{"id":34994,"date":"2020-02-20T00:11:08","date_gmt":"2020-02-19T16:11:08","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34994"},"modified":"2020-10-23T12:48:18","modified_gmt":"2020-10-23T04:48:18","slug":"%e7%a7%91%e5%ad%b8%e5%ae%b6%e5%88%a9%e7%94%a8%e3%80%8c%e9%b9%bd%e3%80%8d%e4%be%86%e9%b9%b9%e6%ad%bb%e7%99%8c%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34994","title":{"rendered":"\u79d1\u5b78\u5bb6\u5229\u7528\u300c\u9e7d\u300d\u4f86\u9e79\u6b7b\u764c\u7d30\u80de"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>\u5728\u98f2\u98df\u4e2d\u6dfb\u52a0\u300c\u9e7d\u300d\u4f86\u8abf\u5473\uff0c\u662f\u7a00\u9b06\u5e73\u5e38\u4e0d\u904e\u7684\u4e8b\u3002\u4f46\u6c92\u60f3\u5230\u79d1\u5b78\u5bb6\u4e5f\u80fd\u5229\u7528\u9e7d\u4f86\u5c0d\u6297\u816b\u7624\uff0c\u6700\u8fd1\u767c\u8868\u5728\u671f\u520a&nbsp;<em>Advanced Materials<\/em>&nbsp;\u7684\u7814\u7a76\uff0c\u79d1\u5b78\u5bb6\u5c07\u9e7d\u6539\u9020\u70ba\u7279\u6b8a\u7684\u300c\u5948\u7c73\u7c92\u5b50\u300d\uff0c\u4e26\u4f7f\u5176\u56f0\u5728\u764c\u7d30\u80de\u4e2d\uff0c\u7834\u58de\u7d30\u80de\u539f\u672c\u7684\u96e2\u5b50\u5e73\u8861\u5f8c\uff0c\u5c31\u80fd\u5b89\u5168\u6709\u6548\u7684\u6bba\u6b7b\u764c\u7d30\u80de\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_35002\" aria-describedby=\"caption-attachment-35002\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-35002\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/salt-3285024_1920.jpeg\" alt=\"\" width=\"450\" height=\"300\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/salt-3285024_1920.jpeg 1920w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/salt-3285024_1920-300x200.jpeg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/salt-3285024_1920-768x512.jpeg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/salt-3285024_1920-1024x683.jpeg 1024w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-35002\" class=\"wp-caption-text\">\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n<p><strong>\u6587\uff0f<\/strong><strong>\u694a\u671d\u5091<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u986f\u7136\u4e0d\u662f\u4e00\u822c\u9e7d\u6c34\u5c31\u80fd\u6bba\u6b7b\u764c\u7d30\u80de<\/strong><\/span><\/p>\n<p>\u7d30\u80de\u819c\u5177\u6709\u534a\u900f\u6027\uff0c\u7d30\u80de\u819c\u5167\u5916\u7684\u96e2\u5b50\u6fc3\u5ea6\u5dee\u7570\uff0c\u7522\u751f\u7684\u6ef2\u900f\u4f5c\u7528\u53ef\u4f7f\u6c34\u5206\u5b50\u79fb\u52d5\u4f86\u9054\u5230\u5167\u5916\u5e73\u8861\uff0c\u9019\u5c0d\u65bc\u7dad\u6301\u7d30\u80de\u57fa\u672c\u7684\u751f\u7406\u4f5c\u7528\u76f8\u7576\u91cd\u8981\u3002\u5148\u8907\u7fd2\u4e00\u4e0b\u570b\u4e2d\u751f\u7269\uff0c\u5047\u8a2d\u7d30\u80de\u5728\u7121\u9e7d\u7684\u84b8\u993e\u6c34\u4e2d\uff08\u4f4e\u5f35\u6eb6\u6db2\uff09\uff0c\u6c34\u5206\u5b50\u6703\u4e0d\u65b7\u6ef2\u900f\u9032\u7d30\u80de\uff0c\u4f7f\u7d30\u80de\u8139\u5927\u6216\u751a\u81f3\u8139\u7834\u88c2\u89e3\u3002\u53cd\u904e\u4f86\u770b\uff0c\u7576\u7d30\u80de\u5728\u9ad8\u6fc3\u5ea6\u7684\u9e7d\u6c34\u4e2d\uff08\u9ad8\u5f35\u6eb6\u6db2\uff09\uff0c\u6c34\u5206\u5b50\u6703\u4e0d\u65b7\u5f9e\u7d30\u80de\u6ef2\u900f\u5230\u9e7d\u6c34\u4e2d\uff0c\u9019\u6703\u4f7f\u5f97\u7d30\u80de\u840e\u7e2e\u8b8a\u5c0f\u3002\u53ea\u6709\u5728\u7d30\u80de\u819c\u5167\u5916\u7684\u6ef2\u900f\u58d3\u76f8\u7b49\u6642\uff08\u7b49\u5f35\u6eb6\u6db2\uff09\uff0c\u624d\u80fd\u7dad\u6301\u6b63\u5e38\u7684\u7d30\u80de\u5927\u5c0f\u3002\u65e5\u5e38\u751f\u6d3b\u4e2d\uff0c\u4f7f\u7528\u9e7d\u6f2c\u4f86\u8b93\u98df\u6750\u812b\u6c34\u4e5f\u662f\u904b\u7528\u76f8\u540c\u7684\u539f\u7406\u3002<\/p>\n<p>\u90a3\u9ebc\uff0c\u53ea\u8981\u901a\u904e\u6539\u8b8a\u764c\u7d30\u80de\u5167\u5916\u7684\u96e2\u5b50\u6fc3\u5ea6\u4e0d\u5c31\u80fd\u8f15\u6613\u5730\u6bba\u6b7b\u816b\u7624\u4e86\u55ce\uff1f\u986f\u7136\u4f60\u6703\u7709\u982d\u4e00\u76ba\uff0c\u8a8d\u70ba\u6848\u60c5\u4e26\u4e0d\u55ae\u7d14\u3002\u9019\u500b\u7406\u8ad6\u96d6\u7136\u7c21\u55ae\uff0c\u4f46\u537b\u96e3\u4ee5\u5be6\u73fe\uff0c\u56e0\u70ba\u7d30\u80de\u672c\u8eab\u5c0d\u65bc\u96e2\u5b50\u6fc3\u5ea6\u6709\u56b4\u683c\u7684\u8abf\u7bc0\u6a5f\u5236\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u9e7d\u7684\u4e3b\u8981\u6210\u5206\u6c2f\u5316\u9209\u6709\u5f88\u597d\u7684\u6c34\u6eb6\u6027\uff0c\u4e00\u65e6\u9047\u5230\u9ad4\u6db2\u6216\u8840\u6db2\u6703\u7acb\u5373\u6eb6\u89e3\uff0c\u800c\u6c2f\u5316\u9209\u6eb6\u6db2\u4e0d\u6703\u4e3b\u52d5\u805a\u96c6\u5728\u816b\u7624\u90e8\u4f4d\uff0c\u7121\u6cd5\u85c9\u6b64\u63d0\u9ad8\u764c\u7d30\u80de\u5167\u90e8\u6216\u5916\u90e8\u7684\u6ef2\u900f\u58d3\u3002\u56e0\u6b64\uff0c\u4e00\u822c\u9e7d\u6c34\u4e26\u4e0d\u5177\u6709\u6bba\u6b7b\u764c\u7d30\u80de\u7684\u80fd\u529b\u3002\u63a5\u8457\u4f86\u770b\u79d1\u5b78\u5bb6\u662f\u600e\u9ebc\u89e3\u6c7a\u9019\u4e9b\u96e3\u984c\u5462\uff1f<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u6c2f\u5316\u9209\u5948\u7c73\u7c92\u5b50\u4f5c\u70ba\u7279\u6d1b\u4f0a\u6728\u99ac\u4f86\u6bba\u6b7b\u764c\u7d30\u80de<\/strong><\/span><\/p>\n<p>\u7f8e\u570b\u55ac\u6cbb\u4e9e\u5927\u5b78\uff08University of Georgia\uff09\u7684\u79d1\u5b78\u5bb6\uff0c\u958b\u767c\u4e86\u4e00\u7a2e\u6c2f\u5316\u9209\u5948\u7c73\u7c92\u5b50\uff08sodium chloride [NaCl] nanoparticles, SCNPs\uff09\uff0c\u5047\u8a2d\u63a1\u7528\u7279\u6d1b\u4f0a\u6728\u99ac\u7684\u7b56\u7565\uff0c\u5c07 SCNPs \u9001\u9032\u764c\u7d30\u80de\u5167\u5c31\u80fd\u7834\u58de\u96e2\u5b50\u5e73\u8861\uff0c\u4ee5\u9054\u5230\u6bba\u6b7b\u764c\u7d30\u80de\u7684\u76ee\u7684\u3002\u7814\u7a76\u9996\u5148\u9a57\u8b49\u4e86 SCNPs \u7684\u7279\u6027\uff0c\u767c\u73fe\u5176\u80fd\u907f\u958b\u7d30\u80de\u96e2\u5b50\u901a\u9053\u7684\u6aa2\u67e5\uff0c\u4e26\u85c9\u7531\u80de\u541e\u4f5c\u7528\uff08endocytosis\uff09\u9032\u5165\u7d30\u80de\uff0cSCNPs \u5728\u7d30\u80de\u5167\u6eb6\u89e3\u4e26\u91cb\u653e\u51fa Na+ \u548c Cl- \u96e2\u5b50\u3002\u9019\u4e9b\u96e2\u5b50\u88ab\u56f0\u5728\u7d30\u80de\u5167\u90e8\u5c0e\u81f4\u6ef2\u900f\u58d3\u589e\u52a0\uff0c\u6ef2\u900f\u58d3\u5287\u70c8\u8b8a\u5316\u5c07\u56b4\u91cd\u5f71\u97ff\u7d30\u80de\u7684\u751f\u7406\u529f\u80fd\u3002\u70ba\u4e86\u907f\u514d SCNPs \u5728\u7d30\u80de\u5916\u5c31\u904e\u65e9\u6eb6\u89e3\uff0c\u7814\u7a76\u53c8\u5728 SCNPs \u7684\u5916\u90e8\u5305\u8986\u4e86\u78f7\u8102\u8cea\uff08phospholipid\uff09\uff0c\u5305\u8986\u5f8c\u7684\u7c92\u5b50\u7c21\u7a31\u70ba PSCNPs\uff0c\u5176\u8868\u73fe\u51fa\u4e00\u5b9a\u7684\u758f\u6c34\u6027\uff0c\u80fd\u5728\u6c34\u6eb6\u6db2\u4e2d\u66f4\u597d\u5730\u5206\u6563\uff0c\u4e26\u5ef6\u9577\u4e86\u7dad\u6301\u5948\u7c73\u7c92\u5b50\u72c0\u614b\u7684\u6642\u9593\uff0c\u4f46\u4e0d\u6703\u963b\u7919\u5176\u5728\u6c34\u4e2d\u964d\u89e3\u3002<\/p>\n<p>\u6709\u8da3\u7684\u662f\uff0c\u7814\u7a76\u9084\u767c\u73fe PSCNPs \u5c0d\u6b63\u5e38\u7d30\u80de\u7684\u5f71\u97ff\u8f03\u5c0f\uff0c\u63a8\u6e2c\u53ef\u80fd\u662f\u764c\u7d30\u80de\u5feb\u901f\u589e\u6b96\u7684\u7279\u6027\uff0c\u6703\u52a0\u5feb\u5c0d\u5948\u7c73\u7c92\u5b50\u7684\u651d\u53d6\uff1b\u6b64\u5916\uff0c\u6b63\u5e38\u7d30\u80de\u5167\u7684 Na+ \u96e2\u5b50\u6bd4\u8d77\u764c\u7d30\u80de\u4f86\u5f97\u4f4e\uff0c\u9019\u4f7f\u5f97\u6b63\u5e38\u7d30\u80de\u5c0d PSCNPs \u66f4\u5177\u627a\u6297\u529b\u3002\u79d1\u5b78\u5bb6\u4e5f\u904b\u7528\u4e86\u5c0f\u9f20\u6a21\u578b\u8b49\u660e\u5176\u7406\u8ad6\uff0c\u5be6\u9a57\u7d44\u5c07 PSCNPs \u6ce8\u5c04\u5230\u816b\u7624\u4e2d\uff0c\u800c\u5c0d\u7167\u7d44\u7684\u816b\u7624\u5247\u662f\u6ce8\u5c04\u7b49\u91cf\u7684\u6c2f\u5316\u9209\u6eb6\u6db2\uff0c\u63a5\u8457\u6bd4\u8f03\u5be6\u9a57\u7d44\u8207\u5c0d\u7167\u7d44\u7684\u816b\u7624\u751f\u9577\u60c5\u6cc1\uff0c\u7d50\u679c\u767c\u73fe\u7d93\u904e PSCNPs \u6cbb\u7642\u7684\u5c0f\u9f20\uff0c\u5728\u7b2c 16 \u5929\u53ef\u6291\u5236 66% \u7684\u816b\u7624\u751f\u9577\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u6c92\u6709\u8de1\u8c61\u986f\u793a PSCNPs \u6703\u5c0d\u5c0f\u9f20\u7684\u4efb\u4f55\u5668\u5b98\u9020\u6210\u640d\u50b7\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u6c2f\u5316\u9209\u5948\u7c73\u7c92\u5b50\u70ba\u816b\u7624\u6cbb\u7642\u958b\u5275\u4e86\u65b0\u5929\u5730<\/strong><\/span><\/p>\n<p>\u7814\u7a76\u7684\u5be6\u9a57\u4e5f\u8b49\u660e\uff0cPSCNPs \u4e0d\u50c5\u80fd\u6709\u6548\u6291\u5236\u539f\u4f4d\u5be6\u9ad4\u816b\u7624\u7684\u751f\u9577\uff0c\u7576\u9020\u6210\u764c\u7d30\u80de\u6b7b\u4ea1\u7834\u88c2\u6642\uff0c\u53c8\u6703\u653e\u51fa\u767c\u708e\u76f8\u95dc\u7684\u514d\u75ab\u53cd\u61c9\u8a0a\u865f\uff0c\u4e26\u8a98\u5c0e\u764c\u7d30\u80de\u7522\u751f\u514d\u75ab\u6027\u7d30\u80de\u6b7b\u4ea1\uff08immunogenic cell death\uff09\uff0c\u4e5f\u5c31\u662f\u6703\u4fc3\u4f7f\u514d\u75ab\u7cfb\u7d71\u5c0d\u6297\u816b\u7624\uff0c\u800c\u53ef\u9032\u4e00\u6b65\u6291\u5236\u9060\u7aef\u816b\u7624\u7684\u751f\u9577\u3002<\/p>\n<p>\u7e3d\u7d50\u4f86\u8aaa\uff0c\u6b64\u7814\u7a76\u958b\u5275\u4e86\u4e00\u7a2e\u65b0\u7a4e\u7684\u5948\u7c73\u7c92\u5b50\u65b9\u6cd5\uff0c\u53ef\u4ee5\u6539\u8b8a\u764c\u7d30\u80de\u5167\u7684\u6ef2\u900f\u58d3\u4e26\u6bba\u6b7b\u5b83\u5011\u3002\u8a72\u6a5f\u5236\u4e5f\u53ef\u61c9\u7528\u65bc\u5176\u4ed6\u985e\u578b\u7684\u96fb\u89e3\u8cea\uff0c\u4f8b\u5982\u6c2f\u5316\u9240\u6216\u6c2f\u548c\u9223\u3002\u7136\u800c\uff0c\u7531\u65bc PSCNPs \u5728\u6c34\u6eb6\u6db2\u4e2d\u7684\u534a\u8870\u671f\u76f8\u5c0d\u8f03\u77ed\uff0c\u4ecd\u6bd4\u8f03\u9069\u5408\u7528\u65bc\u5c40\u90e8\u816b\u7624\u6d88\u878d\u800c\u975e\u5168\u8eab\u6027\u6cbb\u7642\u3002PSCNPs \u7684\u7368\u7279\u4e4b\u8655\u5728\u65bc\uff0c\u6c2f\u5316\u9209\u7684\u5b89\u5168\u7121\u865e\uff0c\u5728\u6cbb\u7642\u5f8c\u5948\u7c73\u9846\u7c92\u88ab\u9084\u539f\u6210\u9e7d\uff0c\u53ef\u6eb6\u65bc\u9ad4\u6db2\u8207\u8840\u6db2\u7cfb\u7d71\u4e2d\uff0c\u4e0d\u6703\u5f15\u8d77\u7cfb\u7d71\u6027\u6216\u7d2f\u7a4d\u6027\u6bd2\u6027\u3002\u79d1\u5b78\u5bb6\u5e0c\u671b\u672a\u4f86\u901a\u904e\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u5f8c\uff0c\u9019\u9805\u6280\u8853\u80fd\u5ee3\u6cdb\u61c9\u7528\u65bc\u8180\u80f1\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u982d\u9838\u764c\u548c\u809d\u764c\u7b49\u6cbb\u7642\u4e4b\u4e2d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Jiang W, et al. Adv Mater. 2019 Nov;31(46):e1904058. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31553099\">NaCl Nanoparticles as a Cancer Therapeutic.<\/a><\/li>\n<li>Tim Newman. 2020 Jan 16. Medical News Today. <a href=\"https:\/\/www.medicalnewstoday.com\/articles\/327468.php#1\">Using salt to fight cancer.<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u98f2\u98df\u4e2d\u6dfb\u52a0\u300c\u9e7d\u300d\u4f86\u8abf\u5473\uff0c\u662f\u7a00\u9b06\u5e73\u5e38\u4e0d\u904e\u7684\u4e8b\u3002\u4f46\u6c92\u60f3\u5230\u79d1\u5b78\u5bb6\u4e5f\u80fd\u5229\u7528\u9e7d\u4f86\u5c0d\u6297\u816b\u7624\uff0c\u6700\u8fd1\u767c\u8868\u5728\u671f\u520a\u00a0Advanced Materials\u00a0\u7684\u7814\u7a76\uff0c\u79d1\u5b78\u5bb6\u5c07\u9e7d\u6539\u9020\u70ba\u7279\u6b8a\u7684\u300c\u5948\u7c73\u7c92\u5b50\u300d\uff0c\u4e26\u4f7f\u5176\u56f0\u5728\u764c\u7d30\u80de\u4e2d\uff0c\u7834\u58de\u7d30\u80de\u539f\u672c\u7684\u96e2\u5b50\u5e73\u8861\u5f8c\uff0c\u5c31\u80fd\u5b89\u5168\u6709\u6548\u7684\u6bba\u6b7b\u764c\u7d30\u80de\u3002<\/p>\n","protected":false},"author":20,"featured_media":35002,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,2977,1025],"tags":[4545,4544,1867,380],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/02\/salt-3285024_1920.jpeg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34994"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34994"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34994\/revisions"}],"predecessor-version":[{"id":35003,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34994\/revisions\/35003"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/35002"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}