{"id":35102,"date":"2020-03-06T00:01:32","date_gmt":"2020-03-05T16:01:32","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35102"},"modified":"2020-03-06T10:33:47","modified_gmt":"2020-03-06T02:33:47","slug":"%e6%b5%81%e8%a1%8c%e6%80%a7%e6%84%9f%e5%86%92%e8%88%87%e5%9a%b4%e9%87%8d%e7%89%b9%e6%ae%8a%e5%82%b3%e6%9f%93%e6%80%a7%e8%82%ba%e7%82%8e%e7%9a%84%e5%b7%ae%e7%95%b0","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35102","title":{"rendered":"\u6d41\u884c\u6027\u611f\u5192\u8207\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u7684\u5dee\u7570"},"content":{"rendered":"

\u6d41\u884c\u6027\u611f\u5192\u662f\u51ac\u5b63\u5e38\u898b\u7684\u50b3\u67d3\u6027\u75be\u75c5\uff0c\u96d6\u7136\u81f4\u6b7b\u7387\u4e0d\u9ad8\uff0c\u4e26\u5df2\u6709\u6709\u6548\u6cbb\u7642\u85e5\u7269\u53ca\u9810\u9632\u75ab\u82d7\u4e0a\u5e02\uff0c\u4f46\u57fa\u65bc\u5176\u767c\u751f\u5b63\u7bc0\u6027\u3001\u9ad8\u5ea6\u50b3\u67d3\u529b\u53ca\u50b3\u64ad\u7bc4\u570d\u5ee3\u7684\u7279\u6027\uff0c\u6211\u5011\u4ecd\u4e0d\u53ef\u5ffd\u8996\u5176\u5c0d\u4eba\u9ad4\u5065\u5eb7\u7684\u91cd\u5927\u885d\u64ca\uff0c\u800c\u4e14\u8fd1\u5e74\u66fe\u7206\u767c\u6578\u6b21\u5168\u7403\u6027\u5927\u6d41\u884c\uff0c\u9020\u6210\u6578\u5341\u842c\u4eba\u6b7b\u4ea1\uff0c\u66f4\u5f15\u8d77\u4e86\u570b\u969b\u793e\u6703\u7684\u95dc\u6ce8\u3002\u6700\u8fd1\u4ee4\u4eba\u805e\u4e4b\u8272\u8b8a\u7684\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u8207\u6d41\u884c\u6027\u611f\u5192\u6709\u985e\u4f3c\u7684\u7279\u6027\uff0c\u5728\u672c\u6587\u6211\u5011\u5c07\u63a2\u8a0e\u4e8c\u8005\u5728\u75be\u75c5\u7684\u7279\u5fb5\u3001\u75c5\u539f\u9ad4\u3001\u85e5\u7269\u6cbb\u7642\u53ca\u9810\u9632\u4e0a\u7684\u5dee\u7570\u3002<\/strong><\/span><\/p>\n

\"\"<\/p>\n

\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u6d41\u884c\u6027\u611f\u5192\u75c5\u6bd2\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

\u611f\u67d3\u4eba\u985e\u7684\u6d41\u884c\u6027\u611f\u5192\uff08\u7c21\u7a31\u6d41\u611f\uff09\u75c5\u6bd2\uff08influenza virus\uff09\u5305\u62ecA\u3001B\u3001C\u4e09\u578b\uff0c\u5176\u4e2d\u8f03\u5e38\u898b\u7684A\u3001B\u578b\u5916\u578b\u5448\u7403\u72c0\uff0cC\u578b\u5247\u5448\u7d72\u72c0\u4e14\u8f03\u70ba\u7f55\u898b\uff08\u901a\u5e38\u53ea\u5728\u5b69\u7ae5\u8eab\u4e0a\u9020\u6210\u8f15\u5fae\u75c7\u72c0\uff09\u3002\u4e09\u7a2e\u6d41\u611f\u75c5\u6bd2\u57fa\u672c\u7d50\u69cb\u985e\u4f3c\uff0c\u6700\u5916\u5c64\u7684\u7d50\u69cb\u662f\u5916\u5957\u819c\uff08envelope\uff09\uff0c\u8868\u9762\u4e3b\u8981\u6709\u8840\u7403\u51dd\u96c6\u7d20<\/a>\uff08hemagglutinin, HA, sialidase\uff09\u53ca\u795e\u7d93\u80fa\u9178\u9176<\/a>\uff08neuraminidase, NA\uff09\u5169\u7a2e\u91a3\u86cb\u767d<\/a>\uff08glycoprotein\uff09\uff0c\u5167\u90e8\u542b\u6709\u8ca0\u93c8\u55ae\u80a1\uff08negative sense, single-stranded\uff09\u7684RNA<\/a>\u7684\u57fa\u56e0\u7d44\u53ca\u5176\u4ed6\u86cb\u767d\u8cea\u3002\u6d41\u611f\u75c5\u6bd2\u7684HA\u8207\u5bbf\u4e3b\u7684\u53e3\u3001\u9f3b\u547c\u5438\u9053\u4e0a\u76ae\u7d30\u80de\u8868\u9762\u7684\u553e\u6db2\u9178<\/a>\uff08sialic acid\uff09\u7d50\u5408\uff0c\u5728HA\u88ab\u86cb\u767d\u9176<\/a>\u5207\u5272<\/a>\u5f8c\uff0c\u85c9\u7531\u7d30\u80de\u5167\u541e\u4f5c\u7528<\/a>\uff08endocytosis\uff09\u4f7fRNA\u57fa\u56e0\u7d44\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u5167\uff1bNA\u53ef\u5728\u75c5\u6bd2\u9846\u7c92\uff08virion\uff09\u6210\u719f\u5f8c\uff0c\u5207\u5272\u5176\u8868\u9762\u4e0a\u7684\u91a3\u985e\uff0c\u5354\u52a9\u5176\u81ea\u5bbf\u4e3b\u7d30\u80de\u91cb\u51fa\uff1b\u57fa\u8cea\u86cb\u767d2\uff08matrix protein 2, M2\uff09\u662f\u5916\u5957\u819c\u4e0a\u7684\u8cea\u5b50\u9078\u64c7\u6027\u86cb\u767d\u8cea\uff08\u50c5A\u578b\u6709\uff09\uff0c\u6703\u5f62\u6210\u4e00\u500b\u96e2\u5b50\u901a\u9053\uff08ion channel\uff09\uff0c\u4f7f\u5f97\u75c5\u6bd2RNA\u5f97\u4ee5\u91cb\u51fa\u800c\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u3002<\/p>\n

\u25cf\u6d41\u884c\u6027\u611f\u5192\u8207\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u7684\u6bd4\u8f03<\/strong><\/span><\/p>\n

\u6d41\u611f\u7684\u50b3\u67d3\u6027\u3001\u75c7\u72c0\u53ca\u50b3\u67d3\u9014\u5f91\u96d6\u8207\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\uff08\u65b0\u51a0\u80ba\u708e\u3001\u6b66\u6f22\u80ba\u708e\u3001COVID-19\uff09\u7684\u76f8\u4f3c\uff0c\u4f46\u4ecd\u6709\u4e0d\u540c\u8655\uff08\u88681\uff09\u3002<\/p>\n

\u8868 1\uff1a\u6d41\u884c\u6027\u611f\u5192\u8207\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u7684\u5dee\u7570<\/p>\n

\"\"<\/p>\n

\u25cf\u6cbb\u7642\u85e5\u7269<\/strong><\/span><\/p>\n

\u5df2\u6709\u6838\u51c6\u4e0a\u5e02\u7684\u85e5\u7269\u4f9b\u4f5c\u70ba\u6cbb\u7642\u6d41\u611f\u4e4b\u7528\uff0c\u4f46\u73fe\u5df2\u767c\u73fe\u5c0d\u795e\u7d93\u80fa\u9178\u9176\u6291\u5236\u5291\u53caM2\u86cb\u767d<\/a>\u8cea\u6291\u5236\u5291\u6709\u6297\u6027\u7684\u75c5\u6bd2\u76db\u884c\u7387\u8d8a\u4f86\u8d8a\u9ad8\uff1bCOVID-19\u7684\u6709\u6548\u6cbb\u7642\u85e5\u7269\u5247\u4ecd\u5728\u7814\u767c\u6216\u8a66\u9a57\u4e2d\uff0c\u5c1a\u672a\u6b63\u5f0f\u7372\u5f97\u570b\u969b\u8a8d\u8b49\uff08\u88682\uff09\u3002<\/p>\n

\u8868 2\uff1a\u6d41\u884c\u6027\u611f\u5192\u8207\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u7684\u6709\u6548\u6cbb\u7642\u85e5\u7269\u4e4b\u6bd4\u8f03<\/p>\n

\"\"<\/p>\n

 <\/p>\n

\u25cf\u75be\u75c5\u9810\u9632<\/strong><\/span><\/p>\n

\u589e\u5f37\u81ea\u8eab\u514d\u75ab\u529b\u3001\u52e4\u6d17\u624b\u53ca\u6234\u53e3\u7f69\u5747\u53ef\u9810\u9632\u6d41\u611f\u53caCOVID-19\u3002\u73fe\u5df2\u6709\u6838\u51c6\u4e0a\u5e02\u7684\u75ab\u82d7\u4f9b\u4f5c\u9810\u9632\u6d41\u611f\u4e4b\u7528\uff0c\u4f46\u56e0\u6d41\u611f\u75c5\u6bd2\u8b8a\u7570\u6027\u9ad8\uff0c\u7576\u524d\u7684\u75ab\u82d7\u901a\u5e38\u50c5\u80fd\u63d0\u4f9b\u77ed\u66ab\u5e7e\u5e74\u7684\u4fdd\u8b77\uff0c\u4e26\u975e\u7d42\u8eab\u6c38\u4e45\u6027\u7684\uff08\u88683\uff09\uff0c\u800cCOVID-19\u7684\u75ab\u82d7\u5247\u4ecd\u5728\u7814\u767c\u4e2d\uff08\u5df2\u6709\u591a\u570b\u76f8\u7e7c\u6210\u529f\u5206\u96e2\u51fa2019-nCoV\u75c5\u6bd2\u682a\uff09\u3002<\/p>\n

\u88683\uff1a\u7f8e\u570b\u53ca\u6b50\u6d32\u5df2\u6838\u51c6\u7684\u6d41\u611f\u75ab\u82d7<\/p>\n

\"\"<\/p>\n

HAI: \u8840\u7403\u51dd\u96c6\u7d20\u6291\u5236\u4f5c\u7528\uff08hemagglutination inhibition\uff09; Alum\uff1a\u542b\u92c1\uff08aluminum\uff09\u7684\u5316\u5408\u7269\uff1bMF59\uff1a\u4e00\u7a2e\u6eb6\u65bc\u6cb9\/\u6c34\u4e73\u72c0\u6db2\u7684\u89d2\u9bca\u70ef\uff08squalene\uff09<\/p>\n

\u6d3b\u7684\u6e1b\u6bd2\u51b7\u9069\u61c9\u6027\u6d41\u611f\u75ab\u82d7\uff1a\u5229\u7528\u6d41\u611f\u75c5\u6bd2\u7a81\u8b8a\u7a2e\u9069\u65bc25\u00b0C\u751f\u9577\uff08\u51b7\u9069\u61c9\u6027\uff09\uff0c\u800c\u5728\u4eba\u9ad4\u9ad4\u6eab\uff0836-37\u2103\uff09\u7121\u6cd5\u5b8c\u5584\u8907\u88fd\u7684\u7279\u6027\uff0c\u4f86\u958b\u767cA\u578b\u548cB\u578b\u6d41\u611f\u75ab\u82d7\u3002\u512a\u9ede\u5305\u62ec\u6e1b\u5f31\u7684\u6bd2\u6027\u3001\u4e0d\u53ef\u50b3\u64ad\u6027\u3001\u907a\u50b3\u7a69\u5b9a\u6027\u3001\u6eab\u5ea6\u654f\u611f\u6027\u3001\u63d0\u4f9b\u5c40\u90e8\u548c\u7d30\u80de\u4ecb\u5c0e\u514d\u75ab\u53cd\u61c9\u7684\u514d\u75ab\u539f\u6027\uff08immunogenicity\uff09\u3002<\/p>\n

 <\/strong><\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Anne M. Global Transmission of Oseltamivir-Resistant Influenza<\/a>. New England Journal of Medicine. 2009 March 5, 360 (10): 953\u2013956. doi: 10.1056\/NEJMp0900648.<\/li>\n
  2. Fukao K, Noshi T, Yamamoto A, Kitano M, Ando Y Higuchi N, Ikeda M, Shishido T, Naito A. Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection<\/a>. J Antimicrob Chemother.<\/a>2019 Mar 1;74(3):654-662. doi: 10.1093\/jac\/dky462.<\/li>\n
  3. Wei CJ<\/a>, Crank MC<\/a>, Shiver J<\/a>, Graham BS<\/a>, Mascola JR<\/a>, Nabel GJ<\/a>. Next-generation influenza vaccines: opportunities and challenges. Nat Rev Drug Discov.<\/a>2020 Feb 14. doi: 10.1038\/s41573-019-0056-x.<\/li>\n
  4. Chen JR, Liu YM, Tseng YC, Ma C. Betterinfluenza vaccines: an industry perspective.<\/a> J Biomed Sci. 2020 Feb 14;27(1):33. doi: 10.1186\/s12929-020-0626-6. Review.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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