{"id":35017,"date":"2020-03-05T00:00:46","date_gmt":"2020-03-04T16:00:46","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=35017"},"modified":"2020-03-06T10:34:24","modified_gmt":"2020-03-06T02:34:24","slug":"%e5%a3%93%e5%9e%ae%e9%a7%b1%e9%a7%9d%e7%9a%84%e6%9c%80%e5%be%8c%e4%b8%80%e6%a0%b9%e7%a8%bb%e8%8d%89%ef%bc%9a%e5%a3%93%e5%8a%9b%e8%88%87%e6%af%92%e7%99%ae%e7%99%bc%e4%bd%9c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=35017","title":{"rendered":"\u58d3\u57ae\u99f1\u99dd\u7684\u6700\u5f8c\u4e00\u6839\u7a3b\u8349\uff1a\u58d3\u529b\u8207\u6bd2\u766e\u767c\u4f5c"},"content":{"rendered":"
\"\"
KONICA MINOLTA DIGITAL CAMERA<\/figcaption><\/figure>\n

\u6587\uff0f\u5468\u739f\u8431<\/strong><\/p>\n

\u57281855\u5e74\uff0c\u6709\u4eba\u767c\u73fe\u5f9e\u53e4\u67ef\u8449\u4e2d\u63d0\u7149\u51fa\u4f86\u7684\u751f\u7269\u9e7c\uff0c\u53ef\u4ee5\u7528\u548c\u5408\u6210\u4e00\u7a2e\u53eb\u505a\u300c\u53e4\u67ef\u9e7c(Cocaine)\u300d\u7684\u7522\u7269\uff0c\u4eba\u5011\u65e9\u671f\u767c\u73fe\u5b83\u6709\u5c40\u90e8\u9ebb\u9189\u7684\u7528\u9014\uff0c\u5c07\u5b83\u8996\u70ba\u91ab\u7642\u7528\u7684\u85e5\u7269\u3002<\/p>\n

\u4f46\u662f80\u5e74\u4ee3\u4ee5\u5f8c\uff0c\u4eba\u5011\u7149\u88fd\u85e5\u7269\u7684\u6280\u8853\u9032\u6b65\u4e86\uff0c\u4f7f\u53e4\u67ef\u9e7c\u300c\u7d14\u5ea6\u300d\u5f97\u4ee5\u63d0\u5347\uff0c\u6210\u70ba\u4e86\u4e00\u7a2e\u5438\u98df\u65b9\u4fbf\u7684\u300c\u4e2d\u6a1e\u795e\u7d93\u8208\u596e\u5291\u300d\uff1a\u5438\u98df\u8005\u6703\u56e0\u6b64\u9ad4\u9a57\u5230\u5fc3\u8df3\u52a0\u901f\u3001\u77b3\u5b54\u653e\u5927\u3001\u4ea2\u596e\u3001\u8840\u58d3\u5347\u9ad8\u4ee5\u53ca\u8eab\u9ad4\u767c\u71b1\u7684\u611f\u53d7\uff0c\u56b4\u91cd\u8005\u5247\u6703\u7522\u751f\u985e\u4f3c\u601d\u89ba\u5931\u8abf\u75c7\u7684\u75c7\u72c0\uff0c\u4f8b\u5982\uff1a\u807d\u5e7b\u89ba(Hallucination)\u3001\u89f8\u5e7b\u89ba\u3001\u5984\u60f3(delusion)\u3001\u904e\u5ea6\u731c\u7591\u7b49\u3002<\/p>\n

\u53e4\u67ef\u9e7c\u7684\u6212\u65b7\u76f8\u7576\u56f0\u96e3\uff0c\u9019\u53ef\u80fd\u662f\u56e0\u70ba\u6212\u65b7\u75c7\u72c0\u672c\u8eab\u5c31\u8b93\u4eba\u75db\u82e6\u96e3\u8010\uff0c\u9577\u671f\u4f7f\u7528\u5f8c\u82e5\u7136\u505c\u85e5\uff0c\u5438\u98df\u8005\u53ef\u80fd\u6703\u7d93\u6b77\u6688\u7729\u3001\u795e\u667a\u4e0d\u6e05\u3001\u6688\u7729\u3001\u795e\u667a\u4e0d\u6e05\u3001\u6414\u7662\u3001\u75b2\u5026\u3001\u6d41\u9f3b\u6c34\u3001\u5192\u51b7\u6c57\u7b49\u526f\u4f5c\u7528\uff1b\u8fd1\u4f86\u6709\u5b78\u8005\u8a8d\u70ba\uff0c\u300c\u58d3\u529b\u4e8b\u4ef6\u300d\u4e5f\u53ef\u80fd\u662f\u4f7f\u53e4\u67ef\u9e7c\u4f7f\u7528\u8005\u518d\u6b21\u5438\u98df\u6bd2\u54c1\u4e4b\u4e00\uff1a\u53e4\u67ef\u9e7c\u4f9d\u8cf4\u8005\u8207\u6b63\u5e38\u4eba\u76f8\u6bd4\uff0c\u4ed6\u5011\u7684\u8166\u90e8\u662f\u5982\u4f55\u56de\u61c9\u58d3\u529b\u60c5\u5883\u7684\u5462\uff1f\u9019\u6a23\u7684\u8166\u90e8\u6d3b\u52d5\u6703\u5982\u4f55\u5f71\u97ff\u4ed6\u5011\u9762\u5c0d\u53e4\u67ef\u9e7c\u6642\u7684\u53cd\u61c9\u5462\uff1f<\/p>\n

\u6c89\u91cd\u7684\u58d3\u529b\u4e8b\u4ef6\uff0c\u8b93\u4eba\u66f4\u96e3\u5c0d\u6bd2\u766e\u8aaa\u4e0d<\/strong><\/span><\/p>\n

\u300c\u6e34\u6c42(craving)\u300d\u662f\u4e00\u7a2e\u5f37\u70c8\u7684\u300c\u60f3\u8981\u300d\uff0c\u6709\u6bd2\u766e\u8005\u5fc5\u9700\u518d\u6b21\u5438\u98df\u6bd2\u54c1\u624d\u53ef\u4ee5\u64ab\u5e73\u9019\u7a2e\u611f\u53d7\uff0c\u56e0\u6b64\u9019\u4e5f\u662f\u300c\u5fa9\u767c(relapse)\u300d\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u6e34\u6c42\u4e0d\u53ea\u589e\u52a0\u4f7f\u7528\u8005\u518d\u6b21\u63a5\u89f8\u6bd2\u54c1\u7684\u6a5f\u6703\uff0c\u540c\u6642\u4e5f\u4f7f\u4eba\u5011\u5c0d\u8207\u6bd2\u54c1\u76f8\u95dc\u7684\u7dda\u7d22(Drug-related cues)\u8d8a\u4f86\u8d8a\u654f\u611f\uff0c\u4e5f\u589e\u52a0\u4e86\u4eba\u5011\u7684\u58d3\u529b\u8ddf\u8ca0\u9762\u60c5\u611f(Negative emotion)\u3002<\/p>\n

\u58d3\u529b\u9084\u6709\u6e34\u6c42\u7684\u51fa\u73fe\uff0c\u90fd\u6703\u555f\u52d5\u6211\u5011\u7684\u300c\u4e0b\u8996\u4e18-\u5782\u9ad4-\u814e\u4e0a\u817a\u8ef8(\u7c21\u7a31\uff1aHPA\u8ef8)\u300d\uff0cHPA\u8ef8\u6703\u900f\u904e\u8abf\u7bc0\u5167\u5206\u7cfb\u3001\u6d88\u5316\u4ee5\u53ca\u514d\u75ab\u7cfb\u7d71\u7b49\uff0c\u4f86\u8b93\u6211\u5011\u7684\u8eab\u9ad4\u505a\u51fa\u9069\u7576\u53cd\u61c9\uff1b\u56e0\u6b64\uff0cRajita Sinha\u7b49\u4eba\u8a8d\u70ba\u53e4\u67ef\u9e7c\u4f9d\u8cf4\u8005\u5927\u591a\u96e3\u4ee5\u8655\u7406\u751f\u6d3b\u58d3\u529b\uff0c\u6240\u4ee5\u78b0\u5230\u58d3\u529b\u4e8b\u4ef6\u6642\u6703\u66f4\u96e3\u62b5\u6297\u6bd2\u54c1\u8a98\u60d1\uff0c\u6703\u9078\u64c7\u518d\u6b21\u5438\u98df\uff0c\u56e0\u6b64HPA\u8ef8\u7684\u555f\u52d5\u4e5f\u8a31\u53ef\u4ee5\u9810\u6e2c\u4ed6\u5011\u4e0b\u4e00\u6b21\u4f55\u6642\u5438\u6bd2\u3002<\/p>\n

\u70ba\u4e86\u77ad\u89e3\u58d3\u529b\u4e8b\u4ef6\u6240\u5f15\u767c\u7684\u6e34\u6c42\uff0c\u5982\u4f55\u5f71\u97ff\u53e4\u67ef\u9e7c\u5438\u98df\u8005\u7684\u8166\u90e8\uff0cSinha\u7b49\u4eba\u8a2d\u8a08\u4e86\u4e00\u500b\u5be6\u9a57\u60c5\u5883\uff1a\u4ed6\u9080\u8acb\u4e8620\u500b\u6b63\u5728\u63a5\u53d7\u6cbb\u7642\u7684\u53e4\u67ef\u9e7c\u4f7f\u7528\u8005\uff0c\u4ee5\u53ca8\u4f4d\u8eab\u5fc3\u5065\u5eb7\u7684\u6b63\u5e38\u4eba\u4f86\u53c3\u8207\u8166\u9020\u5f71\u5be6\u9a57\uff0c\u5728\u8166\u9020\u5f71\u7684\u904e\u7a0b\u4e2d\uff0c\u53d7\u8a66\u8005\u6703\u807d\u898b6\u6bb5\u300c\u5287\u672c(script)\u300d\uff0c\u5176\u4e2d3\u6bb5\u662f\u300c\u58d3\u529b\u4e8b\u4ef6\u5287\u672c\u300d\uff0c\u4f8b\u5982\uff1a\u5728\u91cd\u8981\u7bc0\u65e5\u524d\u5915\u5206\u624b\uff1b\u53e6\u59163\u6bb5\u662f\u300c\u4e00\u822c\u4e2d\u6027\u4e8b\u4ef6\u300d\uff0c\u4f8b\u5982\uff1a\u67d0\u500b\u4e0d\u7528\u53bb\u4e0a\u73ed\u7684\u5468\u516d\u65e9\u6668\uff0c\u6bcf\u4e00\u6bb5\u5287\u672c\u90fd\u662f\u6839\u64da\u53d7\u8a66\u8005\u56de\u9867\u8fd1\u4e00\u5e74\u7684\u751f\u6d3b\u60c5\u6cc1\u6240\u6539\u7de8\u6210\u7684\u3002<\/p>\n

\u7814\u7a76\u7d50\u679c\u767c\u73fe\uff0c\u5169\u7d44\u53d7\u8a66\u8005\u7684\u8166\u90e8\u6d3b\u5316\u60c5\u5f62\uff0c\u5728\u78b0\u5230\u58d3\u529b\u4e8b\u4ef6\u6642\u771f\u7684\u6709\u4e0d\u540c\u7684\u8868\u73fe\uff0c\u5728\u807d\u898b\u58d3\u529b\u4e8b\u4ef6\u767c\u751f\u6642\uff0c\u63a7\u5236\u7d44\u7684\u300c\u524d\u984d\u8449-\u908a\u7de3\u5340\u57df(Frontal-paralimbic areas)\u300d\uff0c\u5305\u542b\u300c\u524d\u6263\u5e36\u8ff4(Anterior cingulate)\u300d\u3001\u300c\u5de6\u5074\u6d77\u99ac\u8ff4(left hippocampus)\u300d\u3001\u300c\u6d77\u99ac\u65c1\u8ff4(parahippocampal gyrus)\u300d\u8207\u300c\u53f3\u5074\u7e2e\u72c0\u8ff4(Right fusiform gyrus)\u300d\u6709\u8457\u6bd4\u8f03\u9ad8\u5ea6\u7684\u6d3b\u5316\u3002<\/p>\n

\u76f8\u53cd\u7684\uff0c\u75c5\u60a3\u7d44\u96d9\u5074\u7684\u300c\u80cc\u5074\u7d0b\u72c0\u9ad4(Dorsolateral striatum)\u300d\u5728\u78b0\u5230\u58d3\u529b\u7684\u60c5\u6cc1\u4e0b\u6d3b\u5316\u5c31\u6703\u589e\u52a0\uff0c\u9019\u500b\u5340\u584a\u8207\u7fd2\u6163\u7684\u5f62\u6210\u6709\u95dc\uff0c\u56e0\u6b64Sinha\u7b49\u4eba\u63a8\u6e2c\uff0c\u8166\u90e8\u9019\u4e9b\u7fd2\u6163\u5316\u3001\u81ea\u52d5\u5316\u7684\u6d3b\u52d5\u6703\u69cb\u6210\u5c0d\u53e4\u67ef\u9e7c\u7dda\u6240\u6e34\u6c42\u7684\u57fa\u790e\uff0c\u7136\u5f8c\u53c8\u6703\u5c0e\u81f4\u66f4\u591a\u5fa9\u767c(Relapse)\u884c\u70ba\uff1b<\/p>\n

\u800c\u53e4\u67ef\u9e7c\u5438\u98df\u8005\u7684\u524d\u6263\u5e36\u8ff4\u6d3b\u5316\u7a0b\u5ea6\u4e0d\u8db3\uff0c\u53ef\u80fd\u4ee3\u8868\u4ed6\u5011\u63a7\u5236\u884c\u70ba\u7684\u80fd\u529b\u6bd4\u8f03\u4e0d\u597d\uff0c\u540c\u6642\u4e5f\u56e0\u70ba\u9019\u500b\u5340\u584a\u6d89\u53ca\u4e86\u60c5\u7dd2\u7684\u8abf\u7bc0\uff0c\u56e0\u6b64\u7576\u4ed6\u5011\u53d7\u5230\u58d3\u529b\u7684\u6311\u6230\u6642\uff0c\u524d\u6263\u5e36\u8ff4\u7121\u6cd5\u505a\u51fa\u9069\u7576\u7684\u8abf\u9069\uff0c\u4e5f\u53ef\u80fd\u4f7f\u53e4\u67ef\u9e7c\u5438\u98df\u8005\u518d\u6b21\u5c0b\u6c42\u6bd2\u54c1\u4f86\u8212\u7de9\u7dca\u5f35\u611f\u3002<\/p>\n

 <\/p>\n

\u8cc7\u6599\u4f86\u6e90\uff1a<\/strong><\/p>\n

    \n
  1. Rajita Sinha., Cheryl Lacadie., Pawel Skudlarski.,  Robert K. Fulbright., Bruce J. Rounsaville., Thomas R. Kosten & Bruce E. Wexler., Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study., Psychopharmacology., 2005<\/a><\/li>\n
  2. Anna Rose Childress., P. David Mozley., William McElgin., Josh Fitzgerald., Martin Reivich., & Charles P. O\u2019Brien., Limbic Activation During Cue-Induced Cocaine Craving., Am J Psychiatry., 1999<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u6212\u65b7\u53e4\u67ef\u9e7c\u76f8\u7576\u56f0\u96e3\uff0c\u9019\u53ef\u80fd\u662f\u56e0\u70ba\u6212\u65b7\u75c7\u72c0\u672c\u8eab\u5c31\u8b93\u4eba\u75db\u82e6\u96e3\u8010\uff0c\u9577\u671f\u4f7f\u7528\u5f8c\u82e5\u7136\u505c\u85e5\uff0c\u5438\u98df\u8005\u53ef\u80fd\u6703\u7d93\u6b77\u6688\u7729\u3001\u795e\u667a\u4e0d\u6e05\u3001\u6688\u7729\u3001\u795e\u667a\u4e0d\u6e05\u3001\u6414\u7662\u3001\u75b2\u5026\u3001\u6d41\u9f3b\u6c34\u3001\u5192\u51b7\u6c57\u7b49\u526f\u4f5c\u7528\uff1b\u8fd1\u4f86\u6709\u5b78\u8005\u8a8d\u70ba\uff0c\u300c\u58d3\u529b\u4e8b\u4ef6\u300d\u4e5f\u53ef\u80fd\u662f\u4f7f\u53e4\u67ef\u9e7c\u4f7f\u7528\u8005\u518d\u6b21\u5438\u98df\u6bd2\u54c1\u4e4b\u4e00\uff1a\u53e4\u67ef\u9e7c\u4f9d\u8cf4\u8005\u8207\u6b63\u5e38\u4eba\u76f8\u6bd4\uff0c\u4ed6\u5011\u7684\u8166\u90e8\u662f\u5982\u4f55\u56de\u61c9\u58d3\u529b\u60c5\u5883\u7684\u5462\uff1f\u9019\u6a23\u7684\u8166\u90e8\u6d3b\u52d5\u6703\u5982\u4f55\u5f71\u97ff\u4ed6\u5011\u9762\u5c0d\u53e4\u67ef\u9e7c\u6642\u7684\u53cd\u61c9\u5462\uff1f<\/p>\n","protected":false},"author":20,"featured_media":35018,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257,3293],"tags":[4557,4558,963,4560,4559],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/Colcoca02.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35017"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35017"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35017\/revisions"}],"predecessor-version":[{"id":35128,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/35017\/revisions\/35128"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35018"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}