{"id":34829,"date":"2020-01-21T00:48:56","date_gmt":"2020-01-20T16:48:56","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34829"},"modified":"2020-01-16T12:03:06","modified_gmt":"2020-01-16T04:03:06","slug":"%e5%b9%b9%e7%b4%b0%e8%83%9e%e6%88%90%e7%82%ba%e6%b2%bb%e7%99%82%e8%97%a5%e7%89%a9%e6%88%90%e7%99%ae%e7%9a%84%e6%96%b0%e6%96%b9%e6%b3%95","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34829","title":{"rendered":"\u5e79\u7d30\u80de\u6210\u70ba\u6cbb\u7642\u85e5\u7269\u6210\u766e\u7684\u65b0\u65b9\u6cd5"},"content":{"rendered":"

\u4eba\u985e\u9577\u671f\u4e0d\u6b63\u5e38\u4f7f\u7528\u85e5\u7269\u6703\u7522\u751f\u5f37\u70c8\u7684\u4f9d\u8cf4\u6027\uff0c\u9020\u6210\u85e5\u7269\u6210\u766e\uff08drug addition\uff09\uff0c\u7834\u58de\u8eab\u5fc3\u5065\u5eb7\u8207\u55aa\u5931\u9053\u5fb7\u89c0\u5ff5\uff0c\u5f15\u767c\u56b4\u91cd\u7684\u793e\u6703\u554f\u984c\u3002\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\u57fa\u56e0\u7de8\u8f2f\u6280\u8853CRISPR\u5728\u5c0f\u9f20\uff08mouse\uff09\u76ae\u819a\u5e79\u7d30\u80de\uff08stem cell\uff09\u4e2d\u5d4c\u5165\u7279\u5b9a\u57fa\u56e0\uff0c\u4f7f\u5176\u7522\u751f\u4e01\u91af\u81bd\u9e7c\u916f\u9176\uff08butyrylcholinesterase, BChE\uff09\u4f86\u5206\u89e3\u53e4\u67ef\u9e7c\uff08cocaine\uff09\uff0c\u518d\u5c07\u6539\u9020\u904e\u7684\u5e79\u7d30\u80de\u8a98\u5c0e\u57f9\u990a\u51fa\u76ae\u819a\u985e\u5668\u5b98\uff08organoid\uff09\u79fb\u690d\u5230\u5c0f\u9f20\u8eab\u4e0a\uff0c\u767c\u73fe\u5c0f\u9f20\u9ad4\u5167\u7684\u53e4\u67ef\u9e7c\u6c34\u5e73\u660e\u986f\u4e0b\u964d\uff0c\u800c\u4e14\u5c0d\u53e4\u67ef\u9e7c\u7684\u9700\u6c42\u4e5f\u6bd4\u5c0d\u7167\u7d44\u66f4\u4f4e\uff0c\u986f\u73fe\u5e79\u7d30\u80de\u53ef\u80fd\u6210\u70ba\u6cbb\u7642\u85e5\u7269\u6210\u766e\u7684\u65b0\u65b9\u6cd5\u3002<\/strong><\/span><\/p>\n

\"\"<\/strong><\/p>\n

\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n

\u25cf\u5e79\u7d30\u80de\u7684\u7a2e\u985e<\/strong><\/span><\/p>\n

\u5e79\u7d30\u80de\u662f\u539f\u59cb\u4e14\u672a\u5b8c\u5168\u5206\u5316\u7684\u7d30\u80de\uff0c\u5177\u6709\u518d\u751f\u6210\u5404\u7a2e\u7d44\u7e54\u5668\u5b98\u7684\u6f5b\u5728\u80fd\u529b\u3002\u5e79\u7d30\u80de\u5b58\u5728\u6240\u6709\u591a\u7d30\u80de\u7d44\u7e54\u88e1\uff0c\u80fd\u7d93\u7531\u6709\u7d72\u5206\u88c2\u8207\u5206\u5316\u4f86\u7522\u751f\u6210\u591a\u7a2e\u7279\u5316\u7d30\u80de\uff0c\u800c\u4e14\u53ef\u4ee5\u5229\u7528\u81ea\u6211\u66f4\u65b0\u4f5c\u7528\u4f86\u63d0\u4f9b\u66f4\u591a\u5e79\u7d30\u80de\u3002<\/p>\n

1. \u4f9d\u767c\u80b2\u904e\u7a0b\u5206\u6210\u5169\u7a2e\uff1a(1)\u80da\u80ce\uff08embryonic\uff09\u5e79\u7d30\u80de\uff1a\u4e00\u7a2e\u9ad8\u5ea6\u672a\u5206\u5316\u7d30\u80de\uff0c\u5728\u80da\u80ce\u767c\u80b2\u65e9\u671f\u7684\u56ca\u80da\u4e2d\uff0c\u53ef\u767c\u80b2\u70ba\u4e0d\u540c\u7684\u7d30\u80de (\u542b\u751f\u6b96\u7d30\u80de) \uff0c\u5177\u6709\u767c\u80b2\u7684\u5168\u80fd\u6027\uff0c\u80fd\u5206\u5316\u51fa\u6240\u6709\u7d44\u7e54\u3001\u5668\u5b98\u53ca\u7cfb\u7d71\uff0c\u6700\u5f8c\u5f62\u6210\u5b8c\u6574\u7684\u500b\u9ad4\u3002(2)\u6210\u4eba\uff08adult\uff09\u5e79\u7d30\u80de\uff1a\u5b58\u5728\u65bc\u6210\u9ad4\u7279\u5b9a\u7684\u7d44\u7e54\u4e2d\uff0c\u5177\u6709\u7531\u5e79\u539f\u7d30\u80de\u5f62\u6210\u5148\u9a45\u7d30\u80de\uff0c\u5206\u5316\u6210\u5177\u7279\u5b9a\u529f\u80fd\u7d30\u80de\u7684\u80fd\u529b\uff0c\u4e3b\u8981\u5305\u62ec\u9aa8\u9ad3\u3001\u9020\u8840\u53ca\u795e\u7d93\u5e79\u7d30\u80de\u3002<\/p>\n

2. \u4f9d\u529f\u80fd\u5206\u6210\u4e09\u7a2e\uff1a(1)\u5168\u529f\u80fd\uff08totipotent\uff09\u5e79\u7d30\u80de\uff1a\u7cbe\u5375\u7d50\u5408\u7522\u751f\u53d7\u7cbe\u5375\u5f8c\uff0c\u53d7\u7cbe\u5375\u5206\u88c2\u6210\u7368\u7acb\u500b\u9ad4\u7684\u80fd\u529b\u3002(2)\u591a\u529f\u80fd\uff08pluripotent\uff09\u5e79\u7d30\u80de\uff1a\u5168\u529f\u80fd\u5e79\u7d30\u80de\u7684\u5f8c\u88d4\uff0c\u96d6\u7121\u6cd5\u767c\u80b2\u6210\u4e00\u500b\u500b\u9ad4\uff0c\u4f46\u53ef\u767c\u80b2\u6210\u591a\u7a2e\u7d44\u7e54\u3002(3)\u55ae\u529f\u80fd\uff08unipotent\uff09\u5e79\u7d30\u80de\uff1a\u53ea\u80fd\u7522\u751f\u4e00\u7a2e\u6216\u5169\u7a2e\u5bc6\u5207\u76f8\u95dc\u7684\u7d30\u80de\u985e\u578b\u5206\u5316\uff0c\u4f46\u5177\u6709\u81ea\u884c\u66f4\u65b0\u80fd\u529b\u3002<\/p>\n

\u25cf\u4ec0\u9ebc\u662f\u85e5\u7269\u6210\u766e<\/strong><\/span><\/p>\n

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\u25cf\u4f7f\u7528\u5e79\u7d30\u80de\u6cbb\u7642\u53e4\u67ef\u9e7c\u6210\u766e<\/strong><\/span><\/p>\n

\u7f8e\u570b\u829d\u52a0\u54e5\u5927\u5b78\uff08University of Chicago\uff09\u7684\u79d1\u5b78\u5bb6\u57282019\u5e74\u767c\u8868\u5728\u570b\u969b\u671f\u520a Nature Biomedical Engineering <\/em>\u7684\u8ad6\u6587\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\uff0d\u53e2\u96c6\u6709\u898f\u5f8b\u9593\u9694\u7684\u77ed\u8ff4\u6587\u91cd\u8907\u5e8f\u5217\uff08clustered regularly interspaced short palindromic repeat, CRISPR\uff09\u7de8\u8f2f\u5c0f\u9f20\u76ae\u819a\u4e0a\u8868\u76ae\u5e79\u7d30\u80de\u7684\u53e4\u67ef\u9e7c\u6c34\u89e3\u9176\uff0d\u5c0f\u9f20\u4e01\u91af\u81bd\u9e7c\u916f\u9176\uff08mouse butyrylcholinesterase, mBChE<\/em>\uff09\u57fa\u56e0\uff0c\u589e\u5f37\u5176\u8868\u73fe\uff08expression\uff09\uff0c\u518d\u5c07\u6539\u9020\u904e\u7684\u76ae\u819a\u7d30\u80de\u79fb\u690d\u5230\u514d\u75ab\u52dd\u4efb\uff08immunocompetent\uff09\u7684C57BL\/6\u5c0f\u9f20\u4e2d\uff0c\u4f7f\u4e4b\u9577\u671f\u91cb\u653e\u8a72\u9175\u7d20\uff0c\u767c\u73fe\u53ef\u6709\u6548\u4fdd\u8b77\u5c0f\u9f20\u514d\u65bc\u5c0b\u6c42\u53e4\u67ef\u9e7c\u7684\u884c\u70ba\u53ca\u907f\u514d\u53e4\u67ef\u9e7c\u904e\u91cf\u3002\u96a8\u5f8c\uff0c\u4ed6\u5011\u70ba\u78ba\u5b9a\u80fd\u81e8\u5e8a\u904b\u7528\u5728\u4eba\u9ad4\uff0c\u518d\u5f9e\u4eba\u985e\u65b0\u751f\u5152\u63d0\u53d6\u76ae\u819a\u5e79\u7d30\u80de\uff0c\u4f7f\u7528CRISPR\u5d4c\u5165\u4eba\u985e\u4e01\u91af\u81bd\u9e7c\u916f\u9176\uff08hBChE<\/em>\uff09\u57fa\u56e0\uff0c\u518d\u8a98\u5c0e\u9019\u4e9b\u7de8\u8f2f\u904e\u7684\u5e79\u7d30\u80de\u767c\u80b2\u6210\u76ae\u819a\u985e\u5668\u5b98\uff0c\u6700\u5f8c\u79fb\u690d\u5230\u514d\u75ab\u7f3a\u9677 \uff08immunodeficient\uff09\u7684\u88f8\u9f20\uff08nude mouse\uff09\u4e0a\u9032\u884c\u540c\u6a23\u7684\u5be6\u9a57\u3002\u4ee5\u4e0a\u7814\u7a76\u7d50\u679c\u5747\u986f\u793a\uff0c\u63a5\u53d7\u57fa\u56e0\u7de8\u8f2f\u76ae\u819a\u5e79\u7d30\u80de\u79fb\u690d\u7684\u5c0f\u9f20\u9ad4\u5167\u7684\u53e4\u67ef\u9e7c\u6c34\u5e73\u660e\u986f\u4e0b\u964d\uff0c\u800c\u4e14\u591a\u5df4\u80fa\u7684\u91cf\u4e5f\u8f03\u672a\u53d7\u6cbb\u7642\u7684\u5c0d\u7167\u7d44\u5c0f\u9f20\u70ba\u4f4e\uff1b\u6b64\u5916\uff0c\u5f9e\u884c\u70ba\u6a21\u5f0f\u4e0a\u89c0\u5bdf\uff0c\u6cbb\u7642\u7d44\u5c0f\u9f20\u6bd4\u5c0d\u7167\u7d44\u51b7\u975c\uff0c\u4e14\u56e0\u5f97\u4e0d\u5230\u6b23\u5feb\u611f\u7684\u6548\u679c\uff0c\u5c0d\u53e4\u67ef\u9e7c\u7684\u9700\u6c42\u4ea6\u8f03\u5c0d\u7167\u7d44\u66f4\u4f4e\u3002\u56e0\u6b64\uff0c\u85c9\u7531\u76ae\u819a\u7d30\u80de\u79fb\u690d\u7684\u5e79\u7d30\u80de\u7642\u6cd5\u53ef\u80fd\u70ba\u85e5\u7269\u6210\u766e\u63d0\u4f9b\u4e00\u7a2e\u65b0\u7a4e\u7684\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n

\u25cf\u7d50\u8ad6<\/strong><\/span><\/p>\n

\u76ee\u524d\u76ae\u819a\u79fb\u690d\u6280\u8853\u5df2\u76f8\u7576\u6210\u719f\uff0c\u53ef\u5728\u5e79\u7d30\u80de\u6cbb\u7642\u4e0a\u63d0\u4f9b\u4e86\u5353\u8d8a\u7684\u8ca2\u737b\uff0c\u4e0a\u8ff0\u7814\u7a76\u7d50\u679c\u70ba\u85e5\u7269\u6210\u766e\u60a3\u8005\u958b\u555f\u4e86\u5b89\u5168\u4e14\u6709\u6548\u6cbb\u7642\u7684\u53ef\u80fd\u6027\uff0c\u800c\u4e14\u8a66\u9a57\u4e2d\u6c92\u6709\u5668\u5b98\u6216\u7d44\u7e54\u6392\u65a5\u53cd\u61c9\u66f4\u652f\u6301\u4e86\u9577\u671f\u6cbb\u7642\u7684\u53ef\u884c\u6027\u3002\u5118\u7ba1\u9019\u9805\u7814\u7a76\u5177\u6709\u76f8\u5c0d\u4f4e\u6210\u672c\u3001\u4e00\u5b9a\u7684\u5b89\u5168\u6027\u53ca\u9577\u671f\u7642\u6548\u7684\u512a\u9ede\uff0c\u4f46\u8981\u5be6\u969b\u61c9\u7528\u5230\u4eba\u9ad4\u4ecd\u9808\u66f4\u9032\u4e00\u6b65\u7684\u52d5\u7269\u5be6\u9a57\u53ca\u81e8\u5e8a\u8a66\u9a57\u3002\u9019\u9805\u7814\u7a76\u5177\u6709\u5f15\u9818\u66f4\u591a\u767c\u5c55\u7684\u6f5b\u529b\uff0c\u4f8b\u5982\u6539\u63a1\u5927\u9f20\uff08rat\uff09\u52d5\u7269\u6a21\u5f0f\uff0c\u4fbf\u65bc\u5be6\u9a57\u6642\u85e5\u7269\u7684\u7ba1\u7406\u3001\u591a\u6b21\u7684\u63a1\u6a23\u3001\u96fb\u751f\u7406\u5b78\uff08electrophysiology\uff09\u7684\u7814\u7a76\u53ca\u795e\u7d93\u624b\u8853\u3001\u6210\u50cf\u7684\u7a0b\u5e8f\uff1b\u6b64\u5916\uff0c\u5927\u9f20\u5177\u6709\u66f4\u7cbe\u78ba\u7684\u904b\u52d5\u5354\u8abf\u6a5f\u5236\uff0c\u4e26\u5c55\u73fe\u66f4\u8907\u96dc\u7684\u793e\u4ea4\u884c\u70ba\uff0c\u8207\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u66f4\u70ba\u63a5\u8fd1\u3002<\/p>\n

 <\/strong><\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

1.      Wang SC<\/a>, Chen YC<\/a>, Lee CH<\/a>, Cheng C<\/a>. Opioid addiction, genetic susceptibility, and medical treatments: a review. Int J Mol Sci.<\/a> 2019 Sep 2;20(17). pii: E4294. doi: 10.3390\/ijms20174294.<\/p>\n

    \n
  1. Li Y<\/a>, Kong Q<\/a>, Yue J<\/a>, Gou X<\/a>, Xu M<\/a>, Wu X<\/a>. Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose. Nat Biomed Eng.<\/a> 2019 Feb;3(2):105-113. doi: 10.1038\/s41551-018-0293-z. Epub 2018 Sep 17.<\/li>\n
  2. \u9673\u6df5\u9293\u3002\u57fa\u56e0\u7de8\u8f2f\u6280\u8853CRISPR\u5728\u7cbe\u795e\u75be\u75c5\u53ca\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u61c9\u7528<\/a>\u3002\u79d1\u6280\u5831\u5c0e\/\u79d1\u5b78\u6708\u520a\uff0c\u79d1\u5b78\u6708\u520a\u96dc\u8a8c\u793e\uff0c2019\u5e7410\u6708\uff0c454\uff0cP.10-13\u3002<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u4eba\u985e\u9577\u671f\u4e0d\u6b63\u5e38\u4f7f\u7528\u85e5\u7269\u6703\u7522\u751f\u5f37\u70c8\u7684\u4f9d\u8cf4\u6027\uff0c\u9020\u6210\u85e5\u7269\u6210\u766e\uff08drug addition\uff09\uff0c\u7834\u58de\u8eab\u5fc3\u5065\u5eb7\u8207\u55aa\u5931\u9053\u5fb7\u89c0\u5ff5\uff0c\u5f15\u767c\u56b4\u91cd\u7684\u793e\u6703\u554f\u984c\u3002\u7814\u7a76\u4eba\u54e1\u4f7f\u7528\u57fa\u56e0\u7de8\u8f2f\u6280\u8853CRISPR\u5728\u5c0f\u9f20\uff08mouse\uff09\u76ae\u819a\u5e79\u7d30\u80de\uff08stem cell\uff09\u4e2d\u5d4c\u5165\u7279\u5b9a\u57fa\u56e0\uff0c\u4f7f\u5176\u7522\u751f\u4e01\u91af\u81bd\u9e7c\u916f\u9176\uff08butyrylcholinesterase, BChE\uff09\u4f86\u5206\u89e3\u53e4\u67ef\u9e7c\uff08cocaine\uff09\uff0c\u518d\u5c07\u6539\u9020\u904e\u7684\u5e79\u7d30\u80de\u8a98\u5c0e\u57f9\u990a\u51fa\u76ae\u819a\u985e\u5668\u5b98\uff08organoid\uff09\u79fb\u690d\u5230\u5c0f\u9f20\u8eab\u4e0a\uff0c\u767c\u73fe\u5c0f\u9f20\u9ad4\u5167\u7684\u53e4\u67ef\u9e7c\u6c34\u5e73\u660e\u986f\u4e0b\u964d\uff0c\u800c\u4e14\u5c0d\u53e4\u67ef\u9e7c\u7684\u9700\u6c42\u4e5f\u6bd4\u5c0d\u7167\u7d44\u66f4\u4f4e\uff0c\u986f\u73fe\u5e79\u7d30\u80de\u53ef\u80fd\u6210\u70ba\u6cbb\u7642\u85e5\u7269\u6210\u766e\u7684\u65b0\u65b9\u6cd5\u3002<\/p>\n","protected":false},"author":20,"featured_media":34842,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[3075,4513,4512,4511],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/01\/cells-1872666_640.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34829"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34829"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34829\/revisions"}],"predecessor-version":[{"id":34845,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34829\/revisions\/34845"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34842"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}