{"id":33981,"date":"2019-05-21T00:34:27","date_gmt":"2019-05-20T16:34:27","guid":{"rendered":"https:\/\/case.ntu.edu.tw\/blog\/?p=33981"},"modified":"2019-05-20T11:57:18","modified_gmt":"2019-05-20T03:57:18","slug":"%e8%85%b8%e9%81%93%e8%8f%8c%e5%8f%a2%e9%a0%90%e6%b8%ac%e5%a4%a7%e8%85%b8%e7%9b%b4%e8%85%b8%e7%99%8c","status":"publish","type":"post","link":"https:\/\/case.ntu.edu.tw\/blog\/?p=33981","title":{"rendered":"\u8178\u9053\u83cc\u53e2\u9810\u6e2c\u5927\u8178\u76f4\u8178\u764c"},"content":{"rendered":"
\"\"
\u5716\u7247\u51fa\u8655 @pixabay<\/figcaption><\/figure>\n

\u64b0\u6587\uff5c<\/strong>\u694a\u671d\u5091<\/strong><\/p>\n

\u5e02\u9762\u4e0a\u5145\u65a5\u8457\u8033\u719f\u80fd\u8a73\u7684\u300c\u589e\u52a0\u8178\u9053\u597d\u83cc\u300d\u5404\u7a2e\u5546\u54c1\uff0c\u800c\u8178\u9053\u83cc\u53e2 (gut microbiome) \u8207\u75be\u75c5\u7684\u95dc\u806f\u4e5f\u662f\u8fd1\u5e74\u6b63\u592f\u7684\u7814\u7a76\u4e3b\u984c\u30022019 \u5e74 4 \u6708 Nature Medicine<\/em> \u66f4\u662f\u540c\u6642\u520a\u767b\u4e86\u5169\u7bc7\u76f8\u95dc\u7814\u7a76\uff0c\u8fa8\u8b58\u51fa\u5927\u8178\u76f4\u8178\u764c (colorectal cancer) \u60a3\u8005\u7684\u8178\u9053\u83cc\u53e2\u7279\u5fb5\uff0c\u672a\u4f86\u80fd\u9032\u4e00\u6b65\u767c\u5c55\u51fa\uff0c\u85c9\u7531\u5206\u6790\u7cde\u4fbf\u4e2d\u7684\u7d30\u83cc\u5c31\u80fd\u9810\u6e2c\u5927\u8178\u76f4\u8178\u764c\u7684\u81e8\u5e8a\u8a3a\u65b7\u5de5\u5177\u3002<\/p>\n

\u25cf\u7834\u89e3\u8178\u9053\u83cc\u53e2\u79d8\u5bc6\u7684\u5229\u5668\uff1a\u7e3d\u9ad4\u57fa\u56e0\u9ad4\u5b78<\/strong><\/span><\/p>\n

\u904e\u53bb\u80c3\u8178\u9053\u66fe\u88ab\u7c21\u55ae\u5730\u8996\u70ba\u6d88\u5316\u5668\u5b98\uff0c\u4f46\u8fd1\u5341\u5e74\u4f86\uff0c\u8a31\u591a\u7814\u7a76\u5f9e\u7cde\u4fbf\u4e2d\u5206\u6790\u8178\u9053\u83cc\u53e2\uff0c\u6709\u8d8a\u4f86\u8d8a\u591a\u8b49\u64da\u53ca\u7dda\u7d22\u986f\u793a\uff0c\u8178\u9053\u83cc\u53e2\u5c0d\u4eba\u9ad4\u5065\u5eb7\u6709\u8457\u91cd\u8981\u5f71\u97ff\u3002\u60e1\u540d\u662d\u5f70\u7684\u5927\u8178\u76f4\u8178\u764c\u662f\u7b2c\u4e8c\u5e38\u898b\u7684\u764c\u75c7\uff0c\u5176\u4e2d\u300c\u5076\u767c\u6027 (sporadic)\u300d\u6bd4\u8d77\u300c\u907a\u50b3\u6027\u300d\u5927\u8178\u76f4\u8178\u764c\uff0c\u5076\u767c\u6027\u5360\u4e86\u9ad8\u9054 70\u201387%\uff0c\u9019\u4ee3\u8868\u907a\u50b3\u6027\u53ea\u80fd\u89e3\u91cb\u4e00\u5c0f\u90e8\u5206\u75be\u75c5\u7684\u767c\u751f\u539f\u56e0\u3002<\/p>\n

\u56e0\u6b64\uff0c\u79d1\u5b78\u5bb6\u60f3\u7834\u982d\u627e\u51fa\u5176\u4ed6\u5927\u8178\u76f4\u8178\u764c\u53ef\u80fd\u7684\u81f4\u75c5\u56e0\u7d20\uff0c\u4e5f\u5c07\u8166\u7b4b\u52d5\u5230\u5927\u8178\u76f4\u8178\u764c\u60a3\u8005\u7684\u300c\u8178\u9053\u83cc\u53e2\u300d\u662f\u5426\u8207\u5065\u5eb7\u8005\u7684\u4e0d\u540c\uff1f\u5176\u5be6\u9019\u500b\u60f3\u6cd5\u5341\u5206\u5408\u7406\uff0c\u56e0\u70ba\u81e8\u5e8a\u4e0a\u5df2\u7d93\u6709\u300c\u5e7d\u9580\u87ba\u65cb\u687f\u83cc (Helicobacter pylori<\/em>)\u300d\u8207\u300c\u80c3\u764c\u300d\u95dc\u4fc2\u7684\u524d\u8eca\u4e4b\u9451\u3002\u7136\u800c\uff0c\u4e0d\u50cf\u80c3\u9178\u74b0\u5883\u4e2d\u5f88\u5c11\u5fae\u751f\u7269\u80fd\u9577\u671f\u5b58\u6d3b\uff0c\u8178\u9053\u83cc\u53e2\u7684\u7d30\u83cc\u8907\u96dc\u6027\u6975\u9ad8\uff0c\u5206\u6790\u8d77\u4f86\u76f8\u7576\u982d\u75bc\u3002\u5e78\u597d\u6709\u62dc DNA \u5b9a\u5e8f\u6280\u8853\u7684\u9032\u6b65\uff0c\u900f\u904e\u6563\u5f48\u69cd\u5b9a\u5e8f\u6cd5 (shotgun sequencing)\uff0c\u5c07 DNA \u6253\u6210\u6578\u4ee5\u842c\u8a08\u7684\u6838\u7518\u9178\u7247\u6bb5\u5f8c\u9032\u884c\u5b9a\u5e8f\uff0c\u518d\u8207\u5e8f\u5217\u8cc7\u6599\u5eab (database) \u9032\u884c\u6bd4\u5c0d\uff0c\u85c9\u6b64\u78ba\u8a8d\u5fae\u751f\u7269\u7684\u7d44\u6210\u3002\u6b64\u65b9\u6cd5\u5728\u5b78\u8853\u4e0a\u7a31\u70ba\u7e3d\u9ad4\u57fa\u56e0\u9ad4\u5b78 (metagenomics)\uff0c\u80fd\u5728\u6975\u77ed\u6642\u9593\u5167\u63d0\u4f9b\u5de8\u91cf\u53ca\u5168\u9762\u7684\u8cc7\u8a0a\u3002<\/p>\n

\u25cf\u5927\u8178\u76f4\u8178\u764c\u60a3\u8005<\/strong>\u7684<\/strong>\u8178\u9053\u83cc\u53e2<\/strong>\u7279\u5fb5<\/strong><\/span><\/p>\n

Nature Medicine<\/em> \u6700\u8fd1\u520a\u767b\u7684\u5169\u7bc7\u8178\u9053\u83cc\u53e2\u7814\u7a76\uff0c\u5718\u968a\u7d44\u54e1\u4e92\u6709\u91cd\u758a\uff0c\u5206\u5225\u7531\u5fb7\u570b\u7684\u6b50\u6d32\u5206\u5b50\u751f\u7269\u5b78\u5be6\u9a57\u5ba4 (EMBL) \u53ca\u7fa9\u5927\u5229\u7279\u502b\u6258\u5927\u5b78 (University of Trento) \u6240\u4e3b\u5c0e\u3002\u56ca\u62ec\u7684\u7cde\u4fbf\u6aa2\u9ad4\u8cc7\u6599\u5eab\u6a6b\u8de8\u6b50\u6d32\u3001\u7f8e\u6d32\u53ca\u4e9e\u6d32\uff0c\u570b\u5bb6\u5305\u542b\u5fb7\u570b\u3001\u7f8e\u570b\u3001\u52a0\u62ff\u5927\u3001\u7fa9\u5927\u5229\u3001\u5967\u5730\u5229\u3001\u6cd5\u570b\u3001\u4e2d\u570b\u3001\u65e5\u672c\uff0c\u53ef\u582a\u7a31\u662f\u8fc4\u4eca\u70ba\u6b62\u898f\u6a21\u6700\u5927\u7684\u76f8\u95dc\u7814\u7a76\u3002\u4e3b\u8981\u539f\u56e0\u662f\u79d1\u5b78\u5bb6\u5e0c\u671b\uff0c\u85c9\u6b64\u627e\u51fa\u7684\u8178\u9053\u83cc\u53e2\u7279\u5fb5\u70ba\u666e\u904d\u5b58\u5728\u7684\uff0c\u4e26\u4e14\u8207\u5730\u7406\u3001\u6587\u5316\u548c\u751f\u6d3b\u65b9\u5f0f\u7121\u95dc\u3002<\/p>\n

\u5169\u7bc7\u7814\u7a76\u90fd\u662f\u904b\u7528\u7e3d\u9ad4\u57fa\u56e0\u9ad4\u5b78 (\u4f46\u7d30\u7bc0\u65b9\u6cd5\u4e0d\u540c)\uff0c\u5404\u5225\u5206\u6790\u51fa\u5927\u8178\u76f4\u8178\u764c\u60a3\u8005\u8178\u9053\u4e2d\u7279\u5225\u5e38\u51fa\u73fe\u7684\u83cc\u7a2e\uff0c\u4e5f\u7372\u5f97\u76f8\u4f3c\u7684\u7d50\u8ad6\u300c\u60a3\u8005\u8178\u9053\u83cc\u53e2\u7684\u8c50\u5bcc\u5ea6\u660e\u986f\u9ad8\u65bc\u5065\u5eb7\u8178\u9053\u300d\u9019\u610f\u6307\u60a3\u8005\u8178\u9053\u4e2d\u7684\u7d30\u83cc\u7a2e\u985e\u66f4\u70ba\u8907\u96dc\u3002\u4e26\u4e14\u4e5f\u767c\u73fe\u4e86\u8207\u904e\u53bb\u6587\u737b\u4e00\u81f4\u7684\u7d50\u679c\uff0c\u60a3\u8005\u8178\u9053\u7684\u5177\u6838\u68ad\u687f\u83cc (Fusobacterium nucleatum<\/em>) \u660e\u986f\u9ad8\u65bc\u5065\u5eb7\u8005\uff0c\u9019\u901a\u5e38\u662f\u5b58\u5728\u4eba\u9ad4\u53e3\u8154\u7684\u7d30\u83cc\uff0c\u4e26\u4e14\u60a3\u8005\u8178\u9053\u4e2d\u51fa\u73fe\u5176\u4ed6\u53e3\u8154\u7d30\u83cc\u6a5f\u6703\u4e5f\u6bd4\u8f03\u9ad8\uff0c\u4f46\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u53e3\u8154\u7d30\u83cc\u9077\u79fb\u5230\u8178\u9053\u7684\u539f\u56e0\u3002<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u5728\u5927\u8178\u76f4\u8178\u764c\u60a3\u8005\u7684\u7cde\u4fbf\u6aa2\u9ad4\u4e2d\uff0c\u4e5f\u767c\u73fe\u5927\u91cf\u589e\u52a0\u4e86\u4e00\u7a2e\u5fae\u751f\u7269\u57fa\u56e0 CutC<\/em>\uff0c\u5176\u70ba\u4e00\u7a2e\u81bd\u9e7c\u89e3\u96e2\u9176 (choline trimethylamine-lyase) \u7684\u57fa\u56e0\uff0c\u9019\u7a2e\u9176\u5728\u5206\u89e3\u98df\u7269\u4e2d\u7684\u81bd\u9e7c\u6642\uff0c\u6703\u91cb\u653e\u51fa\u300c\u4e59\u919b\u300d\u6b64\u4e00\u81f4\u764c\u7269\u8cea\uff0c\u9593\u63a5\u8b49\u5be6\u4e86\u8178\u9053\u83cc\u53e2\u8207\u5927\u8178\u76f4\u8178\u764c\u53ef\u80fd\u5b58\u5728\u7684\u81f4\u75c5\u6a5f\u5236\u3002<\/p>\n

\u25cf\u8178\u9053\u83cc\u53e2<\/strong>\u53ef\u4f5c\u70ba\u7be9\u6aa2\u5927\u8178\u76f4\u8178\u764c\u7684\u975e\u4fb5\u5165\u6027\u8a3a\u65b7\u5de5\u5177<\/strong><\/span><\/p>\n

\u4e16\u754c\u5404\u6c11\u65cf\u7684\u50b3\u8aaa\u6545\u4e8b\u4e2d\uff0c\u5e38\u5e38\u6709\u4e00\u689d\u901a\u884c\u898f\u5247\uff0c\u7576\u5996\u9b54\u9b3c\u602a\u51fa\u73fe\u7684\u6642\u5019\uff0c\u5047\u5982\u4f60\u80fd\u53eb\u51fa\u5b83\u7684\u300c\u540d\u5b57\u300d\uff0c\u5176\u9b54\u529b\u5c31\u6703\u6e1b\u640d\u5927\u534a\u6216\u751a\u81f3\u5b8c\u5168\u55aa\u5931\u3002\u76f8\u540c\u7684\u908f\u8f2f\uff0c\u7576\u7814\u7a76\u5206\u6790\u51fa\u764c\u75c7\u7684\u300c\u8178\u9053\u83cc\u53e2\u7279\u5fb5\u300d\uff0c\u5c31\u50cf\u662f\u80fd\u53eb\u51fa\u505a\u58de\u4e8b\u7684\u300c\u7d30\u83cc\u540d\u5b57\u300d\uff0c\u53ef\u4ee5\u9810\u671f\u91ab\u5b78\u7684\u4e0b\u4e00\u6b65\u5c31\u662f\u964d\u4f4e\u5927\u8178\u76f4\u8178\u764c\u5c0d\u4eba\u985e\u7684\u5f71\u97ff\u3002<\/p>\n

\u9019\u4e9b\u7814\u7a76\u6210\u679c\uff0c\u5df2\u53ef\u4f5c\u70ba\u5927\u8178\u76f4\u8178\u764c\u975e\u4fb5\u5165\u6027\u7be9\u6aa2\u7684\u57fa\u790e\uff0c\u4f46\u5982\u679c\u80fd\u9032\u4e00\u6b65\u53d6\u5f97\u8178\u9053\u83cc\u53e2\u5c0d\u764c\u75c7\u5f62\u6210\u7684\u76f4\u63a5\u8b49\u64da\uff0c\u6216\u8a31\u8178\u9053\u83cc\u53e2\u5c31\u80fd\u6210\u70ba\u9810\u9632\u6216\u6cbb\u7642\u7684\u6a19\u9776\uff0c\u56e0\u70ba\u8178\u9053\u5167\u7684\u7d30\u83cc\u662f\u53ef\u4ee5\u901a\u904e\u98f2\u98df\u52a0\u4ee5\u63a7\u5236\u7684\u3002<\/p>\n

\u5be6\u969b\u4e0a\u61c9\u5766\u8aa0\u7684\u662f\uff0c\u91ab\u5b78\u5c0d\u65bc\u8178\u9053\u83cc\u53e2\u4ecd\u77e5\u4e4b\u751a\u5c11\uff0c\u96d6\u7136\u73fe\u5728\u53ef\u4ee5\u8b58\u5225\u5927\u8178\u76f4\u8178\u764c\u7684\u8178\u9053\u83cc\u53e2\u7279\u5fb5\uff0c\u4f46\u662f\u9084\u4e0d\u77e5\u9053\u9019\u4e9b\u5fae\u751f\u7269\u4f86\u81ea\u54ea\u88e1\uff1f\u4ee5\u53ca\u5982\u4f55\u4f5c\u7528\uff1f\u6700\u5f8c\u5fc5\u9808\u5f37\u8abf\u7684\u662f\uff0c\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u4e26\u6c92\u6709\u986f\u793a\u8178\u9053\u83cc\u53e2\u7684\u6539\u8b8a\u6703\u76f4\u63a5\u5c0e\u81f4\u5927\u8178\u76f4\u8178\u764c\uff0c\u95dc\u806f\u6027\u4e26\u4e0d\u7b49\u65bc\u6709\u56e0\u679c\u95dc\u4fc2\uff0c\u672a\u4f86\u9084\u6709\u4e0d\u5c11\u5de5\u4f5c\u7b49\u8457\u79d1\u5b78\u5bb6\u52a0\u4ee5\u8b49\u5be6\u3002<\/p>\n

 <\/p>\n

\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n

    \n
  1. Thomas AM, et al. Nat Med. 2019 Apr;25(4):667-678. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.<\/a><\/li>\n
  2. Wirbel J, et al. Nat Med. 2019 Apr;25(4):679-689. Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.<\/a><\/li>\n
  3. Cresci GA, et al. Nutr Clin Pract. 2015 Dec;30(6):734-46. Gut Microbiome: What We Do and Don't Know.<\/a><\/li>\n
  4. Craciun S, et al. ACS Chem Biol. 2014 Jul 18;9(7):1408-13. Characterization of choline trimethylamine-lyase expands the chemistry of glycyl radical enzymes.<\/a><\/li>\n<\/ol>\n

    --
    \n\u4f5c\u8005<\/span>\uff1a\u694a\u671d\u5091  \u6210\u5927\u5fae\u514d\u6240\u78a9\u58eb\uff0c\u66fe\u8457\u6709\u300a\u5716\u89e3\u91ab\u5b78\u300b\u4e00\u66f8\uff0c\u6a02\u65bc\u5c07\u91ab\u5b78\u65b0\u77e5\u4ee5\u6dfa\u767d\u7684<\/span>\u6587\u5b57\u8b93\u66f4\u591a\u4eba\u4e86\u89e3\u3002<\/strong><\/p>\n

     <\/p>\n

    \"\u52a0\u5165\u597d\u53cb\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    \u5e02\u9762\u4e0a\u5145\u65a5\u8457\u8033\u719f\u80fd\u8a73\u7684\u300c\u589e\u52a0\u8178\u9053\u597d\u83cc\u300d\u5404\u7a2e\u5546\u54c1\uff0c\u800c\u8178\u9053\u83cc\u53e2 (gut microbiome) \u8207\u75be\u75c5\u7684\u95dc\u806f\u4e5f\u662f\u8fd1\u5e74\u6b63\u592f\u7684\u7814\u7a76\u4e3b\u984c\u30022019 \u5e74 4 \u6708 Nature Medicine \u66f4\u662f\u540c\u6642\u520a\u767b\u4e86\u5169\u7bc7\u76f8\u95dc\u7814\u7a76\uff0c\u8fa8\u8b58\u51fa\u5927\u8178\u76f4\u8178\u764c (colorectal cancer) \u60a3\u8005\u7684\u8178\u9053\u83cc\u53e2\u7279\u5fb5\uff0c\u672a\u4f86\u80fd\u9032\u4e00\u6b65\u767c\u5c55\u51fa\uff0c\u85c9\u7531\u5206\u6790\u7cde\u4fbf\u4e2d\u7684\u7d30\u83cc\u5c31\u80fd\u9810\u6e2c\u5927\u8178\u76f4\u8178\u764c\u7684\u81e8\u5e8a\u8a3a\u65b7\u5de5\u5177\u3002<\/p>\n","protected":false},"author":20,"featured_media":33982,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3293,1025],"tags":[4256,4255,4257,4253,4254,3957],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/case.ntu.edu.tw\/blog\/wp-content\/uploads\/2019\/04\/anatomy-160524_1280.png","_links":{"self":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33981"}],"collection":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33981"}],"version-history":[{"count":3,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33981\/revisions"}],"predecessor-version":[{"id":34093,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/posts\/33981\/revisions\/34093"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=\/wp\/v2\/media\/33982"}],"wp:attachment":[{"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=33981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/case.ntu.edu.tw\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=33981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}