u52a0\u6297\u539f\u5291\u91cf\u3001\u4f7f\u7528\u65b0\u578b\u4f50\u5291\uff08adjuvant\uff09\u3001\u523a\u6fc0\u7d30\u80de\u4ecb\u5c0e\u7684\u514d\u75ab\u4f5c\u7528\u53ca\u6a19\u9776\u4f5c\u7528\u5230\u5176\u4ed6\u75c5\u6bd2\u86cb\u767d\uff0c\u5982\u795e\u7d93\u80fa\u9178\u9176\uff08neuraminidase, NA\uff09\u3001M2\u86cb\u767d\u6216\u6838\u86cb\u767d\uff08nucleoprotein\uff09\u3002<\/strong><\/span><\/p>\n

\"\"<\/p>\n

 <\/strong>\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u5e02\u552e\u6d41\u611f\u75ab\u82d7\u7684\u985e\u578b<\/strong><\/span><\/p>\n

\u63a5\u7a2e\u75ab\u82d7\u662f\u9810\u9632\u6d41\u884c\u6027\u611f\u5192\uff08\u7c21\u7a31\u6d41\u611f\uff09\u6700\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u76ee\u524d\u5e02\u552e\u75ab\u82d7\u4f9d\u88fd\u9020\u6280\u8853\u6216\u5e73\u53f0\uff08platform\uff09\u53ef\u5206\u6210\u4ee5\u4e0b\u4e09\u7a2e\u985e\u578b\uff1a<\/p>\n

    \n
  1. \u5931\u6d3b\u7684\u6d41\u611f\u75ab\u82d7\uff08inactivated influenza vaccine\uff09\uff1a\u7531\u88c2\u89e3\u7684\u6d41\u611f\u75c5\u6bd2\uff08split virus\uff09\u6216\u6b21\u55ae\u4f4d\uff08subunit\uff09\u7d44\u6210\u6297\u539f\u7684\u75ab\u82d7\u3002<\/li>\n
  2. \u6d3b\u7684\u6e1b\u6bd2\u6d41\u611f\u75ab\u82d7\uff08live, attenuated influenza vaccine\uff09\uff1a\u7d50\u5408HA\u548cNA\u7684\u6d3b\u7684\u6e1b\u6bd2\u51b7\u9069\u61c9\u6027\uff08live attenuated cold-adapted\uff09\u7684\u75c5\u6bd2\u682a\uff0c\u88fd\u6210\u53ef\u7531\u9f3b\u8154\u6295\u4e88\u7684\u75ab\u82d7\u3002<\/li>\n
  3. \u91cd\u7d44\u8840\u7403\u51dd\u96c6\u7d20\u75ab\u82d7\uff08recombinant hemagglutinin vaccine\uff09\uff1a\u5229\u7528\u687f\u72c0\u75c5\u6bd2\uff08baculovirus\uff09\u7684\u8868\u9054\u7cfb\u7d71\u5728\u6606\u87f2\u7d30\u80de\u4e2d\u751f\u7522\u91cd\u7d44HA\uff0c\u518d\u5c07\u5176\u7d14\u5316\u914d\u88fd\u6210HA\u4e09\u805a\u9ad4\uff0d\u73ab\u7470\u82b1\u7d50\uff08trimer- rosettes\uff09\u7684HA\u86cb\u767d\u578b\u75ab\u82d7\u3002<\/li>\n<\/ol>\n

    \u25cf\u5e02\u552e\u6d41\u611f\u75ab\u82d7\u7684\u4fb7\u9650\u6027<\/strong><\/span><\/p>\n

    \u6d41\u611f\u75c5\u6bd2\u7684RNA\u8907\u88fd\u6240\u7528\u7684RNA\u4f9d\u8cf4\u6027RNA\u8907\u88fd\u9176\uff08RNA dependent RNA polymerase\uff09\u6821\u8b80\uff08proof reading\uff09\u6d3b\u6027\u4e0d\u4f73\uff08\u932f\u8aa4\u7387\u7d04\u4e00\u842c\u5206\u4e4b\u4e00\uff09\uff0c\u5c0e\u81f4\u5408\u6210\u7684\u75c5\u6bd2RNA\u57fa\u56e0\u7d44\u6709\u90e8\u5206\u7a81\u8b8a\uff0c\u8868\u9762\u6297\u539f\u96a8\u6642\u9593\u5448\u7dda\u6027\u8b8a\u5316\uff0c\u7a31\u70ba\u6297\u539f\u6f02\u8b8a<\/a>\uff08antigenic drift\uff09\u3002\u82e5\u540c\u4e00\u5bbf\u4e3b\u540c\u6642\u611f\u67d3\u5169\u7a2e\u4ee5\u4e0a\u7684\u6d41\u611f\u75c5\u6bd2\uff0c\u57fa\u56e0\u7d44\u53ef\u80fd\u6703\u767c\u751f\u91cd\u7d44\uff08reassortment\uff09\uff0c\u5f15\u8d77\u8868\u9762\u6297\u539f\u7684\u5287\u70c8\u8b8a\u5316\uff0c\u7a31\u70ba\u6297\u539f\u79fb\u578b<\/a>\uff08antigenic shift\uff09\u3002\u9019\u4e9b\u7a81\u7136\u7684\u6539\u8b8a\u53ef\u80fd\u6703\u9020\u6210\u5bbf\u4e3b\u7684\u514d\u75ab\u7cfb\u7d71\u7121\u6cd5\u53ca\u6642\u53cd\u61c9\uff0c\u4f7f\u5f97\u7576\u524d\u7684\u6d41\u611f\u75ab\u82d7\u901a\u5e38\u50c5\u80fd\u63d0\u4f9b\u77ed\u671f\u7684\u4fdd\u8b77\uff0c\u4e26\u975e\u6c38\u4e45\u6027\u4e14\u6709\u6548\u6027\uff08effectiveness\uff09\u4e0d\u7a69\u5b9a\u3002\u56e0\u6b64\uff0c\u958b\u767c\u529f\u6548\u7a69\u5b9a\u3001\u80fd\u5f15\u767c\u591a\u5e74\u671f\u514d\u75ab\u529b\u53ca\u53ef\u5c0d\u6297\u6240\u6709\u6d41\u611f\u75c5\u6bd2\u7684\u5ee3\u6cdb\u9069\u7528\u6027\u75ab\u82d7\u662f\u5fc5\u8981\u7684\uff08\u88681\uff09\u3002<\/p>\n

    \u88681. \u81ea\u50c5\u91dd\u5c0d\u7279\u5b9a\u75c5\u6bd2\u682a\u7684\u75ab\u82d7\u64f4\u5c55\u5230\u771f\u6b63\u5ee3\u6cdb\u9069\u7528\u6027\u7684\u75ab\u82d7<\/p>\n

    \"\"<\/p>\n

    \u25cf\u65b0\u4e16\u4ee3\u6d41\u611f\u75ab\u82d7\u7684\u5c55\u671b<\/strong><\/span><\/p>\n

    \u73fe\u884c\u6d41\u611f\u75ab\u82d7\u7684\u514d\u75ab\u53cd\u61c9\u96c6\u4e2d\u5728\u8b8a\u7570\u6027\u9ad8\u7684HA\u982d\u90e8\u5340\u57df\uff0c\u65b0\u4e16\u4ee3\u75ab\u82d7\u7684\u6a19\u7684\u5247\u805a\u7126\u5728\u8b8a\u7570\u6027\u8f03\u5c0f\u7684\u75c5\u6bd2\u7d50\u69cb\uff08\u5982HA\u57fa\u90e8\uff09\uff0c\u5176\u4ed6\u63d0\u9ad8\u75ab\u82d7\u6709\u6548\u6027\u7684\u65b0\u6280\u8853\u5305\u62ec\u4f7f\u7528\u5948\u7c73\u7c92\u5b50\uff08nanoparticle\uff09\u4ee5\u512a\u5316\u6a19\u7684\u6297\u539f\u4e4b\u6297\u539f\u6027\uff08antigenicity\uff09\u3001\u6a19\u9776\u4f5c\u7528\u65bc\u5176\u4ed6\u75c5\u6bd2\u86cb\u767d\uff08\u5982NA\u3001M2\u6216\u6838\u86cb\u767d\uff09\u3001\u6dfb\u52a0\u65b0\u578b\u4f50\u5291\u3001\u589e\u52a0\u6297\u539f\u5291\u91cf\u548c\/\u6216\u523a\u6fc0\u7d30\u80de\u4ecb\u5c0e\u7684\u514d\u75ab\u4f5c\u7528\uff08cell-mediated immunity\uff09\u3002\u6b63\u5728\u7814\u767c\u6216\u8a66\u9a57\u4e2d\u7684\u65b0\u578b\u6d41\u611f\u75ab\u82d7\u5982\u4e0b\uff1a<\/p>\n

      \n
    1. HA\u57fa\u90e8\u578b\u75ab\u82d7\uff1a\u81ea\u5c0f\u9f20\u5206\u96e2\u51fa\u4f86\u7684 C179\u55ae\u682a\u6297\u9ad4\u53ef\u4f5c\u7528\u5728HA\u57fa\u90e8\uff0c\u5c55\u73fe\u5c08\u4e00\u6027\u4e2d\u548c\u6d41\u611f\u75c5\u6bd2\u7684\u80fd\u529b\uff0c\u986f\u793aHA\u57fa\u90e8\u53ef\u4f5c\u70ba\u5f15\u767c\u66f4\u5ee3\u6cdb\u6297\u9ad4\u53cd\u61c9\u7684\u514d\u75ab\u6297\u539f\uff08immunogen\uff09\u3002<\/li>\n
    2. NA\u578b\u75ab\u82d7\uff1a\u5df2\u77e5NA\u662f\u6d41\u611f\u6cbb\u7642\u85e5\u7269\u7684\u4f5c\u7528\u6a19\u7684\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u4ea6\u8b49\u660e\u5ee3\u6548\u6027\u7684\u4fdd\u8b77\u6027\u6297\u9ad4\u4ea6\u53ef\u4f5c\u7528\u5728NA\u7684\u6d3b\u6027\u90e8\u4f4d\uff0c\u986f\u793aNA\u53ef\u4f5c\u70ba\u5f15\u767c\u6297\u9ad4\u53cd\u61c9\u7684\u514d\u75ab\u6297\u539f\u3002<\/li>\n
    3. \u6838\u86cb\u767d\u578b\u75ab\u82d7\uff1a\u6838\u86cb\u767d\u5df2\u88ab\u9451\u5b9a\u51fa\u4f86\u53ef\u4ee5\u4f5c\u70ba\u514d\u75ab\u6297\u539f\uff0c\u5f15\u767cCD4+<\/sup>\u548c\/\u6216 CD8+<\/sup> T \u7d30\u80de\u514d\u75ab\u53cd\u61c9\u3002<\/li>\n
    4. \u6dfb\u52a0\u65b0\u578b\u4f50\u5291\uff1a\u4f50\u5291\u662f\u4e00\u7a2e\u8207\u6297\u539f\u5171\u540c\u6295\u4e88\u5f8c\u53ef\u589e\u52a0\u514d\u75ab\u539f\u6027\uff08immunogenicity\uff09\u7684\u8abf\u7bc0\u5291\uff0c\u512a\u9ede\u5305\u62ec\u7bc0\u7701\u75ab\u82d7\u5291\u91cf\u3001\u8abf\u6574\u514d\u75ab\u53cd\u61c9\u7684\u65b9\u5411\u53ca\u52a0\u901f\u514d\u75ab\u53cd\u61c9\u7684\u9032\u884c\u7b49\uff0c\u5df2\u6838\u51c6\u7528\u65bc\u6d41\u611f\u75ab\u82d7\u7684\u4f50\u5291\u6709Alum\uff08\u542b\u92c1\u7684\u5316\u5408\u7269\uff09\u3001MF59\u3001AS03\u53caAF03\uff08\u5f8c\u4e09\u8005\u5747\u70ba\u6eb6\u65bc\u6cb9\/\u6c34\u4e73\u72c0\u6db2\u7684\u89d2\u9bca\u70ef\uff08squalene\uff09\uff09\u3002\u7682\u7518\uff08saponin\uff09\u3001TLR\u81f4\u6548\u5291\uff08Toll-like receptor agonist\uff09\u3001\u591a\u91a3\uff08polysacccharide\uff09\u3001\u91a3\u8102\uff08glycolipid\uff09\u53ca matrix-M \u5247\u4ecd\u5728\u8a66\u9a57\u4e2d\u3002<\/li>\n<\/ol>\n

      \u76ee\u524d\u5df2\u6709\u591a\u7a2e\u65b0\u578b\u6d41\u611f\u5019\u9078\u75ab\u82d7\u6b63\u5728\u9032\u884c\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\uff08clinical trial phase I, II, III\uff09\uff08\u88682\uff09\u3002<\/p>\n

      \u8868 2. \u9032\u884c\u81e8\u5e8a\u8a66\u9a57\u4e2d\u7684\u75ab\u82d7<\/p>\n

      \"\"<\/p>\n

      \u7e2e\u5beb\uff1a\u8840\u7403\u51dd\u96c6\u7d20\uff08hemagglutinin, HA\uff09; \u57fa\u8cea\u86cb\u767d1\uff08matrix protein 1, M1\uff09; \u57fa\u8cea\u86cb\u767d2\uff08matrix protein 2, M2\uff09\uff1b\u795e\u7d93\u80fa\u9178\u9176\uff08neuraminidase, NA\uff09; \u4e2d\u548c\u6297\u9ad4\uff08neutralizing antibody, NAb\uff09; \u6838\u86cb\u767d\uff08nucleoprotein, NP\uff09; NIH\uff08National Institutes of Health\uff09; NIAID\uff08National Institute of Allergy and Infectious Disease\uff09<\/p>\n

      \u25cf\u7d50\u8ad6<\/strong><\/span><\/p>\n

      \u7576\u524d\u88ab\u6279\u51c6\u7528\u65bc\u751f\u7522\u6d41\u611f\u75ab\u82d7\u7684\u65b9\u5f0f\u6709\u96de\u86cb\u578b\u3001\u7d30\u80de\u578b\u53ca\u91cd\u7d44\u86cb\u767d\u578b\u4e09\u7a2e\uff0c\u5927\u90e8\u5206\u8a31\u53ef\u75ab\u82d7\u90fd\u662f\u4f7f\u7528\u96de\u86cb\u80da\u80ce\u751f\u7522\uff0c\u96d6\u7136\u9019\u7a2e\u751f\u7522\u7cfb\u7d71\u4ecd\u80fd\u6eff\u8db3\u73fe\u4eca\u5168\u7403\u5c0d\u6d41\u611f\u75ab\u82d7\u7684\u9700\u6c42\uff0c\u4f46\u57fa\u65bc\u6d41\u611f\u4ecd\u662f\u76ee\u524d\u552f\u4e00\u9700\u8981\u6bcf\u5e74\u63a5\u7a2e\u75ab\u82d7\u7684\u5b63\u7bc0\u6027\u50b3\u67d3\u75c5\uff0c\u75ab\u82d7\u9700\u6c42\u91cf\u5927\uff0c\u65b0\u4e16\u4ee3\u7684\u6d41\u611f\u75ab\u82d7\u7684\u751f\u7522\u61c9\u5efa\u7acb\u5feb\u901f\u7684\u7d30\u80de\u57f9\u990a\u7cfb\u7d71\u4f86\u751f\u7522\u75ab\u82d7\u3002\u6b64\u5916\uff0c\u7531\u65bc\u75c5\u6bd2\u8b8a\u7570\u6027\u9ad8\uff0c\u75ab\u82d7\u66ff\u63db\u7387\u9ad8\uff0c\u6545\u61c9\u8457\u91cd\u5728\u958b\u767c\u80fd\u5f15\u767c\u9577\u671f\u514d\u75ab\u529b\u53ca\u53ef\u4ee5\u5c0d\u6297\u6240\u6709\u985e\u578b\u6d41\u611f\u7684\u5ee3\u6cdb\u9069\u7528\u6027\u75ab\u82d7\u3002<\/p>\n

       <\/strong><\/p>\n

      \u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

        \n
      1. Wei CJ<\/a>, Crank MC<\/a>, Shiver J<\/a>, Graham BS<\/a>, Mascola JR<\/a>, Nabel GJ<\/a>. Next-generation influenza vaccines: opportunities and challenges. Nat Rev Drug Discov.<\/a>2020 Feb 14. doi: 10.1038\/s41573-019-0056-x.<\/li>\n
      2. Job ER. Ysenbaert T<\/a>, Smet A<\/a>, Christopoulou I<\/strong><\/a>, Strugnell T<\/strong><\/a>, Oloo EO<\/strong><\/a>, Oomen RP<\/strong><\/a>, Kleanthous H<\/strong><\/a>, Vogel TU<\/a>, Saelens X<\/strong><\/a>. Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs. 2018 Nov 29; 3:55. doi: 10.1038\/s41541-018-0093-1. eCollection 2018.<\/li>\n
      3. Sagawa H, Ohshima A, Kato I, Okuno Y, Isegawa Y. The immunological activity of a deletion mutant of influenza virus haemagglutinin lacking the globular region. J Gen Virol.<\/a>1996 Jul; 77 (Pt 7):1483- doi:10.1099\/0022-1317-77-7-1483<\/a><\/li>\n
      4. Liu YV. Massare MJ<\/a>, Pearce MB<\/a>, Sun X<\/a>, Belser JA<\/strong><\/a>, Maines TR<\/a>, Creager HM<\/a>, Glenn GM<\/a>, Pushko P<\/strong><\/a>, Smith GE<\/a>, Tumpey TM<\/strong><\/a>. Recombinant virus- like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets. Vaccine.<\/a> 2015 Apr 27;33(18):2152-8. doi: 10.1016\/j.vaccine.2015.03.009. Epub 2015 Mar 13.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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