{"id":34221,"date":"2019-07-16T00:09:08","date_gmt":"2019-07-15T16:09:08","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34221"},"modified":"2019-07-12T11:38:35","modified_gmt":"2019-07-12T03:38:35","slug":"%e7%99%bc%e7%8f%be%e6%96%b0%e5%9e%8b%e5%a4%b1%e6%99%ba%e7%97%87%e3%80%8clate%e3%80%8d","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34221","title":{"rendered":"\u767c\u73fe\u65b0\u578b\u5931\u667a\u75c7\u300cLATE\u300d"},"content":{"rendered":"<p><strong><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft wp-image-34222\" src=\"http:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/06\/dependent-100343_960_720-300x225.jpg\" alt=\"\" width=\"450\" height=\"338\" srcset=\"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/06\/dependent-100343_960_720-300x225.jpg 300w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/06\/dependent-100343_960_720-768x576.jpg 768w, https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/06\/dependent-100343_960_720.jpg 960w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/>\u64b0\u6587\uff5c\u9673\u6566\u7406<\/strong><\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u9ad8\u9f61\u793e\u6703\u7684\u96b1\u6182\u2014\u5931\u667a\u75c7<\/strong><\/span><\/p>\n<p>\u6839\u64da\u7d71\u8a08\u81fa\u7063\u516d\u5341\u4e94\u6b72\u4ee5\u4e0a\u8001\u5e74\u4eba\u53e3\u57282018\u5e74\u5e95\u5df3\u7d93\u8d85\u904e343\u842c\u4eba\uff0c\u4f54\u5168\u81fa\u7063\u4eba\u53e3\u7e3d\u6578\u768414.56\uff05\u3002\u81fa\u7063\u5df3\u5728\u4e0d\u77e5\u4e0d\u89ba\u4e2d\u9032\u5165\u9ad8\u9f61\u793e\u6703\uff0c\u8001\u5e74\u4eba\u53e3\u50c5\u6b21\u65bc\u65e5\u672c\u3001\u5357\u97d3\uff0c\u5728\u4e9e\u6d32\u570b\u5bb6\u4e2d\u662f\u7b2c\u4e09\u9ad8\u3002\u5176\u4e2d\u60a3\u6709\u8f15\u5fae\u8a8d\u77e5\u969c\u7919 (MCI) \u8005\u4f5418.23%\uff0c\u7d0463\u842c\u4eba\uff1b\u60a3\u6709\u5931\u667a\u75c7\u8005\u4f547.86%\uff0c\u7d0427\u842c\u4eba\uff0c\u76f8\u7576\u65bc\u6bcf\u5341\u4e8c\u4f4d\u516d\u5341\u4e94\u6b72\u4ee5\u4e0a\u8001\u4eba\u4e2d\u5c31\u6709\u4e00\u4f4d\u60a3\u6709\u5931\u667a\u75c7\uff0c\u800c\u6bcf\u4e94\u4f4d\u516b\u5341\u6b72\u4ee5\u4e0a\u8001\u4eba\u4e2d\u5c31\u6709\u4e00\u4f4d\u60a3\u6709\u5931\u667a\u75c7\u3002\u5931\u667a\u75c7\u60a3\u8005\u96a8\u8457\u75c5\u60c5\u52a0\u91cd\uff0c\u9010\u6f38\u55aa\u5931\u5de5\u4f5c\u3001\u751f\u6d3b\u80fd\u529b\uff0c\u7167\u9867\u5931\u667a\u75c7\u60a3\u8005\u975e\u5e38\u56f0\u96e3\u800c\u8f9b\u82e6\uff0c\u751a\u81f3\u6210\u70ba\u8a31\u591a\u5bb6\u5ead\u6975\u5927\u7684\u91cd\u64d4\u3002\u7d04\u6709300- 500\u842c\u4eba\u751f\u6d3b\u76f4\u63a5\u3001\u9593\u63a5\u53d7\u5230\u5f71\u97ff\uff0c\u9019\u500b\u6578\u76ee\u63a5\u8fd1\u5168\u81fa\u7063\u4eba\u53e3\u7e3d\u6578\u7684\u4e8c\u6210\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u4ec0\u9ebc\u662f\u5931\u667a\u75c7\uff1f<\/strong><\/span><\/p>\n<p>\u5931\u667a\u75c7\u4e0d\u662f\u6b63\u5e38\u7684\u8001\u5316\uff0c\u800c\u662f\u4e00\u7a2e\u75be\u75c5\u3002\u8209\u4f8b\u4f86\u8aaa\u6b63\u5e38\u8001\u5316\u7684\u5e74\u9577\u8005\u5728\u5076\u7136\u5fd8\u8a18\u4e8b\u60c5\u4e4b\u5f8c\u6703\u518d\u60f3\u8d77\u4f86\uff0c\u800c\u5931\u667a\u75c7\u60a3\u8005\u5247\u6703\u5b8c\u5168\u5fd8\u8a18\u3002\u5931\u667a\u75c7\u6709\u5e7e\u500b\u4e0d\u540c\u540d\u7a31\uff0c\u6700\u65e9\u88ab\u7a31\u70ba\u75f4\u5446\u75c7\uff0c\u800c\u6700\u65b0\u88ab\u7a31\u4f5c\u300c\u91cd\u5ea6\u795e\u7d93\u8a8d\u77e5\u75c7\u300d\u3002\u5931\u667a\u75c7\u4e0d\u662f\u55ae\u4e00\u75be\u75c5\uff0c\u800c\u662f\u4e00\u7fa4\u75be\u75c5\u7684\u7d71\u7a31\uff0c\u5e38\u898b\u7684\u50cf\u662f\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7 (Alzheimer`s Disease) \u7d04\u4f54\u5931\u667a\u75c7\u60a3\u800560-80%\u3002\u9019\u4e9b\u75be\u75c5\u7684\u5171\u540c\u75c7\u72c0\u5305\u542b\u8a9e\u8a00\u3001\u601d\u8003\u3001\u8a18\u61b6\u3001\u7a7a\u9593\u611f\u3001\u6ce8\u610f\u529b\u7b49\u529f\u80fd\u8870\u9000\uff0c\u751a\u81f3\u500b\u6027\u6539\u8b8a\u3002\u9020\u6210\u5931\u667a\u75c7\u7684\u539f\u56e0\u4e3b\u8981\u662f\u9000\u5316\u3001\u8166\u4e2d\u98a8\u3001\u8166\u8840\u7ba1\u75c5\u8b8a\uff0c\u5176\u4ed6\u5982\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u611f\u67d3\u3001\u4e2d\u6bd2\u3001\u71df\u990a\u5931\u8abf\u8207\u65b0\u9673\u4ee3\u8b1d\u7570\u5e38\u7b49\u3002<\/p>\n<p><span style=\"color: #008080;\"><strong>\u25cf\u767c\u73fe\u65b0\u578b\u5931\u667a\u75c7<\/strong><\/span><\/p>\n<p>\u7814\u7a76\u767c\u73fe\u8207\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u6975\u76f8\u4f3c\u7684\u65b0\u578b\u5931\u667a\u75c7\uff0c\u4f30\u8a08\u516b\u5341\u4e94\u6b72\u4ee5\u4e0a\u9577\u8005\u4e2d\u6709\u56db\u5206\u4e4b\u4e00\u7f79\u60a3\u6b64\u75c7\u3002\u7f8e\u570b\u80af\u5854\u57fa\u5927\u5b78\u535a\u58eb Peter T. Nelson \u3001\u6885\u7d04\u91ab\u5b78\u4e2d\u5fc3 (Mayo Clinic)&nbsp;\u91ab\u751f&nbsp;Dennis W. Dickson \u8207\u4f86\u81ea\u7f8e\u570b\u5404\u5730\u3001\u745e\u5178\u3001\u6fb3\u6d32\u3001\u5967\u5730\u5229\u3001\u65e5\u672c\u7684\u7814\u7a76\u5718\u968a\u901a\u529b\u5408\u4f5c\u767c\u73fe\u65b0\u578b\u5931\u667a\u75c7\u3002\u9019\u7a2e\u5931\u667a\u75c7\u767c\u75c5\u6642\u9593\u975e\u5e38\u665a\uff0c\u5927\u90fd\u5728\u4eba\u5011\u4e00\u751f\u6700\u5f8c\u5341\u591a\u5e74\uff0c\u76ee\u524d\u5b78\u8853\u754c\u5c0d\u5176\u4e86\u89e3\u4ecd\u5341\u5206\u6709\u9650\uff0c\u751a\u81f3\u9084\u6c92\u6709\u6b63\u5f0f\u547d\u540d\u3002\u66ab\u6642\u4ee5\u63cf\u8ff0\u5176\u75c5\u7406\u7279\u5fb5\u548c\u76f8\u95dc\u75c7\u72c0\u5e7e\u500b\u82f1\u6587\u5b57\u7684\u7b2c\u4e00\u500b\u5b57\u6bcd\u7e2e\u5beb\uff0c\u66b1\u7a31\u70ba\u665a\u767c\u578b\u5931\u667a\u75c7 (LATE\uff0climbic-predominant age-related TDP-43 encephalopathy)\u3002\u9019\u7a2e\u65b0\u578b\u5931\u667a\u75c7\u8207\u5df3\u77e5\u7684\u76f8\u7576\u4e0d\u540c\uff0c\u50cf\u662f\u767c\u75c5\u5e74\u9f61\u975e\u5e38\u665a\uff0c\u5f71\u97ff\u7bc4\u570d\u537b\u4e0d\u5c0f\uff0c\u4f30\u8a08\u516b\u5341\u4e94\u6b72\u4ee5\u4e0a\u5e74\u9577\u8005\u4e2d\u6709\u767e\u5206\u4e4b\u4e8c\u5341\u4e94\u7f79\u60a3\u6b64\u75c7\u3002<\/p>\n<p><strong><span style=\"color: #008080;\">\u25cf\u65b0\u578b\u5931\u667a\u75c7\u8207\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u6975\u76f8\u4f3c<\/span><\/strong><\/p>\n<p>LATE \u75c5\u60a3\u5931\u667a\u5931\u61b6\u7684\u75c7\u72c0\u96d6\u7136\u8207\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u5341\u5206\u76f8\u4f3c\uff0c\u75c5\u7406\u7279\u5fb5\u537b\u5b8c\u5168\u4e0d\u540c\u3002\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u662f\u7531\u5fb7\u570b\u91ab\u751f Alois Alzheimer \u65bc1906\u5e74\u5728\u91ab\u5b78\u6703\u8b70\u4e2d\u9996\u6b21\u767c\u8868\uff0c\u5f8c\u4eba\u70ba\u4e86\u7d00\u5ff5\u4ed6\u800c\u4ee5\u5176\u59d3\u6c0f\u547d\u540d\u81f3\u4eca\u5df3\u5c07\u8fd1115\u5e74\u3002\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u75c5\u60a3\u4e3b\u8981\u75c5\u7406\u7279\u5fb5\u662f\u8166\u4e2d\u7684\u6591\u584a (plaques) \u548c\u7e8f\u7d50 (tangles)\uff0c\u800cLATE \u75c5\u60a3\u8166\u4e2d\u537b\u662f\u7a2e\u8f03\u4e0d\u70ba\u4eba\u6240\u77e5\u7684\u86cb\u767d TDP-43\uff0c\u9019\u7a2e\u86cb\u767d\u6563\u4f48\u6c88\u7a4d\u5728\u5927\u8166\u6d77\u99ac\u8ff4 (hippocampus) \u548c\u674f\u4ec1\u9ad4 (amygdala)\u3002\u6d77\u99ac\u8ff4\u3001\u674f\u4ec1\u9ad4\u90fd\u5c6c\u65bc\u8166\u90e8\u908a\u7de3\u7cfb\u7d71 (limbic system) \u7684\u4e00\u90e8\u5206\uff0cLATE \u7684\u7b2c\u4e00\u500b\u82f1\u6587\u5b57\u6bcd\u6b63\u662f\u908a\u7de3\u7cfb\u7d71\u7684\u7e2e\u5beb\u3002\u908a\u7de3\u7cfb\u7d71\u7531\u6d77\u99ac\u8ff4\u3001\u674f\u4ec1\u9ad4\u3001\u55c5\u89ba\u76ae\u8cea\u3001\u8996\u4e18\u3001\u4e0b\u8996\u4e18\u7b49\u7d44\u6210\uff0c\u74b0\u7e5e\u5728\u8166\u5e79\u5468\u570d\u3002\u5176\u529f\u80fd\u662f\u8996\u89ba\u3001\u807d\u89ba\u3001\u89f8\u89ba\u3001\u55c5\u89ba\u8207\u5473\u89ba\u8a0a\u606f\u7d93\u904e\u908a\u7de3\u7cfb\u7d71\u5f62\u6210\u8a18\u61b6\u548c\u60c5\u611f\u3002\u6d77\u99ac\u8ff4\u3001\u674f\u4ec1\u9ad4\u90fd\u662f\u8207\u4eba\u5011\u60c5\u611f\u8a18\u61b6\u601d\u8003\u81f3\u95dc\u91cd\u8981\u7684\u5340\u57df\u3002LATE \u8207\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u9019\u985e\u795e\u7d93\u9000\u5316\u75be\u75c5\u662f\u6f38\u9032\u800c\u7121\u6cd5\u6539\u8b8a\u7684\uff0c\u5b83\u6703\u6162\u6162\u7834\u58de\u60a3\u8005\u7684\u8a18\u61b6\u548c\u601d\u8003\u80fd\u529b\uff0c\u6700\u5f8c\u751a\u81f3\u7121\u6cd5\u5f9e\u4e8b\u65e5\u5e38\u751f\u6d3b\u4e2d\u6700\u7c21\u55ae\u7684\u4e8b\u60c5\u3002<\/p>\n<p><strong><span style=\"color: #008080;\">\u25cf\u6cbb\u7642LATE \u6240\u9762\u81e8\u7684\u6311\u6230<\/span><\/strong><\/p>\n<p>\u76ee\u524d\u5df3\u7d93\u80fd\u8fa8\u8b58\u51fa LATE \u767c\u75c5\u4e0d\u540c\u968e\u6bb5\u7684\u8166\u90e8\u7279\u5fb5\uff0c\u7136\u800c\u6709\u500b\u5927\u554f\u984c\u5c1a\u5f85\u514b\u670d\uff0c\u5c31\u662f\u8af8\u5982 TDP-43\u86cb\u767d\u5206\u4f48\u3001\u6d77\u99ac\u8ff4\u53d7\u640d\u7b49\u7279\u5fb5\u53ea\u5728\u75c5\u60a3\u6b7b\u5f8c\u767c\u73fe\u3002\u91ab\u751f\u76ee\u524d\u4ecd\u6c92\u6709\u78ba\u8a3a LATE\u7684\u6a19\u6e96\u65b9\u6cd5\u6d41\u7a0b\uff0c\u53ea\u80fd\u7528\u6392\u9664\u6cd5\uff0c\u4f8b\u5982\u516b\u5341\u6b72\u4ee5\u4e0a\u75c5\u60a3\u6709\u5931\u61b6\u3001\u6c92\u6709\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u75c7\u72c0\u3001\u540c\u6642\u6d77\u99ac\u8ff4\u840e\u7e2e\u6642\uff0c\u6975\u53ef\u80fd\u662f\u7f79\u60a3\u6b64\u75c7\u3002\u5e74\u9577\u8005\u8166\u90e8\u7d93\u5e38\u4f34\u96a8\u8a31\u591a\u554f\u984c\u6210\u70ba LATE \u8a3a\u65b7\u6700\u5927\u6311\u6230\uff0c\u9019\u4e9b\u90fd\u6709\u53ef\u80fd\u5c0e\u81f4\u5931\u667a\u75c7\u3002\u8a31\u591a LATE \u75c5\u60a3\u8166\u90e8\u4e5f\u540c\u6642\u6709\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u75c7\u72c0\u3002\u6b63\u662f\u5931\u667a\u75c7\u7684\u8907\u96dc\u6027\u52a0\u4e0a LATE\u8207\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u6975\u76f8\u4f3c\uff0c\u53ef\u80fd\u9020\u6210\u8fd1\u671f\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u5931\u6557\u7684\u539f\u56e0\u4e4b\u4e00\u3002LATE \u75c5\u60a3\u88ab\u7576\u6210\u963f\u8332\u6d77\u9ed8\u6c0f\u75c7\u800c\u52a0\u5165\u81e8\u5e8a\u8a66\u9a57\u9020\u6210\u8aa4\u5dee\uff0c\u78ba\u5be6\u5206\u8fa8\u5169\u8005\u53ef\u4ee5\u63d0\u5347\u6cbb\u7642\u7814\u7a76\u6548\u679c\u3002\u5f9e\u767c\u73fe\u65b0\u578b\u5931\u667a\u75c7\u5230\u767c\u5c55\u51fa\u5b89\u5168\u6709\u6548\u7684\u7642\u6cd5\u8207\u85e5\u7269\u554f\u5e02\u4ecd\u662f\u6f2b\u6f2b\u9577\u8def\uff0c\u537b\u540c\u6642\u4e5f\u662f\u4e00\u5927\u5951\u6a5f\uff0c\u60df\u6709\u6b63\u78ba\u8a3a\u65b7\u624d\u6703\u300c\u5c0d\u75c7\u4e0b\u85e5\u300d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<ol>\n<li>Peter T Nelson, Dennis W Dickson, John Q Trojanowski, etc. <a href=\"https:\/\/academic.oup.com\/brain\/article\/142\/6\/1503\/5481202\">Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report<\/a>. Brain, April 30, 2019<\/li>\n<li><a href=\"http:\/\/www.tada2002.org.tw\/About\/IsntDementia\">\u8a8d\u8b58\u5931\u667a\u75c7<\/a>\u3002\u53f0\u7063\u5931\u667a\u75c7\u5354\u6703\u3002<\/li>\n<li><a href=\"https:\/\/www.alz.org\/alzheimers-dementia\/what-is-alzheimers\">What Is Alzheimer's?<\/a> Alzheimer's Association.<\/li>\n<\/ol>\n<p><img decoding=\"async\" class=\"alignnone\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/zh-Hant.png\" alt=\"\u52a0\u5165\u597d\u53cb\" width=\"212\" height=\"36\" border=\"0\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u80af\u5854\u57fa\u5927\u5b78\u535a\u58eb Peter T. Nelson \u3001\u6885\u7d04\u91ab\u5b78\u4e2d\u5fc3 (Mayo Clinic)\u00a0\u91ab\u751f\u00a0Dennis W. Dickson \u8207\u4f86\u81ea\u7f8e\u570b\u5404\u5730\u3001\u745e\u5178\u3001\u6fb3\u6d32\u3001\u5967\u5730\u5229\u3001\u65e5\u672c\u7684\u7814\u7a76\u5718\u968a\u901a\u529b\u5408\u4f5c\u767c\u73fe\u65b0\u578b\u5931\u667a\u75c7\u3002\u9019\u7a2e\u5931\u667a\u75c7\u767c\u75c5\u6642\u9593\u975e\u5e38\u665a\uff0c\u5927\u90fd\u5728\u4eba\u5011\u4e00\u751f\u6700\u5f8c\u5341\u591a\u5e74\uff0c\u76ee\u524d\u5b78\u8853\u754c\u5c0d\u5176\u4e86\u89e3\u4ecd\u5341\u5206\u6709\u9650\uff0c\u751a\u81f3\u9084\u6c92\u6709\u6b63\u5f0f\u547d\u540d\u3002\u66ab\u6642\u4ee5\u63cf\u8ff0\u5176\u75c5\u7406\u7279\u5fb5\u548c\u76f8\u95dc\u75c7\u72c0\u5e7e\u500b\u82f1\u6587\u5b57\u7684\u7b2c\u4e00\u500b\u5b57\u6bcd\u7e2e\u5beb\uff0c\u66b1\u7a31\u70ba\u665a\u767c\u578b\u5931\u667a\u75c7 (LATE\uff0climbic-predominant age-related TDP-43 encephalopathy)\u3002<\/p>\n","protected":false},"author":20,"featured_media":34222,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[771,779,4302],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/06\/dependent-100343_960_720.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34221"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34221"}],"version-history":[{"count":1,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34221\/revisions"}],"predecessor-version":[{"id":34223,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34221\/revisions\/34223"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34222"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34221"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}