{"id":34602,"date":"2019-11-07T00:25:06","date_gmt":"2019-11-06T16:25:06","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34602"},"modified":"2020-10-23T12:47:22","modified_gmt":"2020-10-23T04:47:22","slug":"%e5%b9%b4%e7%b4%80%e5%a4%a7%e4%ba%86%e8%85%a6%e9%88%8d%e9%88%8d%ef%bc%8c%e7%9c%9f%e7%9a%84%e8%88%87%e3%80%8c%e5%a4%a7%e8%85%a6%e5%83%b5%e5%8c%96%e3%80%8d%e6%9c%89%e9%97%9c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34602","title":{"rendered":"\u5e74\u7d00\u5927\u4e86\u8166\u920d\u920d\uff0c\u771f\u7684\u8207\u300c\u5927\u8166\u50f5\u5316\u300d\u6709\u95dc"},"content":{"rendered":"

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\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

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\u7814\u7a76\u9996\u5148\u6bd4\u8f03\u4e86\u5e74\u8001\u8207\u5e74\u8f15\u8001\u9f20\u5927\u8166\u4e2d\u7684\u5dee\u7570\uff0c\u767c\u73fe\u4e00\u7a2e\u540d\u70ba\u300c\u5be1\u6a39\u7a81\u795e\u7d93\u81a0\u8cea\u524d\u9a45\u7d30\u80de\uff08oligodendrocyte progenitor cells, OPCs\uff09\u300d\u626e\u6f14\u8209\u8db3\u8f15\u91cd\u7684\u89d2\u8272\uff0cOPCs \u662f\u4e00\u7a2e\u7dad\u6301\u5927\u8166\u6b63\u5e38\u529f\u80fd\u5f88\u5fc5\u8981\u7684\u5927\u8166\u5e79\u7d30\u80de\u3002\u6b63\u5e38\u795e\u7d93\u5143\u7684\u8ef8\u7a81\u5468\u570d\u6703\u88ab\u4e00\u5c64\u300c\u9ad3\u9798\u300d\u7d50\u69cb\u6240\u4fdd\u8b77\uff0c\u800c OPCs \u80fd\u5920\u5354\u52a9\u9ad3\u9798\u7684\u518d\u751f\uff0c\u70ba\u795e\u7d93\u5143\u63d0\u4f9b\u6301\u7e8c\u7684\u652f\u6301\u53ca\u4fdd\u8b77\u3002\u591a\u767c\u6027\u786c\u5316\u75c7\uff08multiple sclerosis\uff09\u9019\u7a2e\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\uff0c\u5c31\u662f\u56e0\u70ba\u9ad3\u9798\u88ab\u7834\u58de\u6240\u5c0e\u81f4\uff0c\u800c\u5065\u5eb7\u4eba\u7684 OPCs \u529f\u80fd\u6703\u96a8\u8457\u8870\u8001\u964d\u4f4e\uff0c\u4e5f\u53ef\u80fd\u7522\u751f\u985e\u4f3c\u7684\u9ad3\u9798\u7834\u58de\u3002<\/p>\n

\u70ba\u4ec0\u9ebc OPCs \u6703\u96a8\u8457\u8870\u8001\u9010\u6f38\u5931\u53bb\u529f\u80fd\uff0c\u800c\u524a\u5f31\u4e86\u795e\u7d93\u5143\u7684\u4fdd\u8b77\u5c64\uff1f\u79d1\u5b78\u5bb6\u5011\u731c\u60f3\uff0c\u9019\u4e00\u5207\u6216\u8a31\u8207\u8001\u5316\u7684\u5927\u8166\u74b0\u5883\u6709\u95dc\uff0c\u4e26\u4e14\u4e5f\u70ba\u4e86\u60f3\u8981\u89e3\u7b54\u8870\u8001\u9020\u6210\u7684 OPCs \u529f\u80fd\u55aa\u5931\u662f\u5426\u53ef\u4ee5\u9006\u8f49\uff1f\u7814\u7a76\u901a\u904e\u8001\u9f20\u52d5\u7269\u5be6\u9a57\uff0c\u5c07\u8001\u5e74\u5927\u8166\u4e2d\u7684 OPCs \u79fb\u690d\u5230\u5230\u5e74\u8f15\u7684\u5927\u8166\u4e2d\uff0c\u6c92\u60f3\u5230\u51fa\u73fe\u4e86\u5341\u5206\u6709\u8da3\u7684\u4e00\u5e55\uff0c\u9019\u4e9b\u5e74\u8001 OPCs \u5c31\u50cf\u5403\u4e86\u8fd4\u8001\u9084\u7ae5\u4e39\u4e00\u6a23\uff0c\u7adf\u7136\u958b\u59cb\u6062\u5fa9\u6d3b\u529b\uff0c\u4e26\u958b\u59cb\u8868\u73fe\u5f97\u50cf\u662f\u5e74\u8f15\u6709\u6d3b\u529b\u7684\u7d30\u80de\u3002<\/p>\n

\u25cf\u8166\u7d30\u80de\u901a\u904e<\/strong> PIEZO1 <\/strong>\u86cb\u767d\u611f\u77e5\u5916\u5728\u74b0\u5883\u662f\u8edf\u9084\u662f\u786c<\/strong><\/span><\/p>\n

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\u25cf\u958b\u555f\u5c0d\u6297\u5927\u8166\u8870\u8001\u6216\u6cbb\u7642\u591a\u767c\u6027\u786c\u5316\u75c7\u7684\u65b0\u65b9\u5411<\/strong><\/span><\/p>\n

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 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Segel M, et al. Nature. 2019;573:130-134. Niche stiffness underlies the ageing of central nervous system progenitor cells.<\/a><\/li>\n
  2. University of Cambridge. ScienceDaily. Aug 14, 2019. Scientists reverse aging process in rat brain stem cells.<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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