{"id":34826,"date":"2020-01-09T00:48:53","date_gmt":"2020-01-08T16:48:53","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34826"},"modified":"2020-10-23T12:48:29","modified_gmt":"2020-10-23T04:48:29","slug":"%e5%a4%a7%e8%85%a6%e9%80%90%e6%bc%b8%e9%80%80%e5%8c%96%ef%bc%8c%e9%86%ab%e5%ad%b8%e5%bd%b1%e5%83%8f%e7%99%bc%e7%8f%be%e5%8e%9f%e5%9b%a0%e6%98%af%e3%80%8c%e8%85%a6%e8%a2%8b%e6%9c%89%e6%b4%9e%e3%80%8d","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34826","title":{"rendered":"\u5927\u8166\u9010\u6f38\u9000\u5316\uff0c\u91ab\u5b78\u5f71\u50cf\u767c\u73fe\u539f\u56e0\u662f\u300c\u8166\u888b\u6709\u6d1e\u300d"},"content":{"rendered":"

\u907f\u514d\u5927\u8166\u8001\u5316\u3001\u9810\u9632\u8a8d\u77e5\u8207\u884c\u70ba\u969c\u7919\uff0c\u4e00\u76f4\u662f\u91ab\u5b78\u754c\u6025\u5f85\u89e3\u6c7a\u7684\u96e3\u984c\u30022019 \u5e74 12 \u6708\u5728 ScienceTranslational Medicine<\/em> \u671f\u520a\u767c\u8868\u7684\u5169\u7bc7\u7814\u7a76\uff0c\u767c\u73fe\u8840\u8166\u969c\u58c1\uff08blood-brain barrier\uff09\u51fa\u73fe\u300c\u6f0f\u6d1e\u300d\uff0c\u662f\u8870\u8001\u5f71\u97ff\u8a8d\u77e5\u80fd\u529b\u9000\u5316\u7684\u95dc\u9375\u56e0\u7d20\uff0c\u539f\u4f86\u300c\u8166\u888b\u6709\u6d1e\u300d\u771f\u7684\u662f\u8166\u7b4b\u6f38\u6f38\u4e0d\u9748\u5149\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u4fee\u5fa9\u8166\u6d1e\u9020\u6210\u7684\u554f\u984c\u53ef\u80fd\u662f\u672a\u4f86\u7684\u65b0\u7642\u6cd5\u3002<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf\u8840\u8166\u969c\u58c1\u662f\u4fdd\u8b77\u5927\u8166\u514d\u53d7\u5916\u754c\u7269\u8cea\u5f71\u97ff\u7684\u9632\u8b77\u7db2<\/strong><\/span><\/p>\n

\u8840\u8166\u969c\u58c1\u7684\u529f\u80fd\u5c31\u5982\u540c\u4e00\u9053\u9632\u8b77\u7db2\uff0c\u53ef\u9078\u64c7\u6027\u5730\u963b\u6b62\u67d0\u4e9b\u7269\u8cea\u7531\u8840\u6db2\u9032\u5165\u5927\u8166\uff0c\u4f8b\u5982\u80fd\u8b93\u71df\u990a\u7269\u8cea\u9032\u5165\u8166\u90e8\uff0c\u6216\u8005\u4fdd\u8b77\u5927\u8166\u4e0d\u53d7\u6709\u5bb3\u4e4b\u5316\u5b78\u7269\u8cea\u548c\u7d30\u83cc\u7684\u5f71\u97ff\u3002\u5047\u5982\u5bb6\u4e2d\u7684\u7d17\u7a97\u51fa\u73fe\u7834\u6d1e\uff0c\u5c31\u7121\u6cd5\u6709\u6548\u963b\u9694\u8a0e\u53ad\u7684\u6c99\u5875\u6216\u868a\u87f2\u9032\u5165\u5c4b\u5167\uff0c\u6c92\u60f3\u5230\u9019\u6a23\u985e\u4f3c\u7684\u554f\u984c\u4e5f\u767c\u751f\u5728\u5927\u8166\u7d50\u69cb\u88e1\u3002<\/p>\n

\u8fd1\u65e5\uff0c\u7531\u7f8e\u570b\u52a0\u5dde\u5927\u5b78\u67cf\u514b\u840a\u5206\u6821\uff08University of California, Berkeley\uff09\u8207\u4ee5\u8272\u5217\u672c\u53e4\u91cc\u5b89\u5927\u5b78\uff08Ben- Gurion University\uff09\u79d1\u5b78\u5bb6\u5408\u4f5c\u7684\u7814\u7a76\uff0c\u5229\u7528\u4e00\u7a2e\u65b0\u7684\u91ab\u5b78\u5f71\u50cf\u6280\u8853\u2500\u2500\u300c\u52d5\u614b\u5c0d\u6bd4\u589e\u5f37\u6838\u78c1\u5171\u632f\u9020\u5f71\uff08dynamic contrast-enhanced magnetic resonance imaging, DCE-MRI\uff09\u300d\u4f86\u6aa2\u6e2c\u8840\u8166\u969c\u58c1\uff0c\u7d50\u679c\u767c\u73fe 70 \u6b72\u4ee5\u4e0a\u7684\u6210\u5e74\u4eba\uff0c\u6709\u8fd1 60% \u7684\u8840\u8166\u969c\u58c1\u51fa\u73fe\u300c\u6f0f\u6d1e\u300d\uff0c\u5c24\u5176\u662f\u5728\u6709\u56b4\u91cd\u8a8d\u77e5\u969c\u7919\uff0c\u5982\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u60c5\u6cc1\u66f4\u70ba\u56b4\u91cd\u3002\u800c\u4e14\uff0c\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0c\u8840\u8166\u969c\u58c1\u300c\u6ef2\u6f0f\u554f\u984c\u300d\u65e5\u8da8\u60e1\u5316\uff0c\u7814\u7a76\u7684\u5be6\u9a57\u4e5f\u8b49\u660e\u4eba\u985e\u548c\u5c0f\u9f20\u90fd\u5b58\u5728\u9019\u7a2e\u529f\u80fd\u969c\u7919\u3002\u79d1\u5b78\u5bb6\u63a8\u6e2c\u5c31\u662f\u56e0\u70ba\u5927\u8166\u7684\u9632\u8b77\u7db2\u51fa\u73fe\u6f0f\u6d1e\uff0c\u8840\u6db2\u4e2d\u53ef\u80fd\u5c0e\u81f4\u767c\u708e\u6216\u7d30\u80de\u6b7b\u4ea1\u7684\u5316\u5b78\u7269\u8cea\u9032\u5165\u8166\u7d44\u7e54\uff0c\u6700\u7d42\u9032\u5c55\u70ba\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u3002<\/p>\n

\u25cf\u767d\u86cb\u767d\u5f9e\u8840\u8166\u969c\u58c1\u7684\u6f0f\u6d1e\u9032\u5165\u5927\u8166\uff0c\u6703\u5c0e\u81f4\u8166\u90e8\u8001\u5316\u8207\u795e\u7d93\u7cfb\u7d71\u75be\u75c5<\/strong><\/span><\/p>\n

\u5728\u904e\u53bb\u7684\u7814\u7a76\uff0c\u79d1\u5b78\u5bb6\u5df2\u77e5\u5f9e\u8840\u8166\u969c\u58c1\u6ef2\u6f0f\u9032\u8166\u90e8\u7684\u7269\u8cea\uff0c\u53ef\u80fd\u8207\u8840\u6f3f\u4e2d\u5927\u91cf\u7684\u767d\u86cb\u767d\uff08albumin\uff09\u6709\u95dc\uff0c\u85c9\u7531\u5206\u6790\u4e0d\u540c\u5e74\u9f61\u7684\u5c0f\u9f20\u8166\u7d44\u7e54\u6a23\u672c\uff0c\u767c\u73fe\u5728\u8870\u8001\u7684\u8166\u7d44\u7e54\u4e2d\uff0c\u767d\u86cb\u767d\u7684\u542b\u91cf\u6709\u6240\u589e\u591a\u3002\u90a3\u9ebc\u662f\u5426\u5c31\u662f\u56e0\u70ba\u767d\u86cb\u767d\u6ef2\u5165\u8166\u90e8\uff0c\u624d\u5c0e\u81f4\u795e\u7d93\u767c\u708e\u53ca\u8001\u5316\uff1f\u70ba\u4e86\u9a57\u8b49\u9019\u500b\u731c\u60f3\uff0c\u79d1\u5b78\u5bb6\u5229\u7528\u5c0f\u9f20\u5be6\u9a57\u6a21\u64ec\u8840\u8166\u969c\u58c1\u6ef2\u6f0f\u767d\u86cb\u767d\u7684\u60c5\u6cc1\uff0c\u5c07\u767d\u86cb\u767d\u76f4\u63a5\u6ce8\u5165\u5e74\u8f15\u5c0f\u9f20\u7684\u8166\u90e8\uff0c\u63a5\u8457\u5f9e\u57fa\u56e0\u8868\u9054\u3001\u767c\u708e\u53cd\u61c9\u3001\u5c0d\u8a98\u767c\u6027\u7672\u7647\u7684\u6062\u5fa9\u80fd\u529b\uff08seizure resilience\uff09\u3001\u7672\u7647\u5f8c\u7684\u6b7b\u4ea1\u7387\u3001\u8ff7\u5bae\u6e2c\u8a66\u7b49\u65b9\u9762\u9032\u884c\u8a55\u4f30\u3002\u7d50\u679c\u767c\u73fe\u9019\u4e9b\u8166\u90e8\u88ab\u6ce8\u5165\u767d\u86cb\u767d\u7684\u5e74\u8f15\u5c0f\u9f20\uff0c\u5176\u8868\u73fe\u5c31\u5982\u540c\u5e74\u8001\u5c0f\u9f20\u4e00\u822c\uff0c\u9019\u4ee3\u8868\u6ce8\u5165\u767d\u86cb\u767d\u53ea\u9700\u77ed\u77ed\u4e00\u9031\u7684\u6642\u9593\uff0c\u5c31\u53ef\u8b93\u5e74\u8f15\u5c0f\u9f20\u7684\u5927\u8166\u300c\u52a0\u901f\u8001\u5316\u300d\u3002<\/p>\n

\u79d1\u5b78\u5bb6\u4e5f\u5229\u7528\u8166\u96fb\u5716\uff08electroencephalogram, EEG\uff09\u5206\u6790\u963f\u8332\u6d77\u9ed8\u75c7\u8207\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u540c\u5e74\u9f61\u5065\u5eb7\u5c0d\u7167\u7d44\u4e4b\u5927\u8166\u653e\u96fb\u7684\u8b8a\u5316\uff0c\u7d50\u679c\u767c\u73fe\u60a3\u8005\u5927\u8166\u76ae\u5c64\u7684\u7570\u5e38\u9663\u767c\u6027\u4f4e\u983b\u653e\u96fb\uff08paroxysmal slow cortical activity, PSWE\uff09\u986f\u8457\u8f03\u591a\uff0c\u4e26\u4e14 PSWE \u7684\u767c\u751f\u6a5f\u7387\u8207\u8840\u8166\u969c\u58c1\u640d\u50b7\u4e4b\u7a0b\u5ea6\u5177\u6709\u6b63\u76f8\u95dc\u6027\uff0c\u800c\u5728\u5e74\u8001\u5c0f\u9f20\u8166\u90e8\u5be6\u9a57\u4e5f\u80fd\u770b\u5230\u985e\u4f3c\u7684\u60c5\u6cc1\u3002\u6b64\u5916\uff0c\u79d1\u5b78\u5bb6\u4e5f\u8a66\u8457\u5c07\u767d\u86cb\u767d\u6ce8\u5165\u5e74\u8f15\u5927\u9f20\u7684\u8166\u90e8\uff0c\u7d50\u679c\u89c0\u5bdf\u5230\u6703\u589e\u52a0 PSWE \u767c\u751f\u7387\uff0c\u4e26\u6709\u8207\u4eba\u985e\u60a3\u8005\u76f8\u4f3c\u7684\u8166\u96fb\u5716\u7279\u5fb5\uff0c\u9019\u4e5f\u518d\u6b21\u9a57\u8b49\u4e86\u767d\u86cb\u767d\u6ef2\u9032\u8166\u90e8\uff0c\u8db3\u4ee5\u8a98\u767c\u795e\u7d93\u529f\u80fd\u969c\u7919\u3002<\/p>\n

\u25cf\u6cbb\u7642\u5927\u8166\u8870\u8001\u8207\u8a8d\u77e5\u969c\u7919\u7684\u65b0\u65b9\u5411\uff1a\u89e3\u6c7a\u8840\u8166\u969c\u58c1\u6ef2\u6f0f\u7684\u5f71\u97ff<\/strong><\/span><\/p>\n

\u5df2\u77e5\u767d\u86cb\u767d\u5f15\u8d77\u795e\u7d93\u767c\u708e\u7684\u539f\u56e0\uff0c\u662f\u904e\u5ea6\u6d3b\u5316\u4e86\u661f\u72c0\u7d30\u80de\uff08astrocyte\uff09\u4e2d\u7684\u8f49\u5316\u751f\u9577\u56e0\u5b50-\u03b2\uff08transforming growth factor-\u03b2, TGF-\u03b2\uff09\u3002\u56e0\u6b64\uff0c\u79d1\u5b78\u5bb6\u767c\u5c55\u4e86\u4e00\u7a2e\u80fd\u901a\u904e\u8840\u8166\u969c\u58c1\u7684\u5c0f\u5206\u5b50\u85e5\u7269\uff0c\u4ee3\u865f\u70ba IPW\uff0c\u53ef\u4ee5\u6291\u5236 TGF-\u03b2 \u7684\u6d3b\u5316\u8a0a\u865f\u3002\u900f\u904e\u4f7f\u7528 IPW \u4f86\u6cbb\u7642\u5e74\u8001\u5c0f\u9f20\uff0c\u7d50\u679c\u80fd\u6709\u6548\u6539\u5584\u5e74\u8001\u5c0f\u9f20\u7684\u8a8d\u77e5\u529f\u80fd\u4e26\u6e1b\u5c11 PSWE \u7684\u767c\u751f\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7d93\u904e\u767d\u86cb\u767d\u8655\u7406\u7684\u5c0f\u9f20\uff0c\u4f7f\u7528 IPW \u6cbb\u7642\u5f8c\uff0c\u4e5f\u80fd\u6539\u5584\u8001\u5316\u53ca\u7672\u7647\u7684\u75c7\u72c0\u3002<\/p>\n

\u7814\u7a76\u6210\u679c\u63d0\u4f9b\u4e86 DCE-MRI \u53ca EEG \u9019\u5169\u7a2e\u6aa2\u6e2c\u65b9\u6cd5\uff0c\u53ef\u5e6b\u52a9\u91ab\u5e2b\u8fa8\u8b58\u53ef\u80fd\u5b58\u5728\u8840\u8166\u969c\u58c1\u6f0f\u6d1e\u7684\u60a3\u8005\uff0c\u4e5f\u89e3\u7b54\u4e86\u767d\u86cb\u767d\u6ef2\u5165\u8166\u90e8\u662f\u5f15\u767c\u795e\u7d93\u767c\u708e\u53ca\u8001\u5316\u7684\u81f4\u75c5\u6a5f\u5236\uff0c\u751a\u81f3\u9084\u767c\u5c55\u51fa\u5177\u6709\u6f5b\u529b\u7684\u6cbb\u7642\u85e5\u7269\uff0c\u771f\u7684\u662f\u76f8\u7576\u9762\u9762\u4ff1\u5230\u7684\u7814\u7a76\u3002\u7814\u7a76\u5718\u968a\u7684\u4e3b\u5c0e\u8005 Daniela Kaufer \u53ca Alon Friedman \u6559\u6388\u5df2\u7d93\u5275\u8fa6\u4e86\u4e00\u5bb6\u516c\u53f8\uff0c\u76ee\u6a19\u662f\u958b\u767c\u53ef\u7528\u65bc\u81e8\u5e8a\u7684\u65b0\u85e5\u7269\uff0c\u4ee5\u6cbb\u7642\u8840\u8166\u969c\u58c1\u6ef2\u6f0f\u6240\u7522\u751f\u7684\u4e0d\u826f\u5f71\u97ff\uff0c\u4e26\u5e0c\u671b\u672a\u4f86\u80fd\u5c0d\u4e2d\u98a8\u3001\u8166\u9707\u76ea\u6216\u8166\u5275\u50b7\u7684\u60a3\u8005\u6e1b\u8f15\u8166\u90e8\u767c\u708e\uff0c\u6700\u7d42\u4e5f\u53ef\u4ee5\u5e6b\u52a9\u5230\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u6216\u5176\u4ed6\u5931\u667a\u75c7\u60a3\u8005\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Senatorov VV Jr, et al. Sci Transl Med. 2019 Dec 4;11(521). pii: eaaw8283. Blood-brain barrier dysfunction in aging induces hyperactivation of TGF\u03b2 signaling and chronic yet reversible neural dysfunction.<\/a><\/li>\n
  2. Milikovsky DZ, et al. Sci Transl Med. 2019 Dec 4;11(521). pii: eaaw8954. Paroxysmal slow cortical activity in Alzheimer's disease and epilepsy is associated with blood-brain barrier dysfunction.<\/a><\/li>\n
  3. Robert Sanders. Berkeley 2019 Dec 4. Drugs that quell brain inflammation reverse dementia.<\/a><\/li>\n
  4. \u79d1\u5b78\u4eba\uff0c2016 \u5e74\u7b2c 173 \u671f 07 \u6708\u865f\uff0c\u7a7f\u8d8a\u8166\u4e2d\u5c4f\u969c<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u907f\u514d\u5927\u8166\u8001\u5316\u3001\u9810\u9632\u8a8d\u77e5\u8207\u884c\u70ba\u969c\u7919\uff0c\u4e00\u76f4\u662f\u91ab\u5b78\u754c\u6025\u5f85\u89e3\u6c7a\u7684\u96e3\u984c\u30022019 \u5e74 12 \u6708\u5728 ScienceTranslational Medicine \u671f\u520a\u767c\u8868\u7684\u5169\u7bc7\u7814\u7a76\uff0c\u767c\u73fe\u8840\u8166\u969c\u58c1\uff08blood-brain barrier\uff09\u51fa\u73fe\u300c\u6f0f\u6d1e\u300d\uff0c\u662f\u8870\u8001\u5f71\u97ff\u8a8d\u77e5\u80fd\u529b\u9000\u5316\u7684\u95dc\u9375\u56e0\u7d20\uff0c\u539f\u4f86\u300c\u8166\u888b\u6709\u6d1e\u300d\u771f\u7684\u662f\u8166\u7b4b\u6f38\u6f38\u4e0d\u9748\u5149\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u4fee\u5fa9\u8166\u6d1e\u9020\u6210\u7684\u554f\u984c\u53ef\u80fd\u662f\u672a\u4f86\u7684\u65b0\u7642\u6cd5\u3002<\/p>\n","protected":false},"author":20,"featured_media":34833,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,2977,1025],"tags":[4503,4504,116,4502],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/01\/Brain-blood-3233778_1920.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34826"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34826"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34826\/revisions"}],"predecessor-version":[{"id":34834,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34826\/revisions\/34834"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34833"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}