{"id":34370,"date":"2019-09-11T00:15:29","date_gmt":"2019-09-10T16:15:29","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34370"},"modified":"2019-12-19T12:11:25","modified_gmt":"2019-12-19T04:11:25","slug":"%e5%88%a9%e7%94%a8%e7%b4%b0%e8%8f%8c%e4%b8%8a%e6%bc%94%e6%9c%a8%e9%a6%ac%e5%b1%a0%e3%80%8c%e7%98%a4%e3%80%8d%e8%a8%98","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34370","title":{"rendered":"\u5229\u7528\u7d30\u83cc\u4e0a\u6f14\u6728\u99ac\u5c60\u300c\u7624\u300d\u8a18"},"content":{"rendered":"<figure id=\"attachment_34377\" aria-describedby=\"caption-attachment-34377\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-34377\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/08\/1872666_1920.jpg\" alt=\"\" width=\"650\" height=\"325\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/08\/1872666_1920.jpg 1920w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/08\/1872666_1920-300x150.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/08\/1872666_1920-768x384.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/08\/1872666_1920-1024x512.jpg 1024w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><figcaption id=\"caption-attachment-34377\" class=\"wp-caption-text\">\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n<p><span style=\"color: #333399;\"><strong>\u8033\u719f\u80fd\u8a73\u7684\u6728\u99ac\u5c60\u57ce\u8a18\uff0c\u901a\u904e\u58eb\u5175\u8eb2\u5728\u507d\u88dd\u6210\u6230\u5229\u54c1\u7684\u6728\u99ac\u5167\uff0c\u6210\u529f\u6f5b\u5165\u6575\u71df\u596a\u53d6\u4e86\u7279\u6d1b\u4f0a\u57ce\uff0c\u4e5f\u56e0\u6b64\u5f97\u540d\u70ba\u7279\u6d1b\u4f0a\u6728\u99ac (Trojan Horse)\u3002\u76f4\u63a5\u653b\u6253\u6575\u4eba\u5de2\u7a74\uff0c\u5f80\u5f80\u662f\u6700\u80fd\u5fb9\u5e95\u6d88\u6ec5\u6575\u4eba\u7684\u65b9\u6cd5\uff0c\u6700\u8fd1\u7f8e\u570b\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78\u7684\u79d1\u5b78\u5bb6\u767c\u8868\u5728 <em>Nature Medicine<\/em> \u7684\u7814\u7a76\uff0c\u5c07\u57fa\u56e0\u91cd\u65b0\u7de8\u7a0b\u7684\u975e\u81f4\u75c5\u83cc\u83cc\u682a\uff0c\u63a1\u7528\u7279\u6d1b\u4f0a\u6728\u99ac\u7684\u7b56\u7565\uff0c\u9001\u5230\u5c0f\u9f20\u6a21\u578b\u7684\u5be6\u9ad4\u816b\u7624\u5167\u90e8\uff0c\u53ef\u5f15\u767c\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u816b\u7624\uff0c\u9054\u5230\u6d88\u9664\u764c\u7d30\u80de\u7684\u6548\u679c\u3002<\/strong><\/span><\/p>\n<p><strong>\u64b0\u6587\uff5c<\/strong><strong>\u694a\u671d\u5091<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u70ba\u4ec0\u9ebc\u6cbb\u7642\u764c\u75c7\u9084\u9700\u8981\u627e\u7d30\u83cc\u7576\u5e6b\u624b\uff1f<\/strong><\/span><\/p>\n<p>\u4f60\u4e00\u5b9a\u5f88\u597d\u5947\u9019\u500b\u554f\u984c\uff0c\u5728\u89e3\u7b54\u4e4b\u524d\u5fc5\u9808\u5148\u4e86\u89e3\u4e00\u4e9b\u80cc\u666f\u77e5\u8b58\u3002\u6211\u5011\u77e5\u9053\u9ad4\u5167\u7684\u764c\u7d30\u80de\u9996\u5148\u5f97\u88ab\u514d\u75ab\u7cfb\u7d71\u8fa8\u8a8d\u51fa\u4f86\uff0c\u624d\u80fd\u9032\u4e00\u6b65\u88ab\u6d88\u6ec5\uff0c\u7136\u800c\u72e1\u733e\u7684\u764c\u7d30\u80de\u6703\u507d\u88dd\u81ea\u5df1\u662f\u6b63\u5e38\u7d30\u80de\u4f86\u8eb2\u907f\u653b\u64ca\u3002\u5176\u4e2d\u4e00\u7a2e\u65b9\u6cd5\u662f\uff0c\u764c\u7d30\u80de\u901a\u904e\u8868\u73fe\u539f\u672c\u5c31\u5927\u91cf\u5b58\u5728\u65bc\u7d05\u8840\u7403\u8868\u9762\u7684\u86cb\u767d\u8cea\u300cCD47\u300d\uff0c\u85c9\u6b64\u91cb\u653e\u51fa\u300c\u5225\u653b\u64ca\u6211\u300d\u7684\u8a0a\u865f\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u963b\u65b7\u764c\u7d30\u80de\u4e0a\u7684 CD47 \u7b49\u65bc\u62c6\u6389\u5b83\u7684\u64cb\u7bad\u724c\uff0c\u81e8\u5e8a\u4e0a\u4e5f\u767c\u5c55\u51fa\u6297\u9ad4 anti-CD47 \u4f86\u6cbb\u7642\u764c\u75c7\uff0c\u7136\u800c\u5728\u5148\u524d\u7684\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u4e2d\u767c\u73fe\uff0c\u4f7f\u7528 anti-CD47 \u4f5c\u70ba\u5168\u8eab\u6027\u6cbb\u7642\u6703\u5c0e\u81f4\u8ca7\u8840\u548c\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u7684\u526f\u4f5c\u7528\uff0c\u9019\u662f\u7531\u65bc\u6b63\u5e38\u7d05\u8840\u7403\u53ca\u8840\u5c0f\u677f\u7684\u8868\u9762\u4e5f\u6709 CD47\uff0c\u800c\u56e0\u6b64\u963b\u65b7 CD47 \u4e5f\u6703\u906d\u53d7\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u7684\u6c60\u9b5a\u4e4b\u6b83\u3002\u70ba\u4e86\u6539\u5584\u526f\u4f5c\u7528\uff0c\u53c8\u7814\u767c\u51fa\u88ab\u7a31\u70ba\u5948\u7c73\u6297\u9ad4 (nanobody) \u7684\u5206\u5b50\uff0c\u5728\u7814\u7a76\u4e2d\u7c21\u7a31\u70ba CD47nb\uff0c\u96d6\u7136\u5176\u7d50\u5408\u80fd\u529b\u6bd4\u539f\u672c anti-CD47 \u63d0\u9ad8\u7d04 200 \u500d\uff0c\u53ef\u60dc\u7684\u662f CD47nb \u7f3a\u4e4f\u5b8c\u6574\u7684\u6297\u9ad4\u7d50\u69cb (\u7121 Fc \u5340\u57df)\uff0c\u5c0e\u81f4\u4f5c\u70ba\u55ae\u4e00\u7642\u6cd5\u6642\u7684\u6548\u679c\u6bd4\u8f03\u5dee\u3002<\/p>\n<p>\u5c71\u4e0d\u8f49\u8def\u8f49\uff0c\u8070\u660e\u7684\u79d1\u5b78\u5bb6\u60f3\u5230\uff0c\u5982\u679c\u80fd\u5728\u5be6\u9ad4\u816b\u7624\u5c40\u90e8\u6cbb\u7642\uff0c\u5c31\u53ef\u907f\u514d\u4e0a\u8ff0\u7684\u5168\u8eab\u6027\u526f\u4f5c\u7528\uff0c\u9032\u800c\u6d6e\u73fe\u4e86\u8b93\u7d30\u83cc\u651c\u5e36 CD47nb \u5230\u5be6\u9ad4\u816b\u7624\u4f5c\u6230\u7684\u7b56\u7565\uff0c\u7d30\u83cc\u6210\u4e86\u6ef2\u900f\u6575\u5f8c\u7684\u7a81\u64ca\u5175\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u7d30\u83cc\u5728\u816b<\/strong><strong>\u7624<\/strong><strong>\u5167\u91cb\u653e\u5927\u91cf<\/strong> <strong>CD47nb <\/strong><strong>\u80fd\u6709\u6548\u6291\u5236\u816b\u7624\u9032\u5c55<\/strong><\/span><\/p>\n<p>\u8981\u8a13\u7df4\u4e00\u6279\u9032\u5165\u5be6\u9ad4\u816b\u7624\u5167\u90e8\u4f5c\u6230\u7684\u7d30\u83cc\uff0c\u5148\u6c7a\u689d\u4ef6\u662f\u4e0d\u80fd\u50b7\u6575\u4e00\u5343\u81ea\u640d\u516b\u767e\uff0c\u6240\u4ee5\u70ba\u4e86\u5b89\u5168\u8003\u91cf\uff0c\u79d1\u5b78\u5bb6\u9078\u64c7\u4e86\u300c\u975e\u81f4\u75c5\u300d\u7684\u5927\u8178\u687f\u83cc\u83cc\u682a\uff0c\u518d\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u6280\u8853\u6539\u9020\uff0c\u63a7\u5236\u6b64\u83cc\u682a\u5728\u816b\u7624\u5167\u751f\u9577\u9054\u5230\u81e8\u754c\u6578\u91cf\u6642\u6703\u81ea\u6211\u6bc0\u6ec5\uff0c\u9084\u80fd\u751f\u7522\u4e26\u91cb\u653e\u51fa\u5927\u91cf\u7684 CD47nb\uff0c\u9032\u800c\u9054\u5230\u8a98\u5c0e\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u8a72\u8655\u764c\u7d30\u80de\u7684\u6548\u679c\u3002\u7c21\u55ae\u4f86\u8aaa\uff0c\u6539\u9020\u5f8c\u7684\u7d30\u83cc\u5c31\u50cf\u662f\u4e00\u6279\u8f09\u6eff\u5f48\u85e5\u7684\u795e\u98a8\u7279\u653b\u968a\uff0c\u7a7a\u964d\u5728\u816b\u7624\u5167\u5927\u91cf\u7e41\u6b96\u5f8c\uff0c\u9032\u884c\u96c6\u9ad4\u81ea\u6bba\u5f0f\u653b\u64ca\u3002<\/p>\n<p>\u5be6\u9a57\u904b\u7528\u6dcb\u5df4\u7624\u6a21\u578b\u7684\u5c0f\u9f20\uff0c\u5728\u816b\u7624\u5c40\u90e8\u6ce8\u5c04\u8868\u9054 CD47nb \u7684\u7d30\u83cc\uff0c\u7d50\u679c\u986f\u793a\u6b64\u7642\u6cd5\u4e0d\u50c5\u80fd\u5920\u4f7f\u5f97\u5c0f\u9f20\u9ad4\u5167\u7684\u5c40\u90e8\u816b\u7624\u5b8c\u5168\u6d88\u9000\uff0c\u800c\u4e14\u9084\u80fd\u986f\u8457\u63a7\u5236\u672a\u6ce8\u5c04\u7d30\u83cc\u7684\u9060\u7aef\u816b\u7624\u75c5\u8b8a\uff0c\u4e26\u5ef6\u9577\u6dcb\u5df4\u7624\u5c0f\u9f20\u7684\u5b58\u6d3b\u671f\u3002\u79d1\u5b78\u5bb6\u8a8d\u70ba\u7576\u816b\u7624\u5167\u7684\u7d30\u83cc\u7834\u88c2\u5f8c\uff0c\u6703\u8a98\u5c0e\u5c40\u90e8\u767c\u708e\u548c CD47 \u963b\u65b7\u7684\u806f\u5408\u4f5c\u7528\uff0c\u589e\u52a0\u4e86\u514d\u75ab\u7d30\u80de\u5c0d\u816b\u7624\u7684\u541e\u566c\u4f5c\u7528\uff0c\u4ee5\u53ca\u6d3b\u5316\u4e86\u816b\u7624\u5167\u7279\u6709\u7684\u6d78\u6f64\u6027 T \u7d30\u80de (tumor-infiltrating T cell)\uff0c\u9019\u4e0d\u50c5\u80fd\u6e05\u9664\u76f4\u63a5\u53d7\u5230\u5c40\u90e8\u6cbb\u7642\u7684\u816b\u7624\uff0c\u9084\u9593\u63a5\u964d\u4f4e\u4e86\u5c0f\u9f20\u6dcb\u5df4\u7624\u6a21\u578b\u4e2d\u816b\u7624\u8f49\u79fb\u7684\u767c\u751f\u7387\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u57fa\u56e0<\/strong><strong>\u5de5\u7a0b\u5316\u7d30\u83cc<\/strong><strong>\u4f5c\u70ba<\/strong><strong>\u300c<\/strong><strong>\u85e5\u7269\u8f09\u5177<\/strong><strong>\u300d<\/strong><strong>\u7684\u61c9\u7528\u5ee3\u6cdb<\/strong><\/span><\/p>\n<p>\u7814\u7a76\u89c0\u5bdf\u5230\u5c07\u7d30\u83cc\u5145\u7576\u300c\u7279\u6d1b\u4f0a\u6728\u99ac\u300d\u7684\u5275\u65b0\u7642\u6cd5\uff0c\u53ef\u4f7f\u5f97\u816b\u7624\u6d78\u6f64\u6027\u6dcb\u5df4\u7d30\u80de\u7684\u589e\u6b96\u548c\u6d3b\u5316\u589e\u5f37\uff0c\u4e26\u5c0e\u81f4\u6301\u4e45\u548c\u5168\u8eab\u6027\u6297\u816b\u7624\u7684\u514d\u75ab\u6548\u679c\u3002\u7e3d\u7d50\u4f86\u8aaa\uff0c\u5229\u7528\u6539\u9020\u5f8c\u7684\u7d30\u83cc\u4f5c\u70ba\u300c\u85e5\u7269\u8f09\u5177\u300d\uff0c\u53ef\u4f7f\u5f97\u5c40\u90e8\u514d\u75ab\u7642\u6cd5\u6fc3\u5ea6\u589e\u52a0\uff0c\u4e26\u540c\u6642\u9632\u6b62\u5168\u8eab\u6027\u526f\u4f5c\u7528\uff0c\u517c\u5177\u4e86\u5b89\u5168\u53ca\u7642\u6548\u7684\u512a\u9ede\u3002\u5728\u672c\u7814\u7a76\u53ea\u662f\u4f7f\u7528\u55ae\u4e00\u7a2e\u86cb\u767d\u8cea\u85e5\u7269 CD47nb \u5c31\u6709\u4e0d\u932f\u7684\u6210\u6548\uff0c\u53ef\u4ee5\u60f3\u898b\u5982\u679c\u7576\u5c40\u90e8\u7642\u6cd5\u642d\u914d\u5176\u4ed6\u4e0d\u540c\u7684\u5168\u8eab\u6027\u6297\u764c\u85e5\u7269\uff0c\u53ef\u4ee5\u8b8a\u5316\u51fa\u5404\u7a2e\u6cbb\u7642\u65b9\u6848\uff0c\u5275\u9020\u51fa\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7642\u7d44\u5408\uff0c\u4f55\u6cc1\u57fa\u56e0\u5de5\u7a0b\u9084\u80fd\u8b93\u7d30\u83cc\u651c\u5e36\u4e0d\u540c\u7684\u85e5\u7269\uff0c\u4e00\u6cd5\u901a\u842c\u6cd5\u901a\uff0c\u5404\u7a2e\u6cbb\u7642\u61c9\u7528\u6307\u65e5\u53ef\u5f85\u3002<\/p>\n<p>\u4e0d\u904e\uff0c\u5118\u7ba1\u9019\u9805\u65b0\u6cbb\u7642\u7b56\u7565\u6210\u529f\u904b\u7528\u5728\u5be6\u9a57\u5c0f\u9f20\u6a21\u578b\uff0c\u662f\u5426\u80fd\u5c0d\u4eba\u985e\u6709\u6548\uff1f\u9084\u5f97\u4f9d\u9760\u66f4\u591a\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u52a0\u4ee5\u9a57\u8b49\uff0c\u4f46\u9019\u7a2e\u76f4\u6417\u9ec3\u9f8d\u7684\u65b9\u6cd5\u6df1\u5177\u6f5b\u529b\uff0c\u503c\u5f97\u671f\u5f85\u672a\u4f86\u5c07\u57fa\u56e0\u7de8\u7a0b\u7684\u7d30\u83cc\u904b\u7528\u5728\u5404\u7a2e\u764c\u75c7\u6cbb\u7642\u4e0a\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong>Chowdhury S, et al. Nat Med. 2019 Jul;25(7):1057-1063. <a href=\"https:\/\/www.nature.com\/articles\/s41591-019-0498-z\">Programmable bacteria induce durable tumor regression and systemic antitumor immunity.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8033\u719f\u80fd\u8a73\u7684\u6728\u99ac\u5c60\u57ce\u8a18\uff0c\u901a\u904e\u58eb\u5175\u8eb2\u5728\u507d\u88dd\u6210\u6230\u5229\u54c1\u7684\u6728\u99ac\u5167\uff0c\u6210\u529f\u6f5b\u5165\u6575\u71df\u596a\u53d6\u4e86\u7279\u6d1b\u4f0a\u57ce\uff0c\u4e5f\u56e0\u6b64\u5f97\u540d\u70ba\u7279\u6d1b\u4f0a\u6728\u99ac (Trojan Horse)\u3002\u76f4\u63a5\u653b\u6253\u6575\u4eba\u5de2\u7a74\uff0c\u5f80\u5f80\u662f\u6700\u80fd\u5fb9\u5e95\u6d88\u6ec5\u6575\u4eba\u7684\u65b9\u6cd5\uff0c\u6700\u8fd1\u7f8e\u570b\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78\u7684\u79d1\u5b78\u5bb6\u767c\u8868\u5728 Nature Medicine \u7684\u7814\u7a76\uff0c\u5c07\u57fa\u56e0\u91cd\u65b0\u7de8\u7a0b\u7684\u975e\u81f4\u75c5\u83cc\u83cc\u682a\uff0c\u63a1\u7528\u7279\u6d1b\u4f0a\u6728\u99ac\u7684\u7b56\u7565\uff0c\u9001\u5230\u5c0f\u9f20\u6a21\u578b\u7684\u5be6\u9ad4\u816b\u7624\u5167\u90e8\uff0c\u53ef\u5f15\u767c\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u816b\u7624\uff0c\u9054\u5230\u6d88\u9664\u764c\u7d30\u80de\u7684\u6548\u679c\u3002<\/p>\n","protected":false},"author":20,"featured_media":34377,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4344,4345,214],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/08\/1872666_1920.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34370"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34370"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34370\/revisions"}],"predecessor-version":[{"id":34378,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34370\/revisions\/34378"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34377"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}