{"id":35090,"date":"2020-03-18T00:21:49","date_gmt":"2020-03-17T16:21:49","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35090"},"modified":"2020-10-23T12:47:47","modified_gmt":"2020-10-23T04:47:47","slug":"%e7%94%9c%e9%a3%9f%e8%ae%93%e5%a4%a7%e8%85%a6%e9%9b%a3%e4%bb%a5%e6%8a%97%e6%8b%92","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35090","title":{"rendered":"\u751c\u98df\u8b93\u5927\u8166\u96e3\u4ee5\u6297\u62d2"},"content":{"rendered":"<figure id=\"attachment_35092\" aria-describedby=\"caption-attachment-35092\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-35092\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/03\/cupcakes-690040_960_720.jpg\" alt=\"\" width=\"450\" height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/03\/cupcakes-690040_960_720.jpg 960w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/03\/cupcakes-690040_960_720-300x200.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/03\/cupcakes-690040_960_720-768x512.jpg 768w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-35092\" class=\"wp-caption-text\">\u5716\u7247\u4f86\u6e90\uff1aPixabay.com<\/figcaption><\/figure>\n<p><strong>\u6587\uff0f\u9673\u6566\u7406<\/strong><\/p>\n<p>\u6e05\u6dbc\u9806\u53e3\u7684\u6c7d\u6c34\u3001\u5976\u8336\u3001\u624b\u6416\u98f2\u6599\uff0c\u7f8e\u5473\u8ff7\u4eba\u7684\u5de7\u514b\u529b\u3001\u51b0\u6dc7\u6dcb\u3001\u86cb\u7cd5\u8b93\u4eba\u5782\u6d8e\u6b32\u6ef4\u4e00\u53e3\u63a5\u4e00\u53e3\u505c\u4e0d\u4e0b\u4f86\uff0c\u4e00\u5929\u6c92\u5403\u5c31\u6e3e\u8eab\u4e0d\u5c0d\u52c1\u3002\u70ba\u4ec0\u9ebc\u660e\u660e\u77e5\u9053\u9ad8\u7cd6\u3001\u9ad8\u9e7d\u3001\u9ad8\u8102\u7684\u300c\u5783\u573e\u98df\u7269\u300d\u5c0d\u5065\u5eb7\u6709\u5bb3\u537b\u9084\u662f\u7121\u6cd5\u6297\u62d2\u8a98\u60d1\uff1f\u98df\u7269\u6703\u4e0d\u6703\u8b93\u4eba\u4e0a\u766e\u9019\u500b\u554f\u984c\u5df3\u7d93\u722d\u8ad6\u8a31\u4e45\uff0c\u71df\u990a\u5b78\u5bb6\u548c\u79d1\u5b78\u5bb6\u5927\u591a\u53cd\u5c0d\u98df\u7269\u6210\u766e\u7684\u8aaa\u6cd5\u3002\u5118\u7ba1\u4e4b\u524d\u7814\u7a76\u767c\u73fe\u7fd2\u6163\u751c\u98df\u7684\u5927\u767d\u9f20\u5728\u505c\u6b62\u4f9b\u61c9\u9ad8\u7cd6\u98df\u7269\u51fa\u73fe\u8eab\u9ad4\u986b\u6296\u985e\u4f3c\u6212\u65b7\u7684\u751f\u7406\u75c7\u72c0\uff0c\u537b\u5c0d\u7cd6\u6703\u5728\u5927\u8166\u3001\u884c\u70ba\u7522\u751f\u4ec0\u9ebc\u5f71\u97ff\u4e0d\u751a\u6e05\u695a\u3002<\/p>\n<p>\u4e39\u9ea5\u5967\u80e1\u65af\u5927\u5b78 (Aarhus University) \u81e8\u5e8a\u91ab\u5b78\u7cfb\u7814\u7a76\u5718\u968a\u5728\u5be6\u9a57\u52d5\u7269\u8eab\u4e0a\u767c\u73fe\uff0c\u651d\u53d6\u7cd6\u6703\u6539\u8b8a\u5927\u8166\u734e\u8cde\u6a5f\u5236\u7684\u8ff4\u8def\uff0c\u9019\u8207\u6bd2\u54c1\u5c0d\u5927\u8166\u7684\u5f71\u97ff\u5341\u5206\u76f8\u4f3c\u3002<\/p>\n<p>\u60f3\u8981\u63a2\u8a0e\u7cd6\u5c0d\u4eba\u9ad4\u5927\u8166\u3001\u884c\u70ba\u7684\u5f71\u97ff\uff0c\u6700\u7406\u60f3\u7684\u7814\u7a76\u5c0d\u8c61\u7576\u7136\u662f\u4eba\uff0c\u7136\u800c\u60f3\u8981\u4ee5\u4eba\u505a\u5be6\u9a57\u537b\u9762\u81e8\u5169\u5927\u96e3\u984c\uff0c\u9664\u4e86\u96e3\u4ee5\u63a7\u5236\u4e4b\u5916\u9084\u52a0\u4e0a\u4eba\u9ad4\u591a\u5df4\u80fa (dopamine) \u6fc3\u5ea6\u6703\u53d7\u5230\u8a31\u591a\u4e0d\u540c\u56e0\u7d20\u7684\u5f71\u97ff\u3002\u4eba\u9ad4\u591a\u5df4\u80fa\u6fc3\u5ea6\u6703\u56e0\u70ba\u5403\u6771\u897f\u3001\u73a9\u624b\u6a5f\u904a\u6232\u3001\u6216\u662f\u5728\u5be6\u9a57\u671f\u9593\u589c\u5165\u60c5\u7db2\u800c\u8b93\u5be6\u9a57\u6578\u64da\u7522\u751f\u6975\u5927\u7684\u8b8a\u5316\u3002<\/p>\n<p>\u591a\u5df4\u80fa\u662f\u4e00\u7a2e\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u5728\u5927\u8166\u5206\u4f48\u5ee3\u6cdb\uff0c\u5f71\u97ff\u7761\u7720\u3001\u60c5\u7dd2\u3001\u6ce8\u610f\u529b\u8207\u5b78\u7fd2\u3002\u795e\u7d93\u7d30\u80de\u4e4b\u9593\u5f62\u6210\u5fae\u5c0f\u7a7a\u9699\uff0c\u7576\u795e\u7d93\u8a0a\u606f\u50b3\u5230\u795e\u7d93\u7d30\u80de\u672b\u7aef\uff0c\u9700\u8981\u900f\u904e\u5316\u5b78\u7269\u8cea\u4f86\u50b3\u905e\u8a0a\u865f\u3002 \u9ad4\u5167\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u5982\u679c\u4e0d\u5e73\u8861\u6703\u5c0e\u81f4\u75be\u75c5\u3002\u50cf\u662f\u5e15\u91d1\u68ee\u6c0f\u75c7 (Parkinson's disease) \u60a3\u8005\u5927\u8166\u591a\u5df4\u80fa\u4e0d\u8db3\uff0c\u800c\u601d\u89ba\u5931\u8abf\u75c7 (Schizophrenia) \u60a3\u8005\u5247\u662f\u591a\u5df4\u80fa\u904e\u591a\u3002\u4e4b\u524d\u6709\u985e\u4f3c\u7814\u7a76\u4f7f\u7528\u5927\u767d\u9f20\u505a\u5be6\u9a57\uff0c\u7136\u800c\u7260\u5011\u7684\u9ad4\u91cd\u8abf\u7bc0\u3001\u4ee3\u8b1d\u6046\u5b9a\u7cfb\u7d71\u6a5f\u5236\u537b\u548c\u4eba\u985e\u975e\u5e38\u4e0d\u540c\u3002\u6700\u5f8c\u7814\u7a76\u5718\u968a\u9078\u64c7\u54e5\u5ef7\u6839\u5c0f\u8c6c (G\u00f6ttingen minipig) \u505a\u70ba\u5be6\u9a57\u52d5\u7269\u3002\u62ff\u5c0f\u8c6c\u4f5c\u5be6\u9a57\u7684\u597d\u8655\u662f\u5c0f\u8c6c\u8166\u90e8\u6bd4\u5927\u767d\u9f20\u8907\u96dc\u4e14\u5927\u5c0f\u9069\u4e2d\uff0c\u53ef\u4ee5\u4f7f\u7528\u6383\u63cf\u4eba\u8166\u7684\u5100\u5668\u4f86\u5f97\u5230\u8166\u90e8\u6df1\u8655\u5f71\u50cf\u3002<\/p>\n<p><strong><span style=\"color: #008080;\">\u6b63\u5b50\u9020\u5f71\u7814\u7a76\u734e\u8cde\u7cfb\u7d71<\/span><\/strong><\/p>\n<p>\u7814\u7a76\u5718\u968a\u5728\u5be6\u9a57\u958b\u59cb\u5c0d\u4e03\u96bb\u6bcd\u8c6c\u9ebb\u9189\u9032\u884c\u8166\u90e8\u6b63\u5b50\u9020\u5f71\u6383\u63cf (positron emission tomography\uff0cPET)\u3002\u6b63\u5b50\u9020\u5f71\u7684\u539f\u7406\u662f\u4ee5\u65b7\u5c64\u9020\u5f71\u5100\u6383\u63cf\u5229\u7528\u85e5\u5291\u7522\u751f\u7684\u5e36\u6b63\u96fb\u8377\u96fb\u5b50\u5728\u8eab\u9ad4\u7d44\u7e54\u8207\u5e36\u8ca0\u96fb\u8377\u96fb\u5b50\u649e\u64ca\u7522\u751f\u8f3b\u5c04\u7dda\u5f62\u6210\u7684\u5f71\u50cf\uff0c\u76ee\u524d\u5e38\u7528\u5728\u8a3a\u65b7\u8eab\u5fc3\u75be\u60a3\u3001\u764c\u75c7\u3001\u5fc3\u81df\u75c5\u8207\u57fa\u56e0\u6cbb\u7642\u3002\u6b63\u5b50\u9020\u5f71\u8a3a\u65b7\u8eab\u5fc3\u75be\u60a3\u53ef\u4ee5\u77ad\u89e3\u8166\u90e8\u4ee3\u8b1d\u3001\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u8b8a\u5316\u3002\u4e03\u96bb\u5c0f\u8c6c\u5728\u5e73\u5e38\u98f2\u98df\u5916\u6bcf\u5929\u6709\u4e00\u5c0f\u6642\u53ef\u4ee5\u66a2\u98f2\u8517\u7cd6\u6c34\uff0c\u5be6\u9a57\u7e3d\u5171\u9032\u884c\u5341\u4e8c\u5929\u3002\u5230\u7b2c\u5341\u4e8c\u5929\u559d\u5b8c\u7cd6\u6c3424\u5c0f\u6642\u5f8c\u518d\u6b21\u8b93\u5c0f\u8c6c\u63a5\u53d7\u8166\u90e8\u6b63\u5b50\u9020\u5f71\u3002\u5176\u4e2d\u6709\u4e94\u96bb\u5c0f\u8c6c\u5728\u7b2c\u4e00\u6b21\u559d\u5b8c\u7cd6\u6c34\u5f8c\u591a\u505a\u4e00\u6b21\u6b63\u5b50\u9020\u5f71 \u3002\u70ba\u4e86\u77ad\u89e3\u651d\u53d6\u7cd6\u5c0d\u5927\u8166\u5f71\u97ff\uff0c\u6b63\u5b50\u9020\u5f71\u91dd\u5c0d\u5c0f\u8c6c\u8166\u4e2d\u985e\u9d09\u7247\u53d7\u9ad4\u4fc3\u6548\u5291 (opioid receptor agonist) \u3001\u591a\u5df4\u80fa\u53d7\u9ad4\u62ee\u6297\u5291 (dopamine receptor antagonist) \u89c0\u5bdf\u5206\u6790\u4f86\u4e86\u89e3\u5927\u8166\u734e\u8cde\u7cfb\u7d71 (reward system) \u904b\u4f5c\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u9ad8\u7cd6\u98f2\u98df\u6539\u8b8a\u5927\u8166\u8b93\u4eba\u96e3\u4ee5\u6297\u62d2<\/strong><\/span><\/p>\n<p>\u7d50\u679c\u767c\u73fe\uff0c\u53d6\u651d\u5341\u4e8c\u5929\u7cd6\u6c34\u7684\u5c0f\u8c6c\u8166\u90e8\u53ef\u4ee5\u89c0\u5bdf\u5230\u985e\u9d09\u7247\u3001\u591a\u5df4\u80fa\u7cfb\u7d71\u767c\u751f\u91cd\u5927\u6539\u8b8a\u3002<\/p>\n<p>\u8166\u90e8\u985e\u9d09\u7247\u7cfb\u7d71\u5316\u5b78\u53cd\u61c9\u8207\u6eff\u8db3\u3001\u6109\u6085\u611f\u89ba\u76f8\u95dc\uff0c\u5728\u5c0f\u8c6c\u7b2c\u4e00\u6b21\u66a2\u98f2\u7cd6\u6c34\u5c31\u958b\u59cb\u555f\u52d5\uff0c\u8a31\u591a\u8166\u90e8\u5340\u57df\u90fd\u767c\u751f\u6539\u8b8a\uff0c\u50cf\u662f\u7d0b\u72c0\u9ad4 \u3001\u4f9d\u6838 (nucleus accumbens)\u3001\u8996\u4e18 \u3001\u674f\u4ec1\u6838\u3001\u6263\u5e36\u76ae\u8cea (cingulate cortex)\u3001\u524d\u984d\u8449\u76ae\u8cea\u3002\u7814\u7a76\u767c\u73fe\u9ad8\u7cd6\u98f2\u98df\u4ee4\u4eba\u96e3\u4ee5\u6297\u62d2\u3001\u6b32\u7f77\u4e0d\u80fd\u7684\u539f\u56e0\u5728\u65bc\u9ad8\u7cd6\u98f2\u98df\u5f71\u97ff\u8166\u90e8\u734e\u8cde\u8ff4\u8def\u7684\u65b9\u5f0f\u8207\u6bd2\u54c1\u5c0d\u8166\u90e8\u7684\u5f71\u97ff\u5341\u5206\u985e\u4f3c\u3002\u6bd2\u54c1\u9032\u5165\u5927\u8166\u6703\u523a\u6fc0\u795e\u7d93\u7d30\u80de\u5206\u6ccc\u5927\u91cf\u591a\u5df4\u80fa\uff0c\u7522\u751f\u6109\u5feb\u6eff\u8db3\u7684\u611f\u89ba\uff0c\u9060\u9060\u8d85\u904e\u65e5\u5e38\u751f\u6d3b\u4e2d\u4eba\u969b\u95dc\u4fc2\u8207\u5b78\u7fd2\u3002<\/p>\n<p>\u5728\u9019\u500b\u60e1\u6027\u5faa\u74b0\u4e0b\u4eba\u9ad4\u734e\u8cde\u7cfb\u7d71\u4fbf\u50ac\u4fc3\u6211\u5011\u53bb\u5c0b\u627e\u66f4\u591a\u6bd2\u54c1\u3002\u9019\u500b\u767c\u73fe\u51fa\u4e4e\u79d1\u5b78\u5bb6\u610f\u6599\u4e4b\u5916\uff0c\u9577\u4e45\u4ee5\u4f86\u4eba\u5011\u5c0d\u65bc\u7cd6\u6703\u5c0d\u5927\u8166\u3001\u884c\u70ba\u7522\u751f\u4ec0\u9ebc\u5f71\u97ff\u4e26\u4e0d\u6e05\u695a\uff0c\u53ea\u77e5\u9053\u9ad8\u7cd6\u98f2\u98df\u6703\u5c0d\u4eba\u9ad4\u751f\u7406\u7522\u751f\u5f71\u97ff\uff0c\u800c\u7cd6\u5c0d\u8eab\u9ad4\u4e0d\u5065\u5eb7\u7684\u539f\u56e0\u6709\u8a31\u591a\u7a2e\u3002\u6b63\u5982\u5728\u5be6\u9a57\u8c6c\u8eab\u4e0a\u770b\u5230\u7684\u4e00\u6a23\uff0c\u8517\u7cd6\u6c34\u53ea\u8981\u5341\u4e8c\u5929\u5c31\u6539\u8b8a\u5927\u8166\u734e\u8cde\u7cfb\u7d71\uff0c\u4e0d\u96e3\u60f3\u50cf\u539f\u672c\u5927\u8166\u7684\u5929\u7136\u523a\u6fc0\u7269\u50cf\u5b78\u7fd2\u3001\u4eba\u969b\u95dc\u4fc2\u5c07\u6703\u88ab\u73fe\u4ee3\u751f\u6d3b\u4e2d\u5145\u65a5\u7684\u8517\u7cd6\u3001\u5176\u4ed6\u4eba\u5de5\u523a\u6fc0\u7269\u6240\u53d6\u4ee3\u3002<\/p>\n<p>\u4eba\u985e\u5929\u751f\u6709\u5c0b\u6c42\u591a\u5df4\u80fa\u7684\u885d\u52d5\uff0c\u5982\u679c\u53ef\u4ee5\u627e\u5230\u66f4\u597d\u3001\u66f4\u591a\u7684\u9078\u64c7\uff0c\u4e0d\u7ba1\u7406\u6027\u611f\u6027\u4e0a\u90fd\u96e3\u4ee5\u6297\u62d2\u3002\u98df\u7269\u6210\u766e\u7684\u8aaa\u6cd5\u4ecd\u7136\u5145\u6eff\u722d\u8b70\u8207\u53cd\u5c0d\u8072\u6d6a\uff0c\u7136\u800c\u9ad8\u7cd6\u3001\u9ad8\u9e7d\u3001\u9ad8\u8102\u98df\u7269\u5c0d\u5065\u5eb7\u7684\u5371\u5bb3\u537b\u662f\u4e0d\u5bb9\u5ffd\u8996\uff0c\u7576\u6211\u5011\u5c0d\u65bc\u9ad8\u7cd6\u98f2\u98df\u5982\u4f55\u6539\u8b8a\u5927\u8166\u8b93\u4eba\u96e3\u4ee5\u6297\u62d2\u7684\u6a5f\u5236\u6709\u66f4\u591a\u77ad\u89e3\uff0c\u624d\u66f4\u6709\u6a5f\u6703\u627e\u51fa\u89e3\u6c7a\u65b9\u6cd5\u6e1b\u5c11\u5c0d\u5065\u5eb7\u7684\u5371\u5bb3\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n<p>1\u3001Michael Winterdahl, Ove Noer, Dariusz Orlowski et al , <a href=\"https:\/\/www.nature.com\/articles\/s41598-019-53430-9\">Sucrose intake lowers \u03bc-opioid and dopamine D2\/3 receptor availability in porcine brain<\/a>, Scientific Reports\uff0c 2019.<\/p>\n<p>2\u3001\u6fee\u5bb6\u548c\u3002<a href=\"https:\/\/www.cch.org.tw\/vmpc\/news\/news_detail.aspx?oid=7368&amp;no=7\">\u73fe\u4ee3\u4eba\u7684\u6210\u766e\u884c\u70ba\u8207\u9748\u6027\u5065\u5eb7<\/a>\u3002\u5f70\u57fa\u91ab\u7642\u5065\u5eb7\u9632\u6cbb\u5b63\u520a\u30022019\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e39\u9ea5\u5967\u80e1\u65af\u5927\u5b78 (Aarhus University) 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