{"id":34965,"date":"2020-02-06T00:15:53","date_gmt":"2020-02-05T16:15:53","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34965"},"modified":"2020-03-02T09:58:13","modified_gmt":"2020-03-02T01:58:13","slug":"%e5%86%a0%e7%8b%80%e7%97%85%e6%af%92%e7%9a%84%e8%aa%8d%e8%ad%98%e5%8f%8a%e7%9b%b8%e9%97%9c%e8%97%a5%e7%89%a9%e3%80%81%e7%96%ab%e8%8b%97%e7%9a%84%e7%a0%94%e7%99%bc-2","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34965","title":{"rendered":"\u51a0\u72c0\u75c5\u6bd2\u7684\u8a8d\u8b58\u53ca\u76f8\u95dc\u85e5\u7269\u3001\u75ab\u82d7\u7684\u7814\u767c"},"content":{"rendered":"

\u51a0\u72c0\u75c5\u6bd2\uff08coronavirus\uff09\u662f\u4e00\u7a2e\u5ee3\u6cdb\u5b58\u5728\u65bc\u591a\u7a2e\u52d5\u7269\u9ad4\u7684\u75c5\u539f\u9ad4\uff0c\u611f\u67d3\u4eba\u9ad4\u6703\u5f15\u767c\u547c\u5438<\/a>\u9053\u75be\u75c5\uff0c\u5176\u4e2dSARS-CoV\u3001MERS-CoV\u53ca2019-nCoV\u4e09\u7a2e\u53ef\u9020\u6210\u81f4\u547d\u7684\u80ba\u708e\uff0c\u7279\u5225\u662f\u75312019-nCoV\u5f15\u8d77\u7684\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\uff0c\u8fd1\u4f86\u5df2\u6210\u70ba\u570b\u969b\u95dc\u6ce8\u7684\u7126\u9ede\u3002\u591a\u5e74\u4f86\u570b\u969b\u5b78\u8853\u754c\u53ca\u91ab\u85e5\u754c\u4e00\u76f4\u5728\u958b\u767c\u5c0d\u6297\u51a0\u72c0\u75c5\u6bd2\u5f15\u767c\u4e4b\u81f4\u547d\u6027\u80ba\u708e\u7684\u76f8\u95dc\u85e5\u7269\u53ca\u75ab\u82d7\uff0c\u96d6\u7136\u5c1a\u7121\u7a81\u7834\u6027\u9032\u5c55\uff0c\u4f46\u7d93\u904e\u79d1\u5b78\u754c\u4e0d\u65b7\u7684\u52aa\u529b\u53ca\u57fa\u65bc\u76ee\u524d\u7814\u767c\u7684\u5feb\u901f\u9032\u5c55\uff0c\u76f8\u4fe1\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\u4e00\u5b9a\u53ef\u4ee5\u6709\u6548\u6cbb\u7642\u53ca\u9810\u9632\u6b64\u7a2e\u75c5\u6bd2\u6240\u5f15\u767c\u7684\u75be\u75c5\u3002<\/strong><\/span><\/p>\n

\"\"<\/p>\n

\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u4ec0\u9ebc\u662f\u51a0\u72c0\u75c5\u6bd2<\/strong><\/span><\/p>\n

\u51a0\u72c0\u75c5\u6bd2\u662f\u4e00\u7a2e\u55ae\u93c8\u6b63\u80a1\uff08single-stranded, positive-sense\uff09\u7684 RNA \u75c5\u6bd2\uff0c\u5c6c\u65bc coronaviridae \u79d1\uff0c\u53ef\u518d\u5206\u70ba \u03b1, \u03b2, \u03b3 \u53ca \u03b4 \u56db\u500b\u5c6c\uff08genus\uff09\u3002\u75c5\u6bd2\u7c92\u5b50\uff08virion\uff09\u5177\u6709\u87ba\u65cb\u5c0d\u7a31\u7684\u5916\u6bbc\u86cb\u767d(capsid)\u53ca\u5916\u5957\u819c\uff08envelope\uff09\uff0c\u57fa\u56e0\u7d44\u5927\u5c0f\u7d04\u70ba 26-32\u5343\u9e7c\u57fa\u5c0d\uff08kilo base pair\uff09\uff0c\u662f\u6240\u6709RNA\u75c5\u6bd2\u4e2d\u6700\u5927\u7684\u3002\u5916\u5957\u819c\u908a\u7de3\u6709\u68d2\u72c0\u7684\u68d8\u7a81\u86cb\u767d\uff08spike protein\uff09\uff0c\u53ef\u548c\u5bbf\u4e3b\u7d30\u80de\u7684\u53d7\u9ad4\uff08receptor\uff09\u9023\u63a5\u4ee5\u611f\u67d3\u5bbf\u4e3b\uff0c\u7531\u65bc\u68d8\u7a81\u5f62\u614b\u985e\u4f3c\u738b\u51a0\uff0c\u6545\u88ab\u7a31\u70ba\u51a0\u72c0\u75c5\u6bd2\u3002\u56e0\u5176\u5177\u6709\u4ee5\u4e0b\u7279\u6027\uff0c\u6240\u4ee5\u76f8\u95dc\u75be\u75c5\u7684\u7ba1\u5236\u53ca\u9810\u9632\u5341\u5206\u4e0d\u6613\u3002<\/p>\n

    \n
  1. \u8de8\u7269\u7a2e\u50b3\u64ad\u6027\uff1a\u53ef\u5728\u4e0d\u540c\u7a2e\u52d5\u7269\u4e4b\u9593\u53ca\u4eba\u8207\u52d5\u7269\u4e4b\u9593\u50b3\u64ad\uff0c\u4e5f\u53ef\u4ee5\u5728\u4eba\u8207\u4eba\u4e4b\u9593\u50b3\u64ad\u3002<\/li>\n
  2. \u9ad8\u50b3\u67d3\u6027\uff1a\u53ef\u7d93\u7531\u7a7a\u6c23\u50b3\u67d3\uff08\u98db\u6cab\u50b3\u67d3\uff09\uff0c\u4ea6\u53ef\u7d93\u7531\u76f4\u63a5\u63a5\u89f8\u50b3\u67d3\uff0c\u6709\u6548\u50b3\u67d3\u7387\u9ad8\uff0c\u751a\u81f3\u767c\u73fe\u53ef\u4ee5\u7121\u75c7\u72c0\u50b3\u67d3\u3002<\/li>\n
  3. \u9ad8\u8b8a\u7570\u6027\uff1a\u75c5\u6bd2\u57fa\u56e0\u7d44\u7a81\u8b8a\u7387\u9ad8\uff0c\u75ab\u82d7\u53ca\u85e5\u7269\u7814\u767c\u5f88\u56f0\u96e3\uff0c\u5373\u4fbf\u958b\u767c\u6210\u529f\uff0c\u4e0a\u5e02\u5f8c\u7684\u75ab\u82d7\u7522\u54c1\u53ca\u85e5\u7269\u7684\u6709\u6548\u671f\u9593\u4e5f\u901a\u5e38\u5f88\u77ed\u3002<\/li>\n<\/ol>\n

    \u25cf\u5f15\u8d77\u4eba\u985e\u547c\u5438\u9053\u75be\u75c5<\/strong><\/span><\/p>\n

    \u53ef\u5f15\u8d77\u4eba\u985e\u547c\u5438<\/a>\u9053\u75be\u75c5\u7684\u51a0\u72c0\u75c5\u6bd2\u5171\u6709\u4e03\u7a2e\uff1aHuman coronavirus (HcoV)-229E\uff08\u03b1\uff09\u3001HcoV-NL63\uff08\u03b1\uff09\u3001HcoV-HKU1\uff08\u03b2\uff09\u3001HcoV-OC43\uff08\u03b2\uff09\u56db\u7a2e\u662f\u611f\u5192\u7684\u5e38\u898b\u75c5\u539f\u9ad4\uff0c\u901a\u5e38\u75c7\u72c0\u8f03\u8f15\u5fae\uff0c\u4e0d\u6703\u9020\u6210\u56b4\u91cd\u75be\u75c5\uff0c\u4f46\u5c11\u6578\u514d\u75ab\u529b\u5dee\u7684\u60a3\u8005\u53ef\u80fd\u6703\u51fa\u73fe\u80ba\u708e<\/a>\u7b49\u4f75\u767c\u75c7<\/a>\uff1b\u56b4\u91cd\u6025\u6027\u547c\u5438\u9053\u75c7\u5019\u7fa4\u51a0\u72c0\u75c5\u6bd2<\/a>\uff08Severe acute respiratory syndrome coronavirus, SARS-CoV\uff09\u3001\u4e2d\u6771\u547c\u5438\u9053\u75c7\u5019\u7fa4\u51a0\u72c0\u75c5\u6bd2<\/a>\uff08Middle east respiratory syndrome coronavirus, MERS-CoV\uff09\u53ca2019\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2<\/a>\uff08Novel coronavirus, 2019-nCoV\uff09\u4e09\u7a2e\u5247\u53ef\u5f15\u8d77\u81f4\u547d\u7684\u80ba\u708e\uff1b\u5176\u4e2d\u6700\u8fd1\u7206\u767c\u7684\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\uff08\u6b66\u6f22\u80ba\u708e\uff09\u662f\u75312019\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\uff0d\u6b66\u6f22\u51a0\u72c0\u75c5\u6bd2\uff08Wuhan coronavirus\uff09\u5f15\u767c\uff08\u88681\uff09\u3002<\/p>\n

    \"\"<\/p>\n

    \u25cf\u6cbb\u7642\u85e5\u7269\u53ca\u9810\u9632\u75ab\u82d7\u7684\u7814\u767c<\/strong><\/span><\/p>\n

    \u4e16\u754c\u5404\u570b\u79d1\u5b78\u5bb6\u4e00\u76f4\u5728\u9032\u884c\u5c0d\u6297SARS-nCoV\u53caMERS-CoV\u7684\u85e5\u7269\u53ca\u75ab\u82d7\u4e4b\u7814\u7a76\uff0c\u7814\u767c\u9032\u5c55\u5927\u81f4\u5982\u4e0b\uff0c\u60df\u8fc4\u4eca\u4ecd\u7121\u7372\u5f97\u570b\u969b\u6b63\u5f0f\u8a8d\u8b49\u7684\u6709\u6548\u6cbb\u7642\u85e5\u7269\u53ca\u75ab\u82d7\u7522\u54c1\u4e0a\u5e02\uff1a<\/p>\n

    \u5728 2005\u5e74\uff0c\u53f0\u7063\u7814\u7a76\u4eba\u54e1\u7be9\u9078720\u7a2e\u5177\u6709\u6291\u5236SARS-CoV\u8907\u88fd\u6240\u97003C-\u6a23\u86cb\u767d\u9176\uff08C30 endopeptidase, 3C-like protease, 3CLpro\uff09\u7684\u6d3b\u6027\u5929\u7136\u7269\uff08natural product\uff09\uff0c\u767c\u73fe\u5176\u4e2d\u5169\u7a2e\u5316\u5408\u7269\u6709\u8f03\u660e\u986f\u4f5c\u7528\uff1a\u55ae\u5be7\u9178\uff08tannic acid\uff09\u548c3-\u7570\u9ec4\u916e-3-\u6c92\u98df\u5b50\u9178\u916f\uff083-isotheaflavin-3-gallate\uff09\u3002\u7d93\u9032\u4e00\u6b65\u7814\u7a76\u5f8c\uff0c\u4ed6\u5011\u767c\u73fe\u8336\u9ec3\u7d20-3, 3-\u4e8c\u53bb\u7532\u9178\u916f\uff08theaflavin-3, 3\uff07-digallate\uff09\u662f\u6700\u4f73\u76843CLPro\u6291\u88fd\u5291\uff0c\u5df2\u9451\u5b9a\u51fa\u65b0\u7684\u6709\u6548\u6291\u5236\u75c5\u6bd2\u7684\u5316\u5408\u7269\u3002<\/p>\n

    \u5728 2014\u5e74\uff0c\u7f8e\u570b\u7814\u7a76\u4eba\u54e1\u9451\u5b9a\u51fa\u6703\u4f5c\u7528\u5230MERS-CoV\u7684\u68d8\u7a81\u86cb\u767d\u53d7\u9ad4\u7d50\u5408\u5340\u57df\uff08receptor binding domain\uff09\u7684\u4e03\u7a2e\u4eba\u985e\u4e2d\u548c\u6297\u9ad4\uff08neutralizing antibody\uff09\uff0c\u9019\u4e9b\u6297\u9ad4\u5177\u6709\u7d50\u5408\u5230\u68d8\u7a81\u86cb\u767d\u53d7\u9ad4\u7d50\u5408\u57df\u7684\u4e09\u500b\u4e0d\u540c\u7684\u8868\u4f4d\u6297\u539f\uff08epitope\uff09\u53ca\u4eba\u985e\u4e8c\u80bd\u57fa\u80bd\u91764\uff08dipeptidyl peptidase 4\uff09\u53d7\u9ad4\u7684\u89aa\u548c\u529b\uff0c\u53ef\u963b\u65b7\u75c5\u6bd2\u68d8\u7a81\u86cb\u767d\u8207\u5176\u4eba\u985e\u4e8c\u80bd\u57fa\u80bd\u91764\u53d7\u9ad4\u7684\u7d50\u5408\uff0c\u7814\u7a76\u7d50\u679c\u767c\u73fe\u6709\u52a9\u65bcMERS-CoV\u7684\u6e05\u9664\uff0c\u63d0\u4f9b\u4e86\u958b\u767c\u55ae\u682a\u6297\u9ad4\uff08monoclonal antibody\uff09\uff0d\u514d\u75ab\u7642\u6cd5\uff08immunotherapy\uff09\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

    \u57282019\u5e74\uff0c\u4e2d\u570b\u548c\u6c99\u70cf\u5730\u963f\u62c9\u4f2f\u7684\u7814\u7a76\u4eba\u54e1\u9451\u5b9a\u5e7e\u7a2e\u4e0d\u540cMERS-CoV\u5206\u96e2\u682a\u7684\u68d8\u7a81\u86cb\u767d\u8868\u4f4d\u6297\u539f\uff0c\u518d\u4f7f\u7528\u514d\u75ab\u8cc7\u8a0a\u5b78\uff08immuno-informatics\uff09\u7684\u8a08\u7b97\u6cd5\u4f86\u78ba\u5b9a\u91dd\u5c0d\u68d8\u7a81\u86cb\u767d\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u7684\u8868\u4f4d\u6297\u539f\uff0c\u7d50\u679c\u8b49\u660e\u63a8\u5b9a\u7684\u6297\u539f\u8868\u4f4d\u662f\u6709\u6548\u7684\u5019\u9078\u75ab\u82d7\uff0c\u5177\u6709\u6839\u9664\u548c\u5c0d\u6297MERS-CoV\u611f\u67d3\u7684\u6f5b\u529b\u3002<\/p>\n

    \u5728 2020\u5e74\uff0c\u97d3\u570b\u7814\u7a76\u4eba\u54e1\u7be9\u9078\u5177\u6709\u6291\u5236SARS-CoV\u76843CLpro\u6d3b\u6027\u7684\u985e\u9ec3\u916e\uff08flavonoid\uff09\u5316\u5408\u7269\uff0c\u767c\u73fe\u8349\u8cea\u7d20\uff08herbacetin\uff09\u3001\u91ce\u6f06\u6a39\u82f7<\/a>\uff08rhoifolin\uff09\u548c\u5927\u84df\u82f7<\/a>\uff08pectolinarin\uff09\u53ef\u6709\u6548\u963b\u65b73CLpro\u7684\u6d3b\u6027\uff0c\u7d93\u904e\u9032\u884c\u7cfb\u7d71\u6027\u5206\u6790\u5f8c\uff0c\u5efa\u8b70\u5c07\u9019\u4e09\u7a2e\u985e\u9ec3\u916e\u5316\u5408\u7269\u4f5c\u70ba\u6a21\u677f\u4f86\u8a2d\u8a08\u529f\u80fd\u6539\u9032\u7684\u75c5\u6bd2\u6291\u5236\u5291\u3002<\/p>\n

    \u25cf\u7d50\u8ad6<\/strong><\/span><\/p>\n

    \u65e5\u524d\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08World Health Organization, WHO\uff09\u5df2\u5c07\u7206\u767c\u65bc\u4e2d\u570b\u6b66\u6f22\u7684\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u5217\u70ba\u570b\u969b\u95dc\u6ce8\u7684\u516c\u5171\u885b\u751f\u7dca\u6025\u4e8b\u4ef6\uff08Public Health Emergency of International Concern, PHEIC\uff09\uff0c\u5f15\u8d77\u4e16\u754c\u5404\u570b\u63d0\u9ad8\u8b66\u89ba\uff0c\u7d1b\u7d1b\u63a1\u53d6\u6aa2\u75ab\u3001\u9694\u96e2\u3001\u6d88\u6bd2\u3001\u95dc\u9589\u908a\u754c\u3001\u65b7\u7d55\u4ea4\u901a\u53ca\u9650\u5236\u65c5\u5ba2\u5165\u5883\u7b49\u9632\u75ab\u63aa\u65bd\uff0c\u9632\u7bc4\u75ab\u60c5\u5728\u672c\u570b\u7206\u767c\u3002\u5728\u73fe\u4eca\u5c1a\u7121\u91dd\u5c0d2019-nCoV\u7684\u6709\u6548\u85e5\u7269\u6216\u8a31\u53ef\u75ab\u82d7\u7522\u54c1\u7684\u60c5\u6cc1\u4e0b\uff0c\u7e7c\u4e2d\u570b\u3001\u6fb3\u6d32\u53ca\u65e5\u672c\u4e4b\u5f8c\uff0c\u53f0\u7063\u6700\u8fd1\u4ea6\u6210\u529f\u5206\u96e2\u51fa2019-nCoV\u75c5\u6bd2\u682a\uff0c\u9019\u4e9b\u767c\u5c55\u4f7f\u5f97\u5c0d\u6297\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u7684\u85e5\u7269\u53ca\u75ab\u82d7\u7684\u7814\u767c\u9732\u51fa\u4e00\u7dda\u66d9\u5149\u3002<\/p>\n

     <\/strong><\/p>\n

    \u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    1. Chen CN<\/a>, Lin CP<\/a>, Huang KK<\/a>, Chen WC<\/a>, Hsieh HP<\/a>, Liang PH<\/a>, Hsu JT<\/a>. Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3\u2032-digallate (TF3). Evid Based Complement Alternat Med.<\/a> 2005 Jun;2(2):209-215. Epub 2005 Apr 7.<\/p>\n

    2. Tang XC<\/a>, Agnihothram SS<\/a>, Jiao Y<\/a>, Stanhope J<\/a>, Graham RL<\/a>, Peterson EC<\/a>, Avnir Y<\/a>, Tallarico AS<\/a>, Sheehan J<\/a>, Zhu Q<\/a>, Baric RS<\/a>, Marasco WA<\/a>. Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution. Proc Natl Acad Sci U S A.<\/a> 2014 May 13;111(19): E2018-26. doi: 10.1073\/pnas.1402074111. Epub 2014 Apr 28.<\/p>\n

    3. Tahir Ul Qamar M<\/a>, Saleem S<\/a>, Ashfaq UA<\/a>, Bari A<\/a>, Anwar F<\/a>, Alqahtani S<\/a>. Epitope-based peptide vaccine design and target site depiction against middle east respiratory syndrome coronavirus: an immune-informatics study. J Transl Med.<\/a> 2019 Nov 8;17(1):362. doi: 10.1186\/s12967-019-2116-8.<\/p>\n

    4. Jo S, Kim S, Shin DH, Kim MS. Inhibition of SARS-CoV 3CL protease by flavonoids.<\/a> J Enzyme Inhib Med Chem. 2020 Dec;35(1):145-151. doi: 10.1080\/14756366.2019.1690480.<\/p>\n","protected":false},"excerpt":{"rendered":"

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