{"id":34047,"date":"2019-05-28T00:06:14","date_gmt":"2019-05-27T16:06:14","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=34047"},"modified":"2019-05-24T11:39:35","modified_gmt":"2019-05-24T03:39:35","slug":"%e8%ae%93%e7%9a%ae%e8%86%9a%e9%9d%92%e6%98%a5%e6%b0%b8%e9%a7%90%e7%9a%84%e9%97%9c%e9%8d%b5%ef%bc%9a%e8%86%a0%e5%8e%9f%e8%9b%8b%e7%99%bd-col17a1","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=34047","title":{"rendered":"\u8b93\u76ae\u819a\u9752\u6625\u6c38\u99d0\u7684\u95dc\u9375\uff1a\u81a0\u539f\u86cb\u767d COL17A1"},"content":{"rendered":"

\u597d\u770b\u7684\u4e8b\u7269\u6216\u5916\u8c8c\u4eba\u4eba\u559c\u6b61\uff0c\u5e38\u4fdd\u9752\u6625\u66f4\u662f\u4eba\u985e\u5343\u5e74\u4f86\u8ffd\u9010\u7684\u5922\u60f3\u3002\u773e\u6240\u5468\u77e5\u300c\u81a0\u539f\u86cb\u767d\u300d\u6d41\u5931\u662f\u76ae\u819a\u8870\u8001\u7684\u7f6a\u9b41\u798d\u9996\uff0c\u66ab\u4e14\u4e0d\u8ad6\u8fd1\u5e74\u4f86\u6253\u8457\u81a0\u539f\u86cb\u767d\u540d\u865f\u7d1b\u7d1b\u4e0a\u5e02\u7684\u4fdd\u990a\u7522\u54c1\u4e4b\u6548\u679c\u5982\u4f55\u3002\u6700\u8fd1 Nature<\/em> \u671f\u520a\u767c\u8868\u7684\u7814\u7a76\u627e\u5230\u4e86\u81a0\u539f\u86cb\u767d\u4f5c\u7528\u6a5f\u5236\u7684\u89e3\u7b54\uff0c\u76ae\u819a\u8870\u8001\u8207\u81a0\u539f\u86cb\u767d COL17A1 \u5982\u4f55\u4fc3\u9032\u5e79\u7d30\u80de\u7af6\u722d\u606f\u606f\u76f8\u95dc\u3002<\/strong><\/span><\/p>\n

\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u25cf<\/b>\u76ae\u819a\u81a0\u539f\u86cb\u767d<\/strong> COL17A1 <\/strong>\u542b\u91cf\u6703\u96a8\u5e74\u9f61\u589e\u9577\u800c\u6e1b\u5c11<\/strong><\/span><\/p>\n

\u5b30\u5152\u51fa\u751f\u6642\u7d30\u5ae9\u3001\u5439\u5f48\u53ef\u7834\u7684\u808c\u819a\uff0c\u96a8\u8457\u5e74\u9f61\u589e\u9577\u76ae\u819a\u9010\u6f38\u8001\u5316\uff0c\u662f\u7531\u65bc\u76ae\u819a\u9632\u885b\u53ca\u4fee\u5fa9\u6a5f\u5236\u5931\u8861\uff0c\u5c0e\u81f4\u7684\u640d\u5bb3\u4e0d\u65b7\u7d2f\u7a4d\u3002\u4f7f\u5f97\u76ae\u819a\u539a\u5ea6\u8b8a\u8584\u3001\u5931\u53bb\u5f48\u6027\u3001\u8106\u5f31\u3001\u50b7\u53e3\u7652\u5408\u7de9\u6162\uff0c\u4ee5\u53ca\u89d2\u8cea\u7d30\u80de (keratinocyte) \u8207\u9ed1\u8272\u7d20\u7d30\u80de (melanocyte) \u542b\u91cf\u6e1b\u5c11\uff0c\u6210\u4eba\u5e79\u7d30\u80de (adult stem cell) \u7684\u80fd\u529b\u9010\u6f38\u4e0b\u964d\uff0c\u9019\u4e9b\u90fd\u662f\u76ae\u819a\u8001\u5316\u7684\u7279\u5fb4\uff0c\u4f46\u8001\u5316\u52d5\u614b\u8b8a\u5316\u904e\u7a0b\u7684\u8a73\u7d30\u6a5f\u5236\u4ecd\u4e0d\u6e05\u695a\u3002\u6700\u8fd1\uff0c\u65e5\u672c\u6771\u4eac\u91ab\u79d1\u9f52\u79d1\u5927\u5b78\u5718\u968a\u5728 Nature<\/em> \u671f\u520a\u767c\u8868\u7814\u7a76\u5831\u544a\uff0c\u70ba\u6211\u5011\u63d0\u51fa\u4e86\u4e00\u7a2e\u89e3\u7b54\u3002<\/p>\n

\u5be6\u9a57\u9996\u5148\u8b49\u660e\u5c0f\u9f20\u5c3e\u5df4\u4e0a\u7684\u76ae\u819a\u8207\u4eba\u985e\u76ae\u819a\u76f8\u4f3c\u6027\u6975\u9ad8\uff0c\u800c\u4e14\u4e5f\u4ee5\u985e\u4f3c\u7684\u65b9\u5f0f\u8001\u5316\uff0c\u6240\u4ee5\u79d1\u5b78\u5bb6\u9078\u64c7\u4ee5\u5c0f\u9f20\u5c3e\u5df4\u76ae\u819a\uff0c\u4f86\u9032\u4e00\u6b65\u63a2\u8a0e\u76ae\u819a\u8001\u5316\u7684\u53ef\u80fd\u56e0\u7d20\u3002\u6211\u5011\u5f97\u5148\u7406\u89e3\u76ae\u819a\u69cb\u9020\u4e2d\uff0c\u57fa\u5e95\u819c (basement membrane) \u8ca0\u8cac\u64d4\u4efb\u8868\u76ae\u5c64\u548c\u771f\u76ae\u5c64\u4e4b\u9593\u7684\u6a4b\u6a11\uff0c\u800c\u8868\u76ae\u7d30\u80de\u66f4\u65b0\u548c\u640d\u50b7\u4fee\u5fa9\u6240\u9700\u8981\u7684\u5e79\u7d30\u80de\u5f97\u901a\u904e\u300c\u534a\u80de\u6a4b\u5c0f\u9ad4 (hemidesmosome)\u300d\u9644\u8457\u5728\u57fa\u5e95\u819c\u4e0a\u3002\u7814\u7a76\u5f9e\u5c0f\u9f20\u76ae\u819a\u53ca\u9ad4\u5916\u57f9\u990a\u4e4b\u4eba\u9ad4\u8868\u76ae\u7d30\u80de\u7684\u5be6\u9a57\u90fd\u767c\u73fe\uff0c\u96a8\u8457\u5e74\u9f61\u589e\u9577\uff0c\u534a\u80de\u6a4b\u5c0f\u9ad4\u660e\u986f\u6e1b\u5c11\uff0c\u800c\u534a\u80de\u6a4b\u5c0f\u9ad4\u4e2d\u7684\u300c\u81a0\u539f\u86cb\u767d COL17A1\u300d\u4e5f\u96a8\u4e4b\u6e1b\u5c11\u3002<\/p>\n

\u25cf<\/b>COL17A1 <\/strong>\u4fc3\u9032\u5e79\u7d30\u80de\u826f\u6027\u7af6\u722d\u662f\u9632\u6b62\u76ae\u819a\u8001\u5316\u7684\u95dc\u9375<\/strong><\/span><\/p>\n

\u81a0\u539f\u86cb\u767d COL17A1 \u7684\u542b\u91cf\uff0c\u4e5f\u6703\u56e0\u52a0\u901f\u76ae\u819a\u8870\u8001\u7684\u7d2b\u5916\u7dda\u6216\u904e\u6c27\u5316\u6c2b\u7b49\u7406\u5316\u56e0\u7d20\u800c\u6e1b\u5c11\u3002\u4e26\u4e14\uff0c\u5728 COL17A1<\/em> \u57fa\u56e0\u5254\u9664\u7684\u5c0f\u9f20\u76ae\u819a\u66f4\u6613\u8870\u8001\uff0c\u50b7\u53e3\u7652\u5408\u80fd\u529b\u8b8a\u5dee\uff0c\u53d7\u5230\u7d2b\u5916\u7dda\u7167\u5c04\u6642\u66f4\u5bb9\u6613\u51fa\u73fe\u8272\u7d20\u6c89\u7740 (pigmentation)\uff1b\u53cd\u65b9\u9762\u4f86\u770b\uff0c\u5728 COL17A1<\/em> \u57fa\u56e0\u904e\u5ea6\u8868\u73fe\u7684\u5c0f\u9f20\u76ae\u819a\uff0c\u50b7\u53e3\u7652\u5408\u80fd\u529b\u8f03\u5f37\uff0c\u7d2b\u5916\u7dda\u7167\u5c04\u4e5f\u4e0d\u6613\u51fa\u73fe\u8272\u7d20\u6c89\u7740\u3002\u5f9e\u6b64\u9805\u7d50\u679c\uff0c\u4e5f\u80fd\u5920\u9ad4\u8a8d\u5230\u65e5\u5e38\u9632\u66ec\u7684\u5fc5\u8981\u6027\u554a\u3002<\/p>\n

\u7814\u7a76\u89c0\u5bdf\u5230\u7684\u91cd\u9ede\uff0c\u9084\u6709\u767c\u73fe COL17A1 \u7684\u8868\u73fe\u91cf\u5728\u4e0d\u540c\u5e79\u7d30\u80de\u9593\u5b58\u5728\u5dee\u7570\uff0cCOL17A1 \u8f03\u591a\u7684\u5e79\u7d30\u80de\u6703\u7262\u56fa\u5730\u9644\u8457\u65bc\u57fa\u5e95\u819c\uff0c\u4e26\u5c07\u9644\u8fd1 COL17A1 \u8f03\u5c11\u7684\u5e79\u7d30\u80de\u6392\u64e0\u51fa\u53bb\u3002\u85c9\u7531\u4fc3\u9032\u7d30\u80de\u9593\u7684\u300c\u826f\u6027\u7af6\u722d\u300d\uff0c\u6dd8\u6c70\u90a3\u4e9b COL17A1 \u8f03\u5c11\u3001\u54c1\u8cea\u8f03\u5dee\u7684\u7d30\u80de\uff0c\u7559\u4e0b\u54c1\u8cea\u8f03\u9ad8\u7684\u7d30\u80de\uff0c\u5c07\u6709\u52a9\u65bc\u8b93\u76ae\u819a\u66f4\u70ba\u5e74\u8f15\u4e26\u7dad\u6301\u6574\u9ad4\u7d50\u69cb\u7684\u5b8c\u6574\u6027\u3002\u7136\u800c\uff0c\u5982\u679c COL17A1 \u8f03\u591a\u7684\u9ad8\u54c1\u8cea\u7d30\u80de\u6578\u91cf\u592a\u5c11\uff0c\u7522\u751f\u7684\u7af6\u722d\u58d3\u529b\u6709\u9650\uff0c\u5c31\u4e0d\u80fd\u6709\u6548\u6dd8\u6c70\u54c1\u8cea\u8f03\u5dee\u7684\u7d30\u80de\uff0c\u53cd\u800c\u9020\u6210\u52a3\u5e63\u9a45\u9010\u826f\u5e63\u7684\u60c5\u6cc1\uff0c\u4f7f\u5f97\u76ae\u819a\u8001\u5316\u3002<\/p>\n

\u25cf<\/b>\u5857\u62b9\u6216\u98df\u7528\u7684\u81a0\u539f\u86cb\u767d\u96e3\u4ee5\u9632\u6b62\u76ae\u819a\u8001\u5316<\/strong><\/span><\/p>\n

\u66f4\u5438\u5f15\u76ee\u5149\u7684\u662f\uff0c\u7814\u7a76\u9084\u627e\u51fa\u5169\u7a2e\u5316\u5408\u7269\u300cY27632\u300d\u53ca\u300c\u593e\u7af9\u6843\u9ebb\u7d20 (apocynin)\u300d\uff0c\u53ef\u4ee5\u6709\u6548\u7684\u5728\u9ad4\u5916\u5be6\u9a57\u4e2d\u8a98\u5c0e\u4eba\u985e\u89d2\u8cea\u7d30\u80de\u7522\u751f\u81a0\u539f\u86cb\u767d COL17A1\uff0c\u4e5f\u53ef\u4ee5\u4fc3\u9032\u5c0f\u9f20\u76ae\u819a\u7684\u50b7\u53e3\u7652\u5408\u3002\u7e3d\u7d50\u4f86\u8aaa\uff0c\u9019\u9805\u7814\u7a76\u7d50\u679c\u5c55\u793a\u4e86 COL17A1 \u4fc3\u9032\u5e79\u7d30\u80de\u9593\u7684\u7af6\u722d\uff0c\u5c0d\u76ae\u819a\u6052\u5b9a\u6027\u53ca\u8001\u5316\u7684\u91cd\u8981\u5f71\u97ff\uff0c\u610f\u5473\u8457\u672a\u4f86\u6709\u6a5f\u6703\u958b\u767c\u51fa\u76ae\u819a\u518d\u751f\u6216\u6297\u8001\u5316\u7684\u85e5\u7269\u6216\u7522\u54c1\u3002<\/p>\n

\u53cd\u89c0\u73fe\u5728\u5e02\u9762\u4e0a\u6797\u6797\u7e3d\u7e3d\u7684\u81a0\u539f\u86cb\u767d\u7522\u54c1\uff0c\u751a\u81f3\u662f\u5bcc\u542b\u81a0\u539f\u86cb\u767d\u7684\u98df\u7269\uff0c\u90fd\u88ab\u8cbc\u4e0a\u4e86\u990a\u984f\u7f8e\u5bb9\u7684\u6a19\u8a8c\u3002\u5be6\u969b\u4e0a\uff0c\u7121\u8ad6\u662f\u5857\u62b9\u9084\u662f\u98df\u7528\u7684\u81a0\u539f\u86cb\u767d\u7522\u54c1\uff0c\u90fd\u96e3\u4ee5\u5728\u7d30\u80de\u4e2d\u767c\u63ee\u4f5c\u7528\uff0c\u56e0\u70ba\u6839\u64da\u6b64\u9805\u7814\u7a76\u8b49\u5be6 COL17A1 \u81a0\u539f\u86cb\u767d\u662f\u7531\u7d30\u80de\u81ea\u884c\u7522\u751f\uff0c\u4e26\u975e\u5f9e\u5916\u90e8\u88dc\u5145\u3002\u6b64\u5916\uff0c\u5857\u62b9\u7684\u81a0\u539f\u86cb\u767d\u56e0\u70ba\u5206\u5b50\u5927\uff0c\u800c\u7a7f\u900f\u76ae\u819a\u7684\u6548\u679c\u5dee\uff1b\u98df\u7528\u7684\u81a0\u539f\u86cb\u767d\u9032\u5230\u8178\u80c3\u6d88\u5316\u5f8c\uff0c\u5176\u7d50\u69cb\u6703\u88ab\u7834\u58de\uff0c\u6700\u5f8c\u5206\u89e3\u6210\u80fa\u57fa\u9178\uff0c\u5c31\u8ddf\u98df\u7528\u4e00\u822c\u86cb\u767d\u8cea\u76f8\u540c\u3002<\/p>\n

\u6240\u4ee5\uff0c\u5e0c\u671b\u76ae\u819a\u64c1\u6709\u771f\u6b63\u6709\u6548\u7684\u9752\u6625\u4e4b\u6cc9\uff0c\u9084\u5f97\u9760\u79d1\u5b78\u5bb6\u5011\u591a\u52a0\u628a\u52c1\u4e86\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Liu N1, et al. Nature. 2019 Apr;568(7752):344-350. Stem cell competition orchestrates skin homeostasis and ageing.<\/a><\/li>\n
  2. Bilousova G, et al. Nature. 2019 Apr;568(7752):318-319. Elimination of unfit cells in young and ageing skin.<\/a><\/li>\n
  3. \u694a\u5609\u6167\uff0c\u79d1\u5b78\u4eba\uff0c2011\uff0c\u7d30\u80de\u7684\u652f\u67b6\uff1a\u81a0\u539f\u86cb\u767d<\/a><\/li>\n<\/ol>\n

     <\/p>\n

    --<\/strong>
    \n\u4f5c\u8005\uff1a\u694a\u671d\u5091  \u6210\u5927\u5fae\u514d\u6240\u78a9\u58eb\uff0c\u66fe\u8457\u6709\u300a\u5716\u89e3\u91ab\u5b78\u300b\u4e00\u66f8\uff0c\u6a02\u65bc\u5c07\u91ab\u5b78\u65b0\u77e5\u4ee5\u6dfa\u767d\u7684\u6587\u5b57\u8b93\u66f4\u591a\u4eba\u4e86\u89e3\u3002<\/strong><\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u597d\u770b\u7684\u4e8b\u7269\u6216\u5916\u8c8c\u4eba\u4eba\u559c\u6b61\uff0c\u5e38\u4fdd\u9752\u6625\u66f4\u662f\u4eba\u985e\u5343\u5e74\u4f86\u8ffd\u9010\u7684\u5922\u60f3\u3002\u773e\u6240\u5468\u77e5\u300c\u81a0\u539f\u86cb\u767d\u300d\u6d41\u5931\u662f\u76ae\u819a\u8870\u8001\u7684\u7f6a\u9b41\u798d\u9996\uff0c\u66ab\u4e14\u4e0d\u8ad6\u8fd1\u5e74\u4f86\u6253\u8457\u81a0\u539f\u86cb\u767d\u540d\u865f\u7d1b\u7d1b\u4e0a\u5e02\u7684\u4fdd\u990a\u7522\u54c1\u4e4b\u6548\u679c\u5982\u4f55\u3002\u6700\u8fd1 Nature \u671f\u520a\u767c\u8868\u7684\u7814\u7a76\u627e\u5230\u4e86\u81a0\u539f\u86cb\u767d\u4f5c\u7528\u6a5f\u5236\u7684\u89e3\u7b54\uff0c\u76ae\u819a\u8870\u8001\u8207\u81a0\u539f\u86cb\u767d COL17A1 \u5982\u4f55\u4fc3\u9032\u5e79\u7d30\u80de\u7af6\u722d\u606f\u606f\u76f8\u95dc\u3002<\/p>\n","protected":false},"author":20,"featured_media":34053,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4266,121,4264,4265],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/05\/joy-1698701_1920.jpg","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34047"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34047"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34047\/revisions"}],"predecessor-version":[{"id":34064,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/34047\/revisions\/34064"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/34053"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}