{"id":34371,"date":"2019-08-29T00:15:29","date_gmt":"2019-08-28T16:15:29","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34371"},"modified":"2019-08-23T10:48:00","modified_gmt":"2019-08-23T02:48:00","slug":"%e5%a4%a7%e8%85%a6%e7%9a%84%e7%b3%96%e5%b0%bf%e7%97%85%ef%bc%8d%ef%bc%8d%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34371","title":{"rendered":"\u5927\u8166\u7684\u7cd6\u5c3f\u75c5\uff0d\uff0d\u963f\u8332\u6d77\u9ed8\u75c7\uff1f"},"content":{"rendered":"
\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c\u5468\u739f\u8431<\/strong><\/p>\n

\u904e\u53bb\u7684\u7814\u7a76\u544a\u8a34\u6211\u5011\uff0c\u8166\u5167\u82e5\u662f\u7d2f\u7a4d\u904e\u591a\u7684\u795e\u7d93\u7e96\u7dad\u7cfe\u7d50(Neurofibrillary tangles)\u53ca\u03b2\u6fb1\u7c89\u6a23\u86cb\u767d\u8cea\u57a2\u584a(Plaques  of  \u03b2 amyloid  proteins)\uff0c\u5f88\u53ef\u80fd\u5f15\u767c\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u4f46\u4e5f\u6709\u5b78\u8005\u628a\u963f\u8332\u6d77\u9ed8\u75c7\u5217\u70ba\u300c\u7b2c\u4e09\u578b\u7cd6\u5c3f\u75c5\u300d\u6216\u662f\u300c\u5927\u8166\u7684\u7cd6\u5c3f\u75c5\u300d\uff0c\u56e0\u70ba\u6709\u8d8a\u4f86\u8d8a\u591a\u7814\u7a76\u544a\u8a34\u6211\u5011\uff0c\u80f0\u5cf6\u7d20\u529f\u80fd\u7570\u5e38\u9084\u6709\u8840\u7cd6\u4ee3\u8b1d\u4e0d\u4f73\uff0c\u4e5f\u662f\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u5371\u96aa\u56e0\u5b50\u4e4b\u4e00\u3002\u96e3\u9053\u8aaa\u5728\u672a\u4f86\uff0c\u6211\u5011\u6709\u53ef\u80fd\u85c9\u7531\u53e3\u670d\u6297\u7cd6\u5c3f\u75c5\u85e5\u7269\uff0c\u4f86\u964d\u4f4e\u7f79\u60a3\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u6a5f\u7387\uff0c\u6216\u5ef6\u7de9\u5931\u667a\u75c7\u75c7\u72c0\u767c\u5c55\u55ce\uff1f<\/p>\n

\u25cf\u7cd6\u5c3f\u75c5\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u4e4b\u9593\u7684\u9023\u7d50<\/strong><\/span><\/p>\n

\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u662f\u4e00\u7a2e\u75c5\u7a0b\u7de9\u6162\uff0c\u4e26\u4e14\u6703\u5c0e\u81f4\u60a3\u8005\u8a8d\u77e5\u529f\u80fd\u9010\u6b65\u9000\u5316\u7684\u75be\u75c5\u3002\u60a3\u8005\u6703\u5148\u5fd8\u8a18\u624d\u525b\u767c\u751f\u7684\u4e8b\uff0c\u96a8\u8457\u75c5\u7a0b\u767c\u5c55\uff0c\u65b9\u5411\u611f\u3001\u8a9e\u8a00\u80fd\u529b\u3001\u60c5\u7dd2\u7ba1\u7406\u4ee5\u53ca\u751f\u6d3b\u81ea\u7406\u80fd\u529b\u90fd\u6703\u4e00\u4e00\u9000\u5316\u76f4\u5230\u6b7b\u4ea1\u3002\u5728\u6b63\u5e38\u7684\u60c5\u6cc1\u4e0b\uff0c\u4eba\u985e\u7684\u5927\u8166\u4e3b\u8981\u4ef0\u8cf4\u8840\u7cd6\u4f86\u4fdd\u6301\u6b63\u5e38\u904b\u4f5c\uff0c\u53ef\u662f\u5927\u8166\u4e0d\u6703\u81ea\u884c\u5408\u6210\u6216\u5132\u5b58\u91a3\u985e\uff0c\u8166\u5167\u7684\u8840\u7cd6\u5e73\u8861\u53ea\u80fd\u9760\u80f0\u5cf6\u7d20\u4f86\u7dad\u6301\uff0c\u6240\u4ee5\u7cd6\u5c3f\u75c5\u60a3\u8005\u56e0\u70ba\u80f0\u5cf6\u7d20\u529f\u80fd\u7570\u5e38\uff0c\u5bb9\u6613\u767c\u751f\u4ee5\u4e0b\u5e7e\u7a2e\u72c0\u6cc1\uff1a<\/p>\n

    \n
  1. \u8840\u7cd6\u904e\u9ad8\u7684\u6642\u5019\uff0c\u591a\u9918\u7684\u7cd6\u4efd\u5c31\u6703\u9ecf\u9644\u5728\u8eab\u9ad4\u5404\u500b\u69cb\u9020\u4e0a\uff0c\u5bb9\u6613\u9020\u6210\u52d5\u8108\u786c\u5316\u3001\u4e2d\u98a8\u7b49\u75c7\u72c0\uff0c\u63d0\u9ad8\u5931\u667a\u98a8\u96aa\uff0c\u4f46\u5982\u679c\u70ba\u4e86\u63a7\u5236\u8840\u7cd6\uff0c\u8b93\u8840\u7cd6\u4e00\u4e0b\u5b50\u964d\u5f97\u592a\u4f4e\uff0c\u8a8d\u77e5\u529f\u80fd\u4e5f\u96e3\u4ee5\u6b63\u5e38\u904b\u4f5c\u3002<\/li>\n
  2. \u5927\u5e45\u6ce2\u52d5\u7684\u8840\u7cd6\u503c\u6703\u63d0\u9ad8\u8840\u9ad4\u5167\u6c27\u5316\u58d3\u529b\uff0c\u53d7\u5230\u6c27\u5316\u58d3\u529b\u5f71\u97ff\u7684\u7d30\u80de\u8ddf\u751f\u93fd\u7684\u9435\u4e00\u6a23\u8106\u5f31\uff0c\u5b83\u5011\u6bd4\u6b63\u5e38\u7d30\u80de\u66f4\u5bb9\u6613\u767c\u708e\u8ddf\u8001\u5316\uff0c\u66fe\u6709\u4eba\u5728\u8f15\u5ea6\u8a8d\u77e5\u969c\u7919\u60a3\u8005\u7684\u9873\u8449\u3001\u6d77\u99ac\u8ff4\u4ee5\u53ca\u524d\u984d\u8449\uff0c\u627e\u5230\u8a31\u591a\u904e\u5ea6\u6c27\u5316\u7684\u86cb\u767d\u8cea\u3002<\/li>\n
  3. \u6211\u5011\u7684\u9ad4\u5167\u6709\u4e00\u7a2e\u9175\u7d20\uff0c\u53eb\u505a\u80f0\u5cf6\u7d20\u964d\u89e3\u9176(insulin degrading enzyme)\uff0c\u5b83\u80fd\u5920\u5206\u89e3\u904e\u91cf\u7684\u6fb1\u7c89\u6a23\u86cb\u767d\u8207\u80f0\u5cf6\u7d20\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80f0\u5cf6\u7d20\u963b\u6297(Insulin resistance)\uff0c\u6703\u4f7f\u7d30\u80de\u53d7\u9ad4\u5c0d\u80f0\u5cf6\u7d20\u7684\u654f\u611f\u5ea6\u4e0b\u964d\uff0c\u7121\u6cd5\u6b63\u5e38\u5229\u7528\u8840\u7cd6\uff0c\u9019\u6642\u5019\u9ad4\u5167\u5c31\u6703\u7522\u751f\u66f4\u591a\u7684\u80f0\u5cf6\u7d20\u4f86\u8a66\u5716\u964d\u8840\u7cd6\uff0c\u4f46\u9019\u8b93\u80f0\u5cf6\u7d20\u964d\u89e3\u9176\u66f4\u52aa\u529b\u7684\u60f3\u628a\u591a\u51fa\u4f86\u7684\u80f0\u5cf6\u7d20\u6e05\u4e7e\u6de8\uff0c\u6fb1\u7c89\u6a23\u86cb\u767d\u5c31\u6709\u66f4\u591a\u6a5f\u6703\u56e4\u7a4d\u4e0b\u4f86\uff0c\u589e\u52a0\u5931\u667a\u98a8\u96aa\u3002<\/li>\n<\/ol>\n

    \u25cf\u662f\u5426\u670d\u7528\u6297\u7cd6\u5c3f\u75c5\u85e5\u7269\u7684\u5dee\u7570<\/strong><\/span><\/p>\n

    \u97d3\u570b\u6e05\u6d32\u5927\u5b78\u7684\u5718\u968a\u5f9e2002\u5e74\u8d77\u81f32013\u5e74\uff0c\u900f\u904e\u5168\u6c11\u5065\u4fdd\u8cc7\u6599\u5eab(National Health Insurance Service Database)\u6a94\u6848\uff0c\u5206\u6790\u4ee5\u4e0b\u5169\u7fa4\u4eba\u53e3\u7684\u670d\u85e5\u7fd2\u6163\uff0c\u4ee5\u53ca\u4ed6\u5011\u7f79\u60a3\u5931\u667a\u75c7\u7684\u6a5f\u7387\uff0c\u4f86\u63a2\u8a0e\u53e3\u670d\u6297\u7cd6\u5c3f\u75c5\u85e5\u7269\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u95dc\u4fc2\uff1a<\/p>\n

      \n
    1. \u5df2\u78ba\u8a3a\u70ba\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u768460\u6b72\u4ee5\u4e0a\u4eba\u53e3\uff0c\u767c\u75c5\u4e00\u5e74\u5167\u5373\u4f7f\u7528\u53e3\u670d\u85e5\u7269(\u517144148\u4eba)\u3002<\/li>\n
    2. \u5df2\u78ba\u8a3a\u70ba\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u768460\u6b72\u4ee5\u4e0a\u4eba\u53e3\uff0c\u4f46\u5f9e\u4f86\u6c92\u6709\u5403\u904e\u53e3\u670d\u85e5\u7269(\u517171991\u4eba)\u3002<\/li>\n<\/ol>\n

      \u6574\u9ad4\u800c\u8a00\uff0c\u6709\u670d\u85e5\u7684\u4eba\u53e3\u7f79\u60a3\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u6a5f\u7387\u660e\u986f\u8f03\u4f4e\u65bc\u53e6\u4e00\u7fa4\u4eba\uff0c\u800c\u4f7f\u7528\u8d85\u904e\u4e00\u7a2e\u53e3\u670d\u6297\u7cd6\u5c3f\u75c5\u85e5\u7269\u7684\u4eba\uff0c\u7f79\u60a3\u5931\u667a\u75c7\u7684\u6a5f\u7387\u53c8\u6bd4\u53ea\u5403\u7279\u5b9a\u85e5\u7684\u4eba\u9084\u8981\u4f4e\u3002\u53ef\u662f\u56e0\u70ba\u6297\u7cd6\u5c3f\u75c5\u85e5\u7a2e\u985e\u7e41\u96dc\uff0c\u76ee\u524d\u7684\u7814\u7a76\u7121\u6cd5\u4fdd\u8b49\u8a66\u5403\u54ea\u5e7e\u7a2e\u6548\u679c\u6700\u597d\uff0c\u5728\u672a\u7d93\u5c08\u5bb6\u8a55\u4f30\u7684\u60c5\u6cc1\u4e0b\u4efb\u610f\u670d\u7528\u597d\u5e7e\u7a2e\u85e5\u7269\uff0c\u53ef\u80fd\u6703\u9020\u6210\u53cd\u6548\u679c\uff0c\u7136\u800c\u6211\u5011\u4e26\u4e0d\u78ba\u5b9a\u539f\u56e0\u3002<\/p>\n

      \u70ba\u4ec0\u9ebc\u9019\u4e9b\u53e3\u670d\u6297\u7cd6\u5c3f\u75c5\u85e5\u7269\u7591\u4f3c\u53ef\u4ee5\u964d\u4f4e\u5931\u667a\u6a5f\u7387\uff1f\u76ee\u524d\u591a\u6578\u79d1\u5b78\u5bb6\u8a8d\u70ba\uff0c\u53e3\u670d\u6297\u7cd6\u5c3f\u75c5\u85e5\u7269\u80fd\u5e6b\u52a9\u9577\u8005\u7dad\u6301\u7a69\u5b9a\u7684\u8840\u7cd6\u503c\uff0c\u540c\u6642\u964d\u4f4e\u5927\u8166\u5c0d\u80f0\u5cf6\u7d20\u7684\u6297\u62d2\u6027\uff0c\u4f7f\u5f97\u8840\u7cd6\u53ef\u4ee5\u5145\u5206\u5730\u88ab\u5438\u6536\u904b\u7528\uff0c\u5e6b\u52a9\u5927\u8166\u6e05\u9664\u5404\u7a2e\u5ee2\u7269(\u5305\u542b\uff1a\u4e59\u578b\u6fb1\u7c89\u6a23\u86cb\u767d\u57a2\u584a\u3001\u795e\u7d93\u7e96\u7dad\u7cfe\u7d50\u3001\u6b7b\u4ea1\u7d30\u80de\u7684\u6b98\u7559\u7269\u7b49)\u3002<\/p>\n

      \u4e0d\u904e\u5065\u4fdd\u8cc7\u8a0a\u7cfb\u7d71\u53ea\u80fd\u53cd\u61c9\u9577\u8f29\u90e8\u5206\u7684\u7528\u85e5\u7fd2\u6163\uff0c\u7121\u6cd5\u4ee3\u8868\u751f\u6d3b\u6240\u6709\u5c64\u9762\uff0c\u6240\u4ee5\u7814\u7a76\u7d50\u679c\u7684\u63a8\u8ad6\uff0c\u53ef\u80fd\u53d7\u8a31\u591a\u96e3\u4ee5\u6392\u9664\u7684\u6df7\u6dc6\u8b8a\u9805\u5e72\u64fe\uff0c\u4f8b\u5982\uff1a\u751f\u6d3b\u58d3\u529b\u3001\u5c0b\u6c42\u6c11\u4fd7\u7642\u6cd5\u3001\u793e\u6703\u652f\u6301\u591a\u5be1\u7b49\u3002<\/p>\n

      \u25cf\u7d50\u8a9e<\/strong><\/span><\/p>\n

      \u6211\u5011\u66fe\u7d93\u628a\u7cd6\u5c3f\u75c5\u9084\u6709\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u770b\u6210\u662f\u5169\u7a2e\u4e0d\u540c\u7684\u75be\u75c5\uff0c\u4f46\u8fd1\u5e74\u7684\u7814\u7a76\u5f37\u8abf\uff0c\u5982\u679c\u6211\u5011\u8981\u6df1\u7a76\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u75c5\u56e0\uff0c\u90a3\u5c31\u4e0d\u80fd\u907a\u6f0f\u80f0\u5cf6\u7d20\u529f\u80fd\u7684\u91cd\u8981\u6027\uff1a\u80f0\u5cf6\u7d20\u5931\u5e38\u5c07\u4f7f\u8166\u5167\u7684\u4ee3\u8b1d\u5ee2\u7269\u66f4\u96e3\u6e05\u9664\uff0c\u5927\u5e45\u63d0\u5347\u7f79\u60a3\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u6a5f\u7387\u3002<\/p>\n

      \u96d6\u7136\u6211\u5011\u9084\u662f\u9700\u8981\u66f4\u591a\u8b49\u64da\uff0c\u624d\u80fd\u91d0\u6e05\u6297\u7cd6\u5c3f\u75c5\u85e5\u7269\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u4e4b\u9593\u7684\u95dc\u4fc2\uff0c\u4e0d\u904e\u63db\u500b\u89d2\u5ea6\u601d\u8003\uff1a\u53ea\u5c11\u6211\u5011\u73fe\u5728\u66f4\u52a0\u78ba\u5b9a\uff0c\u9069\u5ea6\u7684\u904b\u52d5\u4ee5\u53ca\u5747\u8861\u7684\u71df\u990a\uff0c\u4e0d\u53ea\u53ef\u4ee5\u5e6b\u52a9\u6211\u5011\u9060\u96e2\u7cd6\u5c3f\u75c5\uff0c\u540c\u6642\u4e5f\u662f\u5728\u964d\u4f4e\u5931\u667a\u98a8\u96aa\u3002<\/p>\n

       <\/p>\n

      \u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

        \n
      1. Ju Young Kim., Young Sook Ku., Hyun Jeong Kim., Nga Thi Trinh., Woorim Kim., Bomi Jeong., Tae Young Heo., Myung Koo Lee & Kyung Eun Lee., Oral diabetes medication and risk of dementia in <\/a>elderly patients with type 2 diabetes., Diabetes Research and Clinical Practice., 2019<\/a><\/li>\n
      2. Virginia Boccardi., Ilenia Murasecco & Patrizia Mecocci., Diabetes drugs in the fight against <\/a>Alzheimer\u2019s disease., Ageing Research Reviews., 2019<\/a><\/li>\n<\/ol>\n

        \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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