{"id":34460,"date":"2019-10-09T00:16:32","date_gmt":"2019-10-08T16:16:32","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34460"},"modified":"2019-10-03T11:42:07","modified_gmt":"2019-10-03T03:42:07","slug":"%e9%81%8b%e7%94%a8%e5%8f%af%e7%a9%bf%e9%80%8f%e7%b4%b0%e8%83%9e%e7%9a%84%e8%9e%a2%e5%85%89%e8%9b%8b%e7%99%bd%e7%a0%b4%e8%a7%a3%e7%99%8c%e7%97%87%e8%bd%89%e7%a7%bb%e6%a9%9f%e5%88%b6","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34460","title":{"rendered":"\u904b\u7528\u53ef\u7a7f\u900f\u7d30\u80de\u7684\u87a2\u5149\u86cb\u767d\u7834\u89e3\u764c\u75c7\u8f49\u79fb\u6a5f\u5236"},"content":{"rendered":"<p><span style=\"color: #333399;\"><strong>2019 \u5e74 8 \u6708\u5e95\u7684 <em>Nature<\/em> \u671f\u520a\u5c01\u9762\uff0c\u520a\u767b\u4e86\u95dc\u65bc\u764c\u75c7\u8f49\u79fb\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\u3002\u764c\u75c7\u5c0d\u65bc\u4eba\u9ad4\u7684\u5371\u5bb3\u8207\u9ad8\u5ea6\u81f4\u6b7b\u6027\uff0c\u5f88\u5927\u7684\u539f\u56e0\u6b63\u662f\u764c\u7d30\u80de\u767c\u751f\u4e86\u300c\u8f49\u79fb\u300d\uff0c\u70ba\u4ec0\u9ebc\u764c\u7d30\u80de\u6703\u8dd1\u96e2\u6700\u521d\u767c\u75c5\u4f4d\u7f6e\uff0c\u4e26\u9032\u5c55\u5230\u8eab\u9ad4\u5176\u4ed6\u90e8\u4f4d\u7e7c\u7e8c\u751f\u9577\u4f5c\u60e1\uff1f\u82f1\u570b\u7814\u7a76\u5718\u968a\u958b\u767c\u7684\u65b0\u87a2\u5149\u86cb\u767d\u6280\u8853\uff0c\u770b\u51fa\u4e86\u764c\u75c7\u8f49\u79fb\u6a5f\u5236\u7684\u4e00\u4e9b\u7aef\u502a\u3002<\/strong><\/span><\/p>\n<figure id=\"attachment_34466\" aria-describedby=\"caption-attachment-34466\" style=\"width: 450px\" class=\"wp-caption alignleft\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-34466\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/09\/cell-3089947_1920.jpg\" alt=\"\" width=\"450\" height=\"229\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/09\/cell-3089947_1920.jpg 1920w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/09\/cell-3089947_1920-300x152.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/09\/cell-3089947_1920-768x390.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/09\/cell-3089947_1920-1024x520.jpg 1024w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><figcaption id=\"caption-attachment-34466\" class=\"wp-caption-text\">\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n<p><strong>\u64b0\u6587\uff5c<\/strong><strong>\u694a\u671d\u5091<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u76ee\u524d\u53ea\u80fd\u4f9d\u9760\u5b9a\u671f\u6aa2\u67e5\u9810\u9632\u764c\u75c7\u5fa9\u767c\u53ca\u8f49\u79fb<\/strong><\/span><\/p>\n<p>\u73fe\u4eca\u7684\u91ab\u85e5\u767c\u9054\uff0c\u96d6\u5df2\u8b93\u764c\u75c7\u4e0d\u518d\u662f\u7d55\u75c7\uff0c\u4f46\u4ecd\u7136\u7121\u6cd5\u5b8c\u5168\u653b\u514b\uff0c\u7406\u7531\u662f\u764c\u75c7\u6709\u5f88\u9ad8\u7684\u6a5f\u7387\u6703\u51fa\u73fe\u5fa9\u767c\u548c\u8f49\u79fb\uff0c\u9019\u4e5f\u662f\u9020\u6210\u8a31\u591a\u60a3\u8005\u96e3\u4ee5\u5b58\u6d3b\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u5047\u5982\u764c\u7d30\u80de\u51fa\u73fe\u64f4\u6563\u4e26\u8f49\u79fb\u5230\u9060\u7aef\u90e8\u4f4d\uff0c\u6b64\u4e00\u968e\u6bb5\u4e5f\u88ab\u7a31\u70ba\u300c\u764c\u75c7\u672b\u671f\u300d\u3002\u82e5\u8981\u8b93\u764c\u75c7\u7372\u5f97\u826f\u597d\u7684\u63a7\u5236\uff0c\u76ee\u524d\u81e8\u5e8a\u7684\u4f5c\u6cd5\u53ea\u80fd\u900f\u904e\u5b9a\u671f\u56de\u8a3a\u8ffd\u8e64\u4f86\u9810\u9632\uff0c\u4ee5\u5229\u65e9\u671f\u767c\u73fe\u8207\u53ca\u6642\u6cbb\u7642\u3002<\/p>\n<p>\u764c\u7d30\u80de\u662f\u5426\u6703\u8f49\u79fb\u4e0d\u50c5\u53d6\u6c7a\u65bc\u7d30\u80de\u672c\u8eab\uff0c\u9084\u53d6\u6c7a\u65bc\u9060\u7aef\u90e8\u4f4d\u7684\u5fae\u74b0\u5883 (microenvironment)\uff0c\u4e0d\u904e\u53ea\u6709\u5c11\u6578\u764c\u7d30\u80de\u5728\u62b5\u9054\u65b0\u4f4d\u7f6e\u5f8c\uff0c\u80fd\u5728\u90a3\u88e1\u6210\u529f\u843d\u8173\u4e26\u589e\u6b96\u3002\u7136\u800c\uff0c\u95dc\u65bc\u7e7c\u767c\u4f4d\u7f6e\u5982\u4f55\u5e6b\u52a9\u764c\u7d30\u80de\u751f\u9577\u7684\u65e9\u671f\u904e\u7a0b\u4ecd\u7136\u77e5\u4e4b\u751a\u5c11\uff0c\u90e8\u5206\u539f\u56e0\u662f\u7f3a\u4e4f\u5408\u9069\u7684\u5206\u6790\u5de5\u5177\uff0c\u7d93\u7531 Luigi Ombrato \u7b49\u4eba\u7d44\u6210\u7684\u82f1\u570b\u7814\u7a76\u5718\u968a\uff0c\u958b\u767c\u51fa\u7684\u65b0\u6280\u8853\u6210\u529f\u514b\u670d\u9019\u9053\u96e3\u984c\uff0c\u63a5\u8457\u4f86\u770b\u770b\u5177\u9ad4\u65b9\u6cd5\u662f\u600e\u9ebc\u505a\u7684\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u7814\u7a76\u764c\u7d30\u80de\u8f49\u79fb\u7684\u5229\u5668\uff1a\u53ef\u6ef2\u900f\u7d30\u80de\u7684\u87a2\u5149\u86cb\u767d<\/strong><\/span><\/p>\n<p>\u60f3\u50cf\u4e00\u4e0b\uff0c\u5728\u4f38\u624b\u4e0d\u898b\u4e94\u6307\u7684\u9ed1\u6697\u4e2d\uff0c\u5982\u679c\u6709\u4e00\u76de\u660e\u71c8\uff0c\u9664\u4e86\u80fd\u7167\u4eae\u5468\u906d\u7684\u4e8b\u7269\uff0c\u4e5f\u80fd\u5920\u5728\u9060\u8655\u8f15\u6613\u7684\u8ffd\u8e64\u71c8\u5149\u7684\u79fb\u52d5\u4f4d\u7f6e\u3002\u79d1\u5b78\u5bb6\u5011\u958b\u767c\u51fa\u4e00\u5957\u6a19\u8a18\u7cfb\u7d71\u5c31\u985e\u4f3c\u9019\u6a23\u7684\u60f3\u6cd5\uff0c\u904b\u7528\u4e86\u4e00\u7a2e\u65b0\u7684\u300c\u87a2\u5149\u86cb\u767d\u300d\uff0c\u5176\u7279\u6b8a\u4e4b\u8655\u5728\u65bc\u80fd\u5920\u6ef2\u900f\u8102\u8cea (\u7d30\u80de\u819c\u7684\u6210\u4efd)\uff0c\u9019\u4f7f\u5f97\u87a2\u5149\u86cb\u767d\u80fd\u4ee5\u53ef\u6eb6\u5f62\u5f0f\u5f9e\u764c\u7d30\u80de\u4e2d\u91cb\u653e\u51fa\u4f86\uff0c\u4e26\u88ab\u76f8\u9130\u7684\u7d30\u80de\u5438\u6536\u3002\u7c21\u55ae\u4f86\u8aaa\uff0c\u5e36\u6709\u6b64\u7279\u6b8a\u87a2\u5149\u86cb\u767d\u7684\u764c\u7d30\u80de\uff0c\u80fd\u5920\u4f7f\u5176\u5468\u906d\u7684\u5065\u5eb7\u7d30\u80de\u88ab\u67d3\u4e0a\u76f8\u540c\u7684\u87a2\u5149\u3002<\/p>\n<p>\u5efa\u7acb\u9019\u5957\u6a19\u8a18\u7cfb\u7d71\u5f8c\uff0c\u79d1\u5b78\u5bb6\u63a5\u8457\u6a21\u64ec\u764c\u7d30\u80de\u662f\u5982\u4f55\u8f49\u79fb\u7684\u3002\u9996\u5148\u5c07\u5e36\u6709\u6b64\u7279\u6b8a\u87a2\u5149\u86cb\u767d\u7684\u5c0f\u9f20\u4e73\u764c\u7d30\u80de\uff0c\u6ce8\u5c04\u5230\u5c0f\u9f20\u5c3e\u5df4\u7684\u975c\u8108\u4e2d\u96a8\u8457\u8840\u6db2\u6d41\u52d5\uff0c\u5982\u679c\u4e73\u764c\u7d30\u80de\u5728\u5c0f\u9f20\u9ad4\u5167\u67d0\u8655\u505c\u7559\u4e26\u751f\u9577\u6210\u816b\u7624\uff0c\u5247\u4ee3\u8868\u51fa\u73fe\u8f49\u79fb\uff0c\u4e5f\u80fd\u9032\u4e00\u6b65\u89c0\u5bdf\u816b\u7624\u5468\u906d\u88ab\u67d3\u4e0a\u87a2\u5149\u7684\u5065\u5eb7\u7d30\u80de\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5f9e\u5c3e\u5df4\u9032\u5165\u5c0f\u9f20\u9ad4\u5167\u7684\u4e73\u764c\u7d30\u80de\uff0c\u5728\u80ba\u90e8\u767c\u751f\u4e86\u8f49\u79fb\uff0c\u85c9\u7531\u5206\u6790\u76f8\u9130\u8457\u764c\u7d30\u80de\u88ab\u67d3\u8272\u7684\u80ba\u90e8\u7d30\u80de\uff0c\u5c31\u80fd\u4e86\u89e3\u9060\u7aef\u90e8\u4f4d\u7684\u5fae\u74b0\u5883\u662f\u600e\u9ebc\u8207\u764c\u7d30\u80de\u4e92\u76f8\u4f5c\u7528\uff0c\u6700\u7d42\u5c0e\u81f4\u8f49\u79fb\u767c\u751f\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u764c\u7d30\u80de\u5728\u8f49\u79fb\u8655\uff0c\u4f7f\u5f97\u76f8\u9130\u5065\u5eb7\u7d30\u80de\u5177\u6709\u985e\u4f3c\u5e79\u7d30\u80de\u7279\u6027<\/strong><\/span><\/p>\n<p>\u7814\u7a76\u767c\u73fe\u88ab\u67d3\u8272\u7684\u5065\u5eb7\u7d30\u80de\u4e3b\u8981\u662f\u4e00\u7a2e\u80ba\u6ce1\u7b2c\u4e8c\u578b\u7d30\u80de (alveolar type II cell)\uff0c\u7c21\u7a31\u70ba AT2 \u7d30\u80de\uff0c\u800c\u5947\u602a\u7684\u662f\u9019\u4e9b AT2 \u7d30\u80de\u5177\u6709\u985e\u4f3c\u5e79\u7d30\u80de\u7279\u6027\uff0c\u56e0\u70ba\u80ba\u90e8\u5927\u591a\u6578 AT2 \u7d30\u80de\u61c9\u8a72\u662f\u6c92\u6709\u5e79\u7d30\u80de\u7279\u6027\u7684\u3002\u6b64\u7d50\u679c\u4ee3\u8868\u8457\u5e7e\u7a2e\u53ef\u80fd\u6027\uff1a\u764c\u7d30\u80de\u53ef\u80fd\u66f4\u559c\u6b61\u843d\u8173\u5728\u80ba\u5e79\u7d30\u80de\u9644\u8fd1\uff1f\u6216\u8005\u80fd\u5c07\u80ba\u5e79\u7d30\u80de\u52df\u96c6\u5230\u81ea\u8eab\u5468\u570d\uff1f\u53c8\u6216\u8005\uff0c\u764c\u7d30\u80de\u6703\u9a45\u52d5\u76f8\u9130\u7684 AT2 \u7d30\u80de\u5448\u73fe\u985e\u4f3c\u5e79\u7d30\u80de\u7279\u6027\uff1f<\/p>\n<p>\u7814\u7a76\u900f\u904e\u9ad4\u5916\u7d30\u80de\u57f9\u990a\u5be6\u9a57\uff0c\u8b49\u5be6\u4e00\u65e6\u6709\u764c\u7d30\u80de\u5b58\u5728\uff0cAT2 \u7d30\u80de\u5c31\u6703\u8868\u73fe\u51fa\u985e\u4f3c\u5e79\u7d30\u80de\u7684\u7279\u6027\uff0c\u9019\u4e5f\u610f\u6307\u4e0a\u8ff0\u6700\u5f8c\u4e00\u7a2e\u63a8\u6e2c\u624d\u662f\u6b63\u78ba\u7684\u3002\u9019\u4e5f\u7522\u751f\u66f4\u7cdf\u7cd5\u7684\u5f8c\u679c\uff0c\u56e0\u70ba\u5e79\u7d30\u80de\u7279\u6027\u53c8\u6703\u4fc3\u9032\u764c\u7d30\u80de\u589e\u6b96\uff0c\u6700\u7d42\u9677\u9032\u4e86\u764c\u75c7\u8f49\u79fb\u548c\u816b\u7624\u751f\u9577\u7684\u300c\u60e1\u6027\u5faa\u74b0\u300d\u6ce5\u6cbc\u88e1\u3002<\/p>\n<p>\u9019\u5957\u6a19\u8a18\u7cfb\u7d71\u6210\u529f\u89c0\u6e2c\u4e86\u764c\u7d30\u80de\u5982\u4f55\u8f49\u79fb\uff0c\u4f46\u7a0d\u5fae\u53ef\u60dc\u7684\u662f\u87a2\u5149\u86cb\u767d\u88ab\u7d30\u80de\u5438\u6536\u5f8c\u53ea\u80fd\u7dad\u6301\u7a69\u5b9a\u7d04 48 \u5c0f\u6642\uff0c\u56e0\u6b64\u50c5\u53ef\u8a55\u4f30\u8f49\u79fb\u90e8\u4f4d\u7684\u521d\u59cb\u8b8a\u5316\uff0c\u4e26\u4e0d\u9069\u5408\u9577\u671f\u8ffd\u8e64\u3002\u4e0d\u904e\u672a\u4f86\u9084\u662f\u6709\u671b\u89e3\u7b54\uff0c\u70ba\u4ec0\u9ebc\u67d0\u985e\u764c\u7d30\u80de\u6703\u50be\u5411\u8f49\u79fb\u5230\u7279\u5b9a\u5668\u5b98\uff1f\u4f8b\u5982\u651d\u8b77\u817a\u764c\u6700\u5bb9\u6613\u767c\u751f\u9aa8\u9abc\u8f49\u79fb\u3002\u96a8\u8457\u91ab\u5b78\u754c\u5c0d\u764c\u75c7\u8f49\u79fb\u6a5f\u5236\u4e86\u89e3\u5f97\u8d8a\u6e05\u695a\uff0c\u5c07\u4f86\u8d8a\u6709\u6a5f\u6703\u963b\u6b62\u764c\u7d30\u80de\u4f7f\u51fa\u8f49\u79fb\u7684\u81f4\u547d\u6bba\u624b\u9427\uff0c\u4ee5\u53ca\u907f\u514d\u764c\u7d30\u80de\u4fb5\u5bb3\u76f8\u9130\u5065\u5eb7\u7d30\u80de\u96a8\u5176\u70ba\u975e\u4f5c\u6b79\uff0c\u9032\u800c\u5f62\u6210\u7e7c\u767c\u6027\u816b\u7624\u3002\u7562\u7adf\uff0c\u5982\u679c\u80fd\u9650\u5236\u764c\u7d30\u80de\u7684\u8f49\u79fb\u884c\u52d5\uff0c\u7121\u6cd5\u50be\u5de2\u800c\u51fa\u7684\u764c\u7d30\u80de\u5c31\u8b8a\u6210\u4e86\u7c60\u4e2d\u4e4b\u9ce5\uff0c\u9019\u6a23\u85e5\u7269\u6cbb\u7642\u4e5f\u53ef\u66f4\u6709\u6548\u5730\u5c07\u5176\u4e00\u7db2\u6253\u76e1\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Asselin-Labat ML. Nature. 2019 Aug;572(7771):589-590. <a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02399-6\">Cells tagged near an early spread of cancer.<\/a><\/li>\n<li>Ombrato L, et al. Nature. 2019 Aug;572(7771):603-608. <a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1487-6\">Metastatic-niche labelling reveals parenchymal cells with stem features.<\/a><\/li>\n<\/ol>\n<p><strong><span class=\"il\">--<br \/>\n\u4f5c\u8005<\/span>\uff1a\u694a\u671d\u5091&nbsp; \u6210\u5927\u5fae\u514d\u6240\u78a9\u58eb\uff0c\u66fe\u8457\u6709\u300a\u5716\u89e3\u91ab\u5b78\u300b\u4e00\u66f8\uff0c<wbr>\u6a02\u65bc\u5c07\u91ab\u5b78\u65b0\u77e5\u4ee5\u6dfa\u767d<span class=\"il\">\u7684<\/span>\u6587\u5b57\u8b93\u66f4\u591a\u4eba\u4e86\u89e3\u3002<\/strong><\/p>\n<p><a href=\"https:\/\/line.me\/R\/ti\/p\/%40fcx6182w\" target=\"_blank\" rel=\"noopener noreferrer\"><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2019 \u5e74 8 \u6708\u5e95\u7684 Nature \u671f\u520a\u5c01\u9762\uff0c\u520a\u767b\u4e86\u95dc\u65bc\u764c\u75c7\u8f49\u79fb\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\u3002\u764c\u75c7\u5c0d\u65bc\u4eba\u9ad4\u7684\u5371\u5bb3\u8207\u9ad8\u5ea6\u81f4\u6b7b\u6027\uff0c\u5f88\u5927\u7684\u539f\u56e0\u6b63\u662f\u764c\u7d30\u80de\u767c\u751f\u4e86\u300c\u8f49\u79fb\u300d\uff0c\u70ba\u4ec0\u9ebc\u764c\u7d30\u80de\u6703\u8dd1\u96e2\u6700\u521d\u767c\u75c5\u4f4d\u7f6e\uff0c\u4e26\u9032\u5c55\u5230\u8eab\u9ad4\u5176\u4ed6\u90e8\u4f4d\u7e7c\u7e8c\u751f\u9577\u4f5c\u60e1\uff1f\u82f1\u570b\u7814\u7a76\u5718\u968a\u958b\u767c\u7684\u65b0\u87a2\u5149\u86cb\u767d\u6280\u8853\uff0c\u770b\u51fa\u4e86\u764c\u75c7\u8f49\u79fb\u6a5f\u5236\u7684\u4e00\u4e9b\u7aef\u502a\u3002<\/p>\n","protected":false},"author":20,"featured_media":34466,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4375,4009,4376],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/09\/cell-3089947_1920.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34460"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34460"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34460\/revisions"}],"predecessor-version":[{"id":34467,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34460\/revisions\/34467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34466"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34460"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34460"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34460"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}