{"id":34521,"date":"2019-10-09T17:57:35","date_gmt":"2019-10-09T09:57:35","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34521"},"modified":"2019-12-19T12:11:00","modified_gmt":"2019-12-19T04:11:00","slug":"2019-%e5%b9%b4%e8%ab%be%e8%b2%9d%e7%88%be%e7%94%9f%e9%86%ab%e7%8d%8e","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34521","title":{"rendered":"\u30102019 \u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u3011\u4e00\u7aba\u7d30\u80de\u5982\u4f55\u300c\u6c27\u300d\u5c0a\u8655\u512a"},"content":{"rendered":"

\"\"<\/strong><\/p>\n

\u64b0\u6587\uff5c\u99f1\u5b9b\u7433<\/strong><\/p>\n

\u6bcf\u7576\u5341\u6708\u4e00\u5230\uff0c\u5927\u5bb6\u7121\u4e0d\u775c\u5927\u773c\u775b\u7b49\u8457\u65b0\u4e00\u5e74\u5ea6\u7684\u8afe\u8c9d\u723e\u596c\u5404\u500b\u734e\u843d\u8ab0\u5bb6\u3002\u79ae\u62dc\u4e00\u752b\u958b\u51fa\u7684\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u4e09\u4f4d\u5f97\u4e3b\uff0c\u4f60\u731c\u5230\u4e86\u55ce\uff1f<\/p>\n

\u4eca\u5e74\u7684\u8afe\u8c9d\u723e\u751f\u91ab\u734e\uff0c\u9812\u7d66\u4e86\u7814\u7a76\u7f3a\u6c27\u72c0\u614b\u4e0b\uff0c\u7d30\u80de\u5982\u4f55\u56e0\u61c9\u8abf\u7bc0\u7684\u751f\u7406\u6a5f\u5236\uff1b\u5206\u5225\u662f\u70ba\u4f4d\u65bc\u7f8e\u570b\u6ce2\u58eb\u9813Dana-Farber Cancer Institute \u7684William Kaelin\u535a\u58eb\uff0c\u8eab\u5728\u5df4\u723e\u7684\u6469Johns Hopkins University \u7684Gregg Semenza\u535a\u58eb\uff0c\u9084\u6709\u82f1\u570b\u725b\u6d25Francis Crick Institute \u7684PeterRatcliffe\u535a\u58eb\u3002\u9019\u7814\u7a76\u6216\u8a31\u4e0d\u5728\u6240\u6709\u4eba\u7684\u5f97\u734e\u8d85\u7d1a\u5927\u71b1\u9580\u540d\u55ae\u4e0a\uff0c\u4f46\u537b\u7d55\u5c0d\u773e\u671b\u6240\u6b78\u3002<\/p>\n

\u4f60\u5982\u679c\u770b\u904ePeter Thiel\u8207 Blake Masters\u6240\u8457\u7684\u300a\u5f9e 0\u5230 1\u300b\uff0c\u4fbf\u77e5\u9053\u4efb\u4f55\u4e00\u4ef6\u4e8b\u8981\u5f9e\u96f6\u505a\u5230\u4e00\u6709\u591a\u4e0d\u7c21\u55ae\u3002\u800c\u9019\u4e09\u4f4d\u79d1\u5b78\u5bb6\uff0c\u4e0d\u50c5\u662f\u6210\u529f\u5730\u5f9e\u96f6\u505a\u5230\u4e86\u4e00\uff0c\u66f4\u662f\u5728\u8de8\u8d8a\u51fa\u4e86\u90a3\u4e00\u5927\u6b65\u4e4b\u5f8c\uff0c\u4e0d\u8ad6\u662f\u81ea\u5df1\u5be6\u9a57\u5ba4\u7684\u5f8c\u7e8c\u7814\u7a76\u4e5f\u597d\uff0c\u6216\u662f\u555f\u767c\u5176\u4ed6\u79d1\u5b78\u5bb6\u7684\u9748\u611f\u4e5f\u7f77\uff0c\u8b93\u7f3a\u6c27\u74b0\u5883\u7684\u76f8\u95dc\u751f\u7406\u53cd\u61c9\u8207\u8abf\u7bc0\uff0c\u4e00\u8def\u505a\u5230\u6210\u5343\u4e0a\u842c\u3001\u6578\u4e0d\u52dd\u6578\u3002\u4ed6\u5011\u4e09\u4eba\u6240\u4e00\u540c\u958b\u7586\u95e2\u571f\u3001\u6210\u5c31\u5960\u57fa\u7684\u7f3a\u6c27\u74b0\u5883\u7814\u7a76\uff0c\u5c0d\u65bc\u5404\u7a2e\u7d30\u80de\u3001\u5404\u7a2e\u75be\u75c5\u6a21\u5f0f\uff0c\u7686\u5f71\u97ff\u6df1\u9060\u3002\u4e8b\u5be6\u4e0a\uff0c\u9019\u4e09\u4f4d\u79d1\u5b78\u5bb6\u57282016 \u5e74\u7684\u6642\u5019\uff0c\u4e5f\u4e00\u540c\u7372\u9812\u6709\u300c\u8afe\u8c9d\u723e\u524d\u54e8\u7ad9\u300d\u4e4b\u7a31\u7684Lasker Award \u6b8a\u69ae\u3002<\/p>\n

\u90a3\uff0c\u9019\u4e09\u4f4d\u79d1\u5b78\u5bb6\u662f\u5982\u4f55\u6253\u958b\u7f3a\u6c27\u74b0\u5883\u4e0b\u7684\u672a\u77e5\u79d8\u5bc6\u5462\uff1f\u9019\u6545\u4e8b\uff0c\u53ef\u662f\u80fd\u5920\u4e00\u8def\u8ffd\u6eaf\u56de\u4e5d\u96f6\u5e74\u4ee3\u3002<\/p>\n

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HIF-1 \u7684\u91cd\u8981\u6027\u4e5f\u662f\u5f9e\u500b\u9ad4\u9084\u5728\u80da\u80ce\u6642\u671f\u6642\u5c31\u5df2\u7d93\u78ba\u7acb\u3002\u5982\u679c\u5728\u5be6\u9a57\u5c0f\u9f20\u6a21\u578b\u4e0a\uff0c\u628aHIF-1\u03b1 <\/span>\u7684\u57fa\u56e0\u7d66\u5254\u9664\u6389\uff0c\u90a3\u5728\u5be6\u9a57\u5c0f\u9f20\u5b55\u671f\u7b2c\u5341\u5929\u5de6\u53f3\uff0c\u80da\u80ce\u5c31\u6703\u505c\u6b62\u767c\u80b2\u4e86\u3002\u9019\u4e9b\u5c0f\u9f20\u80da\u80ce\uff0c\u6703\u56e0\u70ba\u5254\u9664\u6389HIF-1\u03b1 <\/span>\u57fa\u56e0\u800c\u5c0e\u81f4\u8840\u7ba1\u3001\u5fc3\u81df\u767c\u80b2\u4e0d\u5168\uff0c\u53ef\u80fd\u662f\u56e0\u70ba\u5728\u7f3a\u5c11HIF-1\u03b1 <\/span>\u57fa\u56e0\u7684\u72c0\u614b\u4e0b\uff0c\u8840\u7ba1\u7121\u6cd5\u6b63\u5e38\u5f62\u6210\u3002\u5f8c\u4f86\uff0c\u66f4\u6709\u5176\u4ed6\u79d1\u5b78\u5bb6\u7814\u7a76\u767c\u73fe\uff0c\u80ce\u76e4\u8981\u548c\u5b50\u5bae\u5167\u5c64\u5f62\u6210\u5b8c\u6574\u7684\u8840\u7ba1\u7db2\u7d61\uff0c\u4e5f\u662f\u9700\u8981HIF-1\u03b1<\/span> \u7684\u6b63\u5e38\u904b\u4f5c\u3002<\/p>\n

\u800c\u4e14\uff0c\u597d\u7b11\u7684\u662f\uff0c\u5176\u5be6\u5f8c\u4f86\u767c\u73fe\uff0c\u7d05\u8840\u7403\u751f\u6210\u7d20\u5176\u5be6\u66f4\u662f\u6b78HIF \u86cb\u767d\u7684\u8fd1\u89aa\uff1aHIF2-\u03b1<\/span>\u6240\u7ba1\u8f44\u5462\u3002<\/p>\n

\u597d\u7684\u751f\u7269\u5b78\u7b54\u6848\uff0c\u8981\u80fd\u5920\u50cf\u9aa8\u724c\u4e00\u6a23\uff0c\u56de\u7b54\u5b8c\u4e0a\u4e00\u500b\u554f\u984c\u4fbf\u89f8\u767c\u4e86\u4e0b\u4e00\u500b\u554f\u984c\u7684\u5f62\u6210\uff0c\u5982\u6b64\u4e00\u500b\u63a5\u4e00\u500b\u63a5\u529b\u822c\u5730\u50b3\u4e0b\u53bb\u3002\u5728\u627e\u5230HIF-1\u03b1<\/span> \u662f\u6c27\u6c23\u6fc3\u5ea6\u611f\u6e2c\u5668\u7684\u771f\u9762\u76ee\u4e4b\u5f8c\uff0c\u63a5\u8457\uff0c\u79d1\u5b78\u5bb6\u4fbf\u60f3\u77e5\u9053\uff0c\u90a3\u5176\u4e2d\u7684\u4f5c\u7528\u6a5f\u5236\u662f\u4ec0\u9ebc\u5462\uff1f<\/p>\n

\u5f88\u591a\u5be6\u9a57\u5ba4\u90fd\u8b49\u660e\uff0c\u76f8\u8f03\u65bcHIF-1\u03b2<\/span> \u5728\u7d30\u80de\u5167\u7684\u5b58\u91cf\u76f8\u5c0d\u7a69\u5b9a\uff0cHIF-1\u03b1<\/span> \u7684\u86cb\u767d\u8cea\u91cf\u8b8a\u52d5\u6975\u5927\u3002\u4e0d\u904e\uff0c\u6709\u8da3\u7684\u662f\uff0c\u4ee5HIF-1\u03b1<\/span> \u800c\u8a00\uff0c\u9019\u500b\u86cb\u767d\u8cea\u7684\u6d88\u5931\uff0c\u8981\u6bd4\u5176\u5b58\u5728\uff0c\u9084\u66f4\u70ba\u7d30\u80de\u6240\u95dc\u5fc3\u3002\u5728\u4e00\u822c\u6b63\u5e38\u6c27\u91cf\u7684\u74b0\u5883\u5e95\u4e0b\uff0cHIF-1\u03b1<\/span> \u86cb\u767d\u8cea\u6703\u88ab\u898f\u5f8b\u5730\u964d\u89e3\u6389\uff0c\u4e0d\u904e\uff0c\u4e00\u65e6\u6c27\u6c23\u6fc3\u5ea6\u592a\u4f4e\u7684\u6642\u5019\uff0cHIF-1\u03b1<\/span> \u86cb\u767d\u8cea\u5c31\u6703\u9010\u6f38\u7a4d\u7d2f\u5230\u95dc\u9375\u6fc3\u5ea6\uff0c\u7136\u5f8c\u8dd1\u5230\u7d30\u80de\u6838\u88e1\uff0c\u548cHIF-1\u03b2 <\/span>\u86cb\u767d\u5718\u54e1\uff0c\u53bb\u7ba1\u63a7\u8a31\u591a\u57fa\u56e0\u7684\u8868\u73fe\u3002<\/p>\n

\u800c\u53e6\u4e00\u500b\u4eca\u5e74\u8afe\u8c9d\u723e\u6842\u51a0\u5f97\u4e3bKaelin\u535a\u58eb\uff0c\u4fbf\u662f\u89e3\u7b54\u51faHIF-1\u03b1<\/span> \u86cb\u767d\u8cea\u7684\u964d\u89e3\u662f\u5982\u4f55\u88ab\u8abf\u63a7\u7684\u95dc\u9375\u56e0\u7d20\u3002Kaelin\u535a\u58eb\u539f\u672c\u662f\u7814\u7a76\u4e00\u500b\u53eb\u505a VHL \u7684\u6291\u7624\u57fa\u56e0\u3002\u4ed6\u5011\u4e4b\u6240\u4ee5\u5c0d VHL \u57fa\u56e0\u611f\u8208\u8da3\uff0c\u662f\u56e0\u70ba\u4e00\u500b\u8ddf\u6b64\u57fa\u56e0\u8b8a\u7570\u6709\u95dc\u7684\u7f55\u898b\u907a\u50b3\u75be\u75c5\u2014\u2014\u9022\u5e0c\u4f2f-\u6797\u9053\u75c7\u5019\u7fa4\uff08v<\/u>on H<\/u>ippel\u2013Li<\/u>ndau disease\uff09\u3002\u7f79\u75c5\u7684\u75c5\u60a3\u56e0\u70ba\u5728VHL\u57fa\u56e0\u4e0a\u5e36\u6709\u7a81\u8b8a\uff0c\u800c\u4f7f\u5f97\u7d30\u80de\u751f\u9577\u4e0d\u53d7\u63a7\u5236\u904e\u5ea6\u589e\u751f\uff0c\u75c5\u60a3\u4e5f\u6709\u8f03\u9ad8\u7684\u98a8\u96aa\u6703\u7f79\u60a3\u8a31\u591a\u7a2e\u764c\u75c7\u3002<\/p>\n

Kaelin\u535a\u58eb\u5728\u7814\u7a76VHL \u57fa\u56e0\u7684\u6642\u5019\uff0c\u9664\u4e86\u8b49\u5be6\u5176\u6240\u7de8\u78bc\u7684\u86cb\u767d\u8cea\u80fd\u5920\u9632\u7bc4\u764c\u75c7\u7684\u767c\u751f\uff0c\u9084\u767c\u73fe\u7576\u764c\u7d30\u80de\u7f3a\u5c11 VHL \u57fa\u56e0\u7684\u6642\u5019\uff0c\u6703\u540c\u6642\u4e0d\u6b63\u5e38\u5730\u589e\u9ad8\u8ddf\u7f3a\u6c27\u53cd\u61c9\u6709\u95dc\u7684\u57fa\u56e0\u3002\u4e0d\u904e\uff0c\u7576\u6b63\u5e38\u6709\u529f\u80fd\u7684VHL \u57fa\u56e0\u88ab\u91cd\u65b0\u5f15\u5165\u764c\u7d30\u80de\u4e4b\u5f8c\uff0c\u9019\u4e9b\u7f3a\u6c27\u53cd\u61c9\u6709\u95dc\u7684\u57fa\u56e0\u6240\u7de8\u78bc\u7684\u86cb\u767d\u8cea\uff0c\u53c8\u6703\u88ab\u56de\u5fa9\u5230\u6b63\u5e38\u7684\u8868\u73fe\u91cf\u3002\u9019\u662f\u7b2c\u4e00\u500b\u660e\u78ba\u7684\u5be6\u9a57\u8b49\u64da\u6307\u51fa\uff0cVHL \u795e\u5947\u5730\u548c\u7f3a\u6c27\u53cd\u61c9\u7684\u7d30\u80de\u5167\u90e8\u8abf\u7bc0\u6a5f\u8f49\uff0c\u606f\u606f\u76f8\u95dc\u3002<\/p>\n

\u5f8c\u4f86\uff0cKaelin\u535a\u58eb\u548cRatcliffe\u535a\u58eb\u5be6\u9a57\u5ba4\uff08\u9084\u6709\u5176\u4ed6\u5be6\u9a57\u5ba4\u4e5f\u4e00\u540c\u52aa\u529b\uff09\uff0c\u7f3a\u6c27\u8abf\u63a7\u6a5f\u5236\u88e1\u7684\u7e41\u8907\u7d30\u7bc0\uff0c\u624d\u6162\u6162\u62bd\u7d72\u525d\u7e6d\u822c\u7684\u88ab\u91d0\u6e05\u3002\u7d50\u679c\u986f\u793a\uff0c\u7576\u7d30\u80de\u8655\u5728\u6b63\u5e38\u6c27\u6c23\u6fc3\u5ea6\u4e0b\u7684\u6642\u5019\uff0cHIF-1\u03b1 <\/span>\u86cb\u767d\u8cea\u6703\u88ab\u812f\u80fa\u91af\u57fa\u7fa5\u5316\u9176\uff08prolyl-hydroxylase\uff09\u6240\u4f5c\u7528\uff0c\u5728\u5169\u8655\u812f\u80fa\u9178\uff08proline\uff09\u80fa\u57fa\u9178\u7684\u4f4d\u7f6e\u4e0a\u300c\u5b89\u88dd\u4e0a\u300d\u7fa5\u57fa\uff08\u2014OH\uff1bhydroxyl group\uff09\uff0c\u9019\u53cd\u61c9\u5c31\u53eb\u505a\u812f\u80fa\u91af\u57fa\u7fa5\u5316\u4f5c\u7528\uff08prolyl-hydroxylation\uff09\u3002\u88ab\u80fa\u91af\u57fa\u7fa5\u5316\u5f8c\u7684HIF-1a \u86cb\u767d\u8cea\u6703\u767c\u751f\u7d50\u69cb\u4e0a\u6539\u8b8a\uff0c\u80fd\u5920\u88abVHL \u86cb\u767d\u8cea\u6240\u8fa8\u8a8d\u800c\u7d50\u5408\u3002\u4e00\u4f46\u88ab VHL \u86cb\u767d\u8cea\u7d50\u5408\u4e0a\u7684HIF-1\u03b1<\/span>\uff0c\u5c31\u50cf\u662f\u88ab\u597d\u597d\u88dd\u5728\u5783\u573e\u888b\u88e1\u4e86\uff0cVHL \u80fd\u5920\u9032\u4e00\u6b65\u628a\u6cdb\u7d20\uff08ubiquitin\uff09\u5957\u5728 HIF-1\u03b1<\/span>\u8eab\u4e0a\uff0c\u5c0e\u81f4\u5176\u88ab\u6cdb\u86cb\u767d\u5316\u800c\u88ab\u964d\u89e3\u3002<\/p>\n

\u53cd\u4e4b\uff0c\u7576\u7d30\u80de\u8655\u5728\u7f3a\u6c27\u74b0\u5883\u4e0b\u7684\u6642\u5019\uff0c\u6c92\u6709\u6c27\u539f\u6599\u88e1\u7684\u7fa5\u57fa\u53ef\u4f9b\u4ee5\u812f\u80fa\u91af\u57fa\u7fa5\u5316HIF-1\u03b1<\/span>\uff0c\u800c\u6c92\u6709\u7fa5\u57fa\u7684HIF-1\u03b1 <\/span>\u5c31\u50cf\u662f\u6163\u65bc\u6fc3\u599d\u8277\u62b9\u5f8c\u7684\u7d20\u984f\uff0cVHL \u86cb\u767d\u8cea\u6709\u773c\u537b\u8b58\u4e0d\u5f97\uff0c\u4e0d\u6703\u5c07\u5176\u62ce\u9032\u5783\u573e\u888b\u88e1\u6e96\u5099\u4e1f\u6389\uff0c\u65bc\u662f\uff0cHIF-1\u03b1<\/span> \u6fc3\u5ea6\u5c31\u6703\u5728\u7d30\u80de\u8cea\u88e1\u9010\u6f38\u6500\u9ad8\uff0c\u800c\u9054\u5230\u4f5c\u7528\u6fc3\u5ea6\u4e86\u3002<\/p>\n

\u5728\u7f3a\u6c27\u74b0\u5883\u4e0b\uff0c\u7d30\u80de\u6240\u56e0\u61c9\u7684\u611f\u61c9\u6a5f\u5236\u8207\u751f\u7406\u8abf\u7bc0\u4e0d\u4f46\u53ef\u4ee5\u5957\u5165\u4efb\u4f55\u7d30\u80de\uff0c\u764c\u7d30\u80de\u66f4\u662f\u6c92\u653e\u904e\u9019\u500b\u6feb\u7528\u6b64\u6a5f\u5236\u7684\u6a5f\u6703\u3002\u56e0\u6b64\uff0c\u5728\u9019\u689d\u8a0a\u606f\u50b3\u5c0e\u8def\u5f91\u4e0a\u5c0b\u627e\u53ef\u4ee5\u300c\u7528\u85e5\u300d\u7684\u9776\u9ede\uff0c\u4e5f\u4e00\u76f4\u662f\u65b0\u85e5\u7814\u767c\u7684\u91cd\u9ede\u6240\u5728\u3002<\/p>\n

\u8afe\u8c9d\u723e\u91ab\u5b78\u734e\u96d6\u7136\u53ea\u9812\u7d66\u4e86\u4e09\u4f4d\u5be6\u81f3\u540d\u6b78\u7684\u79d1\u5b78\u5bb6\uff0c\u4f46\u66f4\u91cd\u8981\u7684\u662f\u5f8c\u7e8c\u4e00\u68d2\u63a5\u4e00\u68d2\uff0c\u628a\u9019\u6574\u500b\u9818\u57df\u7d66\u767c\u5c55\u6210\u4eca\u65e5\u84ec\u52c3\u4e4b\u8c8c\u7684\u6240\u6709\u79d1\u5b78\u5bb6\u8207\u7814\u7a76\u5718\u968a\u3002\u5982\u679c\uff0c\u4f60\u8eab\u908a\u6709\u4eba\u4e5f\u5728\u5f9e\u4e8b\u76f8\u95dc\u7684\u7814\u7a76\uff0c\u8981\u8a18\u5f97\u4e5f\u597d\u597d\u606d\u559c\u4ed6\u5594\uff01<\/p>\n

\"\"<\/p>\n

\u8afe\u8c9d\u723e\u5f97\u4e3b\u7684\u91cd\u8981\u767c\u8868\uff1a
\n<\/strong><\/p>\n

Semenza<\/strong>\u535a\u58eb\uff1a<\/strong><\/p>\n

    \n
  1. Semenza, G.L<\/u><\/strong>, Nejfelt, M.K., Chi, S.M. &Antonarakis, S.E. (1991). Hypoxia-inducible nuclear factors bind to an enhancer element located 3\u2019 to the human erythropoietin gene. ProcNatlAcadSci USA<\/em>, 88, 5680-5684<\/li>\n
  2. Wang, G.L., Jiang, B.-H., Rue, E.A. &Semenza, G.L<\/u><\/strong>. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.  ProcNatlAcadSci USA<\/em>, 92, 5510-5514<\/li>\n<\/ol>\n

    Ratcliffe<\/strong>\u535a\u58eb\uff1a<\/strong><\/p>\n

      \n
    1. Maxwell, P.H., Wiesener, M.S., Chang, G.-W., Clifford, S.C., Vaux, E.C., Cockman, M.E., Wykoff, C.C., Pugh, C.W., Maher, E.R. &Ratcliffe, P.J<\/u><\/strong>. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature<\/em>, 399, 271-275<\/li>\n
    2. Jaakkola, P., Mole, D.R., Tian, Y.-M., Wilson, M.I., Gielbert, J., Gaskell, S.J., von Kriegsheim, A., Heberstreit, H.F., Mukherji, M., Schofield, C.J., Maxwell, P.H., Pugh, C.W. &Ratcliffe, P.J.<\/u><\/strong> (2001). Targeting of HIF-\u03b1 to the von Hippel-Lindauubiquitylation complex by O2-regulated prolyl hydroxylation. Science<\/em>, 292, 468-472<\/li>\n<\/ol>\n

      Kaelin<\/strong>\u535a\u58eb\uff1a<\/strong><\/p>\n

        \n
      1. Mircea, I., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J.M., Lane, W.S. &Kaelin Jr., W.G. <\/u><\/strong>(2001) HIFa targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science<\/em>, 292, 464-468<\/li>\n<\/ol>\n

         <\/p>\n

        \u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

          \n
        1. Press release: The Nobel Prize in Physiology or Medicine 2019. The Nobel Assembly at KarolinskaInstitutet. https:\/\/www.nobelprize.org\/uploads\/2019\/10\/press-medicine2019.pdf<\/a><\/li>\n
        2. Ledford H, Callaway E. Biologists who decoded how cells sense oxygen win medicine Nobel.Nature<\/em>. 2019 Oct;574(7777):161-162. doi: 10.1038\/d41586-019-02963-0.<\/li>\n
        3. KaelinWGJr, RatcliffePJ, Semenza GL.Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award.JAMA<\/em>. 2016 Sep 27;316(12):1252-3. doi: 10.1001\/jama.2016.12386.<\/li>\n
        4. Marx J.Cell biology. How cells endure low oxygen.Science<\/em>. 2004 Mar 5;303(5663):1454-6.PMID: 15001751 DOI: 10.1126\/science.303.5663.1454<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

          \u990a\u5065\u5eb7\u7d30\u80de\uff0c\u8981\u5bcc\u300c\u6c27\u300d\uff1b\u990a\u75c5\u7d30\u80de\uff0c\u65b9\u7aae\u300c\u6c27\u300d\u3002\u4eca\u5e74\u7684\u8afe\u8c9d\u723e\u751f\u91ab\u734e\uff0c\u9812\u7d66\u4e86\u7814\u7a76\u7f3a\u6c27\u72c0\u614b\u4e0b\uff0c\u7d30\u80de\u5982\u4f55\u56e0\u61c9\u8abf\u7bc0\u7684\u751f\u7406\u6a5f\u5236\uff1b\u5206\u5225\u662f\u70ba\u4f4d\u65bc\u7f8e\u570b\u6ce2\u58eb\u9813Dana-Farber Cancer Institute \u7684William Kaelin\u535a\u58eb\uff0c\u8eab\u5728\u5df4\u723e\u7684\u6469Johns Hopkins University \u7684Gregg Semenza\u535a\u58eb\uff0c\u9084\u6709\u82f1\u570b\u725b\u6d25Francis Crick Institute \u7684PeterRatcliffe\u535a\u58eb\u3002\u9019\u7814\u7a76\u6216\u8a31\u4e0d\u5728\u6240\u6709\u4eba\u7684\u5f97\u734e\u8d85\u7d1a\u5927\u71b1\u9580\u540d\u55ae\u4e0a\uff0c\u4f46\u537b\u7d55\u5c0d\u773e\u671b\u6240\u6b78\u3002<\/p>\n","protected":false},"author":20,"featured_media":34522,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1027,3293,2977,1025],"tags":[3538,1454],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/10\/71935321_10156727398264103_4887808396440371200_n.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34521"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34521"}],"version-history":[{"count":7,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34521\/revisions"}],"predecessor-version":[{"id":34570,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34521\/revisions\/34570"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34522"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}