{"id":34248,"date":"2019-07-30T00:49:11","date_gmt":"2019-07-29T16:49:11","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34248"},"modified":"2019-07-26T16:00:43","modified_gmt":"2019-07-26T08:00:43","slug":"%e5%8c%96%e6%95%b5%e7%82%ba%e5%8f%8b%ef%bc%8c%e7%b4%b0%e8%8f%8c%e5%88%a9%e7%94%a8%e5%99%ac%e8%8f%8c%e9%ab%94%e4%be%86%e8%87%aa%e6%88%91%e8%be%a8%e8%ad%98","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34248","title":{"rendered":"\u5316\u6575\u70ba\u53cb\uff0c\u7d30\u83cc\u5229\u7528\u566c\u83cc\u9ad4\u4f86\u81ea\u6211\u8fa8\u8b58"},"content":{"rendered":"

\u566c\u83cc\u9ad4 (phage) \u5982\u540c\u5176\u540d\uff0c\u662f\u4e00\u7a2e\u6703\u541e\u566c\u6389\u88ab\u5bc4\u751f\u4e4b\u7d30\u83cc\u5bbf\u4e3b\u7684\u75c5\u6bd2\uff0c\u5c0d\u7d30\u83cc\u4f86\u8aaa\u566c\u83cc\u9ad4\u539f\u672c\u662f\u53ef\u60e1\u7684\u6575\u4eba\u3002\u7136\u800c\uff0c\u8fd1\u65e5 Cell Reports<\/em> \u4e0a\u7684\u7814\u7a76\uff0c\u767c\u73fe\u7d30\u83cc\u80fd\u5229\u7528\u662f\u5426\u651c\u5e36\u566c\u83cc\u9ad4\uff0c\u4f86\u4f5c\u70ba\u8fa8\u8b58\u81ea\u5df1\u5925\u4f34\u7684\u6a19\u8a18\uff0c\u4e26\u518d\u4f7f\u559a\u566c\u83cc\u9ad4\u53bb\u653b\u64ca\u7af6\u722d\u98df\u7269\u7684\u5176\u5b83\u7d30\u83cc\u3002\u628a\u6575\u4eba\u8b8a\u5e6b\u624b\uff0c\u771f\u662f\u9ad8\u660e\u7684\u624b\u6bb5\uff01<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf\u7d30\u83cc\u4e0d\u50c5\u6703\u5f7c\u6b64\u6e9d\u901a\uff0c\u9023\u81ea\u6211\u8fa8\u8b58\u4e5f\u96e3\u4e0d\u5012\u5b83<\/strong><\/span><\/p>\n

\u65e9\u5728 1970 \u5e74\u4ee3\uff0c\u79d1\u5b78\u5bb6\u5c31\u5df2\u767c\u73fe\u7d30\u83cc\u80fd\u5920\u5f7c\u6b64\u6e9d\u901a\uff0c\u7d93\u5178\u4f8b\u5b50\u662f\u4e00\u7a2e\u6d77\u6d0b\u767c\u5149\u7d30\u83cc\u2500\u8cbb\u96ea\u6c0f\u5f27\u83cc (Vibrio fischeri<\/em>)\uff0c\u9019\u7a2e\u6d77\u6d0b\u5f27\u83cc\u5c31\u50cf\u87a2\u706b\u87f2\u4e00\u6a23\u53ef\u4ee5\u767c\u51fa\u751f\u7269\u51b7\u5149 (bioluminescence)\uff0c\u5b83\u8207\u590f\u5a01\u5937\u77ed\u5c3e\u70cf\u8cca (Hawaiian bobtail squid) \u662f\u5171\u751f\u95dc\u4fc2\uff0c\u70cf\u8cca\u53ef\u5229\u7528\u7d30\u83cc\u767c\u51fa\u7684\u5149\u4f86\u5e6b\u52a9\u7375\u98df\u3002\u8abf\u63a7\u7d30\u83cc\u662f\u5426\u8a72\u4e00\u8d77\u767c\u5149\u7684\u6a5f\u5236\uff0c\u5c31\u662f\u901a\u904e\u7d30\u83cc\u81ea\u5df1\u5206\u6ccc\u7684\u7269\u8cea\u5728\u81ea\u8eab\u5468\u570d\u7684\u6fc3\u5ea6\u9ad8\u4f4e\uff0c\u9032\u800c\u8abf\u63a7\u7d30\u83cc\u6574\u500b\u7fa4\u9ad4\u7684\u884c\u70ba\u3002<\/p>\n

\u7d30\u83cc\u9664\u4e86\u900f\u904e\u4e0a\u8ff0\u6e9d\u901a\u65b9\u5f0f\u4f86\u6c7a\u5b9a\u96c6\u9ad4\u884c\u52d5\uff0c\u4f46\u53c8\u662f\u600e\u6a23\u624d\u80fd\u5728\u4f5c\u6230\u6642\u4e0d\u6703\u8aa4\u50b7\u53cb\u8ecd\uff1f\u4eba\u985e\u7684\u4f5c\u6cd5\u5f88\u7c21\u55ae\uff0c\u50cf\u662f\u5728\u7403\u8cfd\u4e2d\u53ea\u8981\u7a7f\u4e0a\u4e0d\u540c\u984f\u8272\u7684\u7403\u8863\uff0c\u5c31\u80fd\u5206\u8fa8\u54ea\u4e9b\u4eba\u662f\u968a\u53cb\uff0c\u4e5f\u5c31\u662f\u8aaa\u53ea\u8981\u80fd\u8fa8\u8a8d\u8207\u81ea\u5df1\u6709\u8457\u76f8\u540c\u6a19\u8a18\u7684\u65b9\u6cd5\u5373\u53ef\u3002\u8fd1\u65e5\uff0c\u767c\u8868\u5728 Cell Reports<\/em> \u4e0a\u7684\u7814\u7a76\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u5982\u679c\u7d30\u83cc\u80fd\u5340\u5206\u51fa\u81ea\u8eab\u7fa4\u9ad4\uff0c\u5c07\u6709\u5229\u65bc\u751f\u9577\u8207\u8993\u98df\uff0c\u9019\u500b\u73fe\u8c61\u662f\u5f9e\u53d7\u566c\u83cc\u9ad4\u611f\u67d3\u7684\u5927\u8178\u687f\u83cc K-12 \u83cc\u682a (Escherichia coli <\/em>K-12)\uff0c\u5176\u53ef\u512a\u5148\u6eb6\u89e3\u5176\u4ed6\u672a\u611f\u67d3\u7684 K-12 \u83cc\u682a\uff0c\u9032\u800c\u4f7f\u53d7\u611f\u67d3\u7684\u83cc\u682a\u52dd\u904e\u7121\u611f\u67d3\u7684\u7af6\u722d\u5c0d\u624b\u3002\u651c\u5e36\u566c\u83cc\u9ad4\uff0c\u8b8a\u6210\u662f\u7d30\u83cc\u8fa8\u8996\u6575\u6211\u7684\u6a19\u8a18\u8207\u9632\u79a6\u6b66\u5668\u3002<\/p>\n

\u25cf\u57f9\u990a\u57fa\u4e0a\u7684\u5206\u754c\u7dda\u662f\u7814\u7a76\u4e4b\u958b\u7aef<\/strong><\/span><\/p>\n

\u9019\u9805\u7814\u7a76\u5c31\u50cf\u6b77\u53f2\u4e0a\u767c\u73fe\u9752\u9ef4\u7d20 (penicillin) \u7684\u4e8b\u4ef6\u96f7\u540c\uff0c\u7576\u6642\u82f1\u570b\u5fae\u751f\u7269\u5b78\u5bb6\u4e9e\u6b77\u5c71\u5927\u2027\u4f5b\u840a\u660e (Alexander Fleming)\uff0c\u5f9e\u88ab\u9ef4\u83cc\u6c61\u67d3\u7684\u7d30\u83cc\u57f9\u990a\u57fa\u4e0a\uff0c\u767c\u73fe\u7d30\u83cc\u7121\u6cd5\u751f\u9577\u5728\u9ef4\u83cc\u83cc\u843d\u5468\u570d\uff0c\u5f62\u6210\u4e00\u5708\u6291\u5236\u751f\u9577\u7684\u660e\u986f\u5206\u754c\u7dda\uff0c\u56e0\u6b64\u7b2c\u4e00\u500b\u6297\u751f\u7d20\u2500\u9752\u9ef4\u7d20\u5c31\u88ab\u7d14\u5316\u5206\u96e2\u51fa\u4f86\u4e86\u3002<\/p>\n

\u672c\u7bc7\u7814\u7a76\u7684\u79d1\u5b78\u5bb6\u89c0\u5bdf\u5230\u985e\u4f3c\u60c5\u6cc1\uff0c\u7576\u5927\u8178\u687f\u83cc\u4e0d\u540c\u83cc\u682a\u63a5\u7a2e\u5728\u540c\u4e00\u76e4\u7d30\u83cc\u57f9\u990a\u57fa\u4e0a\u6642\uff0c\u7d93\u904e\u4e00\u6bb5\u6642\u9593\u751f\u9577\uff0c\u4e0d\u540c\u83cc\u682a\u5728\u76f8\u9047\u7684\u5340\u57df\u6703\u5efa\u7acb\u8d77\u4e00\u9053\u300c\u5206\u754c\u7dda\u300d\uff0c\u5c31\u985e\u4f3c\u53e4\u4ee3\u4e2d\u570b\u70ba\u62b5\u79a6\u585e\u5317\u904a\u7267\u90e8\u843d\u806f\u76df\u6240\u7bc9\u7684\u300c\u9577\u57ce\u300d\u4e00\u822c\u3002<\/p>\n

\u70ba\u4e86\u8981\u89e3\u7b54\u5206\u754c\u7dda\u5f62\u6210\u7684\u6a5f\u5236\uff0c\u79d1\u5b78\u5bb6\u5f9e\u5927\u8178\u687f\u83cc\u7684 4,296 \u500b\u55ae\u57fa\u56e0\u5254\u9664 (knockout) \u4e4b\u83cc\u682a\u9032\u884c\u7be9\u9078\uff0c\u7d50\u679c\u767c\u73fe\u5982\u679c\u5254\u9664\u7684\u57fa\u56e0\u6703\u5f71\u97ff\u5230\u566c\u83cc\u9ad4\u8907\u88fd\uff0c\u9019\u7a2e\u5206\u754c\u7dda\u5c31\u6703\u6d88\u5931\uff0c\u6240\u4ee5\u63a8\u6e2c\u5206\u754c\u7dda\u53ef\u80fd\u662f\u901a\u904e\u566c\u83cc\u9ad4\u5f15\u8d77\u7684\u7d30\u83cc\u6eb6\u89e3\u6240\u5f62\u6210\u3002\u4e26\u4e14\u9084\u767c\u73fe\uff0c\u9019\u662f\u7531\u4e00\u7a2e\u9577\u5c3e\u566c\u83cc\u9ad4\u79d1 (Siphoviridae) \u5728\u672c\u7814\u7a76\u547d\u540d\u70ba SW1 \u566c\u83cc\u9ad4\uff0c\u5176\u63a7\u5236\u4e86\u5206\u754c\u7dda\u7684\u5f62\u6210\u3002<\/p>\n

\u25cf\u566c\u83cc\u9ad4\u5f62\u6210\u7684\u5206\u754c\u7dda\u53ef\u4fdd\u8b77\u7d30\u83cc\u5c0d\u6297\u5916\u6575<\/strong><\/span><\/p>\n

\u901a\u904e\u4e00\u9023\u4e32\u7684\u5be6\u9a57\uff0c\u79d1\u5b78\u5bb6\u5047\u8a2d\u5728\u5927\u8178\u687f\u83cc\u9577\u4e45\u7684\u6f14\u5316\u904e\u7a0b\u4e2d\uff0c\u66fe\u7d93\u6355\u7372\u904e\u4e00\u4e9b\u53e4\u8001\u566c\u83cc\u9ad4\u57fa\u56e0\u4e26\u56f0\u5728\u81ea\u8eab\u67d3\u8272\u9ad4\u5167\uff0c\u4e0d\u6703\u5c0d\u81ea\u5df1\u9020\u6210\u50b7\u5bb3\uff0c\u9019\u4e9b\u96b1\u85cf\u7684\u566c\u83cc\u9ad4\u57fa\u56e0\u518d\u642d\u914d\u65b0\u611f\u67d3 SW1 \u566c\u83cc\u9ad4\u80fd\u5920\u4e92\u76f8\u5408\u4f5c\u3002\u7576\u651c\u5e36 SW1 \u7684\u5927\u8178\u687f\u83cc\u8207\u672a\u651c\u5e36 SW1 \u7684\u5927\u8178\u687f\u83cc\u5728\u57f9\u990a\u57fa\u4e0a\u76f8\u9047\u6642\uff0c\u90e8\u5206\u7d30\u83cc\u7684 SW1 \u6703\u88ab\u6d3b\u5316\u800c\u91cb\u653e\u5230\u74b0\u5883\u4e2d\uff0c\u4e26\u4e14\u53bb\u653b\u64ca\u672a\u651c\u5e36 SW1 \u7684\u7d30\u83cc\uff0c\u76f8\u7576\u65bc\u662f\u6bba\u6b7b\u6c92\u6709\u88ab SW1 \u6a19\u8a18\u7684\u5916\u6575\uff0c\u800c\u300c\u5206\u754c\u7dda\u300d\u5c31\u662f\u56e0\u70ba\u5728\u4ea4\u6230\u5340\u57df\u88e1\u6c92\u6709\u7d30\u83cc\u5b58\u6d3b (\u88ab\u566c\u83cc\u9ad4\u6d88\u6ec5) \u800c\u7522\u751f\u3002\u7576\u5f62\u6210\u5206\u754c\u7dda\u5f8c\uff0c\u5728\u9019\u9053\u9632\u79a6\u300c\u9577\u57ce\u300d\u7684\u4fdd\u8b77\u4e0b\uff0c\u5c4f\u969c\u5167\u7684\u7d30\u83cc\u53ef\u4ee5\u9032\u884c\u7e41\u6b96\u548c\u8993\u98df\uff0c\u6240\u4ee5\u651c\u5e36\u6709 SW1 \u566c\u83cc\u9ad4\u7684\u7d30\u83cc\uff0c\u53ef\u4ee5\u5e6b\u52a9\u5176\u5bbf\u4e3b\u62b5\u79a6\u7af6\u722d\u5c0d\u624b\u6216\u662f\u5176\u5b83\u5c0d\u5bbf\u4e3b\u6709\u5bb3\u4e4b\u566c\u83cc\u9ad4\u7684\u5165\u4fb5\uff0c\u4e26\u5728\u7279\u5b9a\u7684\u60c5\u6cc1\u4e0b\u5275\u9020\u51fa\u512a\u52e2\u689d\u4ef6\u3002<\/p>\n

\u7531\u65bc\u9084\u4e0d\u6e05\u695a\u5176\u4e2d\u7684\u5177\u9ad4\u5206\u5b50\u6a5f\u5236\uff0c\u5728\u672a\u4f86\u7684\u7814\u7a76\u88e1\uff0c\u79d1\u5b78\u5bb6\u9810\u8a08\u5c07\u9032\u4e00\u6b65\u63a2\u8a0e SW1 \u566c\u83cc\u9ad4\u5982\u4f55\u907f\u514d\u653b\u64ca\u5176\u5bbf\u4e3b\uff0c\u537b\u80fd\u6bba\u6b7b\u672a\u651c\u5e36 SW1 \u566c\u83cc\u9ad4\u7684\u7d30\u83cc\u3002\u5982\u679c\u80fd\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u566c\u83cc\u9ad4\u662f\u600e\u9ebc\u9078\u64c7\u653b\u64ca\u6642\u6a5f\u8207\u5c0d\u8c61\uff0c\u6216\u8a31\u672a\u4f86\u4e5f\u80fd\u5229\u7528\u566c\u83cc\u9ad4\u4f86\u5c0d\u6297\u6703\u611f\u67d3\u4eba\u9ad4\u7684\u7d30\u83cc\u3002\u9019\u4e5f\u503c\u5f97\u8b93\u79d1\u5b78\u754c\u518d\u91cd\u65b0\u601d\u8003\uff0c\u75c5\u6bd2\u8207\u5176\u4ed6\u7d30\u80de\u5bbf\u4e3b\u4e4b\u9593\u7684\u95dc\u4fc2\uff0c\u56e0\u70ba\u6216\u8a31\u5728\u67d0\u4e9b\u7af6\u722d\u689d\u4ef6\u4e0b\uff0c\u75c5\u6bd2\u611f\u67d3\u53ef\u80fd\u53cd\u800c\u5c0d\u5bbf\u4e3b\u6709\u5229\uff0c\u4e5f\u53ef\u7a31\u5f97\u4e0a\u662f\u53e6\u985e\u7684\u300c\u56e0\u798d\u5f97\u798f\u300d\u4e86\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Song S, et al. Cell Rep. 2019;27:737-749.e4. Phages Mediate Bacterial Self-Recognition.<\/a><\/li>\n
  2. Nealson KH, et al. J Bacteriol. 1970;104:313-22. Cellular control of the synthesis and activity of the bacterial luminescent system.<\/a><\/li>\n
  3. \u937e\u91d1\u6e6f\uff0c2005\/05\/10\uff0c\u79d1\u6280\u5927\u89c0\u5712\uff0c\u4f5b\u840a\u660e\u2013\u9752\u9ef4\u7d20\u7684\u767c\u73fe\u8005<\/a><\/li>\n<\/ol>\n

     <\/p>\n

    --
    \n\u4f5c\u8005<\/span>\uff1a\u694a\u671d\u5091  \u6210\u5927\u5fae\u514d\u6240\u78a9\u58eb\uff0c\u66fe\u8457\u6709\u300a\u5716\u89e3\u91ab\u5b78\u300b\u4e00\u66f8\uff0c\u6a02\u65bc\u5c07\u91ab\u5b78\u65b0\u77e5\u4ee5\u6dfa\u767d\u7684<\/span>\u6587\u5b57\u8b93\u66f4\u591a\u4eba\u4e86\u89e3\u3002<\/strong><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u566c\u83cc\u9ad4 (phage) \u5982\u540c\u5176\u540d\uff0c\u662f\u4e00\u7a2e\u6703\u541e\u566c\u6389\u88ab\u5bc4\u751f\u4e4b\u7d30\u83cc\u5bbf\u4e3b\u7684\u75c5\u6bd2\uff0c\u5c0d\u7d30\u83cc\u4f86\u8aaa\u566c\u83cc\u9ad4\u539f\u672c\u662f\u53ef\u60e1\u7684\u6575\u4eba\u3002\u7136\u800c\uff0c\u8fd1\u65e5 Cell Reports \u4e0a\u7684\u7814\u7a76\uff0c\u767c\u73fe\u7d30\u83cc\u80fd\u5229\u7528\u662f\u5426\u651c\u5e36\u566c\u83cc\u9ad4\uff0c\u4f86\u4f5c\u70ba\u8fa8\u8b58\u81ea\u5df1\u5925\u4f34\u7684\u6a19\u8a18\uff0c\u4e26\u518d\u4f7f\u559a\u566c\u83cc\u9ad4\u53bb\u653b\u64ca\u7af6\u722d\u98df\u7269\u7684\u5176\u5b83\u7d30\u83cc\u3002\u628a\u6575\u4eba\u8b8a\u5e6b\u624b\uff0c\u771f\u662f\u9ad8\u660e\u7684\u624b\u6bb5\uff01<\/p>\n","protected":false},"author":20,"featured_media":34256,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[1703,958,4310],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/07\/bacteria-3658992_640.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34248"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34248"}],"version-history":[{"count":2,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34248\/revisions"}],"predecessor-version":[{"id":34258,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34248\/revisions\/34258"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34256"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}