{"id":34588,"date":"2019-11-14T00:40:45","date_gmt":"2019-11-13T16:40:45","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34588"},"modified":"2019-11-21T08:52:38","modified_gmt":"2019-11-21T00:52:38","slug":"%e5%a6%82%e4%bd%95%e5%be%9e%e9%8c%af%e8%aa%a4%e7%9b%a3%e6%8e%a7%e8%a1%a8%e7%8f%be%e7%9c%8b%e5%bc%b7%e8%bf%ab%e7%97%87%e5%92%8c%e5%85%b6%e4%bb%96%e7%96%be%e7%97%85%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34588","title":{"rendered":"\u5982\u4f55\u5f9e\u932f\u8aa4\u76e3\u63a7\u8868\u73fe\u770b\u5f37\u8feb\u75c7\u548c\u5176\u4ed6\u75be\u75c5\uff1f"},"content":{"rendered":"

\u8fd1\u5e74\u4f86\uff0c\u5f37\u8feb\u75c7\uff08obsessive compulsive disorder, OCD\uff09\u5728\u7f8e\u570b\u7cbe\u795e\u91ab\u5b78\u6703\u7684\u7b2c\u4e94\u7248\u7cbe\u795e\u75be\u75c5\u8a3a\u65b7\u6e96\u5247\u4e2d\uff0c\u5f9e\u539f\u5148\u7684\u7126\u616e\u75c7\u985e\u5225\u88e1\u5206\u51fa\u4f86\u6210\u70ba\u4e00\u500b\u7368\u7acb\u7684\u7cbe\u795e\u75be\u75c5\u8a3a\u65b7\u3002\u800c\u4ec0\u9ebc\u662f\u5f37\u8feb\u75c7\u5462\uff1f\u55ae\u7d14\u53ea\u662f\u8981\u6c42\u5b8c\u7f8e\uff0c\u6216\u662f\u6771\u897f\u8981\u64fa\u7684\u6709\u5c0d\u7a31\u6027\u55ce\uff1f<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c\u8521\u5cb7\u54f2<\/strong><\/p>\n

\u25cf\u5f37\u8feb\u75c7\u8207\u932f\u8aa4\u76e3\u63a7<\/strong><\/span><\/p>\n

\u5f37\u8feb\u75c7\u7684\u5178\u578b\u75c7\u72c0\u8868\u73fe\u5305\u542b\u5f37\u8feb\u601d\u8003\uff08obsession\uff09\u548c\u5f37\u8feb\u884c\u70ba\uff08compulsion\uff09\u6216\u662f\u517c\u6709\u3002\u5f37\u8feb\u601d\u8003\u662f\u4e00\u4e9b\u6301\u7e8c\u3001\u53cd\u8986\u751a\u81f3\u662f\u4fb5\u5165\u6027\u7684\u610f\u5ff5\uff0f\u60f3\u6cd5\uff0c\u9019\u4e9b\u7e08\u7e5e\u5728\u8166\u4e2d\u7684\u60f3\u6cd5\u6703\u8b93\u60a3\u8005\u611f\u5230\u75db\u82e6\u4e0d\u9069\uff1b\u800c\u5f37\u8feb\u884c\u70ba\u5247\u662f\u60a3\u8005\u7528\u4ee5\u62b5\u64cb\u3001\u907f\u514d\u6216\u662f\u9810\u9632\u9019\u4e9b\u610f\u5ff5\u7684\u884c\u70ba\u3002\u9019\u4e9b\u884c\u70ba\u5e38\u662f\u904e\u5ea6\u53ca\u8d85\u4e4e\u9810\u671f\u7684\uff0c\u50cf\u662f\u904e\u5ea6\u6d17\u624b\u6216\u662f\u8a08\u6578\u7b49\u3002\u5f37\u8feb\u75c7\u7684\u75c5\u56e0\u5177\u6709\u8907\u96dc\u7684\u7570\u8cea\u6027\uff0c\u6b64\u5916\uff0c\u5728\u904e\u5f80\u7684\u7814\u7a76\u767c\u73fe\uff1a\u89aa\u4eba\u7f79\u60a3\u5f37\u8feb\u75c7\u7684\u4e00\u7b49\u89aa\uff0c\u7f79\u60a3\u5f37\u8feb\u75c7\u7684\u6bd4\u7387\u662f\u4ed6\u4eba\u7684\u4e00\u7b49\u89aa\u5169\u500d\uff0c\u7576\u89aa\u4eba\u662f\u8f03\u5e74\u8f15\u6642\u5c31\u7f79\u75c5\uff0c\u6bd4\u7387\u53c8\u6703\u66f4\u9ad8\u3002\u800c\u8ac7\u5230\u8207\u5176\u4ed6\u75be\u75c5\u5171\u75c5\u6642\uff0c\u5247\u767c\u73fe\u6709\u9ad8\u6bd4\u7387\u7684\u60a3\u8005\u6703\u5171\u75c5\u6709\u7126\u616e\u75c7\u3002<\/p>\n

\u6709\u95dc\u5f37\u8feb\u75c7\u7684\u75c5\u7406\u5b78\uff0c\u8fd1\u5e74\u6709\u8c50\u5bcc\u7684\u7814\u7a76\u767c\u73fe\u8f03\u9ad8\u7684\u795e\u7d93\u932f\u8aa4\u8a0a\u865f\uff08neural error signal\uff09\u8207\u5f37\u8feb\u75c7\u4ee5\u53ca\u7126\u616e\u75c7\u6709\u95dc\uff0c\u5728\u60a3\u8005\u7684\u5bb6\u4eba\u8eab\u4e0a\u4e5f\u767c\u73fe\u985e\u4f3c\u7684\u7d50\u679c\u3002\u800c\u932f\u8aa4\u95dc\u9023\u8ca0\u6ce2\uff08error-related negativity\uff0cERN\uff09\u5247\u662f\u7528\u4f86\u77ad\u89e3\u932f\u8aa4\u76e3\u63a7\u7684\u826f\u597d\u6307\u6a19\u3002\u70ba\u4e86\u91cd\u73fe\u4e0a\u8ff0\u7684\u7814\u7a76\u767c\u73fe\uff0c\u4ee5\u53ca\u4e86\u89e3ERN\u7684\u632f\u5e45\u8b8a\u5316\u662f\u4e0d\u662f\u53ef\u4ee5\u4f5c\u70ba\u4e00\u500b\u8de8\u8a3a\u65b7\u7684\u75be\u75c5\u8868\u5fb5\uff0c\u4e5f\u5c31\u662f\u547c\u61c9\u904e\u53bb\u5b78\u8005\u63d0\u51fa\u7684\uff1a\u4ee5\u5167\u5728\u8868\u73fe\u578b\u53bb\u770b\u5f85\u7cbe\u795e\u75be\u75c5\u7684\u89c0\u9ede\uff0c\u4f86\u81ea\u5fb7\u570b\u67cf\u6797\u6d2a\u5821\u5927\u5b78\u7684\u5fc3\u7406\u5b78\u5bb6Anja Riesel\uff0c\u4ee5\u53ca\u5176\u4ed6\u6210\u54e1\u6240\u7d44\u7684\u8de8\u570b\u5718\u968a\u5c31\u57282018\u5e74\u6642\uff0c\u5728 Psychological Medicine <\/em>\u671f\u520a\u767c\u8868\u4e86\u4e00\u9805\u7814\u7a76\u3002<\/p>\n

\u9019\u500b\u5be6\u9a57\u627e\u4f86\u4e86\u5f37\u8feb\u75c7\u60a3\u8005\u3001\u4ed6\u5011\u7684\u4e00\u7b49\u89aa\u5bb6\u5c6c\u4ee5\u53ca\u672a\u7f79\u60a3\u5f37\u8feb\u75c7\u7684\u5c0d\u7167\u7d44\u53c3\u8207\u8005\u3002\u800c\u5176\u4e2d\u5728\u5c0d\u7167\u7d44\u6210\u54e1\u4e2d\uff0c\u53c8\u4f9d\u7167\u4ed6\u5011\u5831\u544a\u5404\u81ea\u7684\u4e00\u7b49\u89aa\u6240\u7f79\u60a3\u7684\u5176\u4ed6\u75be\u75c5\u4f86\u52a0\u4ee5\u5206\u985e\uff0c\u5305\u62ec\u4e00\u7b49\u89aa\u60a3\u6709\u7126\u616e\u75c7\u3001\u7269\u8cea\u4f7f\u7528\u969c\u7919\u75c7\u7b49\u5176\u4ed6\u75be\u75c5\uff0c\u4ee5\u53ca\u6c92\u6709\u7f79\u60a3\u4efb\u4f55\u75be\u75c5\u7684\u8a31\u591a\u7d44\u5225\u3002\u5728\u5be6\u9a57\u904e\u7a0b\u4e2d\uff0c\u4ed6\u5011\u5148\u5b8c\u6210\u4e00\u7cfb\u5217\u7684\u75c7\u72c0\u554f\u5377\uff0c\u63a5\u4e0b\u4f86\u4ed6\u5011\u4e00\u908a\u63a5\u53d7\u8166\u96fb\u5716\uff08electroencephalograhy, EEG\uff09\u6e2c\u91cf\uff0c\u540c\u6642\u5b8c\u6210\u65c1\u5074\u593e\u64ca\u4f5c\u696d\uff08flanker task\uff0c\u5e38\u7528\u4ee5\u4e86\u89e3\u932f\u8aa4\u6291\u5236\u80fd\u529b\u7684\u7d93\u5178\u5fc3\u7406\u5b78\u5be6\u9a57\uff09\uff0c\u5728\u9019\u500b\u5be6\u9a57\u4f5c\u696d\u4e2d\uff0c\u53c3\u8207\u8005\u6703\u88ab\u5448\u73fe\u4e00\u6392\u4e94\u500b\u5782\u76f4\u7bad\u982d\u7684\u756b\u9762\uff0c\u800c\u5de6\u53f3\u5169\u500b\u7bad\u982d\u65b9\u5411\u6703\u5728\u6bcf\u500b\u4e0d\u540c\u7684\u8a66\u9a57\u4e2d\uff0c\u8207\u4e2d\u9593\u7684\u76ee\u6a19\u7bad\u982d\u540c\u5411\u6216\u8ca0\u5411\uff0c\u53c3\u8207\u8005\u9700\u8981\u6a19\u793a\u51fa\u76ee\u6a19\u7bad\u982d\u7684\u65b9\u5411\u70ba\u4f55\u3002<\/p>\n

\u25cf\u4e0d\u540c\u7684\u75be\u75c5\u98a8\u96aa\uff0c\u4e0d\u540c\u7684\u6ce2\u578b\u8868\u73fe<\/strong><\/span><\/p>\n

\u5be6\u9a57\u7684\u7d50\u679c\u5c31\u767c\u73fe\uff0c\u5f37\u8feb\u75c7\u60a3\u8005\u548c\u4ed6\u5011\u7684\u4e00\u7b49\u89aa\u5bb6\u4eba\u88ab\u6e2c\u91cf\u5230\u8f03\u5927\u7684ERN\u632f\u5e45\uff0c\u986f\u793a\u51fa\u9664\u4e86\u60a3\u8005\u672c\u8eab\uff0c\u4ed6\u5011\u7684\u5bb6\u4eba\u4e5f\u6703\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u9019\u547c\u61c9\u4e86\u904e\u53bb\u767c\u73fe\u7684\u907a\u50b3\u98a8\u96aa\u8b49\u64da\uff1b\u9664\u6b64\u4e4b\u5916\uff0c\u5728\u7f79\u60a3\u7126\u616e\u75c7\u5bb6\u4eba\u7684\u4e00\u7b49\u89aa\u8eab\u4e0a\u4e5f\u767c\u73fe\u76f8\u4f3c\u7684\u7d50\u679c\uff1b\u6700\u5f8c\uff0c\u5728\u7269\u8cea\u4f7f\u7528\u969c\u7919\u5bb6\u4eba\u7684\u4e00\u7b49\u89aa\u8eab\u4e0a\u5247\u767c\u73fe\u6709\u660e\u986f\u8f03\u4f4e\u7684ERN\u632f\u5e45\u3002<\/p>\n

Riesel\u8868\u793a\uff0c\u5728\u5f37\u8feb\u75c7\u60a3\u8005\u4ee5\u53ca\u7126\u616e\u75c7\u4e00\u7b49\u89aa\u7684\u5bb6\u5c6c\u8eab\u4e0a\u6240\u767c\u73fe\u7684\u8f03\u9ad8\u795e\u7d93\u932f\u8aa4\u4fe1\u865f\u8868\u73fe\uff0c\u8207\u904e\u5ea6\u63a7\u5236\uff08over-controlled\uff09\u7684\u884c\u70ba\u8f03\u6709\u95dc\uff0c\u4f8b\u5982\u907f\u514d\u932f\u8aa4\u53ca\u50b7\u5bb3\uff0c\u50cf\u662f\u6642\u5e38\u64d4\u6182\u548c\u5c0d\u65bc\u6a21\u7cca\u6027\u62b1\u6709\u4f4e\u5ea6\u5bb9\u5fcd\u6027\uff0c\u904e\u53bb\u7814\u7a76\u4e5f\u767c\u73fe\u76f8\u4f3c\u7684\u7d50\u679c\uff1b\u5728\u7269\u8cea\u4f7f\u7528\u969c\u7919\u60a3\u8005\u7684\u4e00\u7b49\u89aa\u8eab\u4e0a\u767c\u73fe\u7684\u7d50\u679c\uff0c\u5247\u5c31\u8207\u4f4e\u5ea6\u63a7\u5236\uff08under-controlled\uff09\u7684\u884c\u70ba\u8f03\u6709\u95dc\uff0c\u986f\u793a\u50cf\u662f\u5c0d\u932f\u8aa4\u4e8b\u4ef6\u6216\u662f\u7d50\u679c\u6709\u8f03\u920d\u5316\u7684\u795e\u7d93\u53cd\u61c9\u3001\u8f03\u4f4e\u7684\u53cd\u61c9\u6027\uff0c\u4e5f\u80fd\u5728\u5177\u6709\u7f79\u75c5\u98a8\u96aa\u7684\u4e00\u7b49\u89aa\u5bb6\u4eba\u8eab\u4e0a\u767c\u73fe\u3002\u5118\u7ba1\u5982\u6b64\uff0cRiesel\u4e5f\u63d0\u5230\u4e00\u4e9b\u5728\u770b\u5f85\u9019\u500b\u7814\u7a76\u6642\u9700\u8981\u6ce8\u610f\u7684\u5730\u65b9\uff0c\u5305\u62ec\u6a23\u672c\u4e2d\u6bcf\u7d44\u7684\u5e74\u9f61\u4e0d\u4e00\uff0c\u6216\u662f\u5728\u4e86\u89e3\u5bb6\u5ead\u6210\u54e1\u7684\u75be\u75c5\u8868\u73fe\u6642\u6240\u4f7f\u7528\u7684\u5bb6\u5ead\u53f2\u8abf\u67e5\u7684\u5de5\u5177\u9650\u5236\uff0c\u4ee5\u53ca\u5167\u5728\u8868\u73fe\u578b\u7684\u89c0\u9ede\u5728\u7cbe\u795e\u75be\u75c5\u4e2d\u7684\u89d2\u8272\u4ecd\u9700\u66f4\u591a\u7814\u7a76\u53bb\u9a57\u8b49\u548c\u8a0e\u8ad6\u3002<\/p>\n

\u9019\u4efd\u7814\u7a76\u540c\u6642\u91dd\u5c0d\u53ef\u80fd\u7f79\u60a3\u4e0d\u540c\u75be\u75c5\u7684\u5bb6\u5ead\u6210\u54e1\u505a\u751f\u7406\u6e2c\u91cf\u4ee5\u53ca\u4efb\u52d9\u76e3\u63a7\uff0c\u800c\u9019\u6a23\u7684\u6a23\u672c\u591a\u5143\u6027\u4ee5\u53ca\u7814\u7a76\u7684\u8a2d\u8a08\uff0c\u5c0d\u65bc\u795e\u7d93\u932f\u8aa4\u4fe1\u865f\u5728\u4e0d\u540c\u7684\u7cbe\u795e\u75be\u75c5\u4e2d\u505a\u70ba\u4e00\u500b\u8de8\u8a3a\u65b7\u7684\u56e0\u5b50\u63d0\u4f9b\u4e86\u826f\u597d\u7684\u8b49\u64da\uff0c\u4e5f\u8457\u5be6\u547c\u61c9\u4e86\u9019\u53ef\u80fd\u662f\u7cbe\u795e\u75be\u75c5\u7684\u5167\u5728\u8868\u73fe\u578b\u8868\u5fb5\u4e4b\u4e00\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry<\/em>, 160<\/em>, 636-645.<\/a><\/li>\n
  2. Riesel, A., Klawohn, J., Gr\u00fctzmann, R., Kaufmann, C., Heinzel, S., Bey, K., ... & Kathmann, N. (2019). Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder. Psychological Medicine<\/em>, 49<\/em>, 1207-1217.<\/a><\/li>\n
  3. American Psychiatric Association (2014)\u3002DSM-5<\/strong>\u7cbe\u795e\u75be\u75c5\u8a3a\u65b7\u6e96\u5247\u624b\u518a<\/strong>\uff08\u53f0\u7063\u7cbe\u795e\u91ab\u5b78\u6703\u8b6f\uff09\u3002\u53f0\u5317\uff1a\u5408\u8a18\u3002\uff08\u539f\u8457\u51fa\u7248\uff1a2013\u5e74\uff09<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u8fd1\u5e74\u4f86\uff0c\u5f37\u8feb\u75c7\uff08obsessive compulsive disorder, OCD\uff09\u5728\u7f8e\u570b\u7cbe\u795e\u91ab\u5b78\u6703\u7684\u7b2c\u4e94\u7248\u7cbe\u795e\u75be\u75c5\u8a3a\u65b7\u6e96\u5247\u4e2d\uff0c\u5f9e\u539f\u5148\u7684\u7126\u616e\u75c7\u985e\u5225\u88e1\u5206\u51fa\u4f86\u6210\u70ba\u4e00\u500b\u7368\u7acb\u7684\u7cbe\u795e\u75be\u75c5\u8a3a\u65b7\u3002\u800c\u4ec0\u9ebc\u662f\u5f37\u8feb\u75c7\u5462\uff1f\u55ae\u7d14\u53ea\u662f\u8981\u6c42\u5b8c\u7f8e\uff0c\u6216\u662f\u6771\u897f\u8981\u64fa\u7684\u6709\u5c0d\u7a31\u6027\u55ce\uff1f<\/p>\n","protected":false},"author":20,"featured_media":34590,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[257,3293],"tags":[4421,1388,4420],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/10\/6541313.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34588"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34588"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34588\/revisions"}],"predecessor-version":[{"id":34669,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34588\/revisions\/34669"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34590"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}