{"id":35023,"date":"2020-03-19T00:06:05","date_gmt":"2020-03-18T16:06:05","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35023"},"modified":"2020-03-13T11:53:47","modified_gmt":"2020-03-13T03:53:47","slug":"%e9%9d%9e%e6%b3%95%e8%97%a5%e7%89%a9%e5%a6%82%e4%bd%95%e5%bc%95%e7%99%bc%e6%80%9d%e8%a6%ba%e5%a4%b1%e8%aa%bf%e7%97%87%e7%97%87%e7%8b%80%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35023","title":{"rendered":"\u975e\u6cd5\u85e5\u7269\u5982\u4f55\u5f15\u767c\u601d\u89ba\u5931\u8abf\u75c7\u75c7\u72c0\uff1f"},"content":{"rendered":"
\"\"
\u5716\u7247\u4f86\u6e90\uff1aunsplash.com<\/figcaption><\/figure>\n

\u6587\uff0f\u5468\u739f\u8431<\/strong><\/p>\n

\u601d\u89ba\u5931\u8abf\u75c7(Schizophrenia)\u662f\u4e00\u7a2e\u7cbe\u795e\u75be\u75c5\uff0c\u820a\u6642\u7a31\u70ba\u300c\u7cbe\u795e\u5206\u88c2\u75c7\u300d\uff0c\u75be\u75c5\u7684\u4e3b\u8981\u75c7\u72c0\u8868\u73fe\u70ba\u300c\u4e00\u7cfb\u5217\u7d0a\u4e82\u7684\u8a8d\u77e5\u3001\u60c5\u611f\u8207\u884c\u70ba\u300d\u3002\u4f8b\u5982\uff1a\u300c\u6b63\u6027\u75c7\u72c0\u300d\u7684\u5178\u578b\u8868\u73fe\u5305\u542b\u300c\u5984\u60f3(Delusion)\u300d\u3001\u300c\u5e7b\u89ba(Hallucination)\u300d\u8207\u300c\u89e3\u69cb\u8a9e\u8a00(Disorganized speech)\u300d\uff1b\u5728\u300c\u8ca0\u6027\u75c7\u72c0\u300d\u767c\u4f5c\u671f\u9593\uff0c\u60a3\u8005\u6703\u8b8a\u5f97\u60c5\u611f\u6de1\u6f20\u3001\u96e3\u4ee5\u611f\u53d7\u5230\u5feb\u6a02\u4e26\u4e14\u55aa\u5931\u52d5\u6a5f\uff1b\u8a8d\u77e5\u529f\u80fd\u4e5f\u53ef\u80fd\u56e0\u75c5\u53d7\u5230\u5f71\u97ff\u3002<\/p>\n

\u9020\u6210\u601d\u89ba\u5931\u8abf\u75c7\u7684\u75c5\u56e0\u6709\u5f88\u591a\u7a2e\uff0c\u57fa\u56e0\u8207\u907a\u50b3\u53ef\u80fd\u662f\u5176\u4e2d\u4e00\u500b\u7406\u7531\uff0c\u4f46\u662f\u5728\u5be6\u9a57\u5ba4\u5efa\u7acb\u8d77\u7684\u52d5\u7269\u6a21\u5f0f(animal model)\u4e0a\uff0c\u6211\u5011\u53ef\u4ee5\u767c\u73fe\u67d0\u4e9b\u85e5\u7269\u53ef\u4ee5\u76f4\u63a5\u8b93\u5065\u5eb7\u7684\u52d5\u7269\u7cbe\u795e\u75c7\u72c0\u767c\u4f5c\uff0c\u4f8b\u5982\uff1a\u82ef\u74b0\u5229\u5b9a(Phencyclidine\uff1bPCP)\u3001K\u4ed6\u547d(Ketamine)\u3001\u9ea5\u89d2\u9178\u4e8c\u4e59\u91af\u80fa(LSD)\u9084\u6709\u5b89\u975e\u4ed6\u547d\u3002\u7a76\u7adf\u85e5\u7269\u662f\u5982\u4f55\u5f15\u767c\u52d5\u7269\u8207\u4eba\u985e\u7684\u7cbe\u795e\u75c7\u72c0\u5462\uff1f<\/p>\n

\u25cf\u4e8c\u6230\u58eb\u5175\u7684\u300c\u63d0\u795e\u5999\u65b9\u300d\uff1a\u5b89\u975e\u4ed6\u547d<\/strong><\/span><\/p>\n

\u5b89\u975e\u4ed6\u547d\u6700\u65e9\u65bc1887\u5e74\u88ab\u5408\u6210\u51fa\u4f86\uff0c\u7576\u6642\u7b2c\u4e8c\u6b21\u4e16\u754c\u5927\u6230\u958b\u6253\uff0c\u8a31\u591a\u8ecd\u4eba\u9760\u670d\u7528\u5b89\u975e\u4ed6\u547d\u4f86\u63d0\u5347\u81ea\u5df1\u5728\u6230\u5834\u4e0a\u7684\u8868\u73fe\uff0c\u800c\u6642\u4ee3\u80cc\u666f\u4e5f\u7d66\u4e86\u9019\u4e9b\u58eb\u5175\u5145\u5206\u7684\u7406\u7531\u3002<\/p>\n

\u53ef\u662f\u5230\u4e86\u5f8c\u4f86\uff0c\u5c08\u5bb6\u767c\u73fe\u56e0\u70ba\u5438\u98df\u904e\u91cf\u5b89\u975e\u4ed6\u547d\u800c\u7f79\u60a3\u7cbe\u795e\u75c7\u72c0\u7684\u4eba\u8d8a\u4f86\u8d8a\u591a\u4e86(Amphetamine-induced psychosis)\uff0c\u4ed6\u5011\u7684\u75c7\u72c0\u8868\u73fe\u8ddf\u601d\u89ba\u5931\u8abf\u75c7\u300c\u6b63\u6027\u300d\u75c7\u72c0\u975e\u5e38\u985e\u4f3c\uff0c\u60a3\u8005\u6703\u51fa\u73fe\u5e7b\u807d\u3001\u5984\u60f3\u4ee5\u53ca\u5e7b\u89ba\u7b49\u75c7\u72c0\uff0c\u800c\u4e14\u4f3c\u4e4e\u53ea\u6709\u5927\u91cf\u6ce8\u5c04\u5b89\u975e\u4ed6\u547d\u8005\u624d\u6703\u767c\u75c5\u3002<\/p>\n

\u6839\u64da\u52d5\u7269\u7814\u7a76\uff0c\u5b89\u975e\u4ed6\u547d\u5f88\u5bb9\u6613\u5f71\u97ff\u52d5\u7269\u524d\u984d\u8449\u7684\u529f\u80fd\uff0c\u56e0\u70ba\u5b89\u975e\u4ed6\u547d\u6703\u589e\u52a0\u7d0b\u72c0\u9ad4(Striatum)\u7684\u591a\u5df4\u80fa(Dopamine)\u5206\u6ccc\uff0c\u540c\u6642\u6703\u4f7f\u524d\u984d\u8449\u7684\u8c37\u6c28\u9178(Glutamate)\u589e\u52a0\uff0c\u9019\u4e9b\u73fe\u8c61\u5f88\u53ef\u80fd\u5c0e\u81f4\u6b63\u6027\u75c7\u72c0\u767c\u4f5c\u3002\u800c\u4e14\u6211\u5011\u5728\u5be6\u9a57\u5ba4\u5b89\u6392\u7684\u60c5\u5883\u5167\uff0c\u53ef\u4ee5\u64fa\u812b\u57fa\u56e0\u907a\u50b3\u7684\u5f71\u97ff\uff0c\u55ae\u9760\u5b89\u975e\u4ed6\u547d\u7684\u6ce8\u5c04\u5c31\u8b93\u5065\u5eb7\u7684\u52d5\u7269\u300c\u767c\u75c5\u300d\u3002<\/p>\n

\u25cf\u9b54\u9b3c\u7684\u547c\u5438\uff1a\u6771\u83a8\u83ea\u9e7c<\/strong><\/span><\/p>\n

\u300c\u6771\u83a8\u83ea\u9e7c(Scopolamine)\u300d\uff0c\u4fd7\u540d\u300c\u9b54\u9b3c\u7684\u547c\u5438\u300d\uff0c\u5b83\u672c\u4f86\u662f\u4e00\u7a2e\u7f3a\u5c11\u6210\u766e\u7279\u6027\u7684\u6297\u75d9\u6523\u85e5\u7269\uff0c\u4f46\u5728\u7f3a\u4e4f\u7ba1\u7406\u7684\u60c5\u6cc1\u4e0b\u5f88\u5bb9\u6613\u88ab\u6feb\u88fd\u6210\u8ff7\u5e7b\u85e5\uff0c\u8b93\u4f7f\u7528\u8005\u7522\u751f\u5e7b\u807d\u3001\u5e7b\u89ba\u3001\u8a18\u61b6\u7f3a\u640d\u7b49\u526f\u4f5c\u7528\uff0c\u5728\u90e8\u5206\u52d5\u7269\u5be6\u9a57\u7684\u7d50\u679c\u4e2d\uff0c\u9019\u7a2e\u85e5\u7269\u9084\u6703\u9020\u6210\u793e\u6703\u8a8d\u77e5\u7f3a\u640d\u3002<\/p>\n

\u6771\u83a8\u83ea\u9e7c\u662f\u4e00\u7a2e\u975e\u9078\u64c7\u6027\u7684\u4e59\u9170\u81bd\u9e7c\u53d7\u9ad4\u62ee\u6297\u5291(Non-selective antagonist of muscarinic acetylcholine receptors)\uff0c\u5b83\u80fd\u5920\u8ddf\u300c\u6bd2\u8548\u9e7c\u578b\u53d7\u5668\u300d\u7684\u4efb\u4f55\u4e00\u7a2e\u4e9e\u578b\u7d50\u5408(\u5373M1\u3001M2\u3001M3\u3001M4\u8207M5\u53d7\u5668)\uff0c\u85c9\u6b64\u8abf\u7bc0\u591a\u5df4\u80fa\u8ddf\u4e59\u91af\u81bd\u9e7c\u7684\u5206\u6ccc\u3002<\/p>\n

\u5728\u300c\u8166\u6a4b\u300d\u9019\u500b\u5340\u57df\uff0c\u6771\u83a8\u83ea\u9e7c\u6703\u5728M2\u53d7\u5668\u7684\u7d42\u7aef\u5f62\u6210\u963b\u65b7(Blockage)\uff0c\u4f7f\u4e2d\u8166\u7684\u9ed1\u8cea\u9084\u6709VTA\u5340\u7684\u4e59\u91af\u81bd\u9e7c\u5206\u6ccc\u63d0\u5347\uff0c\u6709\u4eba\u8a8d\u70ba\u9019\u53ef\u80fd\u5c31\u662f\u9020\u6210\u7cbe\u795e\u75c7\u72c0\u7684\u539f\u56e0\u3002\u4f46\u662f\u65bc\u6b64\u540c\u6642\uff0c\u85e5\u7269\u6703\u6291\u5236\u4f7f\u7528\u8005\u90e8\u5206\u7684\u7684\u8a8d\u77e5\u529f\u80fd\uff0c\u4f8b\u5982\uff1a\u8a18\u61b6\u3001\u6ce8\u610f\u529b\u7b49\uff0c\u800c\u4e14\u9019\u75c7\u72c0\u7d93\u5e38\u662f\u7dca\u63a5\u8457\u5728\u670d\u85e5\u904e\u5f8c\u624d\u6703\u7522\u751f\u3002<\/p>\n

\u25cf\u5929\u4f7f\u5875\u8207K\u4ed6\u547d<\/strong><\/span><\/p>\n

\u82ef\u74b0\u5229\u5b9a(Phencyclidine\uff1bPCP)\u539f\u672c\u662f\u4e00\u7a2e\u9ebb\u9189\u85e5\uff0c\u4f46\u662f\u56e0\u70ba\u526f\u4f5c\u7528\u592a\u904e\u56b4\u91cd\uff0c\u76ee\u524d\u5df2\u88ab\u5176\u4ed6\u9ebb\u9189\u85e5\u7269\u53d6\u4ee3\uff0c\u9019\u4e9b\u75c7\u72c0\u5305\u542b\u5e7b\u807d\u3001\u8b6b\u5984\u3001\u8a18\u61b6\u55aa\u5931\u3001\u610f\u8b58\u4e0d\u6e05\u7b49\uff0c\u8207\u601d\u89ba\u5931\u8abf\u75c7\u6b63\u6027\u75c7\u72c0\u76f8\u7576\u985e\u4f3c\u3002\u5728\u53f0\u7063\u76ee\u524d\u88ab\u5217\u70ba\u7b2c\u4e8c\u7d1a\u6bd2\u54c1\uff0c\u66b1\u7a31\u300c\u5929\u4f7f\u5875(Angel Dust)\u300d\uff0c\u6216\u662f\u300c\u611b\u4e4b\u8239(Love Boat)\u300d\u3002<\/p>\n

\u82ef\u74b0\u5229\u5b9a\u7121\u8ad6\u662f\u85e5\u6548\u9084\u662f\u6a5f\u5236\u90fd\u8ddfK\u4ed6\u547d\u975e\u5e38\u985e\u4f3c\uff0c\u5b83\u5011\u90fd\u662fNMDA\u53d7\u9ad4\u7684\u7d50\u6297\u5291(Antagonist)\uff0c\u4e5f\u90fd\u53ef\u4ee5\u4f7f\u5065\u5eb7\u7684\u52d5\u7269\u5728\u4e0d\u53d7\u57fa\u56e0\u3001\u907a\u50b3\u7684\u5f71\u97ff\u4e4b\u4e0b\uff0c\u5c31\u767c\u5c55\u51fa\u7cbe\u795e\u75c7\u72c0\uff0c\u56e0\u70ba\u5b83\u5011\u90fd\u6703\u523a\u6fc0\u8166\u90e8\u7522\u51fa\u904e\u91cf\u7684\u591a\u5df4\u80fa(Dopamine)\u4ee5\u53ca\u8c37\u6c28\u9178(Glutamate)\uff0c\u53ea\u662f\u901a\u5e38\u800c\u8a00K\u4ed6\u547d\u88fd\u9020\u51fa\u4f86\u7684\u300c\u75c7\u72c0\u300d\u4e0d\u6703\u6bd4PCP\u9084\u8981\u56b4\u91cd\uff0c\u6240\u4ee5\u5438\u6bd2\u8005\u6bd4\u8f03\u5bb9\u6613\u504f\u597dK\u4ed6\u547d\u3002<\/p>\n

\u25cf\u958b\u555f\u5947\u5e7b\u7684\u8996\u91ce\uff1a\u9ea5\u89d2\u9178\u9170\u4e8c\u4e59\u80fa(LSD)<\/strong><\/span><\/p>\n

1943\u5e74\uff0c\u5b78\u8005Albert Hoffman\u4ee5\u5916\u767c\u73fe\u9ea5\u89d2\u9178\u9170\u4e8c\u4e59\u80fa(LSD)\u6703\u88fd\u9020\u5e7b\u807d\u3001\u5e7b\u89ba\u7b49\u6548\u679c\uff0c\u5f8c\u4f86\u906d\u5230\u591a\u570b\u7981\u7528\uff0c\u4f46\u4e8b\u5be6\u4e0a\u5b83\u4e0d\u53ea\u8207\u8fd1\u4ee3\u7684\u300c\u5b09\u76ae\u6587\u5316\u300d\u5f62\u6210\u4e86\u5bc6\u4e0d\u53ef\u5206\u7684\u95dc\u4fc2\uff0c\u540c\u6642\u4e5f\u5e6b\u52a9\u4e86\u8fd1\u4ee3\u7684\u5b78\u8005\u66f4\u52a0\u77ad\u89e3\u601d\u89ba\u5931\u8abf\u75c7\u7684\u6a5f\u5236\u3002<\/p>\n

LSD\u662f\u4e00\u7a2e\u81f4\u6548\u5291(Agonist)\uff0c\u5b83\u6703\u523a\u6fc0\u8840\u6e05\u7d20(Serotonin)\u53d7\u56685-HT2A\uff0c\u53ef\u80fd\u56e0\u6b64\u9020\u6210\u601d\u89ba\u5931\u8abf\u75c7\u6b63\u6027\u75c7\u72c0\u7684\u7522\u751f\uff0c\u7136\u800c\u6211\u5011\u4ecd\u7136\u9700\u8981\u66f4\u591a\u8b49\u64da\uff0c\u624d\u80fd\u89e3\u91cb\u9019\u500b\u6a5f\u5236\uff1b\u4e5f\u6709\u4e00\u8aaa\u8a8d\u70ba\uff0cLSD\u53ef\u80fd\u6703\u589e\u52a0\u524d\u984d\u8449\u795e\u7d93\u5143\u7684\u8c37\u6c28\u9178\uff0c\u5c0e\u81f4\u7cbe\u795e\u75c7\u72c0\u767c\u4f5c\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/p>\n

    \n
  1. Suji Ham. Tae Kyoo Kim., Sooyoung Chung & Heh-In Im., Drug Abuse and Psychosis: New Insights into Drug-induced Psychosis., Experimental Biology., 2017<\/a><\/li>\n
  2. Joel Frohlich & John D Van Horn., Reviewing the ketamine model for schizophrenia., Journal of Pharmacology., 2013<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u9020\u6210\u601d\u89ba\u5931\u8abf\u75c7\u7684\u75c5\u56e0\u6709\u5f88\u591a\u7a2e\uff0c\u57fa\u56e0\u8207\u907a\u50b3\u53ef\u80fd\u662f\u5176\u4e2d\u4e00\u500b\u7406\u7531\uff0c\u4f46\u662f\u5728\u5be6\u9a57\u5ba4\u5efa\u7acb\u8d77\u7684\u52d5\u7269\u6a21\u5f0f(animal model)\u4e0a\uff0c\u6211\u5011\u53ef\u4ee5\u767c\u73fe\u67d0\u4e9b\u85e5\u7269\u53ef\u4ee5\u76f4\u63a5\u8b93\u5065\u5eb7\u7684\u52d5\u7269\u7cbe\u795e\u75c7\u72c0\u767c\u4f5c\uff0c\u4f8b\u5982\uff1a\u82ef\u74b0\u5229\u5b9a(Phencyclidine\uff1bPCP)\u3001K\u4ed6\u547d(Ketamine)\u3001\u9ea5\u89d2\u9178\u4e8c\u4e59\u91af\u80fa(LSD)\u9084\u6709\u5b89\u975e\u4ed6\u547d\u3002\u7a76\u7adf\u85e5\u7269\u662f\u5982\u4f55\u5f15\u767c\u52d5\u7269\u8207\u4eba\u985e\u7684\u7cbe\u795e\u75c7\u72c0\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":35025,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257,3293],"tags":[4564,4565,4567,4563,4566],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/photo-1509557551952-401ede96d8ed.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35023"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35023"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35023\/revisions"}],"predecessor-version":[{"id":35026,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35023\/revisions\/35026"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35025"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}