{"id":34315,"date":"2019-08-13T00:18:12","date_gmt":"2019-08-12T16:18:12","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34315"},"modified":"2019-12-19T12:10:07","modified_gmt":"2019-12-19T04:10:07","slug":"%e8%97%a5%e6%95%88%e4%b8%8d%e8%b6%b3%ef%bc%9f%e5%9b%a0%e7%82%ba%e8%a2%ab%e8%85%b8%e9%81%93%e8%8f%8c%e5%90%83%e6%8e%89%e4%ba%86","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34315","title":{"rendered":"\u85e5\u6548\u4e0d\u8db3\uff1f\u56e0\u70ba\u88ab\u8178\u9053\u83cc\u5403\u6389\u4e86"},"content":{"rendered":"

\u5403\u9032\u809a\u5b50\u88e1\u7684\u85e5\u6709\u6c92\u6709\u6548\u679c\u53d7\u5230\u8a31\u591a\u56e0\u7d20\u5f71\u97ff\uff0c\u4f46\u4f60\u53ef\u80fd\u6c92\u60f3\u5230\u8178\u9053\u83cc\u4e5f\u6703\u4e00\u8d77\u5171\u4eab\u85e5\u7269\uff0c\u751a\u81f3\u4f7f\u5f97\u85e5\u6548\u4e0d\u8db3\uff0c\u6216\u662f\u589e\u52a0\u526f\u4f5c\u7528\u3002\u8fd1\u671f\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u6cbb\u7642\u5df4\u91d1\u68ee\u6c0f\u75c7 (Parkinson's disease) \u7684\u5e38\u7528\u85e5\u7269\u5de6\u65cb\u591a\u5df4 (levodopa, L-dopa)\uff0c\u5728\u62b5\u9054\u8166\u90e8\u767c\u63ee\u4f5c\u7528\u4e4b\u524d\uff0c\u65e9\u5c31\u88ab\u8178\u9053\u83cc\u534a\u8def\u6514\u622a\u4e26\u5403\u6389\u5927\u534a\u4e86\u3002<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u53e3\u670d\u85e5\u7269<\/strong> levodopa <\/strong>\u6709\u9ad8\u9054<\/strong>56% <\/strong>\u7121\u6cd5\u5230\u9054\u8166\u90e8<\/strong><\/span><\/p>\n

\u85e5\u7269\u6cbb\u7642\u7684\u6548\u679c\u5f80\u5f80\u56e0\u4eba\u800c\u7570\uff0c\u904e\u53bb\u5e38\u6b78\u56e0\u65bc\u5e74\u9f61\u3001\u9ad4\u8cea\u3001\u57fa\u56e0\u7b49\u500b\u9ad4\u5dee\u7570\u3002\u4e0d\u904e\uff0c\u6700\u8fd1\u54c8\u4f5b\u5927\u5b78\u7684\u79d1\u5b78\u5bb6\u767c\u73fe\u4e86\u8178\u9053\u83cc\u53e2 (gut microbiome) \u4e5f\u662f\u9020\u6210\u85e5\u6548\u5dee\u7570\u7684\u5143\u5147\u4e4b\u4e00\uff0c\u6587\u7ae0\u767c\u8868\u65bc 2019 \u5e746 \u6708\u7684 Science<\/em> \u671f\u520a\u3002\u6df1\u53d7\u5f71\u97ff\u7684\u5df4\u91d1\u68ee\u6c0f\u75c7\uff0c\u5176\u70ba\u4e00\u7a2e\u9032\u884c\u6027\u7684\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u6703\u51fa\u73fe\u904b\u52d5\u969c\u7919\u75c7\u72c0\uff0c\u50cf\u662f\u9707\u986b (\u624b\u767c\u6296)\u3001\u56db\u80a2\u50f5\u76f4\u548c\u884c\u52d5\u7de9\u6162\u3002\u81f4\u75c5\u539f\u56e0\u662f\u7531\u65bc\u5df4\u91d1\u68ee\u6c0f\u75c7\u60a3\u8005\u7684\u8166\u90e8\u88e1\uff0c\u80fd\u5354\u8abf\u904b\u52d5\u529f\u80fd\u7684\u591a\u5df4\u80fa (dopamine) \u5206\u6ccc\u4e0d\u8db3\u3002\u73fe\u6709\u85e5\u7269\u53ea\u80fd\u5920\u88dc\u5145\u60a3\u8005\u9ad4\u5167\u591a\u5df4\u80fa\u6fc3\u5ea6\u4f86\u63a7\u5236\u75c7\u72c0\uff0c\u4f46\u7121\u6cd5\u6291\u5236\u6301\u7e8c\u9032\u884c\u7684\u795e\u7d93\u7d30\u80de\u9000\u5316\u3002<\/p>\n

Levodopa \u662f\u6700\u5e38\u7528\u7684\u6cbb\u7642\u85e5\u7269\uff0c\u5176\u70ba\u591a\u5df4\u80fa\u7684\u524d\u8da8\u7269\u3002\u7531\u65bc\u591a\u5df4\u80fa\u672c\u8eab\u7121\u6cd5\u7a7f\u900f\u8840\u8166\u969c\u58c1 (blood\u2013brain barrier)\uff0c\u5fc5\u9808\u85c9\u7531 levodopa \u7684\u5f62\u5f0f\u624d\u80fd\u9032\u5165\u8166\u90e8\uff0c\u4e26\u7d93\u904e\u812b\u7fa7\u9176 (decarboxylase) \u7684\u812b\u7fa7\u57fa\u4f5c\u7528\u8f49\u8b8a\u6210\u591a\u5df4\u80fa\uff0c\u300c\u8b8a\u8eab\u5f8c\u300d\u7684 levodopa \u624d\u80fd\u767c\u63ee\u6cbb\u7642\u6548\u679c\u3002\u7136\u800c\uff0c\u5be6\u969b\u72c0\u6cc1\u537b\u662f\u670d\u85e5\u5f8c\u50c5\u6709 1% \u81f3 5% \u5f88\u5c11\u7684 levodopa \u6210\u529f\u7a7f\u900f\u8840\u8166\u969c\u58c1\u3002\u81e8\u5e8a\u4e0a\u70ba\u4e86\u907f\u514d levodopa \u5728\u62b5\u9054\u8166\u90e8\u524d\u5c31\u63d0\u524d\u8b8a\u8eab\uff0c\u53ea\u597d\u540c\u6642\u670d\u7528\u8b8a\u8eab\u6291\u5236\u5291 (\u5982 carbidopa)\u3002\u5118\u7ba1\u5982\u6b64\uff0c\u4ecd\u6709\u9ad8\u905456% \u7684 levodopa \u7121\u6cd5\u5230\u9054\u8166\u90e8\u3002\u9019\u9805\u672a\u89e3\u4e4b\u8b0e\uff0c\u5c31\u662f\u79d1\u5b78\u5bb6\u60f3\u8981\u56de\u7b54\u7684\u3002<\/p>\n

\u25cf\u7cde\u8178\u7403\u83cc\u662f\u5403\u6389<\/strong> levodopa <\/strong>\u8b93\u85e5\u6548\u8b8a\u5dee\u7684\u5143\u5147<\/strong><\/span><\/p>\n

\u85e5\u7269\u7121\u6cd5\u9032\u5165\u8166\u90e8\uff0c\u52e2\u5fc5\u662f\u534a\u8def\u6bba\u51fa\u500b\u7a0b\u54ac\u91d1\uff0c\u904e\u53bb\u7814\u7a76\u6307\u51fa\u4f7f\u7528\u6297\u751f\u7d20\u6709\u52a9\u65bc levodopa \u7684\u7642\u6548\uff0c\u9019\u610f\u5473\u8457\u8178\u9053\u83cc\u53ef\u80fd\u626e\u6f14\u9019\u534a\u8def\u6514\u622a\u7684\u89d2\u8272\u3002\u5f9e\u524d\u6587\u53ef\u77e5\uff0clevodopa \u5fc5\u9808\u6709\u812b\u7fa7\u9176\u624d\u80fd\u8b8a\u8eab\u70ba\u591a\u5df4\u80fa\uff0c\u6240\u4ee5\u8ab0\u80fd\u5206\u6ccc\u5f88\u591a\u812b\u7fa7\u9176\uff0c\u8ab0\u5c31\u662f\u6700\u5927\u7684\u5acc\u7591\u72af\u3002\u70ba\u4e86\u8b93\u5acc\u7591\u72af\u73fe\u8eab\uff0c\u54c8\u4f5b\u79d1\u5b78\u5bb6\u9996\u5148\u5f9e\u5df2\u77e5\u7684\u8178\u9053\u83cc\u57fa\u56e0\u7d44\u8cc7\u6599\u5eab\u4e2d\u6316\u6398\uff0c\u627e\u51fa\u8178\u7403\u83cc\u5c6c (Enterococcus spp.<\/em>) \u53ca\u4e73\u687f\u83cc\u5c6c (Lactobacillus spp.<\/em>) \u4e2d\u5b58\u5728\u5927\u91cf\u812b\u7fa7\u9176\uff0c\u63a5\u8457\u5728\u5171\u540c\u57f9\u990a\u5be6\u9a57\u4e2d\u767c\u73fe\uff0c\u7cde\u8178\u7403\u83cc (Enterococcus faecalis<\/em>) \u5206\u6ccc\u7684\u812b\u7fa7\u9176\u80fd\u8207 levodopa \u5f37\u52e2\u7d50\u5408\u800c\u53cd\u61c9\u6210\u591a\u5df4\u80fa\uff0c\u78ba\u8a8d\u5403\u6389\u85e5\u7269\u7684\u7f6a\u9b41\u798d\u9996\u5c31\u662f\u7cde\u8178\u7403\u83cc\u3002<\/p>\n

\u6709\u6cd5\u5fc5\u6709\u7834\uff0c\u65e2\u7136\u90fd\u627e\u51fa levodopa \u88ab\u534a\u8def\u5403\u6389\u7684\u539f\u56e0\uff0c\u79d1\u5b78\u5bb6\u7576\u7136\u5f97\u76e1\u529b\u627e\u51fa\u80fd\u963b\u6b62\u7cde\u8178\u7403\u83cc\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u7be9\u9078\u51fa\u4e86\u4e00\u7a2e\u540d\u70ba\u300c(S<\/em>)-\u03b1-Fluoromethyltyrosine (AFMT)\u300d\u7684\u5c0f\u5206\u5b50\uff0c\u53ef\u4ee5\u5c08\u4e00\u6027\u5730\u6291\u5236\u7cde\u8178\u7403\u83cc\u88e1\u7684\u812b\u7fa7\u9176\uff0c\u4e26\u4e14\u4e0d\u6703\u5f71\u97ff\u7cde\u8178\u7403\u83cc\u7684\u5b58\u6d3b\uff0c\u9032\u800c\u63d0\u9ad8 levodopa \u7684\u85e5\u6548\u3002\u53cd\u65b9\u9762\uff0c\u5982\u679c\u5468\u908a\u7684\u591a\u5df4\u80fa\u592a\u9ad8\uff0c\u9664\u4e86\u6703\u9020\u6210\u80c3\u8178\u9053\u526f\u4f5c\u7528\uff0c\u9084\u6703\u5f15\u8d77\u59ff\u52e2\u6027\u4f4e\u8840\u58d3\u53ca\u5fc3\u5f8b\u4e0d\u6574\u7b49\u554f\u984c\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u8178\u9053\u4e2d\u7684\u591a\u5df4\u80fa\u9084\u53ef\u4ee5\u6210\u70ba\u53e6\u4e00\u7a2e\u8178\u9053\u83cc\u7684\u300c\u98df\u7269\u300d\uff0c\u8207\u653e\u7dda\u83cc (Actinobacterial) \u76f8\u95dc\u7684\u8fd1\u89aa\u7d30\u83cc\u5403\u6389\u591a\u5df4\u80fa\u5f8c\u7522\u751f\u7684\u4ee3\u8b1d\u5ee2\u7269\uff0c\u4e5f\u53ef\u80fd\u5c0e\u81f4\u5176\u4ed6\u526f\u4f5c\u7528\u3002<\/p>\n

\u25cf\u75be\u75c5\u96e3\u6cbb\uff1f\u539f\u4f86\u8a31\u591a\u85e5\u7269\u4e5f\u6703\u88ab\u8178\u9053\u83cc\u5403\u6389<\/strong><\/span><\/p>\n

\u5982\u679c\u5230\u9054\u8166\u90e8\u7684 levodopa \u6e1b\u5c11\uff0c\u60a3\u8005\u901a\u5e38\u5fc5\u9808\u4f7f\u7528\u66f4\u591a\u85e5\u7269\u4f86\u63a7\u5236\u75c7\u72c0\uff0c\u9019\u53ef\u80fd\u6703\u52a0\u5287\u9019\u4e9b\u526f\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u54c8\u4f5b\u5927\u5b78\u9019\u9805\u7814\u7a76\u70ba levodopa \u767c\u63ee\u85e5\u6548\u63d0\u4f9b\u4e86\u4e00\u7a2e\u89e3\u6c7a\u65b9\u6848\uff0c\u672a\u4f86\u4e5f\u53ef\u4ee5\u901a\u904e\u6aa2\u6e2c\u5df4\u91d1\u68ee\u6c0f\u75c7\u60a3\u8005\u7cde\u4fbf\u4e2d\u7684\u8178\u9053\u83cc\u53e2\uff0c\u4f86\u9810\u6e2c levodopa \u7684\u6548\u679c\uff0c\u9019\u9805\u7814\u7a76\u6210\u679c\u70ba\u5df4\u91d1\u68ee\u6c0f\u75c7\u7684\u6cbb\u7642\u5e36\u4f86\u4e86\u65b0\u7684\u5951\u6a5f\u3002<\/p>\n

\u7121\u7368\u6709\u5076\uff0c\u53e6\u4e00\u7bc7\u76f8\u95dc\u7684\u7814\u7a76\u767c\u8868\u5728 2019 \u5e746 \u6708\u7684 Nature<\/em> \u671f\u520a\uff0c\u8036\u9b6f\u5927\u5b78\u79d1\u5b78\u5bb6\u6e2c\u8a66\u4f86\u81ea\u4e0d\u540c\u652f\u7cfb\u7684 76 \u7a2e\u4eba\u985e\u8178\u9053\u83cc\uff0c\u7814\u7a76\u9019\u4e9b\u8178\u9053\u83cc\u4ee3\u8b1d 271 \u7a2e\u5e38\u7528\u53e3\u670d\u85e5\u7269\u7684\u80fd\u529b\u3002\u51fa\u4eba\u610f\u6599\uff0c\u6709\u591a\u9054\u300c\u4e09\u5206\u4e4b\u4e8c\u300d\u7684\u85e5\u7269\u6703\u88ab\u7d30\u83cc\u5403\u6389 (\u4ee3\u8b1d)\uff0c\u800c\u4e14\u6bcf\u7a2e\u8178\u9053\u83cc\u81f3\u5c11\u53ef\u4ee5\u4ee3\u8b1d 11 \u81f3 95 \u7a2e\u85e5\u7269\u3002\u539f\u4f86\u6211\u5011\u670d\u7528\u7684\u85e5\u7269\uff0c\u6709\u90a3\u9ebc\u591a\u90fd\u62ff\u53bb\u9935\u4e86\u8178\u9053\u83cc\u9019\u4e9b\u300c\u8caa\u5403\u9b3c\u300d\uff0c\u6216\u8a31\u6709\u4e9b\u75be\u75c5\u9019\u9ebc\u96e3\u6cbb\uff0c\u80cc\u5f8c\u7684\u539f\u56e0\u4e5f\u662f\u8178\u9053\u83cc\u5728\u8d81\u6a5f\u6417\u4e82\u554a\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Maini Rekdal V, et al. Science. 2019 Jun 1;364(6445). pii: eaau6323. Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism.<\/a><\/li>\n
  2. \u81fa\u5927\u91ab\u9662\uff0c\u8a8d\u8b58\u5df4\u91d1\u68ee\u6c0f\u75c7<\/a><\/li>\n
  3. Zimmermann M, et al. Nature. 2019 Jun;570(7762):462-467. Mapping human microbiome drug metabolism by gut bacteria and their genes.<\/a><\/li>\n<\/ol>\n

    --
    \n\u4f5c\u8005<\/span>\uff1a\u694a\u671d\u5091  \u6210\u5927\u5fae\u514d\u6240\u78a9\u58eb\uff0c\u66fe\u8457\u6709\u300a\u5716\u89e3\u91ab\u5b78\u300b\u4e00\u66f8\uff0c\u6a02\u65bc\u5c07\u91ab\u5b78\u65b0\u77e5\u4ee5\u6dfa\u767d\u7684<\/span>\u6587\u5b57\u8b93\u66f4\u591a\u4eba\u4e86\u89e3\u3002<\/strong><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u5403\u9032\u809a\u5b50\u88e1\u7684\u85e5\u6709\u6c92\u6709\u6548\u679c\u53d7\u5230\u8a31\u591a\u56e0\u7d20\u5f71\u97ff\uff0c\u4f46\u4f60\u53ef\u80fd\u6c92\u60f3\u5230\u8178\u9053\u83cc\u4e5f\u6703\u4e00\u8d77\u5171\u4eab\u85e5\u7269\uff0c\u751a\u81f3\u4f7f\u5f97\u85e5\u6548\u4e0d\u8db3\uff0c\u6216\u662f\u589e\u52a0\u526f\u4f5c\u7528\u3002\u8fd1\u671f\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u6cbb\u7642\u5df4\u91d1\u68ee\u6c0f\u75c7 (Parkinson's disease) \u7684\u5e38\u7528\u85e5\u7269\u5de6\u65cb\u591a\u5df4 (levodopa, L-dopa)\uff0c\u5728\u62b5\u9054\u8166\u90e8\u767c\u63ee\u4f5c\u7528\u4e4b\u524d\uff0c\u65e9\u5c31\u88ab\u8178\u9053\u83cc\u534a\u8def\u6514\u622a\u4e26\u5403\u6389\u5927\u534a\u4e86\u3002<\/p>\n","protected":false},"author":20,"featured_media":34320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4329,4328,1792,4327],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/07\/hand-3632914_1920.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34315"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34315"}],"version-history":[{"count":2,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34315\/revisions"}],"predecessor-version":[{"id":34365,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34315\/revisions\/34365"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34320"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}