{"id":34993,"date":"2020-02-21T00:11:06","date_gmt":"2020-02-20T16:11:06","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34993"},"modified":"2020-02-17T10:28:08","modified_gmt":"2020-02-17T02:28:08","slug":"%e4%bd%bf%e7%94%a8%e5%be%ae%e9%87%9d%e8%b2%bc%e7%89%87%e4%bd%9c%e7%82%ba%e5%82%b3%e9%81%9e%e5%b7%a5%e5%85%b7%e9%96%8b%e7%99%bc%e6%9c%89%e6%95%88%e7%9a%84f1%ef%bc%8d%e8%84%82%e8%b3%aa%e9%ab%94%e9%bc%a0","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34993","title":{"rendered":"\u4f7f\u7528\u5fae\u91dd\u8cbc\u7247\u4f5c\u70ba\u50b3\u905e\u5de5\u5177\u958b\u767c\u6709\u6548\u7684F1\uff0d\u8102\u8cea\u9ad4\u9f20\u75ab\u75ab\u82d7"},"content":{"rendered":"

\u9f20\u75ab\u687f\u83cc\uff08Yersinia pestis\uff09\u7684F1\u86cb\u767d\u662f\u5f15\u767c\u5c0d\u6297\u9f20\u75ab\uff08plague\uff09\u514d\u75ab\u529b\u7684\u4e3b\u8981\u6297\u539f\uff0c\u88fd\u5099F1\u6297\u539f\u8ca0\u8f09\u7684\u8102\u8cea\u9ad4\uff08F1-liposome\uff09\uff0c\u53ef\u5efa\u7acb\u7522\u751f\u9ad8\u6548\u80fd\u7684\u6297\u9ad4\u6280\u8853\u5e73\u53f0\u3002\u4f7f\u7528\u5fae\u91dd\u8cbc\u7247\uff08microneedle patch, MNP\uff09\u5c07F1-liposome\u65bd\u4e88\u514d\u75ab\u52dd\u4efb\u7684\u5c0f\u9f20\uff0c\u4f7f\u5176\u7522\u751f\u514d\u75ab\u53cd\u61c9\uff0c\u8a55\u4f30\u5176\u5c0d\u6297F1\u6297\u539f\u7684IgG\u6297\u9ad4\u7684\u6548\u50f9\uff08titer\uff09\u3001\u6e2c\u5b9a\u7d30\u80de\u6fc0\u7d20\uff08cytokine\uff09\u542b\u91cf\u53ca\u9032\u884c\u52d5\u7269\u6311\u6230\uff08challenge\uff09\u6e2c\u8a66\u5f8c\uff0c\u8207\u5c0d\u7167\u7d44\u6bd4\u8f03\uff0c\u767c\u73fe\u65bd\u4e88F1-liposome\u7684\u5c0f\u9f20\u8868\u73fe\u51fa\u6700\u5f37\u7684\u514d\u75ab\u529b\uff0c\u986f\u793a\u53ef\u7528MNP\u4f5c\u70ba\u50b3\u905e\u5de5\u5177\u4f86\u958b\u767cF1-\u8102\u8cea\u9ad4\u9f20\u75ab\u75ab\u82d7\u3002<\/strong><\/span><\/p>\n

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\u6587\uff0f\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u9f20\u75ab\u7684\u8a8d\u8b58<\/strong><\/span><\/p>\n

\u9f20\u75ab\u662f\u7531\u9f20\u75ab\u687f\u83cc\u6240\u5f15\u8d77\u7684\u4eba\u755c\u5171\u901a\u50b3\u67d3\u75c5\uff0c\u6b77\u53f2\u4e0a\u66fe\u7206\u767c\u4e09\u6b21\u5927\u6d41\u884c\uff0c\u7279\u5225\u572814\u4e16\u7d00\u4ee5\u201c\u9ed1\u6b7b\u75c5\u201d\uff08black death\uff09\u8086\u8650\u6b50\u6d32\uff0c\u9020\u6210\u6578\u5343\u842c\u4eba\u6b7b\u4ea1\uff0c\u62dc\u516c\u5171\u885b\u751f\u53ca\u91ab\u85e5\u767c\u9054\u4e4b\u8cdc\uff0c\u8fd1\u4f86\u9f20\u75ab\u5df2\u9bae\u5c11\u5927\u898f\u6a21\u6d41\u884c\uff0c\u4f46\u8fc4\u4eca\u4ecd\u5728\u4e0d\u5c11\u5730\u5340\u96f6\u661f\u767c\u751f\uff0c\u9020\u6210\u76f8\u7576\u7a0b\u5ea6\u7684\u516c\u5171\u885b\u751f\u5a01\u8105\u3002\u9f20\u75ab\u521d\u671f\u5fb5\u5019\u5305\u62ec\u767c\u71d2\uff0c\u865b\u5f31\u548c\u982d\u75db\uff0c\u901a\u5e38\u57287\u65e5\u5167\u6703\u767c\u751f\u5178\u578b\u75c7\u72c0\uff0c\u4e09\u7a2e\u4e3b\u8981\u7684\u81e8\u5e8a\u5f62\u5f0f\u662f\u6dcb\u5df4\u817a\u9f20\u75ab\uff08bubonic plague\uff09\u3001\u80ba\u9f20\u75ab\uff08pneumonic plague\uff09\u53ca\u6557\u8840\u6027\u9f20\u75ab\uff08septicemic plague\uff09\uff08\u88681\uff09\u3002\u4eba\u985e\u5982\u679c\u88ab\u611f\u67d3\uff0c\u96d6\u5df2\u6709\u6297\u751f\u7d20\u53ef\u7528\u65bc\u6cbb\u7642\uff0c\u4f46\u5c0d\u65bc\u66b4\u9732\u65bc\u9f20\u75ab\uff08\u7279\u5225\u662f\u80ba\u9f20\u75ab\uff09\u7684\u9ad8\u5371\u96aa\u65cf\u7fa4\u800c\u8a00\uff0c\u4ecd\u6709\u63a5\u7a2e\u75ab\u82d7\u52a0\u4ee5\u9810\u9632\u7684\u9700\u8981\u3002\u7814\u7a76\u4eba\u54e1\u5df2\u63d0\u51fa\u591a\u7a2e\u5019\u9078\u75ab\u82d7\uff0c\u60df\u4ecd\u7121\u7372\u5f97\u8a31\u53ef\u7684\u7522\u54c1\u4e0a\u5e02\u3002<\/p>\n

\u88681.\u9f20\u75ab\u7684\u4e3b\u8981\u985e\u578b<\/p>\n

\"\"<\/p>\n

\u25cfF1<\/strong>\u6297\u539f\u53ca\u8102\u8cea\u9ad4\u7684\u529f\u80fd<\/strong><\/span><\/p>\n

\u9f20\u75ab\u687f\u83cc\u7684F1\u86cb\u767d\u7531caf1\u64cd\u7e31\u5b50\uff08operon\uff09\u7de8\u8b6f\uff0c\u662f\u4e00\u7a2e\u9ad8\u5206\u5b50\u91cf\u805a\u5408\u7269\uff0c\u6703\u5728\u593e\u819c\uff08capsule\uff09\u7522\u751f\u904e\u7a0b\u4e2d\u8f38\u51fa\u5230\u7d30\u83cc\u8868\u9762\uff0c\u53ef\u4ee5\u4fc3\u9032\u9ad4\u6db2\u514d\u75ab\u4f5c\u7528\uff08humoral immunity\uff09\u548c\u7d30\u80de\u4ecb\u5c0e\u514d\u75ab\u4f5c\u7528\uff08cell-mediated immunity\uff09\uff0c\u88ab\u8a8d\u70ba\u662f\u5f15\u767c\u6297\u9f20\u75ab\u514d\u75ab\u529b\u7684\u4e3b\u8981\u6297\u539f\uff0c\u53ef\u88ab\u7528\u4f5c\u6a21\u578b\u6297\u539f\uff0c\u4ee5\u5efa\u7acb\u9ad8\u6548\u7387\u7684\u6297\u9ad4\u8a98\u5c0e\u6280\u8853\u5e73\u53f0\uff0c\u5728\u88fd\u9020\u9f20\u75ab\u75ab\u82d7\u4e0a\u626e\u6f14\u975e\u5e38\u91cd\u8981\u7684\u89d2\u8272\u3002<\/p>\n

\u8102\u8cea\u9ad4\u662f\u5177\u6709\u8102\u8cea\u96d9\u5c64\uff08lipid biolayer\uff09\u7684\u5948\u7c73\u7c92\u5b50\uff08nanoparticle\uff09\u7403\u5f62\u56ca\u6ce1\uff0c\u5177\u6709\u96d9\u6975\u6027\uff08amphiphilicity\uff09\u3001\u751f\u7269\u76f8\u5bb9\u6027\uff08biocompatibility\uff09\u3001\u751f\u7269\u964d\u89e3\u6027\uff08biodegradability\uff09\u3001\u4f4e\u6bd2\u6027\u3001\u7279\u7570\u6027\u3001\u6355\u7372\u89aa\u6c34\u6027\/\u89aa\u8102\u6027\u85e5\u7269\u7684\u80fd\u529b\u53ca\u6613\u65bc\u9032\u884c\u8868\u9762\u4fee\u98fe\u7b49\u7279\u6027\uff0c\u53ef\u4f5c\u70ba\u5c07\u85e5\u7269\u7684\u6d3b\u6027\u5206\u5b50\u50b3\u905e\u81f3\u4f5c\u7528\u90e8\u4f4d\u7684\u8f09\u9ad4\uff08carrier\uff09\uff0c\u5df2\u6210\u70ba\u5546\u696d\u5316\u7684\u85e5\u7269\u8f38\u9001\u7cfb\u7d71\uff0c\u4e26\u5728\u81e8\u5e8a\u4e0a\u5be6\u969b\u61c9\u7528\u3002<\/p>\n

\u25cf\u4f7f\u7528<\/strong>MNP<\/strong>\u4f5c\u70ba\u50b3\u905e\u5de5\u5177\u958b\u767c\u6709\u6548\u7684<\/strong>F1-<\/strong>\u8102\u8cea\u9ad4<\/strong>\u9f20\u75ab\u75ab\u82d7<\/strong><\/span><\/p>\n

\u53f0\u7063\u7814\u7a76\u4eba\u54e1\u57282014\u5e74\u7684\u7814\u7a76\u4e2d\uff0c\u5df2\u7d93\u5229\u7528\u4e73\u5291\/\u6eb6\u5291\u6210\u529f\u7684\u751f\u7522\u9f20\u75ab\u687f\u83ccF1\u6297\u539f\u8ca0\u8f09\u7684\u5948\u7c73\u7c92\u5b50\u5fae\u7403\u9ad4\uff08F1-microsphere\uff09\u75ab\u82d7\uff0c\u4e26\u5728\u52d5\u7269\u5be6\u9a57\u4e2d\u8b49\u660e\u7d93\u7531\u76ae\u4e0b\u6ce8\u5c04\uff08subcutaneous injection\uff09\u7d66\u4e88\u7684F1-microsphere\u75ab\u82d7\u5177\u6709\u6297\u9f20\u75ab\u7684\u80fd\u529b\u3002\u5728\u63a5\u7a2e\u75ab\u82d7\u5f8c\u76842\u9031\u52307\u9031\uff0c\u4fdd\u8b77\u514d\u75ab\u52dd\u4efb\uff08immunocompetent\uff09Balb\/c\u5c0f\u9f20\u7684\u8840\u6f3fIgG\u514d\u75ab\u53cd\u61c9\u986f\u8457\u589e\u52a0\uff0c\u986f\u793aF1-microsphere\u53ef\u4ee5\u512a\u5316\u9f20\u75ab\u75ab\u82d7\u7684\u647b\u5165\u548c\u905e\u9001\u3002\u7136\u800c\uff0c\u5728\u63a5\u7a2eF1-microsphere\u75ab\u82d7\u6642\uff0c\u9700\u8981\u91ab\u7642\u5c08\u696d\u4eba\u54e1\uff08\u5982\u91ab\u751f\u3001\u8b77\u58eb\u7b49\uff09\u5354\u52a9\u57f7\u884c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u800c\u4e14\u7528\u85e5\u904e\u91cf\u3001\u75bc\u75db\u53ca\u53ef\u80fd\u7684\u5fae\u751f\u7269\u6c61\u67d3\uff0c\u4e5f\u662f\u9700\u8981\u8003\u91cf\u7684\u98a8\u96aa\u3002\u70ba\u4e86\u514b\u670d\u9019\u4e9b\u6311\u6230\uff0c\u9019\u500b\u7814\u7a76\u5718\u968a\u57282019\u5e74\u9032\u4e00\u6b65\u4f7f\u7528 MNP\u4f5c\u70ba\u50b3\u905e\u5de5\u5177\u4f86\u958b\u767c\u65b0\u7684\u9f20\u75ab\u75ab\u82d7\uff0c\u4ed6\u5011\u88fd\u5099\u4e86F1-liposome\uff0c\u4ee5\u78f7\u9178\u98df\u9e7d\u6c34\u7de9\u885d\u6db2\uff08phosphate buffer saline, PBS\uff09\u4f5c\u70ba\u6eb6\u5291\u5c0dF1-liposome\u9032\u884c\u6e2c\u8a66\uff0c\u4e26\u6e2c\u5b9a\u5176\u542b\u91cf\u3002\u6700\u5f8c\u5229\u7528\u5df2\u5546\u696d\u5316\u751f\u7522\u7684\u4e00\u7a2eMNP\u4f5c\u70ba\u50b3\u905e\u5de5\u5177\uff0c\u5c07\u88fd\u5099\u7684F1-liposome\u4ee5\u76ae\u819a\u514d\u75ab\u63a5\u7a2e\uff08skin vaccination\uff09\u7684\u65b9\u5f0f\u6295\u4e88\u514d\u75ab\u52dd\u4efb\u7684\u5c0f\u9f20\u3002\u5be6\u9a57\u671f\u9593\u6bcf\u96947\u5929\u5b9a\u671f\u62bd\u53d6\u9019\u4e9b\u5c0f\u9f20\u7684\u8840\u6db2\uff08\u517145\u5929\uff09\uff0c\u4f7f\u7528\u9175\u7d20\u9023\u63a5\u7684\u514d\u75ab\u5438\u9644\u6e2c\u5b9a\uff08enzyme-linked immunosorbent assay\uff09\u8a55\u4f30\u5c0d\u6297F1\u6297\u539f\u7684\u514d\u75ab\u6297\u9ad4IgG\u6548\u50f9\u3002\u6b64\u5916\uff0c\u70ba\u78ba\u8a8d\u514d\u75ab\u53cd\u61c9\uff0c\u5728\u63a5\u7a2e\u75ab\u82d7\u5f8c35\u5929\u6e2c\u5b9a\u7d30\u80de\u6fc0\u7d20\u7684\u542b\u91cf\uff0c\u4f8b\u5982\u767d\u4ecb\u7d204\uff08interleukin-4, IL-4\uff09\u3001\u5e72\u64fe\u7d20-\u03b3\uff08interferon-\u03b3, IFN-\u03b3\uff09\u53ca\u816b\u7624\u58de\u6b7b\u56e0\u5b50-\u03b1\uff08tumor necrosis factor, TNF-\u03b1\uff09\u3002\u6bd4\u8f03\u5be6\u9a57\u7d44\uff08F1-liposome\uff09\u8207\u5c0d\u7167\u7d44\uff08PBS\u548cF1-Alugel\uff09\u5728\u52d5\u7269\u5be6\u9a57\u7684\u7d50\u679c\uff0c\u5305\u62ec IgG\u6297\u9ad4\u6548\u50f9\u5206\u6790\uff08antibody titer assay\uff09\u3001\u7d30\u80de\u6fc0\u7d20\u53cd\u61c9\u6e2c\u8a66\uff08cytokine response test\uff09\u53ca\u52d5\u7269\u6311\u6230\u6e2c\u8a66\uff08animal challenge test\uff09\uff0c\u767c\u73fe\u7d66\u4e88F1-liposome\u7684\u5c0f\u9f20\u8868\u73fe\u51fa\u6700\u5f37\u7684\u514d\u75ab\u529b\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\u7d50\u5408F1\u86cb\u767d\u3001\u8102\u8cea\u9ad4\u53caMNP\u7684\u75ab\u82d7\uff0c\u53ef\u4ee5\u6709\u6548\u8a98\u5c0e\u9069\u61c9\u6027\u514d\u75ab\u53cd\u61c9\uff08adaptive immune response\uff09\u7522\u751f\u3002\u6b64\u5916\uff0cMNP\u9664\u4e86\u662f\u50b3\u905eF1-liposome\u7684\u6709\u6548\u5de5\u5177\u5916\uff0c\u8207\u5176\u4ed6\u7528\u65bc\u65bd\u6253\u75ab\u82d7\u7684\u5e38\u898f\u65b9\u6cd5\uff08\u5982\u808c\u8089\u6ce8\u5c04\u3001\u76ae\u5167\u6ce8\u5c04\u3001\u76ae\u4e0b\u6ce8\u5c04\u7b49\uff09\u6bd4\u8f03\uff0c\u66f4\u5177\u6709\u4ee5\u4e0b\u7684\u512a\u9ede\uff1a\u8f03\u5c11\u7684\u5291\u91cf\u3001\u7121\u75db\u3001\u53ef\u81ea\u6211\u65bd\u7528\u3001\u7121\u91dd\u523a\u50b7\u3001\u5fae\u751f\u7269\u5165\u4fb5\u7387\u4f4e\u3001\u751f\u7269\u6709\u5bb3\u6027\u5ee2\u68c4\u7269\u5c11\u53ca\u904b\u8f38\u3001\u5132\u5b58\u4fbf\u5229\u7b49\u3002<\/p>\n

\u25cf\u7d50\u8ad6<\/strong><\/span><\/p>\n

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 <\/strong><\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

1.      ChenYC,Chen SJ, ChengHF, Yeh MK. Development of Yersinia pestis<\/em><\/a>F1 antigen-loaded liposome vaccine against plague using microneedlesas a delivery system. Journal of Drug Delivery Science and Technology. 2019 Dec. 3.doi.org\/10.1016\/j.jddst.2019.101443<\/a>.<\/p>\n

2.      Huang YH,Hu CS,Ke YJ,Chiang CH,Hong PD, Yeh MK. Evaluatingthe effectivenessofanovelatomizedliquidneedle-freetransdermaldeliverysystem, DrugDeliv.Transl.Res.2017, 7, 609\u2013616. doi.org\/10.1007\/s13346-0170382-7.<\/p>\n

    \n
  1. Huang SS, Li IH, Hong PD, Yeh MK. Development of Yersinia pestis<\/em> F1antigen loaded microspheres vaccine against plague. Int J Nanomed. 2014, 9, 813\u2013822. doi.org\/10.2147\/IJN.S56260.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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