{"id":34790,"date":"2020-01-03T00:41:57","date_gmt":"2020-01-02T16:41:57","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34790"},"modified":"2020-10-23T12:47:41","modified_gmt":"2020-10-23T04:47:41","slug":"%e4%ba%ba%e9%a1%9e%e7%9a%b0%e7%96%b9%e7%97%85%e6%af%92%e7%9a%84%e7%94%9f%e6%b4%bb%e5%8f%b2%e5%8f%8a%e6%bd%9b%e4%bc%8f%e6%80%a7%e6%84%9f%e6%9f%93","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34790","title":{"rendered":"\u4eba\u985e\u76b0\u75b9\u75c5\u6bd2\u7684\u751f\u6d3b\u53f2\u53ca\u6f5b\u4f0f\u6027\u611f\u67d3"},"content":{"rendered":"<p><strong><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-34798\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/01\/31313.png\" alt=\"\" width=\"655\" height=\"384\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/01\/31313.png 655w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/01\/31313-300x176.png 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/01\/31313-600x352.png 600w\" sizes=\"(max-width: 655px) 100vw, 655px\" \/><\/strong><\/p>\n<p><span style=\"color: #333399;\"><strong>\u4eba\u985e\u76b0\u75b9\u75c5\u6bd2\uff08Human herpesvirus,HHV\uff09\u5c0e\u81f4\u7684\u75be\u75c5\u4ecd\u662f\u91cd\u8981\u7684\u5168\u7403\u6027\u4eba\u985e\u5065\u5eb7\u8b70\u984c\uff0c\u6b64\u7a2e\u75c5\u6bd2\u53ef\u9032\u884c\u6eb6\u89e3\u6027\u611f\u67d3\u6216\u6f5b\u6eb6\u6027\u611f\u67d3\uff0c\u4e26\u5177\u6709\u9ad8\u7a81\u8b8a\u7387\u548c\u6f5b\u4f0f\u6027\u611f\u67d3\uff08latent infection\uff09\u7684\u7279\u6027\uff0c\u6240\u4ee5\u5f15\u8d77\u7684\u75be\u75c5\u96e3\u4ee5\u6cbb\u7642\uff0c\u7279\u5225\u662f\u5b8c\u5168\u6e05\u9664\u5bbf\u4e3b\u9ad4\u5167\u7684\u6f5b\u4f0f\u6027\u611f\u67d3\u7684\u75c5\u6bd2\u5e7e\u4e4e\u662f\u4e0d\u53ef\u80fd\u7684\u3002\u5728\u672c\u6587\uff0c\u6211\u5011\u4ecb\u7d39\u8b80\u8005\u8a8d\u8b58HHV\u7684\u751f\u6d3b\u53f2\u3001\u6f5b\u4f0f\u6027\u611f\u67d3\u53ca\u5f15\u8d77\u7684\u75be\u75c5\uff0c\u4e26\u95dc\u6ce8\u5176\u5c0d\u4eba\u9ad4\u5065\u5eb7\u53ef\u80fd\u7522\u751f\u7684\u5f71\u97ff\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c\u9673\u6df5\u9293<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u4ec0\u9ebc\u662f\u4eba\u985e\u76b0\u75b9\u75c5\u6bd2<\/strong><\/span><\/p>\n<p>\u4eba\u985e\u76b0\u75b9\u75c5\u6bd2\uff08HHV\uff09\u662f\u4e00\u7a2e\u7403\u5f62\u6709\u5916\u819c\u5305\u88ab\uff08envelope\uff09\u75c5\u6bd2\u9ad4\uff0c\u76f4\u5f91\u70ba120\u81f3260 nm\uff08\u901a\u5e38\u7d04\u70ba150 nm\uff09\uff0c\u907a\u50b3\u7269\u8cea\u7531\u96d9\u80a1DNA\u57fa\u56e0\u7d44\u69cb\u6210\uff0c\u8a72\u57fa\u56e0\u7d44\u7de8\u78bc\u5305\u88f9\u5728\u4e8c\u5341\u9762\u9ad4\u8863\u6bbc\uff08capsid\uff09\u4e2d\u7684100\u2013200\u500b\u57fa\u56e0\uff0c\u5468\u570d\u88ab\u7121\u5b9a\u5f62\u86cb\u767d\u8cea\u76ae\u5957\uff08tugument\uff09\u5305\u88f9\uff0c\u5176\u5916\u819c\u5305\u88ab\u7684\u8102\u8cea\u96d9\u5c64\u819c\u542b\u6709\u4e0d\u540c\u7684\u7cd6\u86cb\u767d\uff08glycoprotein\uff09\u3002\u76b0\u75b9\u75c5\u6bd2\u5728\u5176\u5bbf\u4e3b\u7d30\u80de\u6838\u5167\u8907\u88fd\uff0c\u6709DNA\u7684\u9806\u5e8f\u8f49\u9304\u53ca\u524d\u671f\uff08immediately early\uff09\uff0c\u65e9\u671f\uff08early\uff09\u548c\u665a\u671f\uff08late\uff09\u57fa\u56e0\u7684\u5206\u5225\u8868\u73fe\uff0c\u7531\u8f03\u65e9\u671f\u7684\u57fa\u56e0\u8abf\u7bc0\u5f8c\u671f\u57fa\u56e0\u7684\u8f49\u9304\u3002HHV\u53ef\u5206\u62109\u7a2e\uff1a\u55ae\u7d14\u76b0\u75b9\u75c5\u6bd21\uff08Herpes simplex virus-1, HHV-1\uff09\u3001\u55ae\u7d14\u76b0\u75b9\u75c5\u6bd22\uff08Herpes simplex virus-2, HHV-2\uff09\u3001\u6c34\u75d8\u5e36\u72c0\u5e96\u75b9\u75c5\u6bd2\uff08<a href=\"https:\/\/en.wikipedia.org\/wiki\/Varicella_zoster_virus\">Varicella zoster virus<\/a>, HHV-3\uff09\u3001\u9f3b\u54bd\u75c5\u6bd2\uff08Epstein-Barr virus, HHV-4\uff09\uff0c\u5de8\u7d30\u80de\u75c5\u6bd2\uff08Cytomegalovirus, HHV-5\uff09\u3001\u73ab\u7470\u75b9\u75c5\u6bd2\uff08<a href=\"https:\/\/en.wikipedia.org\/wiki\/Roseolovirus\">Roseolovirus<\/a>, HHV-6A, HHV-6B, HHV-7\uff09\u548c\u5361\u6ce2\u897f\u6c0f\u7624\u76f8\u95dc\u76b0\u75b9\u75c5\u6bd2\uff08<a href=\"https:\/\/en.wikipedia.org\/wiki\/Kaposi%27s_sarcoma-associated_herpesvirus\">Kaposi's sarcoma-associated herpesvirus<\/a>, HHV-8)\uff08\u88681\uff09\u3002<\/p>\n<p style=\"text-align: center;\">\u88681. 9\u7a2e\u4eba\u985e\u76b0\u75b9\u75c5\u6bd2<\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-34791 size-full\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/12\/2121.png\" alt=\"\" width=\"676\" height=\"664\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/12\/2121.png 676w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/12\/2121-300x295.png 300w\" sizes=\"(max-width: 676px) 100vw, 676px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u751f\u547d\u9031\u671f<\/strong><\/span><\/p>\n<p>HHV\u7684\u751f\u547d\u9031\u671f\u53ef\u4ee5\u5206\u70ba\u6eb6\u89e3\u6027\u8def\u5f91\uff08lytic pathway\uff09\u548c\u6f5b\u6eb6\u6027\u8def\u5f91\uff08lysogenic pathway\uff09\u5169\u7a2e\u3002\u5728\u6eb6\u89e3\u6027\u8def\u5f91\u4e2d\uff0c\u611f\u67d3\u6027\u75c5\u6bd2\u9644\u8457\u5728\u6709\u7279\u5b9a\u63a5\u53d7\u9ad4\u7684\u5bbf\u4e3b\u7d30\u80de\u5f8c\u555f\u52d5\u611f\u67d3\u7684\u904e\u7a0b\uff0c\u75c5\u6bd2\u7684\u5916\u819c\u5305\u88ab\u7cd6\u86cb\u767d\u8207\u5bbf\u4e3b\u7684\u7d30\u80de\u819c\u53d7\u9ad4\u7d50\u5408\u5f8c\uff0c\u901a\u904e\u53d7\u9ad4\u4ecb\u5c0e\u7684\u5167\u541e\u4f5c\u7528\uff08receptor mediated endocytosis\uff09\u6216\u819c\u878d\u5408\uff08membrane fusion\uff09\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u3002\u75c5\u6bd2\u8863\u6bbc\u5206\u89e3\u5f8c\u91cb\u51fa\u57fa\u56e0\u7d44DNA\uff0c\u5165\u4fb5\u7684DNA\u63a5\u7ba1\u5bbf\u4e3b\u7d30\u80de\u4e26\u64cd\u7e31\u5176\u9175\u7d20\u5408\u6210\u65b0\u7684\u75c5\u6bd2DNA\u548c\u86cb\u767d\u8cea\uff0c\u518d\u7d44\u88dd\u5f62\u6210\u65b0\u7684\u75c5\u6bd2\u7c92\u5b50\uff08virion\uff09\uff0c\u6700\u5f8c\u65b0\u75c5\u6bd2\u7c92\u5b50\u6eb6\u89e3\u539f\u5bbf\u4e3b\u7d30\u80de\uff0c\u4e26\u91cb\u51fa\u5c0b\u627e\u65b0\u7684\u5bbf\u4e3b\u7d30\u80de\u3002\u4f46\u662f\uff0c\u5728\u6f5b\u6eb6\u6027\u8def\u5f91\u4e2d\uff0c\u5c11\u6578\u75c5\u6bd2\u57fa\u56e0\u53ef\u80fd\u6703\u5728\u4e00\u4e9b\u5bbf\u4e3b\u7d30\u80de\u4e2d\u8f49\u9304\u6f5b\u4f0f\u76f8\u95dc\u8f49\u9304\u9ad4\uff08latency associated transcript, LAT\uff09\uff0c\u4ee5\u9019\u7a2e\u65b9\u5f0f\uff0c\u75c5\u6bd2\u53ef\u4ee5\u7121\u9650\u671f\u5730\u5b58\u5728\u800c\u4e0d\u6eb6\u89e3\u5bbf\u4e3b\u7d30\u80de\uff0c\u9577\u671f\u6f5b\u4f0f\u4e0d\u5f15\u8d77\u5bbf\u4e3b\u4efb\u4f55\u75c7\u72c0\u53ca\u75be\u75c5\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u6f5b\u4f0f\u6027\u611f\u67d3<\/strong><\/span><\/p>\n<p>\u6f5b\u4f0f\u671f\u662f\u6307\u75c5\u6bd2\u5728\u5bbf\u4e3b\u9ad4\u5167\u8655\u65bc\u4f11\u7720\u7684\u72c0\u614b\uff0c\u7a31\u70ba\u6f5b\u6eb6\u6027\u751f\u547d\u9031\u671f\u3002\u6f5b\u4f0f\u6027\u611f\u67d3\u662f\u4e00\u7a2e\u6301\u7e8c\u6027\u611f\u67d3\uff08persistent infection\uff09\uff0c\u75c5\u6bd2DNA\u5b58\u5728\u65bc\u5bbf\u4e3b\u4e2d\uff0c\u96d6\u7136\u5075\u6e2c\u4e0d\u5230\u611f\u67d3\u6027\u7684\u75c5\u6bd2\u7c92\u5b50\u7684\u5b58\u5728\uff0c\u4ea6\u4e0d\u6703\u5f15\u8d77\u660e\u986f\u75c7\u72c0\uff0c\u4f46\u537b\u53ef\u4ee5\u50b3\u64ad\u7d66\u4ed6\u4eba\u3002\u7576\u75c5\u6bd2\u5728\u53d7\u5230\u523a\u6fc0\u6216\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7d71\u53d7\u5230\u6291\u5236\u6642\uff0c\u4f11\u7720\u75c5\u6bd2\u53ef\u4ee5\u91cd\u65b0\u6d3b\u5316\u7522\u751f\u5927\u91cf\u75c5\u6bd2\u5f8c\u4ee3\u4ee5\u5f15\u8d77\u75c7\u72c0\u548c\u75be\u75c5\u3002\u6709\u5169\u7a2e\u75c5\u6bd2\u6f5b\u4f0f\u65b9\u5f0f\uff1a\u524d\u75c5\u6bd2\u6f5b\u4f0f\uff08proviral latency\uff09\u548c\u6e38\u96e2\u9ad4\u6f5b\u4f0f\uff08episomal latency\uff09\u3002\u5728\u524d\u75c5\u6bd2\u6f5b\u4f0f\u7684\u65b9\u5f0f\u4e2d\uff0c\u539f\u75c5\u6bd2\u9032\u5165\u5bbf\u4e3b\u7d30\u80de\u5f8c\uff0c\u75c5\u6bd2\u57fa\u56e0\u7d44DNA\u5d4c\u5165\u5bbf\u4e3b\u57fa\u56e0\u7d44\u5167\uff0c\u75c5\u6bd2DNA\u8207\u5bbf\u4e3bDNA\u540c\u6b65\u8907\u88fd\uff0c\u5982\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08human immunodeficiency virus, HIV\uff09\uff1b\u5728\u6e38\u96e2\u9ad4\u6f5b\u4f0f\u7684\u65b9\u5f0f\u4e2d\uff0c\u75c5\u6bd2DNA\u4e0d\u6703\u6574\u5408\u5230\u5bbf\u4e3b\u57fa\u56e0\u7d44\u5167\uff0c\u75c5\u6bd2DNA\u4ee5\u7dda\u6027\u6216\u5957\u7d22\u7d50\u69cb\u5b58\u5728\u65bc\u5bbf\u4e3b\u7684\u7d30\u80de\u8cea\u6216\u7d30\u80de\u6838\u4e2d\uff0c\u56e0\u6b64\u75c5\u6bd2\u5728\u6f5b\u4f0f\u671f\u4ecd\u53ef\u4ee5\u5229\u7528\u81ea\u8eab\u907a\u50b3\u7269\u8cea\uff0c\u5982HHV\u3002\u6f5b\u4f0f\u6027HHV\u88ab\u91cd\u65b0\u6fc0\u6d3b\uff08reactivation\uff09\u5f8c\uff0c\u57fa\u56e0\u7684\u8f49\u9304\u5f9eLAT\u57fa\u56e0\u8f49\u8b8a\u70ba\u6eb6\u89e3\u6027\u57fa\u56e0\u800c\u589e\u5f37\u75c5\u6bd2DNA\u8907\u88fd\u548c\u75c5\u6bd2\u7c92\u5b50\u589e\u6b96\uff0c\u81e8\u5e8a\u4e0a\u5e38\u5f15\u767c\u975e\u7279\u7570\u6027\u7684\u521d\u671f\u75c7\u72c0\uff0c\u5982\u767c\u71d2\u3001\u982d\u75db\u3001\u5589\u56a8\u75db\u3001\u5168\u8eab\u4e0d\u9069\u548c\u76ae\u75b9\u7b49\uff0c\u63a5\u8457\u4fbf\u5f15\u8d77\u75c5\u4eba\u5178\u578b\u75c7\u72c0\u53ca\u75be\u75c5\uff0c\u5728\u67d0\u4e9b\u56b4\u91cd\u7684\u60c5\u6cc1\u4e0b\u751a\u81f3\u5c0e\u81f4\u6b7b\u4ea1\u3002<\/p>\n<p>\u5168\u7403\u4eba\u985e\u53d7\u5230HHV\u611f\u67d3\u8005\u4e0d\u5728\u5c11\u6578\uff0c\u5728\u514d\u75ab\u7cfb\u7d71\u6291\u5236\u4e0b\uff0c\u5927\u591a\u6578\u5065\u5eb7\u4eba\u8eab\u4e0a\u4e26\u672a\u767c\u73fe\u660e\u986f\u75c7\u72c0\u6216\u5f15\u767c\u75be\u75c5\uff0c\u4f46\u5728\u5b30\u5e7c\u5152\u3001\u8001\u5e74\u4eba\u3001\u75c5\u4eba\u3001\u5668\u5b98\u79fb\u690d\u8005\u6216\u514d\u75ab\u529f\u80fd\u4e0d\u5168\u60a3\u8005\u8eab\u4e0a\uff0c\u4ecd\u6709\u5f15\u767c\u56b4\u91cd\u75c7\u72c0\u53ca\u75be\u75c5\u7684\u53ef\u80fd\u6027\u3002\u56e0\u6b64\uff0c\u6211\u5011\u4ecd\u61c9\u95dc\u6ce8HHV\u5f15\u767c\u7684\u75be\u75c5\u53ca\u5c0d\u4eba\u9ad4\u5065\u5eb7\u7684\u885d\u64ca\uff0c\u4e26\u6301\u7e8c\u63a2\u8a0e\u6839\u9664\u6f5b\u4f0f\u6027\u611f\u67d3\u7684\u53ef\u80fd\u7b56\u7565\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Chen YC, Sheng J, Trang P, Liu F. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29844277\">Potential Application of the CRISPR\/Cas9 System against Herpesvirus Infections.<\/a> Viruses. 2018 May 29;10(6). pii: E291. doi: 10.3390\/v10060291. Review.<\/li>\n<li>Richard J. Whitley. Chapter 68 Medical Microbiology. 4th edition, 1996. Baron S, editor. Galveston (TX):&nbsp;<a href=\"http:\/\/www.utmb.edu\/\">University of Texas Medical Branch at Galveston<\/a>, USA.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u4eba\u985e\u76b0\u75b9\u75c5\u6bd2\uff08Human herpesvirus,HHV\uff09\u5c0e\u81f4\u7684\u75be\u75c5\u4ecd\u662f\u91cd\u8981\u7684\u5168\u7403\u6027\u4eba\u985e\u5065\u5eb7\u8b70\u984c\uff0c\u6b64\u7a2e\u75c5\u6bd2\u53ef\u9032\u884c\u6eb6\u89e3\u6027\u611f\u67d3\u6216\u6f5b\u6eb6\u6027\u611f\u67d3\uff0c\u4e26\u5177\u6709\u9ad8\u7a81\u8b8a\u7387\u548c\u6f5b\u4f0f\u6027\u611f\u67d3\uff08latent infection\uff09\u7684\u7279\u6027\uff0c\u6240\u4ee5\u5f15\u8d77\u7684\u75be\u75c5\u96e3\u4ee5\u6cbb\u7642\uff0c\u7279\u5225\u662f\u5b8c\u5168\u6e05\u9664\u5bbf\u4e3b\u9ad4\u5167\u7684\u6f5b\u4f0f\u6027\u611f\u67d3\u7684\u75c5\u6bd2\u5e7e\u4e4e\u662f\u4e0d\u53ef\u80fd\u7684\u3002\u5728\u672c\u6587\uff0c\u6211\u5011\u4ecb\u7d39\u8b80\u8005\u8a8d\u8b58HHV\u7684\u751f\u6d3b\u53f2\u3001\u6f5b\u4f0f\u6027\u611f\u67d3\u53ca\u5f15\u8d77\u7684\u75be\u75c5\uff0c\u4e26\u95dc\u6ce8\u5176\u5c0d\u4eba\u9ad4\u5065\u5eb7\u53ef\u80fd\u7522\u751f\u7684\u5f71\u97ff\u3002<\/p>\n","protected":false},"author":20,"featured_media":34798,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4492,4490,4491],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2020\/01\/31313.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34790"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34790"}],"version-history":[{"count":5,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34790\/revisions"}],"predecessor-version":[{"id":34799,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34790\/revisions\/34799"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34798"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}